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Q8R5M8

- CADM1_MOUSE

UniProt

Q8R5M8 - CADM1_MOUSE

Protein

Cell adhesion molecule 1

Gene

Cadm1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 2 (26 Jun 2007)
      Previous versions | rss
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    Functioni

    Mediates homophilic cell-cell adhesion in a Ca2+-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca2+-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.10 Publications

    GO - Molecular functioni

    1. PDZ domain binding Source: UniProtKB
    2. protein binding Source: IntAct
    3. protein homodimerization activity Source: UniProtKB
    4. receptor binding Source: UniProtKB

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. bone development Source: MGI
    3. brain development Source: Ensembl
    4. calcium-independent cell-cell adhesion Source: MGI
    5. cell adhesion Source: MGI
    6. cell differentiation Source: UniProtKB-KW
    7. cell recognition Source: UniProtKB
    8. detection of stimulus Source: UniProtKB
    9. heterophilic cell-cell adhesion Source: UniProtKB
    10. homophilic cell adhesion Source: UniProtKB
    11. immune system process Source: UniProtKB-KW
    12. liver development Source: Ensembl
    13. positive regulation of cytokine secretion Source: Ensembl
    14. positive regulation of natural killer cell mediated cytotoxicity Source: UniProtKB
    15. spermatogenesis Source: UniProtKB-KW
    16. susceptibility to natural killer cell mediated cytotoxicity Source: UniProtKB
    17. synapse assembly Source: MGI
    18. unidimensional cell growth Source: MGI

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Apoptosis, Cell adhesion, Differentiation, Immunity, Spermatogenesis

    Protein family/group databases

    MEROPSiI43.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cell adhesion molecule 1
    Alternative name(s):
    Immunoglobulin superfamily member 4
    Short name:
    IgSF4
    Nectin-like protein 2
    Short name:
    NECL-2
    Spermatogenic immunoglobulin superfamily
    Short name:
    SgIgSF
    Synaptic cell adhesion molecule
    Short name:
    SynCAM
    Tumor suppressor in lung cancer 1
    Short name:
    TSLC-1
    Gene namesi
    Name:Cadm1Imported
    Synonyms:Igsf41 Publication, Necl2Imported, Ra175Imported, Syncam1 Publication, SynCam1, Tslc1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1889272. Cadm1.

    Subcellular locationi

    Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Cell junctionsynapse
    Note: Associates with perinuclear and plasma membranes in vivo. Localized to the basolateral plasma membrane of epithelial cells in gall bladder.By similarity1 PublicationSequence Analysis

    GO - Cellular componenti

    1. axon Source: MGI
    2. basolateral plasma membrane Source: UniProtKB
    3. cell-cell junction Source: UniProtKB
    4. dendrite Source: MGI
    5. integral component of membrane Source: UniProtKB-KW
    6. plasma membrane Source: MGI
    7. synapse Source: MGI
    8. synaptic vesicle Source: MGI

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Synapse

    Pathology & Biotechi

    Disruption phenotypei

    Male mice are infertile, due to a defect at the spermatid stage of spermatogenesis, and show oligoasthenoteratozoospermia with almost no mature motile spermatozoa in the epididymis. Heterozygous males and females and homozygous null females are fertile and have no overt developmental defects.3 Publications

    Keywords - Diseasei

    Tumor suppressor

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 4747Sequence AnalysisAdd
    BLAST
    Chaini48 – 456409Cell adhesion molecule 1Sequence AnalysisPRO_0000291969Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi67 ↔ 127PROSITE-ProRule annotation
    Glycosylationi70 – 701N-linked (GlcNAc...)3 Publications
    Glycosylationi104 – 1041N-linked (GlcNAc...)4 Publications
    Glycosylationi116 – 1161N-linked (GlcNAc...)3 Publications
    Glycosylationi168 – 1681N-linked (GlcNAc...)2 Publications
    Disulfide bondi169 ↔ 223PROSITE-ProRule annotation
    Disulfide bondi270 ↔ 316PROSITE-ProRule annotation
    Glycosylationi304 – 3041N-linked (GlcNAc...); atypical2 Publications
    Glycosylationi307 – 3071N-linked (GlcNAc...)2 Publications
    Glycosylationi311 – 3111N-linked (GlcNAc...)2 Publications
    Modified residuei448 – 4481Phosphoserine1 Publication

    Post-translational modificationi

    N-glycosylated.4 Publications
    Glycosylation at Asn-70 and Asn-104 promotes adhesive binding and synapse induction.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ8R5M8.
    PRIDEiQ8R5M8.

