Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein Tob1

Gene

Tob1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Tob1
Alternative name(s):
Transducer of erbB-2 1
Gene namesi
Name:Tob1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621126 Tob1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001438141 – 365Protein Tob1Add BLAST365

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei204PhosphothreonineBy similarity1

Post-translational modificationi

Phosphorylated on Ser and Thr residues.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8R5K6

Interactioni

Subunit structurei

Interacts with ERBB2 (By similarity). Interacts with CNOT7 (By similarity). Interacts with CPEB3 (via C-terminal RNA-binding region); recruits CNOT7 to CPEB3 to form a ternary complex required for mRNA deadenylation and decay (PubMed:21336257). Interacts with CNOT8 (By similarity). Interacts with CPEB4 (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

MINTiQ8R5K6
STRINGi10116.ENSRNOP00000064047

Structurei

3D structure databases

ProteinModelPortaliQ8R5K6
SMRiQ8R5K6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni82 – 92Important for nuclear localizationBy similarityAdd BLAST11
Regioni161 – 220Required for interaction with CPEB3By similarityAdd BLAST60

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi22 – 39Bipartite nuclear localization signalBy similarityAdd BLAST18
Motifi228 – 236Nuclear export signalBy similarity9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi253 – 260Poly-Pro8
Compositional biasi261 – 283Poly-GlnAdd BLAST23

Sequence similaritiesi

Belongs to the BTG family.Curated

Phylogenomic databases

eggNOGiKOG4006 Eukaryota
ENOG410ZZC0 LUCA
HOVERGENiHBG006617
InParanoidiQ8R5K6
PhylomeDBiQ8R5K6

Family and domain databases

Gene3Di1.20.120.1120, 1 hit
InterProiView protein in InterPro
IPR002087 Anti_prolifrtn
IPR036054 BTG-like_sf
IPR015677 Tob1
IPR015676 Tob1/2
PANTHERiPTHR17537 PTHR17537, 1 hit
PTHR17537:SF6 PTHR17537:SF6, 1 hit
PfamiView protein in Pfam
PF07742 BTG, 1 hit
PRINTSiPR00310 ANTIPRLFBTG1
SMARTiView protein in SMART
SM00099 btg1, 1 hit
SUPFAMiSSF160696 SSF160696, 1 hit
PROSITEiView protein in PROSITE
PS00960 BTG_1, 1 hit
PS01203 BTG_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8R5K6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLEIQVALN FIISYLYNKL PRRRVNIFGE ELERLLKQKY EGHWYPEKPY
60 70 80 90 100
KGSGFRCIHV GEKVDPVIEQ ASKESGLDID DVRGNLPQDL SVWIDPFEVS
110 120 130 140 150
YQIGEKGPVK VLYVDDSNEN GCELDKEIKN SFNPEAQVFM PISDPASSVS
160 170 180 190 200
SSPSPPFGHS AAVSPTFMPR STQPLTFTTA TFAATKFGST KMKNSGRSSK
210 220 230 240 250
VARTSPISLG LNVNVNDLLK QKAISSSMHS LYGLGLGSQQ QPQPQPQQPP
260 270 280 290 300
SQPPPPPPPP QQQQQHQQQQ QQQQQQQQQP QQQTSALSPN AKEFIFPNMQ
310 320 330 340 350
GQGSSTNGMF PGDSPLNLSP LQYSNAFNVF AAYGGLNEKS FVDGLNFSLN
360
NIQYSNQQFQ PVMAN
Length:365
Mass (Da):40,461
Last modified:June 1, 2002 - v1
Checksum:iC202986337E6C350
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF349723 mRNA Translation: AAL79524.1
UniGeneiRn.7819

Similar proteinsi

Entry informationi

Entry nameiTOB1_RAT
AccessioniPrimary (citable) accession number: Q8R5K6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health