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Q8R689

- OGG1_FUSNN

UniProt

Q8R689 - OGG1_FUSNN

Protein

Probable N-glycosylase/DNA lyase

Gene

ogg

Organism
Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites).UniRule annotation

    Catalytic activityi

    The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei138 – 1381UniRule annotation

    GO - Molecular functioni

    1. DNA-(apurinic or apyrimidinic site) lyase activity Source: UniProtKB-HAMAP
    2. hydrolase activity, hydrolyzing N-glycosyl compounds Source: UniProtKB-HAMAP

    GO - Biological processi

    1. base-excision repair Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Glycosidase, Hydrolase, Lyase

    Keywords - Biological processi

    DNA damage, DNA repair

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable N-glycosylase/DNA lyaseUniRule annotation
    Including the following 2 domains:
    8-oxoguanine DNA glycosylaseUniRule annotation (EC:3.2.2.-UniRule annotation)
    DNA-(apurinic or apyrimidinic site) lyaseUniRule annotation (EC:4.2.99.18UniRule annotation)
    Short name:
    AP lyaseUniRule annotation
    Gene namesi
    Name:oggUniRule annotation
    Ordered Locus Names:FN0622
    OrganismiFusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)
    Taxonomic identifieri190304 [NCBI]
    Taxonomic lineageiBacteriaFusobacteriaFusobacterialesFusobacteriaceaeFusobacterium
    ProteomesiUP000002521: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 217217Probable N-glycosylase/DNA lyasePRO_0000159571Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi190304.FN0622.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8R689.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the type-2 OGG1 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1059.
    HOGENOMiHOG000224507.
    KOiK03653.
    OMAiGFGENIA.
    OrthoDBiEOG68SW1J.

    Family and domain databases

    Gene3Di1.10.340.30. 1 hit.
    HAMAPiMF_00241. Ogg.
    InterProiIPR012092. DNA_glyclase/DNA_lyase_thermo.
    IPR011257. DNA_glycosylase.
    IPR003265. HhH-GPD_domain.
    [Graphical view]
    PIRSFiPIRSF005954. Thrmst_ogg. 1 hit.
    SMARTiSM00478. ENDO3c. 1 hit.
    [Graphical view]
    SUPFAMiSSF48150. SSF48150. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8R689-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKNEYFNEI EKIYKEMSSH FKERLKEFKN IWENGTNKDI HLELSFCILT    50
    PQSKALNAWQ AITNLKKDDL IYNGKAEELV EFLNIVRFKN NKSKYLVELR 100
    EKMMKDGEII TKDFFNTLPT VAEKREWIVK NIKGMSYKEA SHFLRNVGFG 150
    ENIAILDRHI LRNLVKLEVI DELPKTLTPK LYLEIEEKMR DYCEFVKIPM 200
    DEMDLLLWYK EAGVIFK 217
    Length:217
    Mass (Da):25,924
    Last modified:June 1, 2002 - v1
    Checksum:iEC7C01E5A616092B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009951 Genomic DNA. Translation: AAL94818.1.
    RefSeqiNP_603519.1. NC_003454.1.

    Genome annotation databases

    EnsemblBacteriaiAAL94818; AAL94818; FN0622.
    GeneIDi993235.
    KEGGifnu:FN0622.
    PATRICi21951007. VBIFusNuc122357_1186.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009951 Genomic DNA. Translation: AAL94818.1 .
    RefSeqi NP_603519.1. NC_003454.1.

    3D structure databases

    ProteinModelPortali Q8R689.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 190304.FN0622.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL94818 ; AAL94818 ; FN0622 .
    GeneIDi 993235.
    KEGGi fnu:FN0622.
    PATRICi 21951007. VBIFusNuc122357_1186.

    Phylogenomic databases

    eggNOGi COG1059.
    HOGENOMi HOG000224507.
    KOi K03653.
    OMAi GFGENIA.
    OrthoDBi EOG68SW1J.

    Family and domain databases

    Gene3Di 1.10.340.30. 1 hit.
    HAMAPi MF_00241. Ogg.
    InterProi IPR012092. DNA_glyclase/DNA_lyase_thermo.
    IPR011257. DNA_glycosylase.
    IPR003265. HhH-GPD_domain.
    [Graphical view ]
    PIRSFi PIRSF005954. Thrmst_ogg. 1 hit.
    SMARTi SM00478. ENDO3c. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48150. SSF48150. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131.

    Entry informationi

    Entry nameiOGG1_FUSNN
    AccessioniPrimary (citable) accession number: Q8R689
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2002
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3