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Protein

Beta-centractin

Gene

Actr1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-2132295. MHC class II antigen presentation.
R-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-centractin
Alternative name(s):
Actin-related protein 1B
Short name:
ARP1B
Gene namesi
Name:Actr1b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1917446. Actr1b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000890611 – 376Beta-centractinAdd BLAST376

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei4Nitrated tyrosineCombined sources1

Keywords - PTMi

Acetylation, Nitration

Proteomic databases

EPDiQ8R5C5.
MaxQBiQ8R5C5.
PaxDbiQ8R5C5.
PeptideAtlasiQ8R5C5.
PRIDEiQ8R5C5.

2D gel databases

UCD-2DPAGEQ8R5C5.

PTM databases

iPTMnetiQ8R5C5.
PhosphoSitePlusiQ8R5C5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000037351.
CleanExiMM_ACTR1B.
ExpressionAtlasiQ8R5C5. baseline and differential.
GenevisibleiQ8R5C5. MM.

Interactioni

Protein-protein interaction databases

BioGridi230579. 29 interactors.
IntActiQ8R5C5. 32 interactors.
MINTiMINT-4086797.
STRINGi10090.ENSMUSP00000047326.

Structurei

3D structure databases

ProteinModelPortaliQ8R5C5.
SMRiQ8R5C5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family. ARP1 subfamily.Curated

Phylogenomic databases

eggNOGiKOG0676. Eukaryota.
COG5277. LUCA.
GeneTreeiENSGT00840000129754.
HOGENOMiHOG000233340.
HOVERGENiHBG003771.
InParanoidiQ8R5C5.
KOiK16575.
OMAiDEWHENP.
OrthoDBiEOG091G08LD.
PhylomeDBiQ8R5C5.
TreeFamiTF300420.

Family and domain databases

InterProiIPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
IPR029909. Arp1.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PTHR11937:SF195. PTHR11937:SF195. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
PROSITEiPS00432. ACTINS_2. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R5C5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESYDIIANQ PVVIDNGSGV IKAGFAGDQI PKYCFPNYVG RPKHMRVMAG
60 70 80 90 100
ALEGDLFIGP KAEEHRGLLT IRYPMEHGVV RDWNDMERIW QYVYSKDQLQ
110 120 130 140 150
TFSEEHPVLL TEAPLNPSKN REKAAEVFFE TFNVPALFIS MQAVLSLYAT
160 170 180 190 200
GRTTGVVLDS GDGVTHAVPI YEGFAMPHSI MRVDIAGRDV SRYLRLLLRK
210 220 230 240 250
EGADFHTSAE FEVVRTIKER ACYLSINPQK DEALETEKVQ YTLPDGSTLD
260 270 280 290 300
VGPARFRAPE LLFQPDLVGD ESEGLHEVLA FAIHKSDMDL RRTLFSNIVL
310 320 330 340 350
SGGSTLFKGF GDRLLSEVKK LAPKDVKIKI SAPQERLYST WIGGSILASL
360 370
DTFKKMWVSK KEYEEDGSRA IHRKTF
Length:376
Mass (Da):42,281
Last modified:June 1, 2002 - v1
Checksum:iC038D186113C1A69
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088839 mRNA. Translation: BAC40604.1.
BC023020 mRNA. Translation: AAH23020.1.
CCDSiCCDS14887.1.
RefSeqiNP_666219.1. NM_146107.2.
UniGeneiMm.28521.
Mm.59151.

Genome annotation databases

EnsembliENSMUST00000043951; ENSMUSP00000047326; ENSMUSG00000037351.
GeneIDi226977.
KEGGimmu:226977.
UCSCiuc007aqx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088839 mRNA. Translation: BAC40604.1.
BC023020 mRNA. Translation: AAH23020.1.
CCDSiCCDS14887.1.
RefSeqiNP_666219.1. NM_146107.2.
UniGeneiMm.28521.
Mm.59151.

3D structure databases

ProteinModelPortaliQ8R5C5.
SMRiQ8R5C5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230579. 29 interactors.
IntActiQ8R5C5. 32 interactors.
MINTiMINT-4086797.
STRINGi10090.ENSMUSP00000047326.

PTM databases

iPTMnetiQ8R5C5.
PhosphoSitePlusiQ8R5C5.

2D gel databases

UCD-2DPAGEQ8R5C5.

Proteomic databases

EPDiQ8R5C5.
MaxQBiQ8R5C5.
PaxDbiQ8R5C5.
PeptideAtlasiQ8R5C5.
PRIDEiQ8R5C5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043951; ENSMUSP00000047326; ENSMUSG00000037351.
GeneIDi226977.
KEGGimmu:226977.
UCSCiuc007aqx.1. mouse.

Organism-specific databases

CTDi10120.
MGIiMGI:1917446. Actr1b.

Phylogenomic databases

eggNOGiKOG0676. Eukaryota.
COG5277. LUCA.
GeneTreeiENSGT00840000129754.
HOGENOMiHOG000233340.
HOVERGENiHBG003771.
InParanoidiQ8R5C5.
KOiK16575.
OMAiDEWHENP.
OrthoDBiEOG091G08LD.
PhylomeDBiQ8R5C5.
TreeFamiTF300420.

Enzyme and pathway databases

ReactomeiR-MMU-2132295. MHC class II antigen presentation.
R-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiActr1b. mouse.
PROiQ8R5C5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037351.
CleanExiMM_ACTR1B.
ExpressionAtlasiQ8R5C5. baseline and differential.
GenevisibleiQ8R5C5. MM.

Family and domain databases

InterProiIPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
IPR029909. Arp1.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PTHR11937:SF195. PTHR11937:SF195. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
PROSITEiPS00432. ACTINS_2. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACTY_MOUSE
AccessioniPrimary (citable) accession number: Q8R5C5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: June 1, 2002
Last modified: November 30, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.