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Protein

Fibroblast growth factor 14

Gene

Fgf14

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probably involved in nervous system development and function.By similarity

GO - Molecular functioni

  • growth factor activity Source: RGD

GO - Biological processi

  • nervous system development Source: InterPro
  • positive regulation of high voltage-gated calcium channel activity Source: MGI
  • regulation of postsynaptic membrane potential Source: MGI
  • regulation of synaptic plasticity Source: MGI
  • regulation of synaptic vesicle recycling Source: MGI

Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

ReactomeiR-RNO-5576892 Phase 0 - rapid depolarisation

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 14
Short name:
FGF-14
Gene namesi
Name:Fgf14
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi620165 Fgf14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001476121 – 247Fibroblast growth factor 14Add BLAST247

Proteomic databases

PaxDbiQ8R5L7
PRIDEiQ8R5L7

PTM databases

PhosphoSitePlusiQ8R5L7

Expressioni

Gene expression databases

BgeeiENSRNOG00000009288
GenevisibleiQ8R5L7 RN

Interactioni

Subunit structurei

Interacts with SCN8A.By similarity

GO - Molecular functioni

  • growth factor activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000042838

Structurei

3D structure databases

ProteinModelPortaliQ8R5L7
SMRiQ8R5L7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00760000118859
HOGENOMiHOG000290676
HOVERGENiHBG007580
InParanoidiQ8R5L7
KOiK22413
OMAiXAMYREP
OrthoDBiEOG091G0NAY
PhylomeDBiQ8R5L7
TreeFamiTF317805

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028284 FGF14
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF18 PTHR11486:SF18, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
PRINTSiPR00263 HBGFFGF
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit

Sequencei

Sequence statusi: Complete.

Q8R5L7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAIASGLI RQKRQAREQH WDRPSASRRR SSPSKNRGLC NGNLVDIFSK
60 70 80 90 100
VRIFGLKKRR LRRQDPQLKG IVTRLYCRQG YYLQMHPDGA LDGTKDDSTN
110 120 130 140 150
STLFNLIPVG LRVVAIQGVK TGLYIAMNGE GYLYPSELFT PECKFKESVF
160 170 180 190 200
ENYYVIYSSM LYRQQESGRA WFLGLNKEGQ VMKGNRVKKT KPAAHFLPKP
210 220 230 240
LEVAMYREPS LHDVGETVPK AGVTPSKSTS ASAIMNGGKP VNKCKTT
Length:247
Mass (Da):27,720
Last modified:June 1, 2002 - v1
Checksum:i427C3C760894996E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB079500 mRNA Translation: BAB84580.1
RefSeqiNP_071559.2, NM_022223.2
UniGeneiRn.44476

Genome annotation databases

EnsembliENSRNOT00000041551; ENSRNOP00000042838; ENSRNOG00000009288
GeneIDi63851
KEGGirno:63851
UCSCiRGD:620165 rat

Similar proteinsi

Entry informationi

Entry nameiFGF14_RAT
AccessioniPrimary (citable) accession number: Q8R5L7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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