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Q8R7C2

- ASSY_CALS4

UniProt

Q8R7C2 - ASSY_CALS4

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Protein

Argininosuccinate synthase

Gene

argG

Organism
Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei88 – 881CitrullineUniRule annotation
Binding sitei93 – 931CitrullineUniRule annotation
Binding sitei118 – 1181ATP; via amide nitrogenUniRule annotation
Binding sitei120 – 1201AspartateUniRule annotation
Binding sitei124 – 1241AspartateUniRule annotation
Binding sitei124 – 1241CitrullineUniRule annotation
Binding sitei125 – 1251AspartateUniRule annotation
Binding sitei128 – 1281CitrullineUniRule annotation
Binding sitei177 – 1771CitrullineUniRule annotation
Binding sitei186 – 1861CitrullineUniRule annotation
Binding sitei262 – 2621CitrullineUniRule annotation
Binding sitei274 – 2741CitrullineUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATPUniRule annotation

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:TTE2494
OrganismiCaldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis)
Taxonomic identifieri273068 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCaldanaerobacter
ProteomesiUP000000555: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 410410Argininosuccinate synthasePRO_0000148659Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi273068.TTE2494.

Structurei

3D structure databases

ProteinModelPortaliQ8R7C2.
SMRiQ8R7C2. Positions 6-398.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiAPPEEAY.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R7C2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLKGEKVVLA YSGGLDTSVI IPWLKENYEC EIIAVCVDVG QREDLRYIKD
60 70 80 90 100
KALASGASKV YIEDVKEEFV KDYIFPTLKA GAIYEGKYLL GTSMARPLIA
110 120 130 140 150
KKLVEIAHKE GAKAIAHGAT GKGNDQVRFE VSIRALDPSI KIIAPWRIWE
160 170 180 190 200
LKSREDEIEY AKKKGIPIPV TKEKIYSVDS NLWHVSHEGG DLEDPWNEPK
210 220 230 240 250
SDIYDIVTPP EKVSDKPEYV YIEFEKGIPV KVNGKTLSPV KLIEELNEIG
260 270 280 290 300
GRNGVGIVDL VENRLVGMKS RGVYETPAGT LLYIAHRELE YLVLDKETMR
310 320 330 340 350
FKELVAQKYA DLVYNGLWFS PLKTALDAFI DETQKNVTGV VRLKLYKGNV
360 370 380 390 400
INAGAKSPYS LYNEEFATFG KDEVYNQKDA EGFINLFGLS LKIRALMEMG
410
RKDMDEAVGR
Length:410
Mass (Da):46,095
Last modified:June 1, 2002 - v1
Checksum:i617D9C1386268485
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008691 Genomic DNA. Translation: AAM25624.1.
RefSeqiNP_624020.1. NC_003869.1.

Genome annotation databases

EnsemblBacteriaiAAM25624; AAM25624; TTE2494.
GeneIDi996136.
KEGGitte:TTE2494.
PATRICi23899735. VBITheTen82880_2486.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008691 Genomic DNA. Translation: AAM25624.1 .
RefSeqi NP_624020.1. NC_003869.1.

3D structure databases

ProteinModelPortali Q8R7C2.
SMRi Q8R7C2. Positions 6-398.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273068.TTE2494.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM25624 ; AAM25624 ; TTE2494 .
GeneIDi 996136.
KEGGi tte:TTE2494.
PATRICi 23899735. VBITheTen82880_2486.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi APPEEAY.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 15242 / JCM 11007 / NBRC 100824 / MB4.

Entry informationi

Entry nameiASSY_CALS4
AccessioniPrimary (citable) accession number: Q8R7C2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: June 1, 2002
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3