Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Potassium channel subfamily K member 15

Gene

Kcnk15

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiR-RNO-5576886. Phase 4 - resting membrane potential.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K member 15
Alternative name(s):
Acid-sensitive potassium channel protein TASK-5
Short name:
rTASK-5
TWIK-related acid-sensitive K(+) channel 5
Gene namesi
Name:Kcnk15
Synonyms:Task5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi619733. Kcnk15.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 88CytoplasmicSequence analysis
Transmembranei9 – 2921HelicalSequence analysisAdd
BLAST
Intramembranei80 – 10122Pore-forming; Name=Pore-forming 1Sequence analysisAdd
BLAST
Transmembranei108 – 12821HelicalSequence analysisAdd
BLAST
Topological domaini129 – 15830CytoplasmicSequence analysisAdd
BLAST
Transmembranei159 – 17921HelicalSequence analysisAdd
BLAST
Intramembranei189 – 20921Pore-forming; Name=Pore-forming 2Sequence analysisAdd
BLAST
Transmembranei223 – 24321HelicalSequence analysisAdd
BLAST
Topological domaini244 – 31875CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Potassium channel subfamily K member 15PRO_0000101766Add
BLAST

Post-translational modificationi

Phosphorylated.Curated

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8R5I0.

Expressioni

Tissue specificityi

Brain-specific. Highly expressed in auditory nuclei, in Purkinje cells and in olfactory bulb mitral cells.

Gene expression databases

GenevisibleiQ8R5I0. RN.

Interactioni

Subunit structurei

Heterodimer.Curated

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014411.

Structurei

3D structure databases

ProteinModelPortaliQ8R5I0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4404. Eukaryota.
ENOG410XRZJ. LUCA.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000231463.
HOVERGENiHBG052239.
InParanoidiQ8R5I0.
KOiK04923.
OMAiHVSAENM.
OrthoDBiEOG7B05DC.
PhylomeDBiQ8R5I0.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR013099. K_chnl_dom.
IPR008073. TASK5.
[Graphical view]
PANTHERiPTHR11003:SF18. PTHR11003:SF18. 1 hit.
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.
PR01690. TASK5CHANNEL.
PR01095. TASKCHANNEL.

Sequencei

Sequence statusi: Complete.

Q8R5I0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKQSARTAA LILCILSYLL VGAAVFDALE SEAERSRQRL LARKRGEFRR
60 70 80 90 100
KYRFSADDYR ELERLALQAE PHRAGRQWRF AGSFYFAITV ITTIGYGHAA
110 120 130 140 150
PGTDSGKVFC MFYALLGIPL TLVTFQSLGE RLNALVRCLL LAAKRCLGLR
160 170 180 190 200
RPHVSAENMV VAGLLLCAAT LALGAAAFAH FEGWTFFHAY YYCFITLTTI
210 220 230 240 250
GFGDFVALQR DEALQKKPPY VAFSFLYILL GLTVIGAFLN LVVLRFLASA
260 270 280 290 300
EAPERAALRR ASVFRRGAPE SRVRIPYPFH PLETWARDNP AFSPPLSPEA
310
VHDCHSSPDR LRARRKSI
Length:318
Mass (Da):35,652
Last modified:June 1, 2002 - v1
Checksum:iA0629212F56834ED
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti315 – 3151R → W in AAK97094 (PubMed:11749039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF467250 mRNA. Translation: AAL77036.1.
AF294353 mRNA. Translation: AAK97094.1.
RefSeqiNP_570826.1. NM_130813.1.
UniGeneiRn.161865.

Genome annotation databases

EnsembliENSRNOT00000014411; ENSRNOP00000014411; ENSRNOG00000010816.
GeneIDi156873.
KEGGirno:156873.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF467250 mRNA. Translation: AAL77036.1.
AF294353 mRNA. Translation: AAK97094.1.
RefSeqiNP_570826.1. NM_130813.1.
UniGeneiRn.161865.

3D structure databases

ProteinModelPortaliQ8R5I0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014411.

Proteomic databases

PaxDbiQ8R5I0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000014411; ENSRNOP00000014411; ENSRNOG00000010816.
GeneIDi156873.
KEGGirno:156873.

Organism-specific databases

CTDi60598.
RGDi619733. Kcnk15.

Phylogenomic databases

eggNOGiKOG4404. Eukaryota.
ENOG410XRZJ. LUCA.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000231463.
HOVERGENiHBG052239.
InParanoidiQ8R5I0.
KOiK04923.
OMAiHVSAENM.
OrthoDBiEOG7B05DC.
PhylomeDBiQ8R5I0.

Enzyme and pathway databases

ReactomeiR-RNO-5576886. Phase 4 - resting membrane potential.

Miscellaneous databases

PROiQ8R5I0.

Gene expression databases

GenevisibleiQ8R5I0. RN.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR013099. K_chnl_dom.
IPR008073. TASK5.
[Graphical view]
PANTHERiPTHR11003:SF18. PTHR11003:SF18. 1 hit.
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.
PR01690. TASK5CHANNEL.
PR01095. TASKCHANNEL.
ProtoNetiSearch...

Publicationsi

  1. Kawano T., Nakajima S., Nakajima Y.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Long Evans.
    Tissue: Brain.
  2. "Expression pattern in brain of TASK-1, TASK-3, and a tandem pore domain K(+) channel subunit, TASK-5, associated with the central auditory nervous system."
    Karschin C., Wischmeyer E., Preisig-Mueller R., Rajan S., Derst C., Grzeschik K.-H., Daut J., Karschin A.
    Mol. Cell. Neurosci. 18:632-648(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 82-318.
    Strain: Wistar.

Entry informationi

Entry nameiKCNKF_RAT
AccessioniPrimary (citable) accession number: Q8R5I0
Secondary accession number(s): Q920G1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: June 1, 2002
Last modified: June 8, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.