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Q8R5M8

- CADM1_MOUSE

UniProt

Q8R5M8 - CADM1_MOUSE

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Protein

Cell adhesion molecule 1

Gene
Cadm1, Igsf4, Necl2, Ra175, Syncam, SynCam1, Tslc1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Mediates homophilic cell-cell adhesion in a Ca2+-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca2+-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.By similarity10 Publications

GO - Molecular functioni

  1. PDZ domain binding Source: UniProtKB
  2. protein binding Source: IntAct
  3. protein C-terminus binding Source: UniProtKB
  4. protein homodimerization activity Source: UniProtKB
  5. receptor binding Source: UniProtKB

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. bone development Source: MGI
  3. brain development Source: Ensembl
  4. calcium-independent cell-cell adhesion Source: MGI
  5. cell adhesion Source: MGI
  6. cell differentiation Source: UniProtKB-KW
  7. cell recognition Source: UniProtKB
  8. detection of stimulus Source: UniProtKB
  9. heterophilic cell-cell adhesion Source: UniProtKB
  10. homophilic cell adhesion Source: UniProtKB
  11. immune system process Source: UniProtKB-KW
  12. liver development Source: Ensembl
  13. positive regulation of cytokine secretion Source: Ensembl
  14. positive regulation of natural killer cell mediated cytotoxicity Source: UniProtKB
  15. spermatogenesis Source: UniProtKB-KW
  16. susceptibility to natural killer cell mediated cytotoxicity Source: UniProtKB
  17. synapse assembly Source: MGI
  18. unidimensional cell growth Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Apoptosis, Cell adhesion, Differentiation, Immunity, Spermatogenesis

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell adhesion molecule 1
Alternative name(s):
Immunoglobulin superfamily member 4
Short name:
IgSF4
Nectin-like protein 2
Short name:
NECL-2
Spermatogenic immunoglobulin superfamily
Short name:
SgIgSF
Synaptic cell adhesion molecule
Short name:
SynCAM
Tumor suppressor in lung cancer 1
Short name:
TSLC-1
Gene namesi
Name:Cadm1
Synonyms:Igsf4, Necl2, Ra175, Syncam, SynCam1, Tslc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1889272. Cadm1.

Subcellular locationi

Cell membrane; Single-pass type I membrane protein. Cell junctionsynapse
Note: Associates with perinuclear and plasma membranes in vivo. Localized to the basolateral plasma membrane of epithelial cells in gall bladder.By similarity3 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini48 – 388341Extracellular Reviewed predictionAdd
BLAST
Transmembranei389 – 40921Helical; Reviewed predictionAdd
BLAST
Topological domaini410 – 45647Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. axon Source: MGI
  2. basolateral plasma membrane Source: UniProtKB
  3. cell-cell junction Source: UniProtKB
  4. dendrite Source: MGI
  5. integral component of membrane Source: UniProtKB-KW
  6. plasma membrane Source: MGI
  7. synapse Source: MGI
  8. synaptic vesicle Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

Pathology & Biotechi

Disruption phenotypei

Male mice are infertile, due to a defect at the spermatid stage of spermatogenesis, and show oligoasthenoteratozoospermia with almost no mature motile spermatozoa in the epididymis. Heterozygous males and females and homozygous null females are fertile and have no overt developmental defects.3 Publications

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4747 Reviewed predictionAdd
BLAST
Chaini48 – 456409Cell adhesion molecule 1PRO_0000291969Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi67 ↔ 127 By similarity
Glycosylationi70 – 701N-linked (GlcNAc...)2 Publications
Glycosylationi104 – 1041N-linked (GlcNAc...)3 Publications
Glycosylationi116 – 1161N-linked (GlcNAc...)2 Publications
Glycosylationi168 – 1681N-linked (GlcNAc...)1 Publication
Disulfide bondi169 ↔ 223 By similarity
Disulfide bondi270 ↔ 316 By similarity
Glycosylationi304 – 3041N-linked (GlcNAc...); atypical1 Publication
Glycosylationi307 – 3071N-linked (GlcNAc...)1 Publication
Glycosylationi311 – 3111N-linked (GlcNAc...)1 Publication
Modified residuei448 – 4481Phosphoserine1 Publication

Post-translational modificationi

N-glycosylated.2 Publications
Glycosylation at Asn-70 and Asn-104 promotes adhesive binding and synapse induction By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8R5M8.
PRIDEiQ8R5M8.

PTM databases

PhosphoSiteiQ8R5M8.

