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Q8R689

- OGG1_FUSNN

UniProt

Q8R689 - OGG1_FUSNN

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Protein

Probable N-glycosylase/DNA lyase

Gene

ogg

Organism
Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites).UniRule annotation

Catalytic activityi

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei138 – 1381UniRule annotation

GO - Molecular functioni

  1. DNA-(apurinic or apyrimidinic site) lyase activity Source: UniProtKB-HAMAP
  2. hydrolase activity, hydrolyzing N-glycosyl compounds Source: UniProtKB-HAMAP

GO - Biological processi

  1. base-excision repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase, Lyase

Keywords - Biological processi

DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Probable N-glycosylase/DNA lyaseUniRule annotation
Including the following 2 domains:
8-oxoguanine DNA glycosylaseUniRule annotation (EC:3.2.2.-UniRule annotation)
DNA-(apurinic or apyrimidinic site) lyaseUniRule annotation (EC:4.2.99.18UniRule annotation)
Short name:
AP lyaseUniRule annotation
Gene namesi
Name:oggUniRule annotation
Ordered Locus Names:FN0622
OrganismiFusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)
Taxonomic identifieri190304 [NCBI]
Taxonomic lineageiBacteriaFusobacteriaFusobacterialesFusobacteriaceaeFusobacterium
ProteomesiUP000002521: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 217217Probable N-glycosylase/DNA lyasePRO_0000159571Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi190304.FN0622.

Structurei

3D structure databases

ProteinModelPortaliQ8R689.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the type-2 OGG1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1059.
HOGENOMiHOG000224507.
InParanoidiQ8R689.
KOiK03653.
OMAiGFGENIA.
OrthoDBiEOG68SW1J.

Family and domain databases

Gene3Di1.10.340.30. 1 hit.
HAMAPiMF_00241. Ogg.
InterProiIPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
[Graphical view]
PIRSFiPIRSF005954. Thrmst_ogg. 1 hit.
SMARTiSM00478. ENDO3c. 1 hit.
[Graphical view]
SUPFAMiSSF48150. SSF48150. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8R689-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKNEYFNEI EKIYKEMSSH FKERLKEFKN IWENGTNKDI HLELSFCILT
60 70 80 90 100
PQSKALNAWQ AITNLKKDDL IYNGKAEELV EFLNIVRFKN NKSKYLVELR
110 120 130 140 150
EKMMKDGEII TKDFFNTLPT VAEKREWIVK NIKGMSYKEA SHFLRNVGFG
160 170 180 190 200
ENIAILDRHI LRNLVKLEVI DELPKTLTPK LYLEIEEKMR DYCEFVKIPM
210
DEMDLLLWYK EAGVIFK
Length:217
Mass (Da):25,924
Last modified:June 1, 2002 - v1
Checksum:iEC7C01E5A616092B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009951 Genomic DNA. Translation: AAL94818.1.
RefSeqiNP_603519.1. NC_003454.1.
WP_011016533.1. NC_003454.1.

Genome annotation databases

EnsemblBacteriaiAAL94818; AAL94818; FN0622.
GeneIDi993235.
KEGGifnu:FN0622.
PATRICi21951007. VBIFusNuc122357_1186.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009951 Genomic DNA. Translation: AAL94818.1 .
RefSeqi NP_603519.1. NC_003454.1.
WP_011016533.1. NC_003454.1.

3D structure databases

ProteinModelPortali Q8R689.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 190304.FN0622.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL94818 ; AAL94818 ; FN0622 .
GeneIDi 993235.
KEGGi fnu:FN0622.
PATRICi 21951007. VBIFusNuc122357_1186.

Phylogenomic databases

eggNOGi COG1059.
HOGENOMi HOG000224507.
InParanoidi Q8R689.
KOi K03653.
OMAi GFGENIA.
OrthoDBi EOG68SW1J.

Family and domain databases

Gene3Di 1.10.340.30. 1 hit.
HAMAPi MF_00241. Ogg.
InterProi IPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
[Graphical view ]
PIRSFi PIRSF005954. Thrmst_ogg. 1 hit.
SMARTi SM00478. ENDO3c. 1 hit.
[Graphical view ]
SUPFAMi SSF48150. SSF48150. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131.

Entry informationi

Entry nameiOGG1_FUSNN
AccessioniPrimary (citable) accession number: Q8R689
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: June 1, 2002
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3