Q8R5H1 (UBP15_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ubiquitin carboxyl-terminal hydrolase 15
EC=3.4.19.12

Alternative name(s):
Deubiquitinating enzyme 15
Ubiquitin thioesterase 15
Ubiquitin-specific-processing protease 15

Gene names

Name:	Usp15
Synonyms:	Kiaa0529

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	981 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes. According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal. Able to mediate deubiquitination of monoubiquitinated substrates as well as 'Lys-48'-linked polyubiquitin chains, protecting them against proteasomal degradation. Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP By similarity.
Catalytic activity	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Subunit structure	Identified in a complex with the COP9 signalosome complex (CSN). Interacts with SMAD1, SMAD2 and SMAD3; the interaction is direct. Forms a complex with SMURF2 and SMAD7. Interacts with TGFBR1 By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Tissue specificity	Widely expressed with highest levels in testis, heart and liver. Ref.1
Post-translational modification	Phosphorylated. Phosphorylation protects against ubiquitination and subsequent degradation by the proteasome By similarity. Ubiquitinated, leading to degradation by the proteasome By similarity.
Sequence similarities	Belongs to the peptidase C19 family. Contains 1 DUSP domain.
Sequence caution	The sequence BAC65583.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence EDL24441.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing
Molecular function	Hydrolase Protease Thiol protease
PTM	Acetylation Phosphoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	BMP signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB monoubiquitinated protein deubiquitination Inferred from sequence or structural similarity. Source: UniProtKB pathway-restricted SMAD protein phosphorylation Inferred from sequence or structural similarity. Source: UniProtKB transforming growth factor beta receptor signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB nucleus Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	cysteine-type endopeptidase activity Inferred from sequence or structural similarity. Source: UniProtKB ubiquitin thiolesterase activity Inferred from sequence or structural similarity. Source: UniProtKB ubiquitin-specific protease activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Note: Experimental confirmation may be lacking for some isoforms.

Isoform 1 (identifier: Q8R5H1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8R5H1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     18-25: TLLKTSLR → DAWLKPRSG
     228-256: Missing.

Isoform 3 (identifier: Q8R5H1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     229-981: Missing.

Isoform 4 (identifier: Q8R5H1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     209-227: LVIEQKNEDGTWPRGPSTP → PRCIQFFNFTKDLSFISIK
     228-981: Missing.

Isoform 5 (identifier: Q8R5H1-5)