Expressioni

Tissue specificityi

Expressed in brain, lung, kidney, testis, heart, spleen and liver, but not expressed in skeletal muscle. In brain, enriched in the synaptic plasma membrane. Expressed dominantly in epithelial cells but not expressed in fibroblast cells (at protein level).4 Publications

Developmental stagei

Expressed in spermatogenic cells during early spermatogenesis. Expression increases in intermediate spermatogonia through to zygotene spermatocytes but becomes diminished in the steps from early pachytene spermatocytes through to round spermatids. After meiosis, expression reappears in spermatids and is present in elongating spermatids until spermiation. Not detected in Sertoli cells.1 Publication

Gene expression databases

ArrayExpressiQ8R5M8.
BgeeiQ8R5M8.
CleanExiMM_CADM1.
GenevestigatoriQ8R5M8.

Interactioni

Subunit structurei

Homodimer. Interacts with CRTAM. Interacts (via C-terminus) with EPB41L3/DAL1. The interaction with EPB41L3/DAL1 may act to anchor CADM1 to the actin cytoskeleton. Interacts via its C-terminus with the PDZ domain of MPP3 and the PDZ domain of MPP6. Interacts with FARP1.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ITGB4P161443EBI-5651941,EBI-948678From a different organism.

Protein-protein interaction databases

IntActiQ8R5M8. 3 interactions.
MINTiMINT-4131381.
STRINGi10090.ENSMUSP00000083073.

Structurei

3D structure databases

ProteinModelPortaliQ8R5M8.
SMRiQ8R5M8. Positions 48-337.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 14295Ig-like V-typeAdd
BLAST
Domaini147 – 24195Ig-like C2-type 1Add
BLAST
Domaini246 – 33287Ig-like C2-type 2Add
BLAST

Domaini

The cytoplasmic domain appears to play a critical role in proapoptosis and tumor suppressor activity in NSCLC By similarity.By similarity

Sequence similaritiesi

Belongs to the nectin family.

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG69486.
GeneTreeiENSGT00610000085800.
HOVERGENiHBG057086.
InParanoidiQ8R5M8.
KOiK06781.
OrthoDBiEOG7PVWPD.
PhylomeDBiQ8R5M8.
TreeFamiTF334317.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR003585. Neurexin-like.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: Q8R5M8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MASAVLPSGS QCAAAAAVAA AAAPPGLRLR LLLLLLSAAA LIPTGDGQNL    50
FTKDVTVIEG EVATISCQVN KSDDSVIQLL NPNRQTIYFR DFRPLKDSRF 100
QLLNFSSSEL KVSLTNVSIS DEGRYFCQLY TDPPQESYTT ITVLVPPRNL 150
MIDIQKDTAV EGEEIEVNCT AMASKPATTI RWFKGNKELK GKSEVEEWSD 200
MYTVTSQLML KVHKEDDGVP VICQVEHPAV TGNLQTQRYL EVQYKPQVHI 250
QMTYPLQGLT REGDAFELTC EAIGKPQPVM VTWVRVDDEM PQHAVLSGPN 300
LFINNLNKTD NGTYRCEASN IVGKAHSDYM LYVYDPPTTI PPPTTTTTTT 350
TTTTTTILTI ITDTTATTEP AVHDSRAGEE GTIGAVDHAV IGGVVAVVVF 400
AMLCLLIILG RYFARHKGTY FTHEAKGADD AADADTAIIN AEGGQNNSEE 450
KKEYFI 456
Length:456
Mass (Da):49,788
Last modified:June 26, 2007 - v2
Checksum:i3226E86C04161C7F
GO
Isoform 24 Publications (identifier: Q8R5M8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     364-374: Missing.

Show »
Length:445
Mass (Da):48,664
Checksum:iC5D5A070DAF70E55
GO
Isoform 31 Publication (identifier: Q8R5M8-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     336-363: Missing.

Show »
Length:428
Mass (Da):46,903
Checksum:iB10DFF1A2B893573
GO
Isoform 42 Publications (identifier: Q8R5M8-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     336-374: Missing.

Show »
Length:417
Mass (Da):45,779
Checksum:i98500180D37845C2
GO
Isoform 52 Publications (identifier: Q8R5M8-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     335-336: DP → GT
     337-456: Missing.

Show »
Length:336
Mass (Da):37,155
Checksum:i9EF3D8B8BE5E8F72
GO
Isoform 61 Publication (identifier: Q8R5M8-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-150: Missing.
     355-365: Missing.

Show »
Length:295
Mass (Da):32,459
Checksum:iF557E3FAF8174671
GO
Isoform 71 Publication (identifier: Q8R5M8-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-150: Missing.
     336-352: Missing.