    PTM databases

    PhosphoSiteiQ8R5M8.

    Expressioni

    Tissue specificityi

    Expressed in brain, lung, kidney, testis, heart, spleen and liver, but not expressed in skeletal muscle. In brain, enriched in the synaptic plasma membrane. Expressed dominantly in epithelial cells but not expressed in fibroblast cells (at protein level).4 Publications

    Developmental stagei

    Expressed in spermatogenic cells during early spermatogenesis. Expression increases in intermediate spermatogonia through to zygotene spermatocytes but becomes diminished in the steps from early pachytene spermatocytes through to round spermatids. After meiosis, expression reappears in spermatids and is present in elongating spermatids until spermiation. Not detected in Sertoli cells.1 Publication

    Gene expression databases

    ArrayExpressiQ8R5M8.
    BgeeiQ8R5M8.
    CleanExiMM_CADM1.
    GenevestigatoriQ8R5M8.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with CRTAM. Interacts (via C-terminus) with EPB41L3/DAL1. The interaction with EPB41L3/DAL1 may act to anchor CADM1 to the actin cytoskeleton. Interacts via its C-terminus with the PDZ domain of MPP3 and the PDZ domain of MPP6. Interacts with FARP1.4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ITGB4P161443EBI-5651941,EBI-948678From a different organism.

    Protein-protein interaction databases

    IntActiQ8R5M8. 3 interactions.
    MINTiMINT-4131381.
    STRINGi10090.ENSMUSP00000083073.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8R5M8.
    SMRiQ8R5M8. Positions 48-337.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini48 – 388341ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini410 – 45647CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei389 – 40921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini48 – 14295Ig-like V-typeSequence AnalysisAdd
    BLAST
    Domaini147 – 24195Ig-like C2-type 1Sequence AnalysisAdd
    BLAST
    Domaini246 – 33287Ig-like C2-type 2Sequence AnalysisAdd
    BLAST

    Domaini

    The cytoplasmic domain appears to play a critical role in proapoptosis and tumor suppressor activity in NSCLC.By similarity

    Sequence similaritiesi

    Belongs to the nectin family.Curated
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.Sequence Analysis
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.Sequence Analysis

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG69486.
    GeneTreeiENSGT00610000085800.
    HOVERGENiHBG057086.
    InParanoidiQ8R5M8.
    KOiK06781.
    OrthoDBiEOG7PVWPD.
    PhylomeDBiQ8R5M8.
    TreeFamiTF334317.

    Family and domain databases

    Gene3Di2.60.40.10. 3 hits.
    InterProiIPR013162. CD80_C2-set.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR013106. Ig_V-set.
    IPR003585. Neurexin-like.
    [Graphical view]
    PfamiPF08205. C2-set_2. 1 hit.
    PF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00294. 4.1m. 1 hit.
    SM00409. IG. 1 hit.
    SM00408. IGc2. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 3 hits.
    [Graphical view]

    Sequences (7)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 7 isoformsi produced by alternative splicing. Align

