Reviewed, UniProtKB/Swiss-Prot Q8R5M5 (ACMSD_RAT)

Names and origin

Protein names

Recommended name:
    2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
    EC=4.1.1.45

Gene names

Name:

Acmsd

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	336 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate, a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. Ref.1
Catalytic activity	2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate = 2-aminomuconate semialdehyde + CO2.
Pathway	Secondary metabolite metabolism; quinolate metabolism.
Tissue specificity	Liver and kidney. Very low levels detected in brain. Ref.1 Ref.2
Sequence similarities	Belongs to the ACMSD family.

Ontologies

Keywords
Molecular function	Decarboxylase Lyase
PTM	Phosphoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	nicotinamide metabolic process Ref.1 Traceable author statement. Source: RGD quinolinate metabolic process Ref.1 Inferred from sequence or structural similarity. Source: UniProtKB tryptophan metabolic process Ref.1 Traceable author statement. Source: RGD
Cellular component	cytosol Ref.1 Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	aminocarboxymuconate-semialdehyde decarboxylase activity Ref.1 Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 336	336	2-amino-3-carboxymuconate-6-semialdehyde decarboxylase		PRO_0000190982
Amino acid modifications
	Modified residue	7	1	Phosphothreonine By similarity
	Modified residue	116	1	Phosphothreonine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8R5M5-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 4030A54E93DDD04B	FASTA	336	38,091
	10 20 30 40 50 60 MKIDIHTHIL PKEWPDLEKR FGYGGWVQLQ QQGKGEAKMM KDGKVFRVIQ QNCWDPEVRI 70 80 90 100 110 120 REMNQKGVTV QALSTVPVMF SYWAKPKDTL ELCQFLNNDL AATVARYPRR FVGLGTLPMQ 130 140 150 160 170 180 APGLAVEEME RCVKELGFPG IQIGSHINMW DLNDPELFPI YTAAERLNCS LFVHPWDMQM 190 200 210 220 230 240 DGRMAKYWLP WLVGMPSETT TAICSMIMGG VFEKFPKLKV CFAHGGGAFP FTIGRIAHGF 250 260 270 280 290 300 NMRPDLCARD NSSDPRKYLG SFYTDSLVHD PLSLKLLTDV IGKDRVILGT DYPFPLGEQE 310 320 330 PGKLIESMAD FDEETKDKLT AGNALTFLGL ERKLFE

References

[1]	"Purification and molecular cloning of rat 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase." Tanabe A., Egashira Y., Fukuoka S., Shibata K., Sanada H. Biochem. J. 361:567-575(2002) [PubMed: 11802786] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 1-20 AND 136-152, TISSUE SPECIFICITY. Strain: Wistar. Tissue: Liver.
[2]	"Identification and expression of a cDNA encoding human alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD). A key enzyme for the tryptophan-niacine pathway and 'quinolinate hypothesis'." Fukuoka S., Ishiguro K., Yanagihara K., Tanabe A., Egashira Y., Sanada H., Shibata K. J. Biol. Chem. 277:35162-35167(2002) [PubMed: 12140278] [Abstract] Cited for: TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB069781 mRNA. Translation: BAB84692.1.
IPI	IPI00201953.
RefSeq	NP_599199.1.
UniGene	Rn.162389
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q8R5M5.
Genome annotation databases
Ensembl	ENSRNOT00000005206; ENSRNOP00000005206; ENSRNOG00000003884; Rattus norvegicus. [Genome view]
GeneID	171385.
KEGG	rno:171385.
NMPDR	fig|10116.3.peg.9005.
Organism-specific databases
CTD	171385.
RGD	620868. Acmsd.
Phylogenomic databases
HOVERGEN	Q8R5M5.
Enzyme and pathway databases
BRENDA	4.1.1.45. 248.
Gene expression databases
ArrayExpress	Q8R5M5.
Genevestigator	Q8R5M5.
GermOnline	ENSRNOG00000003884. Rattus norvegicus.
Family and domain databases
InterPro	IPR006992. Amidohydro_2. [Graphical view]
Pfam	PF04909. Amidohydro_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	622218.

Entry information

Entry name

ACMSD_RAT

Accession

Primary (citable) accession number: Q8R5M5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 24, 2003
Last sequence update:	June 1, 2002
Last modified:	October 13, 2009
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)