Show »
Length:289
Mass (Da):31,922
Checksum:iFC718DBCCEA8C452
GO

Sequence cautioni

The sequence AAC67243.1 differs from that shown. Reason: Frameshift at position 65.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 150150Missing in isoform 6 and isoform 7. 2 PublicationsVSP_052463Add
BLAST
Alternative sequencei335 – 3362DP → GT in isoform 5. 1 PublicationVSP_052464
Alternative sequencei336 – 37439Missing in isoform 4. 2 PublicationsVSP_052465Add
BLAST
Alternative sequencei336 – 36328Missing in isoform 3. 1 PublicationVSP_052466Add
BLAST
Alternative sequencei336 – 35217Missing in isoform 7. 1 PublicationVSP_052467Add
BLAST
Alternative sequencei337 – 456120Missing in isoform 5. 1 PublicationVSP_052468Add
BLAST
Alternative sequencei355 – 36511Missing in isoform 6. 1 PublicationVSP_052469Add
BLAST
Alternative sequencei364 – 37411Missing in isoform 2. 4 PublicationsVSP_052470Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 81S → C in AAN01614. 1 Publication
Sequence conflicti8 – 81S → C in BAD30018. 1 Publication
Sequence conflicti266 – 2661F → L in BAA87914. 1 Publication
Sequence conflicti266 – 2661F → L in BAA87915. 1 Publication
Sequence conflicti315 – 3151R → P in BAA87914. 1 Publication
Sequence conflicti315 – 3151R → P in BAA87915. 1 Publication
Sequence conflicti330 – 3301M → I in BAA87914. 1 Publication
Sequence conflicti330 – 3301M → I in BAA87915. 1 Publication
Sequence conflicti356 – 3561T → S in AAN01614. 1 Publication
Sequence conflicti356 – 3561T → S in BAD30018. 1 Publication
Sequence conflicti429 – 4291D → N in BAB83501. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF434663 mRNA. Translation: AAL86736.1.
AF539424 mRNA. Translation: AAN01614.1.
AB021964 mRNA. Translation: BAA87914.1.
AB021965 mRNA. Translation: BAA87915.1.
AB064265 mRNA. Translation: BAB83501.2.
AY351388 mRNA. Translation: AAQ02381.1.
AF061260 mRNA. Translation: AAC67243.1. Frameshift.
AB092414 mRNA. Translation: BAC66173.1.
AB183399 mRNA. Translation: BAD30018.1.
AB183400 mRNA. Translation: BAD30019.1.
AB183401 mRNA. Translation: BAD30020.1.
AB183402 mRNA. Translation: BAD30021.1.
CCDSiCCDS23147.1. [Q8R5M8-4]
CCDS23148.1. [Q8R5M8-2]
CCDS23149.1. [Q8R5M8-1]
CCDS23150.1. [Q8R5M8-3]
RefSeqiNP_001020771.1. NM_001025600.1. [Q8R5M8-4]
NP_061240.3. NM_018770.3. [Q8R5M8-2]
NP_997558.2. NM_207675.2. [Q8R5M8-1]
NP_997559.1. NM_207676.2. [Q8R5M8-3]
UniGeneiMm.234832.

Genome annotation databases

EnsembliENSMUST00000034581; ENSMUSP00000034581; ENSMUSG00000032076. [Q8R5M8-4]
ENSMUST00000085909; ENSMUSP00000083073; ENSMUSG00000032076. [Q8R5M8-1]
ENSMUST00000114547; ENSMUSP00000110194; ENSMUSG00000032076. [Q8R5M8-2]
ENSMUST00000114548; ENSMUSP00000110195; ENSMUSG00000032076. [Q8R5M8-3]
GeneIDi54725.
KEGGimmu:54725.
UCSCiuc009phn.1. mouse. [Q8R5M8-5]
uc009pho.1. mouse. [Q8R5M8-1]
uc009phq.1. mouse. [Q8R5M8-3]
uc009phr.1. mouse. [Q8R5M8-4]
uc009phs.1. mouse. [Q8R5M8-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF434663 mRNA. Translation: AAL86736.1 .
AF539424 mRNA. Translation: AAN01614.1 .
AB021964 mRNA. Translation: BAA87914.1 .
AB021965 mRNA. Translation: BAA87915.1 .
AB064265 mRNA. Translation: BAB83501.2 .
AY351388 mRNA. Translation: AAQ02381.1 .
AF061260 mRNA. Translation: AAC67243.1 . Frameshift.
AB092414 mRNA. Translation: BAC66173.1 .
AB183399 mRNA. Translation: BAD30018.1 .
AB183400 mRNA. Translation: BAD30019.1 .
AB183401 mRNA. Translation: BAD30020.1 .
AB183402 mRNA. Translation: BAD30021.1 .
CCDSi CCDS23147.1. [Q8R5M8-4 ]
CCDS23148.1. [Q8R5M8-2 ]
CCDS23149.1. [Q8R5M8-1 ]
CCDS23150.1. [Q8R5M8-3 ]
RefSeqi NP_001020771.1. NM_001025600.1. [Q8R5M8-4 ]
NP_061240.3. NM_018770.3. [Q8R5M8-2 ]
NP_997558.2. NM_207675.2. [Q8R5M8-1 ]
NP_997559.1. NM_207676.2. [Q8R5M8-3 ]
UniGenei Mm.234832.

