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Protein

Potassium channel subfamily K member 15

Gene

Kcnk15

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-RNO-5576886. Phase 4 - resting membrane potential.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K member 15
Alternative name(s):
Acid-sensitive potassium channel protein TASK-5
Short name:
rTASK-5
TWIK-related acid-sensitive K(+) channel 5
Gene namesi
Name:Kcnk15
Synonyms:Task5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi619733. Kcnk15.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8CytoplasmicSequence analysis8
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Intramembranei80 – 101Pore-forming; Name=Pore-forming 1Sequence analysisAdd BLAST22
Transmembranei108 – 128HelicalSequence analysisAdd BLAST21
Topological domaini129 – 158CytoplasmicSequence analysisAdd BLAST30
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Intramembranei189 – 209Pore-forming; Name=Pore-forming 2Sequence analysisAdd BLAST21
Transmembranei223 – 243HelicalSequence analysisAdd BLAST21
Topological domaini244 – 318CytoplasmicSequence analysisAdd BLAST75

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001017661 – 318Potassium channel subfamily K member 15Add BLAST318

Post-translational modificationi

Phosphorylated.Curated

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8R5I0.

Expressioni

Tissue specificityi

Brain-specific. Highly expressed in auditory nuclei, in Purkinje cells and in olfactory bulb mitral cells.

Gene expression databases

BgeeiENSRNOG00000010816.
GenevisibleiQ8R5I0. RN.

Interactioni

Subunit structurei

Heterodimer.Curated

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014411.

Structurei

3D structure databases

ProteinModelPortaliQ8R5I0.
SMRiQ8R5I0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4404. Eukaryota.
ENOG410XRZJ. LUCA.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000231463.
HOVERGENiHBG052239.
InParanoidiQ8R5I0.
KOiK04923.
OMAiFAHFEGW.
OrthoDBiEOG091G08DH.
PhylomeDBiQ8R5I0.

Family and domain databases

InterProiView protein in InterPro
IPR003280. 2pore_dom_K_chnl.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR013099. K_chnl_dom.
IPR008073. TASK5.
PfamiView protein in Pfam
PF07885. Ion_trans_2. 2 hits.
PRINTSiPR01333. 2POREKCHANEL.
PR01690. TASK5CHANNEL.
PR01095. TASKCHANNEL.

Sequencei

Sequence statusi: Complete.

Q8R5I0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKQSARTAA LILCILSYLL VGAAVFDALE SEAERSRQRL LARKRGEFRR
60 70 80 90 100
KYRFSADDYR ELERLALQAE PHRAGRQWRF AGSFYFAITV ITTIGYGHAA
110 120 130 140 150
PGTDSGKVFC MFYALLGIPL TLVTFQSLGE RLNALVRCLL LAAKRCLGLR
160 170 180 190 200
RPHVSAENMV VAGLLLCAAT LALGAAAFAH FEGWTFFHAY YYCFITLTTI
210 220 230 240 250
GFGDFVALQR DEALQKKPPY VAFSFLYILL GLTVIGAFLN LVVLRFLASA
260 270 280 290 300
EAPERAALRR ASVFRRGAPE SRVRIPYPFH PLETWARDNP AFSPPLSPEA
310
VHDCHSSPDR LRARRKSI
Length:318
Mass (Da):35,652
Last modified:June 1, 2002 - v1
Checksum:iA0629212F56834ED
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti315R → W in AAK97094 (PubMed:11749039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF467250 mRNA. Translation: AAL77036.1.
AF294353 mRNA. Translation: AAK97094.1.
RefSeqiNP_570826.1. NM_130813.1.
UniGeneiRn.161865.

Genome annotation databases

EnsembliENSRNOT00000014411; ENSRNOP00000014411; ENSRNOG00000010816.
GeneIDi156873.
KEGGirno:156873.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiKCNKF_RAT
AccessioniPrimary (citable) accession number: Q8R5I0
Secondary accession number(s): Q920G1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: June 1, 2002
Last modified: July 5, 2017
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families