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Protein

TBC1 domain family member 22A

Gene

Tbc1d22a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May act as a GTPase-activating protein for Rab family protein(s).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
TBC1 domain family member 22A
Gene namesi
Name:Tbc1d22a
Synonyms:D15Ertd781e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1289265. Tbc1d22a.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 516515TBC1 domain family member 22APRO_0000208053Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei144 – 1441PhosphoserineCombined sources
Modified residuei166 – 1661PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8R5A6.
MaxQBiQ8R5A6.
PaxDbiQ8R5A6.
PRIDEiQ8R5A6.

PTM databases

iPTMnetiQ8R5A6.
PhosphoSiteiQ8R5A6.

Expressioni

Gene expression databases

BgeeiQ8R5A6.
CleanExiMM_TBC1D22A.
GenevisibleiQ8R5A6. MM.

Interactioni

Subunit structurei

Homodimer. Interacts with ACBD3 and ARFGEF1. Interacts with YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ and YWHAZ.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065721.

Structurei

3D structure databases

ProteinModelPortaliQ8R5A6.
SMRiQ8R5A6. Positions 195-507.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini221 – 445225Rab-GAP TBCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Rab-GAP TBC domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1092. Eukaryota.
ENOG410XQ68. LUCA.
GeneTreeiENSGT00840000129806.
HOGENOMiHOG000162526.
HOVERGENiHBG057030.
InParanoidiQ8R5A6.
OMAiFICEYIE.
OrthoDBiEOG7HHWSK.
PhylomeDBiQ8R5A6.
TreeFamiTF314211.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
PROSITEiPS50086. TBC_RABGAP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8R5A6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASDGARKQF WKRSNSKVPG SIQHVYGAQH PPFDPLLHGT LLKSTPKVPT
60 70 80 90 100
TPVKAKRVST FQEFESNTSD AWDAGEDDDE LLAMATESLN SEVVMETAHR
110 120 130 140 150
VLRNHSQRQS QPSQKTTEPE PEPQPIAEPP VPPSGDLRLV KSVSESHTPC
160 170 180 190 200
PSESTGDTVP LQRSQSLPHS ATVTLSGTSD PHALADSALS KRETSRLDKF
210 220 230 240 250
KQLLAGPNTD LEELRKLSWS GIPKPVRPMT WKLLSGYLPA NVDRRPATLQ
260 270 280 290 300
RKQKEYFAFI EHYYSSRNDE VHQDTYRQIH IDIPRMSPEA LILQPKVTEI
310 320 330 340 350
FERILFIWAI RHPASGYVQG INDLVTPFFV VFICEYTDRE DVDKVDVSSV
360 370 380 390 400
PAEVLRNIEA DTYWCMSKLL DGIQDNYTFA QPGIQMKVKM LEELVSRIDE
410 420 430 440 450
RVHRHLDGHE VRYLQFAFRW MNNLLMRELP LRCTIRLWDT YQSEPEGFSH
460 470 480 490 500
FHLYVCAAFL VRWRREILEE RDFQELLLFL QNLPTARWDD QDVSLLLAEA
510
YRLKFAFADA PNHYKK
Length:516
Mass (Da):59,362
Last modified:December 20, 2005 - v3
Checksum:iA838069E77897B10
GO
Isoform 2 (identifier: Q8R5A6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: MASDGARKQF...PFDPLLHGTL → MRSGHGQRRG...RLIRCYMAPC

Note: No experimental confirmation available.
Show »
Length:521
Mass (Da):59,938
Checksum:i4919E0B97A2E363B
GO

Sequence cautioni

The sequence AAH23106.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti120 – 1201E → D in BAE33274 (PubMed:16141072).Curated
Sequence conflicti120 – 1201E → D in BAE32447 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4141MASDG…LHGTL → MRSGHGQRRGQEAVLEAQQQ QGSRAASSMCMEPSTHRLIR CYMAPC in isoform 2. 1 PublicationVSP_016761Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039627 mRNA. Translation: BAC30403.1.
AK154226 mRNA. Translation: BAE32447.1.
AK154602 mRNA. Translation: BAE32705.1.
AK155459 mRNA. Translation: BAE33274.1.
AK155770 mRNA. Translation: BAE33429.1.
AK146872 mRNA. Translation: BAE27495.1.
BC023106 mRNA. Translation: AAH23106.1. Different initiation.
BC066009 mRNA. Translation: AAH66009.1.
CCDSiCCDS27729.1. [Q8R5A6-1]
RefSeqiNP_663451.2. NM_145476.2. [Q8R5A6-1]
UniGeneiMm.138512.
Mm.28904.

Genome annotation databases

EnsembliENSMUST00000063414; ENSMUSP00000065721; ENSMUSG00000051864. [Q8R5A6-1]
GeneIDi223754.
KEGGimmu:223754.
UCSCiuc007xea.1. mouse. [Q8R5A6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039627 mRNA. Translation: BAC30403.1.
AK154226 mRNA. Translation: BAE32447.1.
AK154602 mRNA. Translation: BAE32705.1.
AK155459 mRNA. Translation: BAE33274.1.
AK155770 mRNA. Translation: BAE33429.1.
AK146872 mRNA. Translation: BAE27495.1.
BC023106 mRNA. Translation: AAH23106.1. Different initiation.
BC066009 mRNA. Translation: AAH66009.1.
CCDSiCCDS27729.1. [Q8R5A6-1]
RefSeqiNP_663451.2. NM_145476.2. [Q8R5A6-1]
UniGeneiMm.138512.
Mm.28904.

3D structure databases

ProteinModelPortaliQ8R5A6.
SMRiQ8R5A6. Positions 195-507.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065721.

PTM databases

iPTMnetiQ8R5A6.
PhosphoSiteiQ8R5A6.

Proteomic databases

EPDiQ8R5A6.
MaxQBiQ8R5A6.
PaxDbiQ8R5A6.
PRIDEiQ8R5A6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063414; ENSMUSP00000065721; ENSMUSG00000051864. [Q8R5A6-1]
GeneIDi223754.
KEGGimmu:223754.
UCSCiuc007xea.1. mouse. [Q8R5A6-1]

Organism-specific databases

CTDi25771.
MGIiMGI:1289265. Tbc1d22a.

Phylogenomic databases

eggNOGiKOG1092. Eukaryota.
ENOG410XQ68. LUCA.
GeneTreeiENSGT00840000129806.
HOGENOMiHOG000162526.
HOVERGENiHBG057030.
InParanoidiQ8R5A6.
OMAiFICEYIE.
OrthoDBiEOG7HHWSK.
PhylomeDBiQ8R5A6.
TreeFamiTF314211.

Miscellaneous databases

ChiTaRSiTbc1d22a. mouse.
PROiQ8R5A6.
SOURCEiSearch...

Gene expression databases

BgeeiQ8R5A6.
CleanExiMM_TBC1D22A.
GenevisibleiQ8R5A6. MM.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
PROSITEiPS50086. TBC_RABGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J and NOD.
    Tissue: Heart and Spinal cord.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Brain and Mammary gland.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-144, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-166, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Lung, Spleen and Testis.

Entry informationi

Entry nameiTB22A_MOUSE
AccessioniPrimary (citable) accession number: Q8R5A6
Secondary accession number(s): Q3U268, Q3U3T0, Q8CA49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: December 20, 2005
Last modified: June 8, 2016
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.