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Q8R7L3

- FTHS_CALS4

UniProt

Q8R7L3 - FTHS_CALS4

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:TTE2391
OrganismiCaldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis)
Taxonomic identifieri273068 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCaldanaerobacter
ProteomesiUP000000555: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555Formate--tetrahydrofolate ligasePRO_0000199402Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273068.TTE2391.

Structurei

3D structure databases

ProteinModelPortaliQ8R7L3.
SMRiQ8R7L3. Positions 4-553.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiQLRYIND.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R7L3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKSDIEIAQE AKMLHIRDVA AKLGIEEDYL EYYGKYKAKI SPALWDKIKD
60 70 80 90 100
RKDGKLILVT AITPTPAGEG KTTTTVGLGQ ALAKLGKKAM IALREPSLGP
110 120 130 140 150
SFGIKGGAAG GGYSQVVPME DINLHFTGDI HAITAAHNLL AAMIDNHIHH
160 170 180 190 200
GNELNIDIRT ITWKRAMDMN DRALREIIVG LGGKANGYPR QDGFIITVAS
210 220 230 240 250
EIMAILCLSH DLMDLKRRLG DIIVAYDKDG SPVTARDLKA DGAMAVLLKD
260 270 280 290 300
AIKPNLVQTI ENVPAFVHGG PFANIAHGCN SLIATKYGLK LADYLVTEAG
310 320 330 340 350
FGADLGAEKF FDVKARFGGL TPNAAVVVAT VRALKMHGGV KKEDLQKEDV
360 370 380 390 400
EAVRRGIENL EKQVENVRKF GVPVVVALNK FVFDTEREIE EVRKACDRIG
410 420 430 440 450
VDMAVAEVWE KGGEGGIELA EKVIKAADTP SNFRFLYDVN LPIKDKLHII
460 470 480 490 500
ATEIYGADGV EYTASALKDI ANIEKLGLDK MPIVVAKTQY SLSDDPKLLG
510 520 530 540 550
RPRGFKITVR ELRISRGAGF IVALTGDIMT MPGLPKHPAA ENIDIDENGR

IKGLF
Length:555
Mass (Da):60,247
Last modified:June 1, 2002 - v1
Checksum:i17A21E989373C6A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008691 Genomic DNA. Translation: AAM25530.1.
RefSeqiNP_623926.1. NC_003869.1.

Genome annotation databases

EnsemblBacteriaiAAM25530; AAM25530; TTE2391.
GeneIDi997359.
KEGGitte:TTE2391.
PATRICi23899517. VBITheTen82880_2381.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008691 Genomic DNA. Translation: AAM25530.1 .
RefSeqi NP_623926.1. NC_003869.1.

3D structure databases

ProteinModelPortali Q8R7L3.
SMRi Q8R7L3. Positions 4-553.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273068.TTE2391.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM25530 ; AAM25530 ; TTE2391 .
GeneIDi 997359.
KEGGi tte:TTE2391.
PATRICi 23899517. VBITheTen82880_2381.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi QLRYIND.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 15242 / JCM 11007 / NBRC 100824 / MB4.

Entry informationi

Entry nameiFTHS_CALS4
AccessioniPrimary (citable) accession number: Q8R7L3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 2002
Last modified: October 29, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3