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Protein

Putative threonine-phosphate decarboxylase

Gene

cobD

Organism
Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.By similarity

Catalytic activityi

L-threonine O-3-phosphate = (R)-1-aminopropan-2-yl phosphate + CO2.

Cofactori

Pathwayi: adenosylcobalamin biosynthesis

This protein is involved in the pathway adenosylcobalamin biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Cobalamin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciCSUB273068:GJEB-685-MONOMER.
UniPathwayiUPA00148.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative threonine-phosphate decarboxylase (EC:4.1.1.81)
Alternative name(s):
L-threonine-O-3-phosphate decarboxylase
Gene namesi
Name:cobD
Ordered Locus Names:TTE0380
OrganismiCaldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis)
Taxonomic identifieri273068 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCaldanaerobacter
Proteomesi
  • UP000000555 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 367367Putative threonine-phosphate decarboxylasePRO_0000163823Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei213 – 2131N6-(pyridoxal phosphate)lysineBy similarity

Interactioni

Protein-protein interaction databases

STRINGi273068.TTE0380.

Structurei

3D structure databases

ProteinModelPortaliQ8R5U4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CIH. Bacteria.
COG0079. LUCA.
HOGENOMiHOG000288511.
KOiK04720.
OrthoDBiEOG64N9ZK.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR005860. CobD.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01140. L_thr_O3P_dcar. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8R5U4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEGEKMKPY EHGGNIYDYQ GNLIDFSSNI NPLGPPEWIW EAIKEVDLSR
60 70 80 90 100
YPDIKYRRLK EAIAEYVGCD RENIIVGNGA AELIHLFARA FKLKKPLIPS
110 120 130 140 150
PSFLEYERAV KLNGGEPVYL KLEEEEGFRV NFAKVISKIE EADGLILGNP
160 170 180 190 200
NNPTGQGIIR EEIGILLKKA ELMNIPVLID EAFIEFMKDY KKYEALPLVK
210 220 230 240 250
KHDKLFVVRA VTKFFGMPGI RLGYGIGSPS LIQKLEEYKE PWTVNAFAEA
260 270 280 290 300
VGRWLFKDRE YIEKTREYVN AEIEHMLFSL RTIDYLVAFD TKVNFILLKL
310 320 330 340 350
KAGTVDEVKE KLLKKGILIR DASNFRYLDK RFFRVAVKRR EDNMCLIEAL
360
RGLYEEGVMP DKERVVV
Length:367
Mass (Da):42,396
Last modified:June 1, 2002 - v1
Checksum:i292512F7EE1F8435
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008691 Genomic DNA. Translation: AAM23667.1.

Genome annotation databases

EnsemblBacteriaiAAM23667; AAM23667; TTE0380.
KEGGitte:TTE0380.
PATRICi23895405. VBITheTen82880_0378.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008691 Genomic DNA. Translation: AAM23667.1.

3D structure databases

ProteinModelPortaliQ8R5U4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273068.TTE0380.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM23667; AAM23667; TTE0380.
KEGGitte:TTE0380.
PATRICi23895405. VBITheTen82880_0378.

Phylogenomic databases

eggNOGiENOG4105CIH. Bacteria.
COG0079. LUCA.
HOGENOMiHOG000288511.
KOiK04720.
OrthoDBiEOG64N9ZK.

Enzyme and pathway databases

UniPathwayiUPA00148.
BioCyciCSUB273068:GJEB-685-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR005860. CobD.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01140. L_thr_O3P_dcar. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 15242 / JCM 11007 / NBRC 100824 / MB4.

Entry informationi

Entry nameiCOBD_CALS4
AccessioniPrimary (citable) accession number: Q8R5U4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: June 1, 2002
Last modified: November 11, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.