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Protein

Hypoxanthine phosphoribosyltransferase

Gene

Hpt

Organism
Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: IMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes IMP from hypoxanthine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Hypoxanthine phosphoribosyltransferase (Hpt)
This subpathway is part of the pathway IMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes IMP from hypoxanthine, the pathway IMP biosynthesis via salvage pathway and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi7CalciumCombined sources1
Metal bindingi135CalciumCombined sources1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotationImported, Transferase
Biological processPurine salvageUniRule annotation
LigandCalciumCombined sources, MagnesiumUniRule annotation, Metal-bindingUniRule annotationCombined sources, Nucleotide-bindingUniRule annotation

Enzyme and pathway databases

BRENDAi2.4.2.8. 6784.
SABIO-RKiQ8R7L0.
UniPathwayiUPA00591; UER00648.

Names & Taxonomyi

Protein namesi
Recommended name:
Hypoxanthine phosphoribosyltransferaseUniRule annotation (EC:2.4.2.8UniRule annotation)
Gene namesi
Name:HptImported
Ordered Locus Names:TTE2394Imported
OrganismiCaldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis)Imported
Taxonomic identifieri273068 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCaldanaerobacter
Proteomesi
  • UP000000555 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Proteomic databases

PRIDEiQ8R7L0.

Interactioni

Protein-protein interaction databases

STRINGi273068.TTE2394.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1R3UX-ray2.50A/B1-181[»]
1YFZX-ray2.20A/B1-181[»]
2GEBX-ray1.70A1-181[»]
ProteinModelPortaliQ8R7L0.
SMRiQ8R7L0.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8R7L0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 162PribosyltranInterPro annotationAdd BLAST147

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UGV. Bacteria.
COG0634. LUCA.
HOGENOMiHOG000236520.
KOiK00760.
OMAiTMDWMAV.
OrthoDBiPOG091H02F3.

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
InterProiView protein in InterPro
IPR005904. Hxn_phspho_trans.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
PfamiView protein in Pfam
PF00156. Pribosyltran. 1 hit.
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01203. HGPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8R7L0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSPMEDIEE ILITEEQLKA KVKELGEMIT RDYEGKDLVL IGVLKGAIMF
60 70 80 90 100
MSDLSRAIDL PLSIDFMAVS SYGSSTKSSG IVKIIKDHDI DIEGKDVLIV
110 120 130 140 150
EDIIDSGLTL AYLRETLLGR KPRSLKICTI LDKPERREAD VKVDYCGFKI
160 170 180
PDKFVVGYGL DYAEKYRNLP FIGVLKPELY K
Length:181
Mass (Da):20,379
Last modified:June 1, 2002 - v1
Checksum:i4B9907E434A093E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008691 Genomic DNA. Translation: AAM25533.1.
RefSeqiWP_011026425.1. NC_003869.1.

Genome annotation databases

EnsemblBacteriaiAAM25533; AAM25533; TTE2394.
KEGGitte:TTE2394.

Similar proteinsi

Entry informationi

Entry nameiQ8R7L0_CALS4
AccessioniPrimary (citable) accession number: Q8R7L0
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: November 22, 2017
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported