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Protein
Submitted name:

Glutathione S-transferase mu 4

Gene

Gstm4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. enzyme binding Source: MGI
  2. glutathione binding Source: MGI
  3. glutathione transferase activity Source: MGI
  4. protein homodimerization activity Source: MGI

GO - Biological processi

  1. glutathione metabolic process Source: MGI
  2. nitrobenzene metabolic process Source: MGI
  3. xenobiotic catabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

TransferaseImported

Enzyme and pathway databases

ReactomeiREACT_317599. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Submitted name:
Glutathione S-transferase mu 4Imported
Submitted name:
Glutathione S-transferase, mu 4Imported
Submitted name:
Glutathione transferase GSTM7-7Imported (EC:2.5.1.18Imported)
Submitted name:
Protein Gstm4Imported
Gene namesi
Name:Gstm4Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:95862. Gstm4.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. cytosol Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ8R5I6.

Family & Domainsi

Sequence similaritiesi

Belongs to the GST superfamily.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00550000074559.
HOGENOMiHOG000115735.
HOVERGENiHBG106842.
KOiK00799.
OMAiTKIAVWG.
OrthoDBiEOG7KH9M3.
TreeFamiTF353040.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003081. GST_mu.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01267. GSTRNSFRASEM.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R5I6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPMTLGYWDI RGLAHAIRLL LEYTGSSYEE KRYTMGDAPD YDRSQWLSEK
60 70 80 90 100
FKLGLDFPNL PYLIDGSHKI TQSNAILRYI ARKHNLCGET EEEKIRVDIL
110 120 130 140 150
ENQAMDVSNQ LARVCYSPDF EKLKVEYLEQ LPGMVKLFSQ FLGQRTWFVG
160 170 180 190 200
EKITFVDFLA YDILDLHLIF EPTCLDAFPN LKDFVARFEV LKRISAYMKT
210
SRFLRTPLYT KVATWGNK
Length:218
Mass (Da):25,519
Last modified:June 1, 2002 - v1
Checksum:i81F15DBB46118102
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL671877 Genomic DNA. No translation available.
BC030444 mRNA. Translation: AAH30444.1.
AF464943 mRNA. Translation: AAL76248.1.
AF501320 mRNA. Translation: AAM67419.1.
RefSeqiNP_081040.1. NM_026764.3.
UniGeneiMm.31203.

Genome annotation databases

EnsembliENSMUST00000029489; ENSMUSP00000029489; ENSMUSG00000027890.
GeneIDi14865.
KEGGimmu:14865.
UCSCiuc008qxy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL671877 Genomic DNA. No translation available.
BC030444 mRNA. Translation: AAH30444.1.
AF464943 mRNA. Translation: AAL76248.1.
AF501320 mRNA. Translation: AAM67419.1.
RefSeqiNP_081040.1. NM_026764.3.
UniGeneiMm.31203.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029489; ENSMUSP00000029489; ENSMUSG00000027890.
GeneIDi14865.
KEGGimmu:14865.
UCSCiuc008qxy.2. mouse.

Organism-specific databases

CTDi2948.
MGIiMGI:95862. Gstm4.

Phylogenomic databases

GeneTreeiENSGT00550000074559.
HOGENOMiHOG000115735.
HOVERGENiHBG106842.
KOiK00799.
OMAiTKIAVWG.
OrthoDBiEOG7KH9M3.
TreeFamiTF353040.

Enzyme and pathway databases

ReactomeiREACT_317599. Glutathione conjugation.

Miscellaneous databases

NextBioi287117.
PROiQ8R5I6.
SOURCEiSearch...

Gene expression databases

GenevestigatoriQ8R5I6.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003081. GST_mu.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01267. GSTRNSFRASEM.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice."
    Chanas S.A., Jiang Q., McMahon M., McWalter G.K., McLellan L.I., Elcombe C.R., Henderson C.J., Wolf C.R., Moffat G.J., Itoh K., Yamamoto M., Hayes J.D.
    Biochem. J. 365:405-416(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ICRxBALB/cAImported.
  2. "Cloning and expression of a novel Mu class murine glutathione transferase isoenzyme."
    Guo J., Zimniak L., Zimniak P., Orchard J.L., Singh S.V.
    Biochem. J. 366:817-824(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: A/JImported.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N-3Imported.
    Tissue: Mammary tumor. MMTV-LTR/INT3 model. 5 month old mouse. Taken by biopsy.Imported.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  5. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ8R5I6_MOUSE
AccessioniPrimary (citable) accession number: Q8R5I6
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: April 29, 2015
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.