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Protein

Protein Wnt-9a

Gene

Wnt9a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • anatomical structure development Source: MGI
  • canonical Wnt signaling pathway Source: MGI
  • cell fate commitment Source: GO_Central
  • embryonic forelimb morphogenesis Source: MGI
  • embryonic skeletal system morphogenesis Source: MGI
  • mitotic cell cycle checkpoint Source: MGI
  • negative regulation of canonical Wnt signaling pathway Source: Reactome
  • negative regulation of cartilage development Source: MGI
  • negative regulation of cell death Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • negative regulation of chondrocyte differentiation Source: MGI
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  • neuron differentiation Source: GO_Central
  • positive regulation of cell differentiation Source: MGI
  • positive regulation of smoothened signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiR-MMU-3238698. WNT ligand biogenesis and trafficking.
R-MMU-3772470. Negative regulation of TCF-dependent signaling by WNT ligand antagonists.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-9a
Alternative name(s):
Protein Wnt-14
Gene namesi
Name:Wnt9a
Synonyms:Wnt14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2446084. Wnt9a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence analysisAdd
BLAST
Chaini30 – 365336Protein Wnt-9aPRO_0000041456Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi93 ↔ 104By similarity
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence analysis
Disulfide bondi141 ↔ 149By similarity
Disulfide bondi151 ↔ 168By similarity
Disulfide bondi215 ↔ 229By similarity
Disulfide bondi217 ↔ 224By similarity
Lipidationi221 – 2211O-palmitoleyl serine; by PORCNBy similarity
Disulfide bondi313 ↔ 324By similarity
Disulfide bondi339 ↔ 354By similarity
Disulfide bondi341 ↔ 351By similarity
Disulfide bondi346 ↔ 347By similarity

Post-translational modificationi

Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

MaxQBiQ8R5M2.
PaxDbiQ8R5M2.
PRIDEiQ8R5M2.

PTM databases

iPTMnetiQ8R5M2.

Expressioni

Tissue specificityi

Expressed in adult brain, lung, skeletal muscle, heart, and 17-day embryo.1 Publication

Gene expression databases

BgeeiQ8R5M2.
CleanExiMM_WNT9A.
ExpressionAtlasiQ8R5M2. baseline and differential.
GenevisibleiQ8R5M2. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi229787. 3 interactions.
STRINGi10090.ENSMUSP00000104411.

Structurei

3D structure databases

ProteinModelPortaliQ8R5M2.
SMRiQ8R5M2. Positions 92-356.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3913. Eukaryota.
ENOG410XQZ1. LUCA.
GeneTreeiENSGT00690000101857.
HOGENOMiHOG000039529.
HOVERGENiHBG001595.
InParanoidiQ8R5M2.
KOiK01064.
PhylomeDBiQ8R5M2.

Family and domain databases

InterProiIPR005817. Wnt.
IPR013303. Wnt9a.
IPR018161. Wnt_CS.
[Graphical view]
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01894. WNT14PROTEIN.
PR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R5M2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDGSLLARW LAAAFGLTLL LAALRPSAAY FGLTGSEPLT ILPLTLETEA
60 70 80 90 100
AAQAHYKACD RLKLERKQRR MCRRDPGVAE TLVEAVSMSA LECQYQFRFE
110 120 130 140 150
RWNCTLEGRY RASLLKRGFK ETAFLYAISS AGLTHALAKA CSAGRMERCT
160 170 180 190 200
CDEAPDLENR EAWQWGGCGD NLKYSSKFVK EFLGRRSSKD LRARVDFHNN
210 220 230 240 250
LVGVKVIKAG VETTCKCHGV SGSCTVRTCW RQLAPFHEVG KHLKHKYETS
260 270 280 290 300
LKVGSTTNEA TGEAGAISPP RGRASGSGGG DPLPRTPELV HLDDSPSFCL
310 320 330 340 350
AGRFSPGTAG RRCHREKNCE SICCGRGHNT QSRVVTRPCQ CQVRWCCYVE
360
CRQCTQREEV YTCKG
Length:365
Mass (Da):40,388
Last modified:June 1, 2002 - v1
Checksum:iC6EBBE1897D2FA8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB072311 mRNA. Translation: BAB84710.1.
CCDSiCCDS36169.1.
RefSeqiNP_647459.1. NM_139298.2.
UniGeneiMm.218794.

Genome annotation databases

EnsembliENSMUST00000108783; ENSMUSP00000104411; ENSMUSG00000000126.
GeneIDi216795.
KEGGimmu:216795.
UCSCiuc007jdq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB072311 mRNA. Translation: BAB84710.1.
CCDSiCCDS36169.1.
RefSeqiNP_647459.1. NM_139298.2.
UniGeneiMm.218794.

3D structure databases

ProteinModelPortaliQ8R5M2.
SMRiQ8R5M2. Positions 92-356.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229787. 3 interactions.
STRINGi10090.ENSMUSP00000104411.

PTM databases

iPTMnetiQ8R5M2.

Proteomic databases

MaxQBiQ8R5M2.
PaxDbiQ8R5M2.
PRIDEiQ8R5M2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000108783; ENSMUSP00000104411; ENSMUSG00000000126.
GeneIDi216795.
KEGGimmu:216795.
UCSCiuc007jdq.1. mouse.

Organism-specific databases

CTDi7483.
MGIiMGI:2446084. Wnt9a.

Phylogenomic databases

eggNOGiKOG3913. Eukaryota.
ENOG410XQZ1. LUCA.
GeneTreeiENSGT00690000101857.
HOGENOMiHOG000039529.
HOVERGENiHBG001595.
InParanoidiQ8R5M2.
KOiK01064.
PhylomeDBiQ8R5M2.

Enzyme and pathway databases

ReactomeiR-MMU-3238698. WNT ligand biogenesis and trafficking.
R-MMU-3772470. Negative regulation of TCF-dependent signaling by WNT ligand antagonists.

Miscellaneous databases

PROiQ8R5M2.
SOURCEiSearch...

Gene expression databases

BgeeiQ8R5M2.
CleanExiMM_WNT9A.
ExpressionAtlasiQ8R5M2. baseline and differential.
GenevisibleiQ8R5M2. MM.

Family and domain databases

InterProiIPR005817. Wnt.
IPR013303. Wnt9a.
IPR018161. Wnt_CS.
[Graphical view]
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01894. WNT14PROTEIN.
PR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and expression of mouse Wnt14, and structural comparison between mouse Wnt14-Wnt3a gene cluster and human WNT14-WNT3A gene cluster."
    Katoh M.
    Int. J. Mol. Med. 9:221-227(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.

Entry informationi

Entry nameiWNT9A_MOUSE
AccessioniPrimary (citable) accession number: Q8R5M2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: June 1, 2002
Last modified: July 6, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.