Q8R7L0 (Q8R7L0_THETN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Hypoxanthine-guanine phosphoribosyltransferase EMBL AAM25533.1

Gene names

Name:	Hpt EMBL AAM25533.1
Ordered Locus Names:	TTE2394

Organism

Thermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Caldanaerobacter subterraneus subsp. tengcongensis) [Complete proteome] [HAMAP]

Taxonomic identifier

273068 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacteriaceae › Caldanaerobacter

Protein attributes

Sequence length	181 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Molecular function	Glycosyltransferase EMBL AAM25533.1 Transferase
Technical term	3D-structure PDB 2GEB PDB 1R3U PDB 1YFZ Complete proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside salvage Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	hypoxanthine phosphoribosyltransferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8R7L0 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 4B9907E434A093E8	FASTA	181	20,379
	10 20 30 40 50 60 MPSPMEDIEE ILITEEQLKA KVKELGEMIT RDYEGKDLVL IGVLKGAIMF MSDLSRAIDL 70 80 90 100 110 120 PLSIDFMAVS SYGSSTKSSG IVKIIKDHDI DIEGKDVLIV EDIIDSGLTL AYLRETLLGR 130 140 150 160 170 180 KPRSLKICTI LDKPERREAD VKVDYCGFKI PDKFVVGYGL DYAEKYRNLP FIGVLKPELY K

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A complete sequence of the T. tengcongensis genome." Bao Q., Tian Y., Li W., Xu Z., Xuan Z., Hu S., Dong W., Yang J., Chen Y., Xue Y., Xu Y., Lai X., Huang L., Dong X., Ma Y., Ling L., Tan H., Chen R. , Wang J., Yu J., Yang H. Genome Res. 12:689-700(2002) [PubMed: 11997336] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 15242 / JCM 11007 / NBRC 100824 / MB4.
[2]	"Alternative IMP binding in feedback inhibition of hypoxanthine-guanine phosphoribosyltransferase from Thermoanaerobacter tengcongensis." Chen Q., Liang Y., Su X., Gu X., Zheng X., Luo M. J. Mol. Biol. 348:1199-1210(2005) [PubMed: 15854655] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS).
[3]	"Crystal structure of Thermoanaerobacter tengcongensis hypoxanthine-guanine phosphoribosyl transferase L160I mutant--insights into inhibitor design." Chen Q., You D., Liang Y., Su X., Gu X., Luo M., Zheng X. FEBS J. 274:4408-4415(2007) [PubMed: 17662107] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS).
[4]	"Crystal Structure of Hypoxanthine-Guanine Phosphoribosyltransferase from Thermoanaerobacter tengcongensis." Chen Q., Liang Y.H., GU X.C., LUO M., SU X.D. Submitted (OCT-2003) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS).
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE008691 Genomic DNA. Translation: AAM25533.1.

RefSeq

NP_623929.1. NC_003869.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1R3U	X-ray	2.50	A/B	1-181	[»]
1YFZ	X-ray	2.20	A/B	1-181	[»]
2GEB	X-ray	1.70	A	1-181	[»]

ProteinModelPortal

Q8R7L0.

SMR

Q8R7L0. Positions 1-180.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

997357.

GenomeReviews

Gene locus TTE2394 in contig AE008691_GR.

KEGG

tte:TTE2394.

NMPDR

fig|273068.3.peg.2570.

PATRIC

23899523. VBITheTen82880_2384.

Organism-specific databases

CMR

Search...

Phylogenomic databases

HOGENOM

HBG536385.

OMA

INAHYAD.

ProtClustDB

CLSK901684.

Enzyme and pathway databases

BioCyc

TTEN273068:TTE2394-MONOMER.

BRENDA

2.4.2.8. 276887.

Family and domain databases

InterPro

IPR005904. Hxn_phspho_trans.
IPR000836. PRibTrfase.
[Graphical view]

KO

K00760.

Pfam

PF00156. Pribosyltran. 1 hit.
[Graphical view]

TIGRFAMs

TIGR01203. HGPRTase. 1 hit.

ProtoNet

Search...

Entry information

Entry name

Q8R7L0_THETN

Accession

Primary (citable) accession number: Q8R7L0

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2002
Last sequence update:	June 1, 2002
Last modified:	December 14, 2011
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)