Reviewed,
UniProtKB/Swiss-Prot Q8R5H1 (UBP15_MOUSE)
Last modified
June 16, 2009.
Version 62.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Ubiquitin carboxyl-terminal hydrolase 15 EC=3.1.2.15 Alternative name(s): Ubiquitin thioesterase 15 Ubiquitin-specific-processing protease 15 Deubiquitinating enzyme 15 | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 981 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | Ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol. |
| Tissue specificity | Widely expressed with highest levels in testis, heart and liver. Ref.1 |
| Sequence similarities | Belongs to the peptidase C19 family. Contains 1 DUSP domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Ubl conjugation pathway |
| Coding sequence diversity | Alternative splicing |
| Molecular function | Hydrolase Protease Thiol protease |
| PTM | Acetylation Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro |
| Molecular function | ubiquitin thiolesterase activity Inferred from electronic annotation. Source: EC ubiquitin-specific protease activity Ref.1Inferred from direct assay. Source: MGI |
| Complete GO annotation... | |
Alternative products
| This entry describes 4 isoforms produced by alternative splicing. [Align] [Select] Note: Experimental confirmation may be lacking for some isoforms. | ||||||
| Isoform 1 (identifier: Q8R5H1-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q8R5H1-2) The sequence of this isoform differs from the canonical sequence as follows: 18-25: TLLKTSLR → DAWLKPRSG 228-256: Missing. | ||||||
| Isoform 3 (identifier: Q8R5H1-3) The sequence of this isoform differs from the canonical sequence as follows: 229-981: Missing. | ||||||
| Isoform 4 (identifier: Q8R5H1-4) The sequence of this isoform differs from the canonical sequence as follows: 209-227: LVIEQKNEDGTWPRGPSTP → PRCIQFFNFTKDLSFISIK 228-981: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed By similarity | ||||||
| Chain | 2 – 981 | 980 | Ubiquitin carboxyl-terminal hydrolase 15 | PRO_0000080642 | |||||
Regions | |||||||||
| Domain | 7 – 118 | 112 | DUSP | ||||||
Sites | |||||||||
| Active site | 298 | 1 | By similarity UniProtKB Q9Y4E8 | ||||||
| Active site | 883 | 1 | By similarity UniProtKB Q9Y4E8 | ||||||
| Active site | 891 | 1 | By similarity UniProtKB Q9Y4E8 | ||||||
Amino acid modifications | |||||||||
| Modified residue | 2 | 1 | N-acetylalanine By similarity | ||||||
| Modified residue | 229 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 961 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 965 | 1 | Phosphoserine By similarity | ||||||
Natural variations | |||||||||
| Alternative sequence | 18 – 25 | 8 | TLLKTSLR → DAWLKPRSG in isoform 2. Ref.1 | VSP_005262 | |||||
| Alternative sequence | 209 – 227 | 19 | LVIEQ…GPSTP → PRCIQFFNFTKDLSFISIK in isoform 4. | VSP_005265 | |||||
| Alternative sequence | 228 – 981 | 754 | Missing in isoform 4. | VSP_005266 | |||||
| Alternative sequence | 228 – 256 | 29 | Missing in isoform 2. Ref.1 | VSP_005263 | |||||
| Alternative sequence | 229 – 981 | 753 | Missing in isoform 3. | VSP_005264 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Isolation and characterization of the mouse ubiquitin-specific protease Usp15." Angelats C., Wang X.-W., Jermiin L.S., Copeland N.G., Jenkins N.A., Baker R.T. Mamm. Genome 14:31-46(2003) [PubMed: 12532266] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY. Strain: C57BL/6. |
| [2] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4). Strain: C57BL/6J. Tissue: Corpora quadrigemina, Testis and Thymus. |
Cross-references
Sequence databases | |
|---|---|
| AF468037 mRNA. Translation: AAL77418.1. AK046332 mRNA. Translation: BAC32683.1. AK083303 mRNA. Translation: BAC38854.1. AK145749 mRNA. Translation: BAE26626.1. | |
| IPI | IPI00154012. IPI00222152. IPI00222154. IPI00403342. |
| RefSeq | NP_081880.2. |
| UniGene | Mm.244209 Mm.470032 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1NB8 based on UniProtKB Q93009. |
| SMR | Q8R5H1. Positions 1-120. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q8R5H1. |
Proteomic databases | |
| PRIDE | Q8R5H1. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000020124. Mus musculus. [Contig view] |
| GeneID | 14479. |
| KEGG | mmu:14479. |
Organism-specific databases | |
| MGI | MGI:101857. Usp15. |
Phylogenomic databases | |
| HOGENOM | Q8R5H1. |
| HOVERGEN | Q8R5H1. |
| OMA | Q8R5H1. LCTEETC. |
Enzyme and pathway databases | |
| BRENDA | 3.1.2.15. 244. |
Gene expression databases | |
| ArrayExpress | Q8R5H1. |
| Bgee | Q8R5H1. |
| CleanEx | MM_USP15. |
| GermOnline | ENSMUSG00000020124. Mus musculus. |
Family and domain databases | |
| InterPro | IPR006615. Pept_C19_DUSP. IPR010460. Pept_C19_N_2. IPR018200. Pept_C19ubi-hydrolase_C_CS. IPR001394. Peptidase_C19. [Graphical view] |
| Pfam | PF06337. DUF1055. 1 hit. PF00443. UCH. 1 hit. [Graphical view] |
| SMART | SM00695. DUSP. 1 hit. [Graphical view] |
| PROSITE | PS51283. DUSP. 1 hit. PS00972. UCH_2_1. 1 hit. PS00973. UCH_2_2. 1 hit. PS50235. UCH_2_3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 286150. |
| SOURCE | Search... |
Entry information
| Entry name | UBP15_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q8R5H1 Secondary accession number(s): Q3UL25 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| Peptidase families Classification of peptidase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


