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Protein

Potassium channel subfamily K member 15

Gene

Kcnk15

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-RNO-5576886 Phase 4 - resting membrane potential

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K member 15
Alternative name(s):
Acid-sensitive potassium channel protein TASK-5
Short name:
rTASK-5
TWIK-related acid-sensitive K(+) channel 5
Gene namesi
Name:Kcnk15
Synonyms:Task5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi619733 Kcnk15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8CytoplasmicSequence analysis8
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Intramembranei80 – 101Pore-forming; Name=Pore-forming 1Sequence analysisAdd BLAST22
Transmembranei108 – 128HelicalSequence analysisAdd BLAST21
Topological domaini129 – 158CytoplasmicSequence analysisAdd BLAST30
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Intramembranei189 – 209Pore-forming; Name=Pore-forming 2Sequence analysisAdd BLAST21
Transmembranei223 – 243HelicalSequence analysisAdd BLAST21
Topological domaini244 – 318CytoplasmicSequence analysisAdd BLAST75

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001017661 – 318Potassium channel subfamily K member 15Add BLAST318

Post-translational modificationi

Phosphorylated.Curated

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8R5I0
PRIDEiQ8R5I0

PTM databases

PhosphoSitePlusiQ8R5I0

Expressioni

Tissue specificityi

Brain-specific. Highly expressed in auditory nuclei, in Purkinje cells and in olfactory bulb mitral cells.

Gene expression databases

BgeeiENSRNOG00000010816
GenevisibleiQ8R5I0 RN

Interactioni

Subunit structurei

Heterodimer.Curated

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014411

Structurei

3D structure databases

ProteinModelPortaliQ8R5I0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4404 Eukaryota
ENOG410XRZJ LUCA
GeneTreeiENSGT00760000118858
HOGENOMiHOG000231463
HOVERGENiHBG052239
InParanoidiQ8R5I0
KOiK04923
OMAiFAHFEGW
OrthoDBiEOG091G08DH
PhylomeDBiQ8R5I0

Family and domain databases

InterProiView protein in InterPro
IPR003280 2pore_dom_K_chnl
IPR003092 2pore_dom_K_chnl_TASK
IPR013099 K_chnl_dom
IPR008073 TASK5
PfamiView protein in Pfam
PF07885 Ion_trans_2, 2 hits
PRINTSiPR01333 2POREKCHANEL
PR01690 TASK5CHANNEL
PR01095 TASKCHANNEL

Sequencei

Sequence statusi: Complete.

Q8R5I0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKQSARTAA LILCILSYLL VGAAVFDALE SEAERSRQRL LARKRGEFRR
60 70 80 90 100
KYRFSADDYR ELERLALQAE PHRAGRQWRF AGSFYFAITV ITTIGYGHAA
110 120 130 140 150
PGTDSGKVFC MFYALLGIPL TLVTFQSLGE RLNALVRCLL LAAKRCLGLR
160 170 180 190 200
RPHVSAENMV VAGLLLCAAT LALGAAAFAH FEGWTFFHAY YYCFITLTTI
210 220 230 240 250
GFGDFVALQR DEALQKKPPY VAFSFLYILL GLTVIGAFLN LVVLRFLASA
260 270 280 290 300
EAPERAALRR ASVFRRGAPE SRVRIPYPFH PLETWARDNP AFSPPLSPEA
310
VHDCHSSPDR LRARRKSI
Length:318
Mass (Da):35,652
Last modified:June 1, 2002 - v1
Checksum:iA0629212F56834ED
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti315R → W in AAK97094 (PubMed:11749039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF467250 mRNA Translation: AAL77036.1
AF294353 mRNA Translation: AAK97094.1
RefSeqiNP_570826.1, NM_130813.1
UniGeneiRn.161865

Genome annotation databases

EnsembliENSRNOT00000014411; ENSRNOP00000014411; ENSRNOG00000010816
GeneIDi156873
KEGGirno:156873

Similar proteinsi

Entry informationi

Entry nameiKCNKF_RAT
AccessioniPrimary (citable) accession number: Q8R5I0
Secondary accession number(s): Q920G1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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