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Protein

Fibroblast growth factor 14

Gene

Fgf14

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probably involved in nervous system development and function.By similarity

GO - Molecular functioni

  • growth factor activity Source: RGD

GO - Biological processi

  • nervous system development Source: InterPro
  • positive regulation of defense response to virus by host Source: Ensembl
  • positive regulation of high voltage-gated calcium channel activity Source: MGI
  • regulation of postsynaptic membrane potential Source: MGI
  • regulation of synaptic plasticity Source: MGI
  • regulation of synaptic vesicle recycling Source: MGI
  • xenophagy Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiR-RNO-5576892. Phase 0 - rapid depolarisation.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 14
Short name:
FGF-14
Gene namesi
Name:Fgf14
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi620165. Fgf14.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001476121 – 247Fibroblast growth factor 14Add BLAST247

Proteomic databases

PaxDbiQ8R5L7.
PRIDEiQ8R5L7.

PTM databases

PhosphoSitePlusiQ8R5L7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000009288.
ExpressionAtlasiQ8R5L7. differential.
GenevisibleiQ8R5L7. RN.

Interactioni

Subunit structurei

Interacts with SCN8A.By similarity

GO - Molecular functioni

  • growth factor activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000042838.

Structurei

3D structure databases

ProteinModelPortaliQ8R5L7.
SMRiQ8R5L7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000290676.
HOVERGENiHBG007580.
InParanoidiQ8R5L7.
KOiK04358.
OMAiCEAYDNY.
OrthoDBiEOG091G0NAY.
PhylomeDBiQ8R5L7.
TreeFamiTF317805.

Family and domain databases

CDDicd00058. FGF. 1 hit.
InterProiIPR008996. Cytokine_IL1-like.
IPR028284. FGF14.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF18. PTHR11486:SF18. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R5L7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAIASGLI RQKRQAREQH WDRPSASRRR SSPSKNRGLC NGNLVDIFSK
60 70 80 90 100
VRIFGLKKRR LRRQDPQLKG IVTRLYCRQG YYLQMHPDGA LDGTKDDSTN
110 120 130 140 150
STLFNLIPVG LRVVAIQGVK TGLYIAMNGE GYLYPSELFT PECKFKESVF
160 170 180 190 200
ENYYVIYSSM LYRQQESGRA WFLGLNKEGQ VMKGNRVKKT KPAAHFLPKP
210 220 230 240
LEVAMYREPS LHDVGETVPK AGVTPSKSTS ASAIMNGGKP VNKCKTT
Length:247
Mass (Da):27,720
Last modified:June 1, 2002 - v1
Checksum:i427C3C760894996E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB079500 mRNA. Translation: BAB84580.1.
RefSeqiNP_071559.2. NM_022223.2.
UniGeneiRn.44476.

Genome annotation databases

EnsembliENSRNOT00000041551; ENSRNOP00000042838; ENSRNOG00000009288.
GeneIDi63851.
KEGGirno:63851.
UCSCiRGD:620165. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB079500 mRNA. Translation: BAB84580.1.
RefSeqiNP_071559.2. NM_022223.2.
UniGeneiRn.44476.

3D structure databases

ProteinModelPortaliQ8R5L7.
SMRiQ8R5L7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000042838.

PTM databases

PhosphoSitePlusiQ8R5L7.

Proteomic databases

PaxDbiQ8R5L7.
PRIDEiQ8R5L7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000041551; ENSRNOP00000042838; ENSRNOG00000009288.
GeneIDi63851.
KEGGirno:63851.
UCSCiRGD:620165. rat.

Organism-specific databases

CTDi2259.
RGDi620165. Fgf14.

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000290676.
HOVERGENiHBG007580.
InParanoidiQ8R5L7.
KOiK04358.
OMAiCEAYDNY.
OrthoDBiEOG091G0NAY.
PhylomeDBiQ8R5L7.
TreeFamiTF317805.

Enzyme and pathway databases

ReactomeiR-RNO-5576892. Phase 0 - rapid depolarisation.

Miscellaneous databases

PROiQ8R5L7.

Gene expression databases

BgeeiENSRNOG00000009288.
ExpressionAtlasiQ8R5L7. differential.
GenevisibleiQ8R5L7. RN.

Family and domain databases

CDDicd00058. FGF. 1 hit.
InterProiIPR008996. Cytokine_IL1-like.
IPR028284. FGF14.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF18. PTHR11486:SF18. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFGF14_RAT
AccessioniPrimary (citable) accession number: Q8R5L7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: June 1, 2002
Last modified: November 30, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.