The sequence of this isoform differs from the canonical sequence as follows:
     228-256: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 981	980	Ubiquitin carboxyl-terminal hydrolase 15		PRO_0000080642
Regions
	Domain	7 – 118	112	DUSP
Sites
	Active site	298	1	Nucleophile By similarity UniProtKB Q9Y4E8
	Active site	891	1	Proton acceptor By similarity UniProtKB Q9Y4E8
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity
	Modified residue	229	1	Phosphoserine By similarity
	Modified residue	242	1	Phosphoserine By similarity
	Modified residue	961	1	Phosphoserine By similarity
	Modified residue	965	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	18 – 25	8	TLLKTSLR → DAWLKPRSG in isoform 2. Ref.1		VSP_005262
	Alternative sequence	209 – 227	19	LVIEQ…GPSTP → PRCIQFFNFTKDLSFISIK in isoform 4.		VSP_005265
	Alternative sequence	228 – 981	754	Missing in isoform 4.		VSP_005266
	Alternative sequence	228 – 256	29	Missing in isoform 2 and isoform 5. Ref.1		VSP_005263
	Alternative sequence	229 – 981	753	Missing in isoform 3.		VSP_005264
Experimental info
	Sequence conflict	130	1	E → G in BAE40593. Ref.3
	Sequence conflict	158	1	I → M in BAE36413. Ref.3
	Sequence conflict	184	1	M → V in AAH50042. Ref.5
	Sequence conflict	662	1	D → G in AAH50042. Ref.5
	Sequence conflict	800	1	K → E in AAH50042. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 6D5377C3FEA6E40A	FASTA	981	112,325
	10 20 30 40 50 60 MAEGGAADLD TQRSDIATLL KTSLRKGDTW YLVDSRWFKQ WKKYVGFDSW DKYQMGDQNV 70 80 90 100 110 120 YPGPIDNSGL LKDGDAQSLK EHLIDELDYI LLPTEGWNKL VSWYTLMEGQ EPIARKVVEQ 130 140 150 160 170 180 GMFVKHCKVE VYLTELKLCE NGNMNNVVTR RFSKADTIDT IEKEIRKIFN IPDEKEARLW 190 200 210 220 230 240 NKYMSNTFEP LNKPDSTIQD AGLYQGQVLV IEQKNEDGTW PRGPSTPKSP GASNFSTLPK 250 260 270 280 290 300 ISPSSLSNNY NNINNRNVKN SNYCLPSYTA YKNYDYSEPG RNNEQPGLCG LSNLGNTCFM 310 320 330 340 350 360 NSAIQCLSNT PPLTEYFLND KYQEELNFDN PLGMRGEIAK SYAELIKQMW SGKFSYVTPR 370 380 390 400 410 420 AFKTQVGRFA PQFSGYQQQD CQELLAFLLD GLHEDLNRIR KKPYIQLKDA DGRPDKVVAE 430 440 450 460 470 480 EAWENHLKRN DSIIVDIFHG LFKSTLVCPE CAKISVTFDP FCYLTLPLPM KKERSLEVYL 490 500 510 520 530 540 VRMDPLAKPM QYKVIVPKIG NILDLCTALS ALSGVPADKM IVTDIYNHRF HRIFAVDENL 550 560 570 580 590 600 SSIMERDDIY VFEININRAE DTEHVVIPVC LREKFRHSSY THHTGSSLFG QPFLMAIPRN 610 620 630 640 650 660 NTEDKLYNLL LLRMCRYVKM STETEETDGH LRCCEDQNIN GNGPNGLHEE GSPSEMETDE 670 680 690 700 710 720 PDDESSQDQE LPSENENSQS EDSVGGDNDS ENGLCTEETC KGQLTGHKKR LFTFQFNNLG 730 740 750 760 770 780 NNDINYIKDD TSHIRFDDRQ LRLDERSFLA LDWDPDLKKR YFDENAAEDF EKHESVEYKP 790 800 810 820 830 840 PKRPFVKLKD CIELFTTKEK LGAEDPWYCP NCKEHQQATK KLDLWSLPPV LVVHLKRFSY 850 860 870 880 890 900 SRYMRDKLDT LVDFPISDLD MSEFLINPNA GPCRYNLIAV SNHYGGMGGG HYTAFAKNKD 910 920 930 940 950 960 DGKWYYFDDS SVSTASEDQI VSKAAYVLFY QRQDTFSGTG FFPLDRETKG ASAATGIPLE 970 980 SDEDSNDNDN DLENENCMHT N
	Isoform 2 [UniParc]. Checksum: D56685B92C029188	FASTA	953	109,318