    Isoform 11 Publication (identifier: Q8R5M8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASAVLPSGS QCAAAAAVAA AAAPPGLRLR LLLLLLSAAA LIPTGDGQNL    50
    FTKDVTVIEG EVATISCQVN KSDDSVIQLL NPNRQTIYFR DFRPLKDSRF 100
    QLLNFSSSEL KVSLTNVSIS DEGRYFCQLY TDPPQESYTT ITVLVPPRNL 150
    MIDIQKDTAV EGEEIEVNCT AMASKPATTI RWFKGNKELK GKSEVEEWSD 200
    MYTVTSQLML KVHKEDDGVP VICQVEHPAV TGNLQTQRYL EVQYKPQVHI 250
    QMTYPLQGLT REGDAFELTC EAIGKPQPVM VTWVRVDDEM PQHAVLSGPN 300
    LFINNLNKTD NGTYRCEASN IVGKAHSDYM LYVYDPPTTI PPPTTTTTTT 350
    TTTTTTILTI ITDTTATTEP AVHDSRAGEE GTIGAVDHAV IGGVVAVVVF 400
    AMLCLLIILG RYFARHKGTY FTHEAKGADD AADADTAIIN AEGGQNNSEE 450
    KKEYFI 456
    Length:456
    Mass (Da):49,788
    Last modified:June 26, 2007 - v2
    Checksum:i3226E86C04161C7F
    GO
    Isoform 24 Publications (identifier: Q8R5M8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         364-374: Missing.

    Show »
    Length:445
    Mass (Da):48,664
    Checksum:iC5D5A070DAF70E55
    GO
    Isoform 31 Publication (identifier: Q8R5M8-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         336-363: Missing.

    Show »
    Length:428
    Mass (Da):46,903
    Checksum:iB10DFF1A2B893573
    GO
    Isoform 42 Publications (identifier: Q8R5M8-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         336-374: Missing.

    Show »
    Length:417
    Mass (Da):45,779
    Checksum:i98500180D37845C2
    GO
    Isoform 52 Publications (identifier: Q8R5M8-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         335-336: DP → GT
         337-456: Missing.

    Show »
    Length:336
    Mass (Da):37,155
    Checksum:i9EF3D8B8BE5E8F72
    GO
    Isoform 61 Publication (identifier: Q8R5M8-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-150: Missing.
         355-365: Missing.

    Show »
    Length:295
    Mass (Da):32,459
    Checksum:iF557E3FAF8174671
    GO
    Isoform 71 Publication (identifier: Q8R5M8-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-150: Missing.
         336-352: Missing.

    Show »
    Length:289
    Mass (Da):31,922
    Checksum:iFC718DBCCEA8C452
    GO

    Sequence cautioni

    The sequence AAC67243.1 differs from that shown. Reason: Frameshift at position 65.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti8 – 81S → C in AAN01614. (PubMed:12202822)Curated
    Sequence conflicti8 – 81S → C in BAD30018. 1 PublicationCurated
    Sequence conflicti266 – 2661F → L in BAA87914. (PubMed:12799182)Curated
    Sequence conflicti266 – 2661F → L in BAA87915. (PubMed:12799182)Curated
    Sequence conflicti315 – 3151R → P in BAA87914. (PubMed:12799182)Curated
    Sequence conflicti315 – 3151R → P in BAA87915. (PubMed:12799182)Curated
    Sequence conflicti330 – 3301M → I in BAA87914. (PubMed:12799182)Curated
    Sequence conflicti330 – 3301M → I in BAA87915. (PubMed:12799182)Curated
    Sequence conflicti356 – 3561T → S in AAN01614. (PubMed:12202822)Curated
    Sequence conflicti356 – 3561T → S in BAD30018. 1 PublicationCurated
    Sequence conflicti429 – 4291D → N in BAB83501. (PubMed:12799182)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 150150Missing in isoform 6 and isoform 7. 3 PublicationsVSP_052463Add
    BLAST
    Alternative sequencei335 – 3362DP → GT in isoform 5. 3 PublicationsVSP_052464
    Alternative sequencei336 – 37439Missing in isoform 4. 2 PublicationsVSP_052465Add
    BLAST
    Alternative sequencei336 – 36328Missing in isoform 3. 2 PublicationsVSP_052466Add
    BLAST
    Alternative sequencei336 – 35217Missing in isoform 7. 2 PublicationsVSP_052467Add
    BLAST
    Alternative sequencei337 – 456120Missing in isoform 5. 3 PublicationsVSP_052468Add
    BLAST
    Alternative sequencei355 – 36511Missing in isoform 6. 2 PublicationsVSP_052469Add
    BLAST
    Alternative sequencei364 – 37411Missing in isoform 2. 4 PublicationsVSP_052470Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF434663 mRNA. Translation: AAL86736.1.
    AF539424 mRNA. Translation: AAN01614.1.
    AB021964 mRNA. Translation: BAA87914.1.
    AB021965 mRNA. Translation: BAA87915.1.
    AB064265 mRNA. Translation: BAB83501.2.
    AY351388 mRNA. Translation: AAQ02381.1.
    AF061260 mRNA. Translation: AAC67243.1. Frameshift.
    AB092414 mRNA. Translation: BAC66173.1.
    AB183399 mRNA. Translation: BAD30018.1.
    AB183400 mRNA. Translation: BAD30019.1.
    AB183401 mRNA. Translation: BAD30020.1.
    AB183402 mRNA. Translation: BAD30021.1.
    CCDSiCCDS23147.1. [Q8R5M8-4]
    CCDS23148.1. [Q8R5M8-2]
    CCDS23149.1. [Q8R5M8-1]
    CCDS23150.1. [Q8R5M8-3]
    RefSeqiNP_001020771.1. NM_001025600.1. [Q8R5M8-4]
    NP_061240.3. NM_018770.3. [Q8R5M8-2]
    NP_997558.2. NM_207675.2. [Q8R5M8-1]
    NP_997559.1. NM_207676.2. [Q8R5M8-3]
    UniGeneiMm.234832.