3D structure databases

ProteinModelPortali Q8R5M8.
SMRi Q8R5M8. Positions 48-337.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8R5M8. 3 interactions.
MINTi MINT-4131381.
STRINGi 10090.ENSMUSP00000083073.

Protein family/group databases

MEROPSi I43.001.

PTM databases

PhosphoSitei Q8R5M8.

Proteomic databases

PaxDbi Q8R5M8.
PRIDEi Q8R5M8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000034581 ; ENSMUSP00000034581 ; ENSMUSG00000032076 . [Q8R5M8-4 ]
ENSMUST00000085909 ; ENSMUSP00000083073 ; ENSMUSG00000032076 . [Q8R5M8-1 ]
ENSMUST00000114547 ; ENSMUSP00000110194 ; ENSMUSG00000032076 . [Q8R5M8-2 ]
ENSMUST00000114548 ; ENSMUSP00000110195 ; ENSMUSG00000032076 . [Q8R5M8-3 ]
GeneIDi 54725.
KEGGi mmu:54725.
UCSCi uc009phn.1. mouse. [Q8R5M8-5 ]
uc009pho.1. mouse. [Q8R5M8-1 ]
uc009phq.1. mouse. [Q8R5M8-3 ]
uc009phr.1. mouse. [Q8R5M8-4 ]
uc009phs.1. mouse. [Q8R5M8-2 ]

Organism-specific databases

CTDi 23705.
MGIi MGI:1889272. Cadm1.

Phylogenomic databases

eggNOGi NOG69486.
GeneTreei ENSGT00610000085800.
HOVERGENi HBG057086.
InParanoidi Q8R5M8.
KOi K06781.
OrthoDBi EOG7PVWPD.
PhylomeDBi Q8R5M8.
TreeFami TF334317.

