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Protein

Fas apoptotic inhibitory molecule 1

Gene

Faim

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells.By similarity

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • I-kappaB kinase/NF-kappaB signaling Source: RGD
  • negative regulation of apoptotic process Source: InterPro
  • positive regulation of neurogenesis Source: RGD
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Fas apoptotic inhibitory molecule 1
Short name:
rFAIM
Gene namesi
Name:Faim
Synonyms:Faim1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi620572. Faim.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 201201Fas apoptotic inhibitory molecule 1PRO_0000087175Add
BLAST

Proteomic databases

PaxDbiQ8R5H8.

Expressioni

Gene expression databases

GenevisibleiQ8R5H8. RN.

Interactioni

Protein-protein interaction databases

BioGridi250864. 1 interaction.
STRINGi10116.ENSRNOP00000049149.

Family & Domainsi

Sequence similaritiesi

Belongs to the FAIM1 family.Curated

Phylogenomic databases

eggNOGiKOG4352. Eukaryota.
ENOG410XRNP. LUCA.
GeneTreeiENSGT00390000007364.
HOGENOMiHOG000007913.
HOVERGENiHBG051543.
InParanoidiQ8R5H8.
OMAiRCIIRVD.
OrthoDBiEOG7R56TX.
PhylomeDBiQ8R5H8.
TreeFamiTF314971.

Family and domain databases

InterProiIPR010695. FAIM1.
[Graphical view]
PANTHERiPTHR13088. PTHR13088. 1 hit.
PfamiPF06905. FAIM1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8R5H8-1) [UniParc]FASTAAdd to basket

Also known as: Long, FAIM-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASGDDSPIF EDDESPLCSL EKMTDLVAVW DVALSDGVHK IEFEHGTTSG
60 70 80 90 100
KRVVYVDGKE EIRREWMFKL VGKETFFVGA AKTKATINID AISGFAYEYT
110 120 130 140 150
LEIDGKSLKK YMENRSKTTN TWVLHLDGEE LRVVLEKDTM DVWCNGQRME
160 170 180 190 200
TAGEFVDDGT ETHFSVGNHD CYIKAVSSGK RREGIIHTLI VDNREIPELT

Q
Note: No experimental confirmation available.
Length:201
Mass (Da):22,705
Last modified:June 1, 2002 - v1
Checksum:i36AED1F0CB60E3C3
GO
Isoform 2 (identifier: Q8R5H8-2) [UniParc]FASTAAdd to basket

Also known as: Short, FAIM-S

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: Missing.

Show »
Length:179
Mass (Da):20,337
Checksum:iFA38E432AE50E0CE
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2222Missing in isoform 2. 1 PublicationVSP_008993Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF412334 mRNA. Translation: AAL60162.1.
AF467453 mRNA. Translation: AAL77007.1.
RefSeqiNP_543171.1. NM_080895.1. [Q8R5H8-2]
XP_002730005.1. XM_002729959.3. [Q8R5H8-1]
XP_006243673.1. XM_006243611.2. [Q8R5H8-1]
XP_006243675.1. XM_006243613.2. [Q8R5H8-2]
XP_006243676.1. XM_006243614.2. [Q8R5H8-2]
XP_006243677.1. XM_006243615.2. [Q8R5H8-2]
XP_006243678.1. XM_006243616.2. [Q8R5H8-1]
XP_006243679.1. XM_006243617.2. [Q8R5H8-1]
XP_006243681.1. XM_006243619.2. [Q8R5H8-2]
XP_006243682.1. XM_006243620.2. [Q8R5H8-2]
UniGeneiRn.106419.

Genome annotation databases

EnsembliENSRNOT00000045329; ENSRNOP00000038960; ENSRNOG00000030463. [Q8R5H8-2]
ENSRNOT00000045821; ENSRNOP00000039749; ENSRNOG00000030463. [Q8R5H8-1]
ENSRNOT00000047613; ENSRNOP00000049149; ENSRNOG00000030069. [Q8R5H8-1]
GeneIDi100362113.
140930.
KEGGirno:100362113.
rno:140930.
UCSCiRGD:620572. rat. [Q8R5H8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF412334 mRNA. Translation: AAL60162.1.
AF467453 mRNA. Translation: AAL77007.1.
RefSeqiNP_543171.1. NM_080895.1. [Q8R5H8-2]
XP_002730005.1. XM_002729959.3. [Q8R5H8-1]
XP_006243673.1. XM_006243611.2. [Q8R5H8-1]
XP_006243675.1. XM_006243613.2. [Q8R5H8-2]
XP_006243676.1. XM_006243614.2. [Q8R5H8-2]
XP_006243677.1. XM_006243615.2. [Q8R5H8-2]
XP_006243678.1. XM_006243616.2. [Q8R5H8-1]
XP_006243679.1. XM_006243617.2. [Q8R5H8-1]
XP_006243681.1. XM_006243619.2. [Q8R5H8-2]
XP_006243682.1. XM_006243620.2. [Q8R5H8-2]
UniGeneiRn.106419.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250864. 1 interaction.
STRINGi10116.ENSRNOP00000049149.

Proteomic databases

PaxDbiQ8R5H8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000045329; ENSRNOP00000038960; ENSRNOG00000030463. [Q8R5H8-2]
ENSRNOT00000045821; ENSRNOP00000039749; ENSRNOG00000030463. [Q8R5H8-1]
ENSRNOT00000047613; ENSRNOP00000049149; ENSRNOG00000030069. [Q8R5H8-1]
GeneIDi100362113.
140930.
KEGGirno:100362113.
rno:140930.
UCSCiRGD:620572. rat. [Q8R5H8-1]

Organism-specific databases

CTDi55179.
RGDi620572. Faim.

Phylogenomic databases

eggNOGiKOG4352. Eukaryota.
ENOG410XRNP. LUCA.
GeneTreeiENSGT00390000007364.
HOGENOMiHOG000007913.
HOVERGENiHBG051543.
InParanoidiQ8R5H8.
OMAiRCIIRVD.
OrthoDBiEOG7R56TX.
PhylomeDBiQ8R5H8.
TreeFamiTF314971.

Miscellaneous databases

NextBioi620795.
PROiQ8R5H8.

Gene expression databases

GenevisibleiQ8R5H8. RN.

Family and domain databases

InterProiIPR010695. FAIM1.
[Graphical view]
PANTHERiPTHR13088. PTHR13088. 1 hit.
PfamiPF06905. FAIM1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and characterization of rat Fas-apoptosis inhibitory molecule (rFAIM)."
    Sole C., Yuste V.J., Bayascas J.R., Espinet C., Comella J.X.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Strain: Sprague-Dawley.
    Tissue: Heart.

Entry informationi

Entry nameiFAIM1_RAT
AccessioniPrimary (citable) accession number: Q8R5H8
Secondary accession number(s): Q8VHR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: June 1, 2002
Last modified: February 17, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.