    Genome annotation databases

    EnsembliENSMUST00000034581; ENSMUSP00000034581; ENSMUSG00000032076. [Q8R5M8-4]
    ENSMUST00000085909; ENSMUSP00000083073; ENSMUSG00000032076. [Q8R5M8-1]
    ENSMUST00000114547; ENSMUSP00000110194; ENSMUSG00000032076. [Q8R5M8-2]
    ENSMUST00000114548; ENSMUSP00000110195; ENSMUSG00000032076. [Q8R5M8-3]
    GeneIDi54725.
    KEGGimmu:54725.
    UCSCiuc009phn.1. mouse. [Q8R5M8-5]
    uc009pho.1. mouse. [Q8R5M8-1]
    uc009phq.1. mouse. [Q8R5M8-3]
    uc009phr.1. mouse. [Q8R5M8-4]
    uc009phs.1. mouse. [Q8R5M8-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF434663 mRNA. Translation: AAL86736.1 .
    AF539424 mRNA. Translation: AAN01614.1 .
    AB021964 mRNA. Translation: BAA87914.1 .
    AB021965 mRNA. Translation: BAA87915.1 .
    AB064265 mRNA. Translation: BAB83501.2 .
    AY351388 mRNA. Translation: AAQ02381.1 .
    AF061260 mRNA. Translation: AAC67243.1 . Frameshift.
    AB092414 mRNA. Translation: BAC66173.1 .
    AB183399 mRNA. Translation: BAD30018.1 .
    AB183400 mRNA. Translation: BAD30019.1 .
    AB183401 mRNA. Translation: BAD30020.1 .
    AB183402 mRNA. Translation: BAD30021.1 .
    CCDSi CCDS23147.1. [Q8R5M8-4 ]
    CCDS23148.1. [Q8R5M8-2 ]
    CCDS23149.1. [Q8R5M8-1 ]
    CCDS23150.1. [Q8R5M8-3 ]
    RefSeqi NP_001020771.1. NM_001025600.1. [Q8R5M8-4 ]
    NP_061240.3. NM_018770.3. [Q8R5M8-2 ]
    NP_997558.2. NM_207675.2. [Q8R5M8-1 ]
    NP_997559.1. NM_207676.2. [Q8R5M8-3 ]
    UniGenei Mm.234832.

    3D structure databases

    ProteinModelPortali Q8R5M8.
    SMRi Q8R5M8. Positions 48-337.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8R5M8. 3 interactions.
    MINTi MINT-4131381.
    STRINGi 10090.ENSMUSP00000083073.

    Protein family/group databases

    MEROPSi I43.001.

    PTM databases

    PhosphoSitei Q8R5M8.