Miscellaneous databases

NextBioi 311582.
PROi Q8R5M8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8R5M8.
Bgeei Q8R5M8.
CleanExi MM_CADM1.
Genevestigatori Q8R5M8.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
InterProi IPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR003585. Neurexin-like.
[Graphical view ]
Pfami PF08205. C2-set_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00294. 4.1m. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of the Tslc1 gene, a mouse orthologue of the human tumor suppressor TSLC1 gene."
    Fukami T., Satoh H., Fujita E., Maruyama T., Fukuhara H., Kuramochi M., Takamoto S., Momoi T., Murakami Y.
    Gene 295:7-12(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
    Strain: 129/SvJ.
  2. "SynCAM, a synaptic adhesion molecule that drives synapse assembly."
    Biederer T., Sara Y., Mozhayeva M., Atasoy D., Liu X., Kavalali E.T., Sudhof T.C.
    Science 297:1525-1531(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY.
    Strain: C57BL/6.
  3. "RA175, which is the mouse ortholog of TSLC1, a tumor suppressor gene in human lung cancer, is a cell adhesion molecule."
    Fujita E., Soyama A., Momoi T.
    Exp. Cell Res. 287:57-66(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 6 AND 7), FUNCTION.
    Tissue: Embryonic carcinoma.
  4. "Implications of nectin-like molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion and transmembrane protein localization in epithelial cells."
    Shingai T., Ikeda W., Kakunaga S., Morimoto K., Takekuni K., Itoh S., Satoh K., Takeuchi M., Imai T., Monden M., Takai Y.
    J. Biol. Chem. 278:35421-35427(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), FUNCTION, INTERACTION WITH MPP6, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: C57BL/6.
    Tissue: Brain.
  5. "Nectin-like molecule 1 is a protein 4.1N associated protein and recruits protein 4.1N from cytoplasm to the plasma membrane."
    Zhou Y., Du G., Hu X., Yu S., Liu Y., Xu Y., Huang X., Liu J., Yin B., Fan M., Peng X., Qiang B., Yuan J.
    Biochim. Biophys. Acta 1669:142-154(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 49-456 (ISOFORM 2).
  6. "A secretion form of SgIGSF/TSLC1."
    Ito A., Koma Y., Nagano T.
    Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
    Strain: C57BL/6.
    Tissue: Mast cell.
  7. "Neuron-specific isoforms of RA175/TSLC1/SynCAM."
    Fujita E., Aikawa K., Momoi T.
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4 AND 5).
  8. "Expression and functional characterization of the adhesion molecule spermatogenic immunoglobulin superfamily in the mouse testis."
    Wakayama T., Koami H., Ariga H., Kobayashi D., Sai Y., Tsuji A., Yamamoto M., Iseki S.
    Biol. Reprod. 68:1755-1763(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, GLYCOSYLATION.
  9. "Contribution of the SgIGSF adhesion molecule to survival of cultured mast cells in vivo."
    Ito A., Koma Y., Watabe K., Jippo T., Wakayama T., Iseki S., Kitamura Y.
    Biochem. Biophys. Res. Commun. 319:200-206(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. "The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM."
    Boles K.S., Barchet W., Diacovo T., Cella M., Colonna M.
    Blood 106:779-786(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CADM1.
  11. "Distribution of RA175/TSLC1/SynCAM, a member of the immunoglobulin superfamily, in the developing nervous system."
    Fujita E., Urase K., Soyama A., Kouroku Y., Momoi T.
    Brain Res. Dev. Brain Res. 154:199-209(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  12. "Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I-restricted T-cell-associated molecule."
    Galibert L., Diemer G.S., Liu Z., Johnson R.S., Smith J.L., Walzer T., Comeau M.R., Rauch C.T., Wolfson M.F., Sorensen R.A., Van der Vuurst de Vries A.-R., Branstetter D.G., Koelling R.M., Scholler J., Fanslow W.C., Baum P.R., Derry J.M., Yan W.
    J. Biol. Chem. 280:21955-21964(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CRTAM.
  13. "MITF and SgIGSF: an essential transcription factor and its target adhesion molecule for development and survival of mast cells."
    Kitamura Y.
    Novartis Found. Symp. 271:4-11(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  14. "Oligo-astheno-teratozoospermia in mice lacking RA175/TSLC1/SynCAM/IGSF4A, a cell adhesion molecule in the immunoglobulin superfamily."
    Fujita E., Kouroku Y., Ozeki S., Tanabe Y., Toyama Y., Maekawa M., Kojima N., Senoo H., Toshimori K., Momoi T.
    Mol. Cell. Biol. 26:718-726(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  15. "Loss of TSLC1 causes male infertility due to a defect at the spermatid stage of spermatogenesis."
    van der Weyden L., Arends M.J., Chausiaux O.E., Ellis P.J., Lange U.C., Surani M.A., Affara N., Murakami Y., Adams D.J., Bradley A.
    Mol. Cell. Biol. 26:3595-3609(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  16. "Disruption of spermatogenic cell adhesion and male infertility in mice lacking TSLC1/IGSF4, an immunoglobulin superfamily cell adhesion molecule."
    Yamada D., Yoshida M., Williams Y.N., Fukami T., Kikuchi S., Masuda M., Maruyama T., Ohta T., Nakae D., Maekawa A., Kitamura T., Murakami Y.
    Mol. Cell. Biol. 26:3610-3624(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  17. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-448, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
    Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.
    Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-104 AND ASN-116.
    Tissue: Myoblast.
  19. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-70; ASN-104; ASN-116; ASN-168; ASN-304; ASN-307 AND ASN-311.
  20. "N-glycosylation at the SynCAM (synaptic cell adhesion molecule) immunoglobulin interface modulates synaptic adhesion."
    Fogel A.I., Li Y., Giza J., Wang Q., Lam T.T., Modis Y., Biederer T.
    J. Biol. Chem. 285:34864-34874(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-70 AND ASN-104, SUBCELLULAR LOCATION.
  21. "The novel synaptogenic protein Farp1 links postsynaptic cytoskeletal dynamics and transsynaptic organization."
    Cheadle L., Biederer T.
    J. Cell Biol. 199:985-1001(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH FARP1.

Entry informationi

Entry nameiCADM1_MOUSE
AccessioniPrimary (citable) accession number: Q8R5M8
Secondary accession number(s): Q6F3J3
, Q7TNL1, Q80VG4, Q8K3T6, Q8R4L1, Q9QYL5, Q9QYL6, Q9Z2H8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 26, 2007
Last modified: July 9, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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