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Protein

Type III pantothenate kinase

Gene

coaX

Organism
Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.UniRule annotation

Catalytic activityi

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.UniRule annotation

Cofactori

NH4(+)UniRule annotation, K+UniRule annotationNote: A monovalent cation. Ammonium or potassium.UniRule annotation

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Type III pantothenate kinase (coaX)
  2. Coenzyme A biosynthesis bifunctional protein CoaBC (Dfp)
  3. Coenzyme A biosynthesis bifunctional protein CoaBC (Dfp)
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei100SubstrateUniRule annotation1
Active sitei109Proton acceptorUniRule annotation1
Metal bindingi129Monovalent cationUniRule annotation1
Binding sitei132ATPUniRule annotation1
Binding sitei184SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi6 – 13ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processCoenzyme A biosynthesis
LigandATP-binding, Metal-binding, Nucleotide-binding, Potassium

Enzyme and pathway databases

BioCyciTTEN273068:G1FZJ-2502-MONOMER
UniPathwayiUPA00241; UER00352

Names & Taxonomyi

Protein namesi
Recommended name:
Type III pantothenate kinaseUniRule annotation (EC:2.7.1.33UniRule annotation)
Alternative name(s):
PanK-IIIUniRule annotation
Pantothenic acid kinaseUniRule annotation
Gene namesi
Name:coaXUniRule annotation
Ordered Locus Names:TTE2381
OrganismiCaldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis)
Taxonomic identifieri273068 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCaldanaerobacter
Proteomesi
  • UP000000555 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002675961 – 255Type III pantothenate kinaseAdd BLAST255

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi273068.TTE2381

Structurei

3D structure databases

ProteinModelPortaliQ8R7M2
SMRiQ8R7M2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni107 – 110Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the type III pantothenate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CGM Bacteria
COG1521 LUCA
HOGENOMiHOG000066025
KOiK03525
OMAiHEPWLTL
OrthoDBiPOG091H01V7

Family and domain databases

HAMAPiMF_01274 Pantothen_kinase_3, 1 hit
InterProiView protein in InterPro
IPR004619 Type_III_PanK
PANTHERiPTHR34265 PTHR34265, 1 hit
PfamiView protein in Pfam
PF03309 Pan_kinase, 1 hit
TIGRFAMsiTIGR00671 baf, 1 hit

Sequencei

Sequence statusi: Complete.

Q8R7M2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLAFDVGNT NIVMGVFKGK KLLHSFRIST DKNKTYDEYG MLVNQLIGYN
60 70 80 90 100
GISLTEIDDV IISSVVPPLM NTLQVMSLKY FRTKPIVVGP GIKTGINIKY
110 120 130 140 150
DNPKEVGADR IVNAVAAYEL YGGPVIVIDF GTATTFCAIS EKGEYLGGII
160 170 180 190 200
APGLMISADA LFQRTAKLPK IDLTKPPTVI NRNTVASMQS GIIYGHVGMV
210 220 230 240 250
DYIVTRMKGE FAPSAYVVAT GGFANMIAEE SKTIDTVNEM LTLEGLRIIY

ERNKE
Length:255
Mass (Da):27,816
Last modified:June 1, 2002 - v1
Checksum:iC3C620ECBC8CA6ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008691 Genomic DNA Translation: AAM25520.1
RefSeqiWP_009611077.1, NC_003869.1

Genome annotation databases

EnsemblBacteriaiAAM25520; AAM25520; TTE2381
KEGGitte:TTE2381

Similar proteinsi

Entry informationi

Entry nameiCOAX_CALS4
AccessioniPrimary (citable) accession number: Q8R7M2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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