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Q8R5H1

- UBP15_MOUSE

UniProt

Q8R5H1 - UBP15_MOUSE

Protein

Ubiquitin carboxyl-terminal hydrolase 15

Gene

Usp15

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes. According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal. Able to mediate deubiquitination of monoubiquitinated substrates as well as 'Lys-48'-linked polyubiquitin chains, protecting them against proteasomal degradation. Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei298 – 2981NucleophilePROSITE-ProRule annotation
    Active sitei891 – 8911Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type endopeptidase activity Source: UniProtKB
    2. ubiquitin-specific protease activity Source: UniProtKB
    3. ubiquitin thiolesterase activity Source: UniProtKB

    GO - Biological processi

    1. BMP signaling pathway Source: UniProtKB
    2. monoubiquitinated protein deubiquitination Source: UniProtKB
    3. pathway-restricted SMAD protein phosphorylation Source: UniProtKB
    4. protein deubiquitination Source: UniProtKB
    5. transforming growth factor beta receptor signaling pathway Source: UniProtKB
    6. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Enzyme and pathway databases

    ReactomeiREACT_215733. Downregulation of TGF-beta receptor signaling.

    Protein family/group databases

    MEROPSiC19.022.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 15 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 15
    Ubiquitin thioesterase 15
    Ubiquitin-specific-processing protease 15
    Gene namesi
    Name:Usp15
    Synonyms:Kiaa0529
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:101857. Usp15.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 981980Ubiquitin carboxyl-terminal hydrolase 15PRO_0000080642Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei229 – 2291Phosphoserine1 Publication
    Modified residuei242 – 2421PhosphoserineBy similarity
    Modified residuei961 – 9611PhosphoserineBy similarity
    Modified residuei965 – 9651PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylated. Phosphorylation protects against ubiquitination and subsequent degradation by the proteasome By similarity.By similarity
    Ubiquitinated, leading to degradation by the proteasome.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ8R5H1.
    PaxDbiQ8R5H1.
    PRIDEiQ8R5H1.

    PTM databases

    PhosphoSiteiQ8R5H1.

    Expressioni

    Tissue specificityi

    Widely expressed with highest levels in testis, heart and liver.1 Publication

    Gene expression databases

    ArrayExpressiQ8R5H1.
    BgeeiQ8R5H1.
    CleanExiMM_USP15.
    GenevestigatoriQ8R5H1.

    Interactioni

    Subunit structurei

    Identified in a complex with the COP9 signalosome complex (CSN). Interacts with SMAD1, SMAD2 and SMAD3; the interaction is direct. Forms a complex with SMURF2 and SMAD7. Interacts with TGFBR1 By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ8R5H1. 1 interaction.
    MINTiMINT-4139191.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8R5H1.
    SMRiQ8R5H1. Positions 2-222, 285-470, 786-934.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini7 – 118112DUSPPROSITE-ProRule annotationAdd
    BLAST
    Domaini289 – 933645USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 DUSP domain.PROSITE-ProRule annotation
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5560.
    GeneTreeiENSGT00670000097750.
    HOGENOMiHOG000264375.
    HOVERGENiHBG000864.
    InParanoidiQ8R5H1.
    KOiK11835.
    OMAiRYVKTCT.
    OrthoDBiEOG77Q4VW.
    PhylomeDBiQ8R5H1.
    TreeFamiTF106276.

    Family and domain databases

    Gene3Di3.30.2230.10. 1 hit.
    InterProiIPR006615. Pept_C19_DUSP.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
    IPR028135. Ub_USP-typ.
    IPR029071. Ubiquitin-rel_dom.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF06337. DUSP. 1 hit.
    PF14836. Ubiquitin_3. 1 hit.
    PF00443. UCH. 1 hit.
    [Graphical view]
    SMARTiSM00695. DUSP. 1 hit.
    [Graphical view]
    SUPFAMiSSF143791. SSF143791. 1 hit.
    SSF54236. SSF54236. 1 hit.
    SSF55205. SSF55205. 1 hit.
    PROSITEiPS51283. DUSP. 1 hit.
    PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Note: Experimental confirmation may be lacking for some isoforms.