    Proteomic databases

    PaxDbi Q8R5M8.
    PRIDEi Q8R5M8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000034581 ; ENSMUSP00000034581 ; ENSMUSG00000032076 . [Q8R5M8-4 ]
    ENSMUST00000085909 ; ENSMUSP00000083073 ; ENSMUSG00000032076 . [Q8R5M8-1 ]
    ENSMUST00000114547 ; ENSMUSP00000110194 ; ENSMUSG00000032076 . [Q8R5M8-2 ]
    ENSMUST00000114548 ; ENSMUSP00000110195 ; ENSMUSG00000032076 . [Q8R5M8-3 ]
    GeneIDi 54725.
    KEGGi mmu:54725.
    UCSCi uc009phn.1. mouse. [Q8R5M8-5 ]
    uc009pho.1. mouse. [Q8R5M8-1 ]
    uc009phq.1. mouse. [Q8R5M8-3 ]
    uc009phr.1. mouse. [Q8R5M8-4 ]
    uc009phs.1. mouse. [Q8R5M8-2 ]

    Organism-specific databases

    CTDi 23705.
    MGIi MGI:1889272. Cadm1.

    Phylogenomic databases

    eggNOGi NOG69486.
    GeneTreei ENSGT00610000085800.
    HOVERGENi HBG057086.
    InParanoidi Q8R5M8.
    KOi K06781.
    OrthoDBi EOG7PVWPD.
    PhylomeDBi Q8R5M8.
    TreeFami TF334317.

    Miscellaneous databases

    NextBioi 311582.
    PROi Q8R5M8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8R5M8.
    Bgeei Q8R5M8.
    CleanExi MM_CADM1.
    Genevestigatori Q8R5M8.