	10 20 30 40 50 60 MAEGGAADLD TQRSDIADAW LKPRSGKGDT WYLVDSRWFK QWKKYVGFDS WDKYQMGDQN 70 80 90 100 110 120 VYPGPIDNSG LLKDGDAQSL KEHLIDELDY ILLPTEGWNK LVSWYTLMEG QEPIARKVVE 130 140 150 160 170 180 QGMFVKHCKV EVYLTELKLC ENGNMNNVVT RRFSKADTID TIEKEIRKIF NIPDEKEARL 190 200 210 220 230 240 WNKYMSNTFE PLNKPDSTIQ DAGLYQGQVL VIEQKNEDGT WPRGPSTPNV KNSNYCLPSY 250 260 270 280 290 300 TAYKNYDYSE PGRNNEQPGL CGLSNLGNTC FMNSAIQCLS NTPPLTEYFL NDKYQEELNF 310 320 330 340 350 360 DNPLGMRGEI AKSYAELIKQ MWSGKFSYVT PRAFKTQVGR FAPQFSGYQQ QDCQELLAFL 370 380 390 400 410 420 LDGLHEDLNR IRKKPYIQLK DADGRPDKVV AEEAWENHLK RNDSIIVDIF HGLFKSTLVC 430 440 450 460 470 480 PECAKISVTF DPFCYLTLPL PMKKERSLEV YLVRMDPLAK PMQYKVIVPK IGNILDLCTA 490 500 510 520 530 540 LSALSGVPAD KMIVTDIYNH RFHRIFAVDE NLSSIMERDD IYVFEININR AEDTEHVVIP 550 560 570 580 590 600 VCLREKFRHS SYTHHTGSSL FGQPFLMAIP RNNTEDKLYN LLLLRMCRYV KMSTETEETD 610 620 630 640 650 660 GHLRCCEDQN INGNGPNGLH EEGSPSEMET DEPDDESSQD QELPSENENS QSEDSVGGDN 670 680 690 700 710 720 DSENGLCTEE TCKGQLTGHK KRLFTFQFNN LGNNDINYIK DDTSHIRFDD RQLRLDERSF 730 740 750 760 770 780 LALDWDPDLK KRYFDENAAE DFEKHESVEY KPPKRPFVKL KDCIELFTTK EKLGAEDPWY 790 800 810 820 830 840 CPNCKEHQQA TKKLDLWSLP PVLVVHLKRF SYSRYMRDKL DTLVDFPISD LDMSEFLINP 850 860 870 880 890 900 NAGPCRYNLI AVSNHYGGMG GGHYTAFAKN KDDGKWYYFD DSSVSTASED QIVSKAAYVL 910 920 930 940 950 FYQRQDTFSG TGFFPLDRET KGASAATGIP LESDEDSNDN DNDLENENCM HTN
	Isoform 3 [UniParc]. Checksum: 43F1F4F48122703B	FASTA	228	26,305
	10 20 30 40 50 60 MAEGGAADLD TQRSDIATLL KTSLRKGDTW YLVDSRWFKQ WKKYVGFDSW DKYQMGDQNV 70 80 90 100 110 120 YPGPIDNSGL LKDGDAQSLK EHLIDELDYI LLPTEGWNKL VSWYTLMEGQ EPIARKVVEQ 130 140 150 160 170 180 GMFVKHCKVE VYLTELKLCE NGNMNNVVTR RFSKADTIDT IEKEIRKIFN IPDEKEARLW 190 200 210 220 NKYMSNTFEP LNKPDSTIQD AGLYQGQVLV IEQKNEDGTW PRGPSTPK
	Isoform 4 [UniParc]. Checksum: A92B80D4BEE7E26E	FASTA	227	26,357
	10 20 30 40 50 60 MAEGGAADLD TQRSDIATLL KTSLRKGDTW YLVDSRWFKQ WKKYVGFDSW DKYQMGDQNV 70 80 90 100 110 120 YPGPIDNSGL LKDGDAQSLK EHLIDELDYI LLPTEGWNKL VSWYTLMEGQ EPIARKVVEQ 130 140 150 160 170 180 GMFVKHCKVE VYLTELKLCE NGNMNNVVTR RFSKADTIDT IEKEIRKIFN IPDEKEARLW 190 200 210 220 NKYMSNTFEP LNKPDSTIQD AGLYQGQVPR CIQFFNFTKD LSFISIK
	Isoform 5 [UniParc]. Checksum: D779A1FB3667963A	FASTA	952	109,220
	10 20 30 40 50 60 MAEGGAADLD TQRSDIATLL KTSLRKGDTW YLVDSRWFKQ WKKYVGFDSW DKYQMGDQNV 70 80 90 100 110 120 YPGPIDNSGL LKDGDAQSLK EHLIDELDYI LLPTEGWNKL VSWYTLMEGQ EPIARKVVEQ 130 140 150 160 170 180 GMFVKHCKVE VYLTELKLCE NGNMNNVVTR RFSKADTIDT IEKEIRKIFN IPDEKEARLW 190 200 210 220 230 240 NKYMSNTFEP LNKPDSTIQD AGLYQGQVLV IEQKNEDGTW PRGPSTPNVK NSNYCLPSYT 250 260 270 280 290 300 AYKNYDYSEP GRNNEQPGLC GLSNLGNTCF MNSAIQCLSN TPPLTEYFLN DKYQEELNFD 310 320 330 340 350 360 NPLGMRGEIA KSYAELIKQM WSGKFSYVTP RAFKTQVGRF APQFSGYQQQ DCQELLAFLL 370 380 390 400 410 420 DGLHEDLNRI RKKPYIQLKD ADGRPDKVVA EEAWENHLKR NDSIIVDIFH GLFKSTLVCP 430 440 450 460 470 480 ECAKISVTFD PFCYLTLPLP MKKERSLEVY LVRMDPLAKP MQYKVIVPKI GNILDLCTAL 490 500 510 520 530 540 SALSGVPADK MIVTDIYNHR FHRIFAVDEN LSSIMERDDI YVFEININRA EDTEHVVIPV 550 560 570 580 590 600 CLREKFRHSS YTHHTGSSLF GQPFLMAIPR NNTEDKLYNL LLLRMCRYVK MSTETEETDG 610 620 630 640 650 660 HLRCCEDQNI NGNGPNGLHE EGSPSEMETD EPDDESSQDQ ELPSENENSQ SEDSVGGDND 670 680 690 700 710 720 SENGLCTEET CKGQLTGHKK RLFTFQFNNL GNNDINYIKD DTSHIRFDDR QLRLDERSFL 730 740 750 760 770 780 ALDWDPDLKK RYFDENAAED FEKHESVEYK PPKRPFVKLK DCIELFTTKE KLGAEDPWYC 790 800 810 820 830 840 PNCKEHQQAT KKLDLWSLPP VLVVHLKRFS YSRYMRDKLD TLVDFPISDL DMSEFLINPN 850 860 870 880 890 900 AGPCRYNLIA VSNHYGGMGG GHYTAFAKNK DDGKWYYFDD SSVSTASEDQ IVSKAAYVLF 910 920 930 940 950 YQRQDTFSGT GFFPLDRETK GASAATGIPL ESDEDSNDND NDLENENCMH TN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of the mouse ubiquitin-specific protease Usp15." Angelats C., Wang X.