    Isoform 1 (identifier: Q8R5H1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAEGGAADLD TQRSDIATLL KTSLRKGDTW YLVDSRWFKQ WKKYVGFDSW    50
    DKYQMGDQNV YPGPIDNSGL LKDGDAQSLK EHLIDELDYI LLPTEGWNKL 100
    VSWYTLMEGQ EPIARKVVEQ GMFVKHCKVE VYLTELKLCE NGNMNNVVTR 150
    RFSKADTIDT IEKEIRKIFN IPDEKEARLW NKYMSNTFEP LNKPDSTIQD 200
    AGLYQGQVLV IEQKNEDGTW PRGPSTPKSP GASNFSTLPK ISPSSLSNNY 250
    NNINNRNVKN SNYCLPSYTA YKNYDYSEPG RNNEQPGLCG LSNLGNTCFM 300
    NSAIQCLSNT PPLTEYFLND KYQEELNFDN PLGMRGEIAK SYAELIKQMW 350
    SGKFSYVTPR AFKTQVGRFA PQFSGYQQQD CQELLAFLLD GLHEDLNRIR 400
    KKPYIQLKDA DGRPDKVVAE EAWENHLKRN DSIIVDIFHG LFKSTLVCPE 450
    CAKISVTFDP FCYLTLPLPM KKERSLEVYL VRMDPLAKPM QYKVIVPKIG 500
    NILDLCTALS ALSGVPADKM IVTDIYNHRF HRIFAVDENL SSIMERDDIY 550
    VFEININRAE DTEHVVIPVC LREKFRHSSY THHTGSSLFG QPFLMAIPRN 600
    NTEDKLYNLL LLRMCRYVKM STETEETDGH LRCCEDQNIN GNGPNGLHEE 650
    GSPSEMETDE PDDESSQDQE LPSENENSQS EDSVGGDNDS ENGLCTEETC 700
    KGQLTGHKKR LFTFQFNNLG NNDINYIKDD TSHIRFDDRQ LRLDERSFLA 750
    LDWDPDLKKR YFDENAAEDF EKHESVEYKP PKRPFVKLKD CIELFTTKEK 800
    LGAEDPWYCP NCKEHQQATK KLDLWSLPPV LVVHLKRFSY SRYMRDKLDT 850
    LVDFPISDLD MSEFLINPNA GPCRYNLIAV SNHYGGMGGG HYTAFAKNKD 900
    DGKWYYFDDS SVSTASEDQI VSKAAYVLFY QRQDTFSGTG FFPLDRETKG 950
    ASAATGIPLE SDEDSNDNDN DLENENCMHT N 981
    Length:981
    Mass (Da):112,325
    Last modified:June 1, 2002 - v1
    Checksum:i6D5377C3FEA6E40A
    GO
    Isoform 2 (identifier: Q8R5H1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         18-25: TLLKTSLR → DAWLKPRSG
         228-256: Missing.

    Show »
    Length:953
    Mass (Da):109,318
    Checksum:iD56685B92C029188
    GO
    Isoform 3 (identifier: Q8R5H1-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         229-981: Missing.

    Show »
    Length:228
    Mass (Da):26,305
    Checksum:i43F1F4F48122703B
    GO
    Isoform 4 (identifier: Q8R5H1-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         209-227: LVIEQKNEDGTWPRGPSTP → PRCIQFFNFTKDLSFISIK
         228-981: Missing.

    Show »
    Length:227
    Mass (Da):26,357
    Checksum:iA92B80D4BEE7E26E
    GO
    Isoform 5 (identifier: Q8R5H1-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         228-256: Missing.

    Show »
    Length:952
    Mass (Da):109,220
    Checksum:iD779A1FB3667963A
    GO

    Sequence cautioni

    The sequence BAC65583.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence EDL24441.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti130 – 1301E → G in BAE40593. (PubMed:16141072)Curated
    Sequence conflicti158 – 1581I → M in BAE36413. (PubMed:16141072)Curated
    Sequence conflicti184 – 1841M → V in AAH50042. (PubMed:15489334)Curated
    Sequence conflicti662 – 6621D → G in AAH50042. (PubMed:15489334)Curated
    Sequence conflicti800 – 8001K → E in AAH50042. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei18 – 258TLLKTSLR → DAWLKPRSG in isoform 2. 1 PublicationVSP_005262
    Alternative sequencei209 – 22719LVIEQ…GPSTP → PRCIQFFNFTKDLSFISIK in isoform 4. 1 PublicationVSP_005265Add
    BLAST
    Alternative sequencei228 – 981754Missing in isoform 4. 1 PublicationVSP_005266Add
    BLAST
    Alternative sequencei228 – 25629Missing in isoform 2 and isoform 5. 3 PublicationsVSP_005263Add
    BLAST
    Alternative sequencei229 – 981753Missing in isoform 3. 1 PublicationVSP_005264Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF468037 mRNA. Translation: AAL77418.1.
    AK046332 mRNA. Translation: BAC32683.1.
    AK083303 mRNA. Translation: BAC38854.1.
    AK133852 mRNA. Translation: BAE21887.1.
    AK145749 mRNA. Translation: BAE26626.1.
    AK161469 mRNA. Translation: BAE36413.1.
    AK168755 mRNA. Translation: BAE40593.1.
    AK122301 mRNA. Translation: BAC65583.1. Different initiation.
    CH466578 Genomic DNA. Translation: EDL24441.1. Different initiation.
    BC050042 mRNA. Translation: AAH50042.1.
    CCDSiCCDS24217.1. [Q8R5H1-1]
    RefSeqiNP_081880.2. NM_027604.3. [Q8R5H1-1]
    XP_006513287.1. XM_006513224.1. [Q8R5H1-5]
    UniGeneiMm.244209.
    Mm.470032.

