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Q8R5I6

- Q8R5I6_MOUSE

UniProt

Q8R5I6 - Q8R5I6_MOUSE

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Protein
Submitted name: Glutathione S-transferase mu 4
Gene
Gstm4
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. glutathione transferase activity Source: MGI

GO - Biological processi

  1. nitrobenzene metabolic process Source: MGI
  2. xenobiotic catabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

TransferaseImported

Enzyme and pathway databases

ReactomeiREACT_215316. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Submitted name:
Glutathione S-transferase mu 4Imported
Submitted name:
Glutathione S-transferase, mu 4Imported
Submitted name:
Glutathione transferase GSTM7-7Imported (EC:2.5.1.18Imported)
Submitted name:
Protein Gstm4Imported
Gene namesi
Name:Gstm4Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:95862. Gstm4.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ8R5I6.

Family & Domainsi

Sequence similaritiesi

Belongs to the GST superfamily.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00550000074559.
HOGENOMiHOG000115735.
HOVERGENiHBG106842.
InParanoidiQ8R5I6.
KOiK00799.
OMAiTKIAVWG.
OrthoDBiEOG7KH9M3.
TreeFamiTF353040.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003081. GST_mu.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01267. GSTRNSFRASEM.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R5I6-1 [UniParc]FASTAAdd to Basket

« Hide

MPMTLGYWDI RGLAHAIRLL LEYTGSSYEE KRYTMGDAPD YDRSQWLSEK    50
FKLGLDFPNL PYLIDGSHKI TQSNAILRYI ARKHNLCGET EEEKIRVDIL 100
ENQAMDVSNQ LARVCYSPDF EKLKVEYLEQ LPGMVKLFSQ FLGQRTWFVG 150
EKITFVDFLA YDILDLHLIF EPTCLDAFPN LKDFVARFEV LKRISAYMKT 200
SRFLRTPLYT KVATWGNK 218
Length:218
Mass (Da):25,519
Last modified:June 1, 2002 - v1
Checksum:i81F15DBB46118102
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL671877 Genomic DNA. No translation available.
BC030444 mRNA. Translation: AAH30444.1.
AF464943 mRNA. Translation: AAL76248.1.
AF501320 mRNA. Translation: AAM67419.1.
RefSeqiNP_081040.1. NM_026764.3.
UniGeneiMm.31203.

Genome annotation databases

EnsembliENSMUST00000029489; ENSMUSP00000029489; ENSMUSG00000027890.
GeneIDi14865.
KEGGimmu:14865.
UCSCiuc008qxy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL671877 Genomic DNA. No translation available.
BC030444 mRNA. Translation: AAH30444.1 .
AF464943 mRNA. Translation: AAL76248.1 .
AF501320 mRNA. Translation: AAM67419.1 .
RefSeqi NP_081040.1. NM_026764.3.
UniGenei Mm.31203.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029489 ; ENSMUSP00000029489 ; ENSMUSG00000027890 .
GeneIDi 14865.
KEGGi mmu:14865.
UCSCi uc008qxy.2. mouse.

Organism-specific databases

CTDi 2948.
MGIi MGI:95862. Gstm4.

Phylogenomic databases

GeneTreei ENSGT00550000074559.
HOGENOMi HOG000115735.
HOVERGENi HBG106842.
InParanoidi Q8R5I6.
KOi K00799.
OMAi TKIAVWG.
OrthoDBi EOG7KH9M3.
TreeFami TF353040.

Enzyme and pathway databases

Reactomei REACT_215316. Glutathione conjugation.

Miscellaneous databases

NextBioi 287117.
PROi Q8R5I6.
SOURCEi Search...

Gene expression databases

Genevestigatori Q8R5I6.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003081. GST_mu.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
PRINTSi PR01267. GSTRNSFRASEM.
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice."
    Chanas S.A., Jiang Q., McMahon M., McWalter G.K., McLellan L.I., Elcombe C.R., Henderson C.J., Wolf C.R., Moffat G.J., Itoh K., Yamamoto M., Hayes J.D.
    Biochem. J. 365:405-416(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ICRxBALB/cAImported.
  2. "Cloning and expression of a novel Mu class murine glutathione transferase isoenzyme."
    Guo J., Zimniak L., Zimniak P., Orchard J.L., Singh S.V.
    Biochem. J. 366:817-824(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: A/JImported.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N-3Imported.
    Tissue: Mammary tumor. MMTV-LTR/INT3 model. 5 month old mouse. Taken by biopsy.Imported.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  5. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ8R5I6_MOUSE
AccessioniPrimary (citable) accession number: Q8R5I6
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: September 3, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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