-W., Jermiin L.S., Copeland N.G., Jenkins N.A., Baker R.T. Mamm. Genome 14:31-46(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY. Strain: C57BL/6.
[2]	"Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H. DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5). Tissue: Brain.
[3]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3; 4 AND 5). Strain: C57BL/6J. Tissue: Amnion, Corpora quadrigemina, Testis and Thymus.
[4]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Trophoblast stem cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF468037 mRNA. Translation: AAL77418.1. AK046332 mRNA. Translation: BAC32683.1. AK083303 mRNA. Translation: BAC38854.1. AK133852 mRNA. Translation: BAE21887.1. AK145749 mRNA. Translation: BAE26626.1. AK161469 mRNA. Translation: BAE36413.1. AK168755 mRNA. Translation: BAE40593.1. AK122301 mRNA. Translation: BAC65583.1. Different initiation. CH466578 Genomic DNA. Translation: EDL24441.1. Different initiation. BC050042 mRNA. Translation: AAH50042.1.
IPI	IPI00154012. IPI00222152. IPI00222154. IPI00403342.
RefSeq	NP_081880.2. NM_027604.3.
UniGene	Mm.244209. Mm.470032.
3D structure databases
ProteinModelPortal	Q8R5H1.
SMR	Q8R5H1. Positions 2-222, 285-470, 786-934.
ModBase	Search...
Protein family/group databases
MEROPS	C19.022.
PTM databases
PhosphoSite	Q8R5H1.
Proteomic databases
PaxDb	Q8R5H1.
PRIDE	Q8R5H1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000020334; ENSMUSP00000020334; ENSMUSG00000020124.
GeneID	14479.
KEGG	mmu:14479.
UCSC	uc007hgn.1. mouse. uc007hgt.1. mouse. uc011xpf.1. mouse.
Organism-specific databases
CTD	9958.
MGI	MGI:101857. Usp15.
Rouge	Search...
Phylogenomic databases
eggNOG	COG5560.
GeneTree	ENSGT00670000097750.
HOGENOM	HOG000264375.
HOVERGEN	HBG000864.
InParanoid	Q8R5H1.
KO	K11835.
OMA	RMDPLAK.
OrthoDB	EOG4DNF3R.
Gene expression databases
ArrayExpress	Q8R5H1.
Bgee	Q8R5H1.
CleanEx	MM_USP15.
Genevestigator	Q8R5H1.
GermOnline	ENSMUSG00000020124. Mus musculus.
Family and domain databases
InterPro	IPR006615. Pept_C19_DUSP. IPR018200. Pept_C19ubi-hydrolase_C_CS. IPR001394. Peptidase_C19. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. [Graphical view]
Pfam	PF06337. DUSP. 1 hit. PF00443. UCH. 1 hit. [Graphical view]
SMART	SM00695. DUSP. 1 hit. [Graphical view]
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
PROSITE	PS51283. DUSP. 1 hit. PS00972. UCH_2_1. 1 hit. PS00973. UCH_2_2. 1 hit. PS50235. UCH_2_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	USP15. mouse.
NextBio	286150.
SOURCE	Search...

Entry information

Entry name

UBP15_MOUSE

Accession

Primary (citable) accession number: Q8R5H1
Secondary accession number(s): Q3TGF5 , Q3TTB2, Q3UL25, Q3UZH0, Q80TY6, Q80UK9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 22, 2003
Last sequence update:	June 1, 2002
Last modified:	April 3, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program