    Genome annotation databases

    EnsembliENSMUST00000020334; ENSMUSP00000020334; ENSMUSG00000020124. [Q8R5H1-1]
    GeneIDi14479.
    KEGGimmu:14479.
    UCSCiuc007hgn.1. mouse. [Q8R5H1-1]
    uc007hgt.1. mouse. [Q8R5H1-3]
    uc011xpf.1. mouse. [Q8R5H1-4]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF468037 mRNA. Translation: AAL77418.1 .
    AK046332 mRNA. Translation: BAC32683.1 .
    AK083303 mRNA. Translation: BAC38854.1 .
    AK133852 mRNA. Translation: BAE21887.1 .
    AK145749 mRNA. Translation: BAE26626.1 .
    AK161469 mRNA. Translation: BAE36413.1 .
    AK168755 mRNA. Translation: BAE40593.1 .
    AK122301 mRNA. Translation: BAC65583.1 . Different initiation.
    CH466578 Genomic DNA. Translation: EDL24441.1 . Different initiation.
    BC050042 mRNA. Translation: AAH50042.1 .
    CCDSi CCDS24217.1. [Q8R5H1-1 ]
    RefSeqi NP_081880.2. NM_027604.3. [Q8R5H1-1 ]
    XP_006513287.1. XM_006513224.1. [Q8R5H1-5 ]
    UniGenei Mm.244209.
    Mm.470032.

    3D structure databases

    ProteinModelPortali Q8R5H1.
    SMRi Q8R5H1. Positions 2-222, 285-470, 786-934.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8R5H1. 1 interaction.
    MINTi MINT-4139191.

    Protein family/group databases

    MEROPSi C19.022.

    PTM databases

    PhosphoSitei Q8R5H1.

    Proteomic databases

    MaxQBi Q8R5H1.
    PaxDbi Q8R5H1.
    PRIDEi Q8R5H1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020334 ; ENSMUSP00000020334 ; ENSMUSG00000020124 . [Q8R5H1-1 ]
    GeneIDi 14479.
    KEGGi mmu:14479.
    UCSCi uc007hgn.1. mouse. [Q8R5H1-1 ]
    uc007hgt.1. mouse. [Q8R5H1-3 ]
    uc011xpf.1. mouse. [Q8R5H1-4 ]

    Organism-specific databases

    CTDi 9958.
    MGIi MGI:101857. Usp15.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG5560.
    GeneTreei ENSGT00670000097750.
    HOGENOMi HOG000264375.
    HOVERGENi HBG000864.
    InParanoidi Q8R5H1.
    KOi K11835.
    OMAi RYVKTCT.
    OrthoDBi EOG77Q4VW.
    PhylomeDBi Q8R5H1.
    TreeFami TF106276.

    Enzyme and pathway databases

    Reactomei REACT_215733. Downregulation of TGF-beta receptor signaling.

    Miscellaneous databases

    ChiTaRSi USP15. mouse.
    NextBioi 286150.
    PROi Q8R5H1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8R5H1.
    Bgeei Q8R5H1.
    CleanExi MM_USP15.
    Genevestigatori Q8R5H1.

    Family and domain databases

    Gene3Di 3.30.2230.10. 1 hit.
    InterProi IPR006615. Pept_C19_DUSP.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
    IPR028135. Ub_USP-typ.
    IPR029071. Ubiquitin-rel_dom.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF06337. DUSP. 1 hit.
    PF14836. Ubiquitin_3. 1 hit.
    PF00443. UCH. 1 hit.
    [Graphical view ]
    SMARTi SM00695. DUSP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF143791. SSF143791. 1 hit.
    SSF54236. SSF54236. 1 hit.
    SSF55205. SSF55205. 1 hit.
    PROSITEi PS51283. DUSP. 1 hit.
    PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of the mouse ubiquitin-specific protease Usp15."
      Angelats C., Wang X.-W., Jermiin L.S., Copeland N.G., Jenkins N.A., Baker R.T.
      Mamm. Genome 14:31-46(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
      Strain: C57BL/6.
    2. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
      DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
      Tissue: Brain.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3; 4 AND 5).
      Strain: C57BL/6J.
      Tissue: Amnion, Corpora quadrigemina, Testis and Thymus.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Trophoblast stem cell.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-229, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiUBP15_MOUSE
    AccessioniPrimary (citable) accession number: Q8R5H1
    Secondary accession number(s): Q3TGF5
    , Q3TTB2, Q3UL25, Q3UZH0, Q80TY6, Q80UK9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 22, 2003
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3