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Q8R7L3 (FTHS_THETN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:TTE2391
OrganismThermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Caldanaerobacter subterraneus subsp. tengcongensis) [Complete proteome] [HAMAP]
Taxonomic identifier273068 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCaldanaerobacter

Protein attributes

Sequence length555 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 555555Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000199402

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8R7L3 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 17A21E989373C6A6

FASTA55560,247
        10         20         30         40         50         60 
MKSDIEIAQE AKMLHIRDVA AKLGIEEDYL EYYGKYKAKI SPALWDKIKD RKDGKLILVT 

        70         80         90        100        110        120 
AITPTPAGEG KTTTTVGLGQ ALAKLGKKAM IALREPSLGP SFGIKGGAAG GGYSQVVPME 

       130        140        150        160        170        180 
DINLHFTGDI HAITAAHNLL AAMIDNHIHH GNELNIDIRT ITWKRAMDMN DRALREIIVG 

       190        200        210        220        230        240 
LGGKANGYPR QDGFIITVAS EIMAILCLSH DLMDLKRRLG DIIVAYDKDG SPVTARDLKA 

       250        260        270        280        290        300 
DGAMAVLLKD AIKPNLVQTI ENVPAFVHGG PFANIAHGCN SLIATKYGLK LADYLVTEAG 

       310        320        330        340        350        360 
FGADLGAEKF FDVKARFGGL TPNAAVVVAT VRALKMHGGV KKEDLQKEDV EAVRRGIENL 

       370        380        390        400        410        420 
EKQVENVRKF GVPVVVALNK FVFDTEREIE EVRKACDRIG VDMAVAEVWE KGGEGGIELA 

       430        440        450        460        470        480 
EKVIKAADTP SNFRFLYDVN LPIKDKLHII ATEIYGADGV EYTASALKDI ANIEKLGLDK 

       490        500        510        520        530        540 
MPIVVAKTQY SLSDDPKLLG RPRGFKITVR ELRISRGAGF IVALTGDIMT MPGLPKHPAA 

       550 
ENIDIDENGR IKGLF 

« Hide

References

[1]"A complete sequence of the T. tengcongensis genome."
Bao Q., Tian Y., Li W., Xu Z., Xuan Z., Hu S., Dong W., Yang J., Chen Y., Xue Y., Xu Y., Lai X., Huang L., Dong X., Ma Y., Ling L., Tan H., Chen R. expand/collapse author list , Wang J., Yu J., Yang H.
Genome Res. 12:689-700(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 15242 / JCM 11007 / NBRC 100824 / MB4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE008691 Genomic DNA. Translation: AAM25530.1.
RefSeqNP_623926.1. NC_003869.1.

3D structure databases

ProteinModelPortalQ8R7L3.
SMRQ8R7L3. Positions 4-553.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273068.TTE2391.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM25530; AAM25530; TTE2391.
GeneID997359.
KEGGtte:TTE2391.
PATRIC23899517. VBITheTen82880_2381.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMAQLRYIND.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_THETN
AccessionPrimary (citable) accession number: Q8R7L3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 2002
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways