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Q8R689 (OGG1_FUSNN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable N-glycosylase/DNA lyase

Including the following 2 domains:

  1. 8-oxoguanine DNA glycosylase
    EC=3.2.2.-
  2. DNA-(apurinic or apyrimidinic site) lyase
    Short name=AP lyase
    EC=4.2.99.18
Gene names
Name:ogg
Ordered Locus Names:FN0622
OrganismFusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131) [Reference proteome] [HAMAP]
Taxonomic identifier190304 [NCBI]
Taxonomic lineageBacteriaFusobacteriaFusobacterialesFusobacteriaceaeFusobacterium

Protein attributes

Sequence length217 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites) By similarity. HAMAP-Rule MF_00241

Catalytic activity

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. HAMAP-Rule MF_00241

Sequence similarities

Belongs to the type-2 OGG1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 217217Probable N-glycosylase/DNA lyase HAMAP-Rule MF_00241
PRO_0000159571

Sites

Active site1381 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8R689 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: EC7C01E5A616092B

FASTA21725,924
        10         20         30         40         50         60 
MKKNEYFNEI EKIYKEMSSH FKERLKEFKN IWENGTNKDI HLELSFCILT PQSKALNAWQ 

        70         80         90        100        110        120 
AITNLKKDDL IYNGKAEELV EFLNIVRFKN NKSKYLVELR EKMMKDGEII TKDFFNTLPT 

       130        140        150        160        170        180 
VAEKREWIVK NIKGMSYKEA SHFLRNVGFG ENIAILDRHI LRNLVKLEVI DELPKTLTPK 

       190        200        210 
LYLEIEEKMR DYCEFVKIPM DEMDLLLWYK EAGVIFK 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE009951 Genomic DNA. Translation: AAL94818.1.
RefSeqNP_603519.1. NC_003454.1.

3D structure databases

ProteinModelPortalQ8R689.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING190304.FN0622.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL94818; AAL94818; FN0622.
GeneID993235.
KEGGfnu:FN0622.
PATRIC21951007. VBIFusNuc122357_1186.

Phylogenomic databases

eggNOGCOG1059.
HOGENOMHOG000224507.
KOK03653.
OMAGFGENIA.
OrthoDBEOG68SW1J.

Family and domain databases

Gene3D1.10.340.30. 1 hit.
HAMAPMF_00241. Ogg.
InterProIPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
[Graphical view]
PIRSFPIRSF005954. Thrmst_ogg. 1 hit.
SMARTSM00478. ENDO3c. 1 hit.
[Graphical view]
SUPFAMSSF48150. SSF48150. 1 hit.
ProtoNetSearch...

Entry information

Entry nameOGG1_FUSNN
AccessionPrimary (citable) accession number: Q8R689
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: June 1, 2002
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families