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Q8R7L3

- FTHS_THETN

UniProt

Q8R7L3 - FTHS_THETN

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Protein

Formate--tetrahydrofolate ligase

Gene
fhs, TTE2391
Organism
Thermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Caldanaerobacter subterraneus subsp. tengcongensis)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:TTE2391
OrganismiThermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Caldanaerobacter subterraneus subsp. tengcongensis)
Taxonomic identifieri273068 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCaldanaerobacter
ProteomesiUP000000555: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555Formate--tetrahydrofolate ligaseUniRule annotationPRO_0000199402Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273068.TTE2391.

Structurei

3D structure databases

ProteinModelPortaliQ8R7L3.
SMRiQ8R7L3. Positions 4-553.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiQLRYIND.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R7L3-1 [UniParc]FASTAAdd to Basket

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MKSDIEIAQE AKMLHIRDVA AKLGIEEDYL EYYGKYKAKI SPALWDKIKD    50
RKDGKLILVT AITPTPAGEG KTTTTVGLGQ ALAKLGKKAM IALREPSLGP 100
SFGIKGGAAG GGYSQVVPME DINLHFTGDI HAITAAHNLL AAMIDNHIHH 150
GNELNIDIRT ITWKRAMDMN DRALREIIVG LGGKANGYPR QDGFIITVAS 200
EIMAILCLSH DLMDLKRRLG DIIVAYDKDG SPVTARDLKA DGAMAVLLKD 250
AIKPNLVQTI ENVPAFVHGG PFANIAHGCN SLIATKYGLK LADYLVTEAG 300
FGADLGAEKF FDVKARFGGL TPNAAVVVAT VRALKMHGGV KKEDLQKEDV 350
EAVRRGIENL EKQVENVRKF GVPVVVALNK FVFDTEREIE EVRKACDRIG 400
VDMAVAEVWE KGGEGGIELA EKVIKAADTP SNFRFLYDVN LPIKDKLHII 450
ATEIYGADGV EYTASALKDI ANIEKLGLDK MPIVVAKTQY SLSDDPKLLG 500
RPRGFKITVR ELRISRGAGF IVALTGDIMT MPGLPKHPAA ENIDIDENGR 550
IKGLF 555
Length:555
Mass (Da):60,247
Last modified:June 1, 2002 - v1
Checksum:i17A21E989373C6A6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008691 Genomic DNA. Translation: AAM25530.1.
RefSeqiNP_623926.1. NC_003869.1.

Genome annotation databases

EnsemblBacteriaiAAM25530; AAM25530; TTE2391.
GeneIDi997359.
KEGGitte:TTE2391.
PATRICi23899517. VBITheTen82880_2381.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008691 Genomic DNA. Translation: AAM25530.1 .
RefSeqi NP_623926.1. NC_003869.1.

3D structure databases

ProteinModelPortali Q8R7L3.
SMRi Q8R7L3. Positions 4-553.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273068.TTE2391.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM25530 ; AAM25530 ; TTE2391 .
GeneIDi 997359.
KEGGi tte:TTE2391.
PATRICi 23899517. VBITheTen82880_2381.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi QLRYIND.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 15242 / JCM 11007 / NBRC 100824 / MB4.

Entry informationi

Entry nameiFTHS_THETN
AccessioniPrimary (citable) accession number: Q8R7L3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 2002
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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