    Family and domain databases

    Gene3Di 2.60.40.10. 3 hits.
    InterProi IPR013162. CD80_C2-set.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR013106. Ig_V-set.
    IPR003585. Neurexin-like.
    [Graphical view ]
    Pfami PF08205. C2-set_2. 1 hit.
    PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00294. 4.1m. 1 hit.
    SM00409. IG. 1 hit.
    SM00408. IGc2. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of the Tslc1 gene, a mouse orthologue of the human tumor suppressor TSLC1 gene."
      Fukami T., Satoh H., Fujita E., Maruyama T., Fukuhara H., Kuramochi M., Takamoto S., Momoi T., Murakami Y.
      Gene 295:7-12(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
      Strain: 129/SvJImported.
    2. "SynCAM, a synaptic adhesion molecule that drives synapse assembly."
      Biederer T., Sara Y., Mozhayeva M., Atasoy D., Liu X., Kavalali E.T., Sudhof T.C.
      Science 297:1525-1531(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY.
      Strain: C57BL/6Imported.
    3. "RA175, which is the mouse ortholog of TSLC1, a tumor suppressor gene in human lung cancer, is a cell adhesion molecule."
      Fujita E., Soyama A., Momoi T.
      Exp. Cell Res. 287:57-66(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 6 AND 7), FUNCTION.
      Tissue: Embryonic carcinomaImported.
    4. "Implications of nectin-like molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion and transmembrane protein localization in epithelial cells."
      Shingai T., Ikeda W., Kakunaga S., Morimoto K., Takekuni K., Itoh S., Satoh K., Takeuchi M., Imai T., Monden M., Takai Y.
      J. Biol. Chem. 278:35421-35427(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), FUNCTION, INTERACTION WITH MPP6, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Strain: C57BL/6Imported.
      Tissue: BrainImported.
    5. "Nectin-like molecule 1 is a protein 4.1N associated protein and recruits protein 4.1N from cytoplasm to the plasma membrane."
      Zhou Y., Du G., Hu X., Yu S., Liu Y., Xu Y., Huang X., Liu J., Yin B., Fan M., Peng X., Qiang B., Yuan J.
      Biochim. Biophys. Acta 1669:142-154(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 49-456 (ISOFORM 2).
    6. "A secretion form of SgIGSF/TSLC1."
      Ito A., Koma Y., Nagano T.
      Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
      Strain: C57BL/6Imported.
      Tissue: Mast cellImported.
    7. "Neuron-specific isoforms of RA175/TSLC1/SynCAM."
      Fujita E., Aikawa K., Momoi T.
      Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4 AND 5).
    8. "Expression and functional characterization of the adhesion molecule spermatogenic immunoglobulin superfamily in the mouse testis."
      Wakayama T., Koami H., Ariga H., Kobayashi D., Sai Y., Tsuji A., Yamamoto M., Iseki S.
      Biol. Reprod. 68:1755-1763(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, GLYCOSYLATION.
    9. "Contribution of the SgIGSF adhesion molecule to survival of cultured mast cells in vivo."
      Ito A., Koma Y., Watabe K., Jippo T., Wakayama T., Iseki S., Kitamura Y.
      Biochem. Biophys. Res. Commun. 319:200-206(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    10. "The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM."
      Boles K.S., Barchet W., Diacovo T., Cella M., Colonna M.
      Blood 106:779-786(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CADM1.
    11. "Distribution of RA175/TSLC1/SynCAM, a member of the immunoglobulin superfamily, in the developing nervous system."
      Fujita E., Urase K., Soyama A., Kouroku Y., Momoi T.
      Brain Res. Dev. Brain Res. 154:199-209(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    12. "Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I-restricted T-cell-associated molecule."
      Galibert L., Diemer G.S., Liu Z., Johnson R.S., Smith J.L., Walzer T., Comeau M.R., Rauch C.T., Wolfson M.F., Sorensen R.A., Van der Vuurst de Vries A.-R., Branstetter D.G., Koelling R.M., Scholler J., Fanslow W.C., Baum P.R., Derry J.M., Yan W.
      J. Biol. Chem. 280:21955-21964(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CRTAM.
    13. "MITF and SgIGSF: an essential transcription factor and its target adhesion molecule for development and survival of mast cells."
      Kitamura Y.
      Novartis Found. Symp. 271:4-11(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    14. "Oligo-astheno-teratozoospermia in mice lacking RA175/TSLC1/SynCAM/IGSF4A, a cell adhesion molecule in the immunoglobulin superfamily."
      Fujita E., Kouroku Y., Ozeki S., Tanabe Y., Toyama Y., Maekawa M., Kojima N., Senoo H., Toshimori K., Momoi T.
      Mol. Cell. Biol. 26:718-726(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.
    15. "Loss of TSLC1 causes male infertility due to a defect at the spermatid stage of spermatogenesis."
      van der Weyden L., Arends M.J., Chausiaux O.E., Ellis P.J., Lange U.C., Surani M.A., Affara N., Murakami Y., Adams D.J., Bradley A.
      Mol. Cell. Biol. 26:3595-3609(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.
    16. "Disruption of spermatogenic cell adhesion and male infertility in mice lacking TSLC1/IGSF4, an immunoglobulin superfamily cell adhesion molecule."
      Yamada D., Yoshida M., Williams Y.N., Fukami T., Kikuchi S., Masuda M., Maruyama T., Ohta T., Nakae D., Maekawa A., Kitamura T., Murakami Y.
      Mol. Cell. Biol. 26:3610-3624(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    17. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-448, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    18. "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
      Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.
      Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-104 AND ASN-116.
      Tissue: Myoblast.
    19. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-70; ASN-104; ASN-116; ASN-168; ASN-304; ASN-307 AND ASN-311.
    20. "N-glycosylation at the SynCAM (synaptic cell adhesion molecule) immunoglobulin interface modulates synaptic adhesion."
      Fogel A.I., Li Y., Giza J., Wang Q., Lam T.T., Modis Y., Biederer T.
      J. Biol. Chem. 285:34864-34874(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT ASN-70 AND ASN-104, SUBCELLULAR LOCATION.
    21. "The novel synaptogenic protein Farp1 links postsynaptic cytoskeletal dynamics and transsynaptic organization."
      Cheadle L., Biederer T.
      J. Cell Biol. 199:985-1001(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH FARP1.

    Entry informationi

    Entry nameiCADM1_MOUSE
    AccessioniPrimary (citable) accession number: Q8R5M8
    Secondary accession number(s): Q6F3J3
    , Q7TNL1, Q80VG4, Q8K3T6, Q8R4L1, Q9QYL5, Q9QYL6, Q9Z2H8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: June 26, 2007
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3