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Q8R7L3

- FTHS_THETN

UniProt

Q8R7L3 - FTHS_THETN

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Thermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Caldanaerobacter subterraneus subsp. tengcongensis)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:TTE2391
    OrganismiThermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Caldanaerobacter subterraneus subsp. tengcongensis)
    Taxonomic identifieri273068 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCaldanaerobacter
    ProteomesiUP000000555: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 555555Formate--tetrahydrofolate ligasePRO_0000199402Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi273068.TTE2391.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8R7L3.
    SMRiQ8R7L3. Positions 4-553.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiQLRYIND.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8R7L3-1 [UniParc]FASTAAdd to Basket

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    MKSDIEIAQE AKMLHIRDVA AKLGIEEDYL EYYGKYKAKI SPALWDKIKD    50
    RKDGKLILVT AITPTPAGEG KTTTTVGLGQ ALAKLGKKAM IALREPSLGP 100
    SFGIKGGAAG GGYSQVVPME DINLHFTGDI HAITAAHNLL AAMIDNHIHH 150
    GNELNIDIRT ITWKRAMDMN DRALREIIVG LGGKANGYPR QDGFIITVAS 200
    EIMAILCLSH DLMDLKRRLG DIIVAYDKDG SPVTARDLKA DGAMAVLLKD 250
    AIKPNLVQTI ENVPAFVHGG PFANIAHGCN SLIATKYGLK LADYLVTEAG 300
    FGADLGAEKF FDVKARFGGL TPNAAVVVAT VRALKMHGGV KKEDLQKEDV 350
    EAVRRGIENL EKQVENVRKF GVPVVVALNK FVFDTEREIE EVRKACDRIG 400
    VDMAVAEVWE KGGEGGIELA EKVIKAADTP SNFRFLYDVN LPIKDKLHII 450
    ATEIYGADGV EYTASALKDI ANIEKLGLDK MPIVVAKTQY SLSDDPKLLG 500
    RPRGFKITVR ELRISRGAGF IVALTGDIMT MPGLPKHPAA ENIDIDENGR 550
    IKGLF 555
    Length:555
    Mass (Da):60,247
    Last modified:June 1, 2002 - v1
    Checksum:i17A21E989373C6A6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008691 Genomic DNA. Translation: AAM25530.1.
    RefSeqiNP_623926.1. NC_003869.1.

    Genome annotation databases

    EnsemblBacteriaiAAM25530; AAM25530; TTE2391.
    GeneIDi997359.
    KEGGitte:TTE2391.
    PATRICi23899517. VBITheTen82880_2381.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008691 Genomic DNA. Translation: AAM25530.1 .
    RefSeqi NP_623926.1. NC_003869.1.

    3D structure databases

    ProteinModelPortali Q8R7L3.
    SMRi Q8R7L3. Positions 4-553.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273068.TTE2391.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM25530 ; AAM25530 ; TTE2391 .
    GeneIDi 997359.
    KEGGi tte:TTE2391.
    PATRICi 23899517. VBITheTen82880_2381.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi QLRYIND.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 15242 / JCM 11007 / NBRC 100824 / MB4.

    Entry informationi

    Entry nameiFTHS_THETN
    AccessioniPrimary (citable) accession number: Q8R7L3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3