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Protein
Submitted name:

Cyclin-dependent kinase inhibitor 2C (P18, inhibits CDK4)

Gene

Cdkn2c

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase inhibitor activity Source: RGD
  • kinase activity Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

CyclinImported, KinaseImported, Transferase

Enzyme and pathway databases

ReactomeiR-RNO-2559580. Oxidative Stress Induced Senescence.
R-RNO-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-RNO-2559585. Oncogene Induced Senescence.
R-RNO-69231. Cyclin D associated events in G1.

Names & Taxonomyi

Protein namesi
Submitted name:
Cyclin-dependent kinase inhibitor 2C (P18, inhibits CDK4)Imported
Submitted name:
Cyclin-dependent kinase inhibitor 2C (P18, inhibits CDK4), isoform CRA_aImported
Submitted name:
Cyclin-dependent kinase inhibitor 2cImported
Submitted name:
Protein Cdkn2cImported
Gene namesi
Name:Cdkn2cImported
ORF Names:rCG_50475Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi2325. Cdkn2c.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

PTM databases

PhosphoSiteiQ8R5G4.

Expressioni

Gene expression databases

BgeeiENSRNOG00000008956.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012088.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 161153ANK_REP_REGIONInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ANK repeats.UniRule annotation

Keywords - Domaini

ANK repeatUniRule annotation

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00390000004527.
HOGENOMiHOG000290191.
HOVERGENiHBG050870.
KOiK06622.
OMAiLLRHTAC.
OrthoDBiEOG091G0PMC.
TreeFamiTF333311.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R5G4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEPWGNELA SAAARGDLEQ LTSLLQNNVN VNAQNGFGRT ALQVMKLGNP
60 70 80 90 100
EIARRLLLRG ANPNLKDRTG FAVIHDAARA GFLDTVQALL EFQADVNIED
110 120 130 140 150
NEGNLPLHLA AKEGHLPVVE FLMKHTACNV GHRNHKGDTA FDLARFYGRN
160
EVISLMEANG VGGATSLQ
Length:168
Mass (Da):18,165
Last modified:June 1, 2002 - v1
Checksum:i1C88C4598EAC8C9E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07049578 Genomic DNA. No translation available.
BC088864 mRNA. Translation: AAH88864.1.
AF474980 mRNA. Translation: AAL76342.1.
AF474981 mRNA. Translation: AAL76343.2.
CH474008 Genomic DNA. Translation: EDL90356.1.
CH474008 Genomic DNA. Translation: EDL90357.1.
RefSeqiNP_571977.1. NM_131902.3.
UniGeneiRn.63865.

Genome annotation databases

EnsembliENSRNOT00000012088; ENSRNOP00000012088; ENSRNOG00000008956.
GeneIDi54238.
KEGGirno:54238.
UCSCiRGD:2325. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07049578 Genomic DNA. No translation available.
BC088864 mRNA. Translation: AAH88864.1.
AF474980 mRNA. Translation: AAL76342.1.
AF474981 mRNA. Translation: AAL76343.2.
CH474008 Genomic DNA. Translation: EDL90356.1.
CH474008 Genomic DNA. Translation: EDL90357.1.
RefSeqiNP_571977.1. NM_131902.3.
UniGeneiRn.63865.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012088.

PTM databases

PhosphoSiteiQ8R5G4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000012088; ENSRNOP00000012088; ENSRNOG00000008956.
GeneIDi54238.
KEGGirno:54238.
UCSCiRGD:2325. rat.

Organism-specific databases

CTDi1031.
RGDi2325. Cdkn2c.

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00390000004527.
HOGENOMiHOG000290191.
HOVERGENiHBG050870.
KOiK06622.
OMAiLLRHTAC.
OrthoDBiEOG091G0PMC.
TreeFamiTF333311.

Enzyme and pathway databases

ReactomeiR-RNO-2559580. Oxidative Stress Induced Senescence.
R-RNO-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-RNO-2559585. Oncogene Induced Senescence.
R-RNO-69231. Cyclin D associated events in G1.

Gene expression databases

BgeeiENSRNOG00000008956.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ8R5G4_RAT
AccessioniPrimary (citable) accession number: Q8R5G4
Secondary accession number(s): Q8R5G3
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: September 7, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.