Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8R5I6

- Q8R5I6_MOUSE

UniProt

Q8R5I6 - Q8R5I6_MOUSE

Protein
Submitted name:

Glutathione S-transferase mu 4

Gene

Gstm4

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. glutathione transferase activity Source: MGI

    GO - Biological processi

    1. nitrobenzene metabolic process Source: MGI
    2. xenobiotic catabolic process Source: MGI

    Keywords - Molecular functioni

    TransferaseImported

    Enzyme and pathway databases

    ReactomeiREACT_215316. Glutathione conjugation.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Glutathione S-transferase mu 4Imported
    Submitted name:
    Glutathione S-transferase, mu 4Imported
    Submitted name:
    Glutathione transferase GSTM7-7Imported (EC:2.5.1.18Imported)
    Submitted name:
    Protein Gstm4Imported
    Gene namesi
    Name:Gstm4Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:95862. Gstm4.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: MGI

    Expressioni

    Gene expression databases

    GenevestigatoriQ8R5I6.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GST superfamily.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00550000074559.
    HOGENOMiHOG000115735.
    HOVERGENiHBG106842.
    InParanoidiQ8R5I6.
    KOiK00799.
    OMAiTKIAVWG.
    OrthoDBiEOG7KH9M3.
    TreeFamiTF353040.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR003081. GST_mu.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view]
    PRINTSiPR01267. GSTRNSFRASEM.
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8R5I6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPMTLGYWDI RGLAHAIRLL LEYTGSSYEE KRYTMGDAPD YDRSQWLSEK    50
    FKLGLDFPNL PYLIDGSHKI TQSNAILRYI ARKHNLCGET EEEKIRVDIL 100
    ENQAMDVSNQ LARVCYSPDF EKLKVEYLEQ LPGMVKLFSQ FLGQRTWFVG 150
    EKITFVDFLA YDILDLHLIF EPTCLDAFPN LKDFVARFEV LKRISAYMKT 200
    SRFLRTPLYT KVATWGNK 218
    Length:218
    Mass (Da):25,519
    Last modified:June 1, 2002 - v1
    Checksum:i81F15DBB46118102
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL671877 Genomic DNA. No translation available.
    BC030444 mRNA. Translation: AAH30444.1.
    AF464943 mRNA. Translation: AAL76248.1.
    AF501320 mRNA. Translation: AAM67419.1.
    RefSeqiNP_081040.1. NM_026764.3.
    UniGeneiMm.31203.

    Genome annotation databases

    EnsembliENSMUST00000029489; ENSMUSP00000029489; ENSMUSG00000027890.
    GeneIDi14865.
    KEGGimmu:14865.
    UCSCiuc008qxy.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL671877 Genomic DNA. No translation available.
    BC030444 mRNA. Translation: AAH30444.1 .
    AF464943 mRNA. Translation: AAL76248.1 .
    AF501320 mRNA. Translation: AAM67419.1 .
    RefSeqi NP_081040.1. NM_026764.3.
    UniGenei Mm.31203.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029489 ; ENSMUSP00000029489 ; ENSMUSG00000027890 .
    GeneIDi 14865.
    KEGGi mmu:14865.
    UCSCi uc008qxy.2. mouse.

    Organism-specific databases

    CTDi 2948.
    MGIi MGI:95862. Gstm4.

    Phylogenomic databases

    GeneTreei ENSGT00550000074559.
    HOGENOMi HOG000115735.
    HOVERGENi HBG106842.
    InParanoidi Q8R5I6.
    KOi K00799.
    OMAi TKIAVWG.
    OrthoDBi EOG7KH9M3.
    TreeFami TF353040.

    Enzyme and pathway databases

    Reactomei REACT_215316. Glutathione conjugation.

    Miscellaneous databases

    NextBioi 287117.
    PROi Q8R5I6.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q8R5I6.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR003081. GST_mu.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view ]
    PRINTSi PR01267. GSTRNSFRASEM.
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice."
      Chanas S.A., Jiang Q., McMahon M., McWalter G.K., McLellan L.I., Elcombe C.R., Henderson C.J., Wolf C.R., Moffat G.J., Itoh K., Yamamoto M., Hayes J.D.
      Biochem. J. 365:405-416(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: ICRxBALB/cAImported.
    2. "Cloning and expression of a novel Mu class murine glutathione transferase isoenzyme."
      Guo J., Zimniak L., Zimniak P., Orchard J.L., Singh S.V.
      Biochem. J. 366:817-824(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: A/JImported.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N-3Imported.
      Tissue: Mammary tumor. MMTV-LTR/INT3 model. 5 month old mouse. Taken by biopsy.Imported.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    5. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ8R5I6_MOUSE
    AccessioniPrimary (citable) accession number: Q8R5I6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2002
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3