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Protein

TBC1 domain family member 22A

Gene

Tbc1d22a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a GTPase-activating protein for Rab family protein(s).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
TBC1 domain family member 22A
Gene namesi
Name:Tbc1d22a
Synonyms:D15Ertd781e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1289265 Tbc1d22a

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002080532 – 516TBC1 domain family member 22AAdd BLAST515

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei144PhosphoserineCombined sources1
Modified residuei166PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8R5A6
PaxDbiQ8R5A6
PeptideAtlasiQ8R5A6
PRIDEiQ8R5A6

PTM databases

iPTMnetiQ8R5A6
PhosphoSitePlusiQ8R5A6

Expressioni

Gene expression databases

BgeeiENSMUSG00000051864
CleanExiMM_TBC1D22A
GenevisibleiQ8R5A6 MM

Interactioni

Subunit structurei

Homodimer. Interacts with ACBD3 and ARFGEF1. Interacts with YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ and YWHAZ.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065721

Structurei

3D structure databases

ProteinModelPortaliQ8R5A6
SMRiQ8R5A6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini221 – 445Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST225

Phylogenomic databases

eggNOGiKOG1092 Eukaryota
ENOG410XQ68 LUCA
GeneTreeiENSGT00860000133753
HOGENOMiHOG000162526
HOVERGENiHBG057030
InParanoidiQ8R5A6
KOiK20360
OMAiAHWGDED
OrthoDBiEOG091G055X
PhylomeDBiQ8R5A6
TreeFamiTF314211

Family and domain databases

InterProiView protein in InterPro
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
PfamiView protein in Pfam
PF00566 RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00164 TBC, 1 hit
SUPFAMiSSF47923 SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS50086 TBC_RABGAP, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8R5A6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASDGARKQF WKRSNSKVPG SIQHVYGAQH PPFDPLLHGT LLKSTPKVPT
60 70 80 90 100
TPVKAKRVST FQEFESNTSD AWDAGEDDDE LLAMATESLN SEVVMETAHR
110 120 130 140 150
VLRNHSQRQS QPSQKTTEPE PEPQPIAEPP VPPSGDLRLV KSVSESHTPC
160 170 180 190 200
PSESTGDTVP LQRSQSLPHS ATVTLSGTSD PHALADSALS KRETSRLDKF
210 220 230 240 250
KQLLAGPNTD LEELRKLSWS GIPKPVRPMT WKLLSGYLPA NVDRRPATLQ
260 270 280 290 300
RKQKEYFAFI EHYYSSRNDE VHQDTYRQIH IDIPRMSPEA LILQPKVTEI
310 320 330 340 350
FERILFIWAI RHPASGYVQG INDLVTPFFV VFICEYTDRE DVDKVDVSSV
360 370 380 390 400
PAEVLRNIEA DTYWCMSKLL DGIQDNYTFA QPGIQMKVKM LEELVSRIDE
410 420 430 440 450
RVHRHLDGHE VRYLQFAFRW MNNLLMRELP LRCTIRLWDT YQSEPEGFSH
460 470 480 490 500
FHLYVCAAFL VRWRREILEE RDFQELLLFL QNLPTARWDD QDVSLLLAEA
510
YRLKFAFADA PNHYKK
Length:516
Mass (Da):59,362
Last modified:December 20, 2005 - v3
Checksum:iA838069E77897B10
GO
Isoform 2 (identifier: Q8R5A6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: MASDGARKQF...PFDPLLHGTL → MRSGHGQRRG...RLIRCYMAPC

Note: No experimental confirmation available.
Show »
Length:521
Mass (Da):59,938
Checksum:i4919E0B97A2E363B
GO

Sequence cautioni

The sequence AAH23106 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti120E → D in BAE33274 (PubMed:16141072).Curated1
Sequence conflicti120E → D in BAE32447 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0167611 – 41MASDG…LHGTL → MRSGHGQRRGQEAVLEAQQQ QGSRAASSMCMEPSTHRLIR CYMAPC in isoform 2. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039627 mRNA Translation: BAC30403.1
AK154226 mRNA Translation: BAE32447.1
AK154602 mRNA Translation: BAE32705.1
AK155459 mRNA Translation: BAE33274.1
AK155770 mRNA Translation: BAE33429.1
AK146872 mRNA Translation: BAE27495.1
BC023106 mRNA Translation: AAH23106.1 Different initiation.
BC066009 mRNA Translation: AAH66009.1
CCDSiCCDS27729.1 [Q8R5A6-1]
RefSeqiNP_663451.2, NM_145476.2 [Q8R5A6-1]
XP_017172065.1, XM_017316576.1
UniGeneiMm.138512
Mm.28904

Genome annotation databases

EnsembliENSMUST00000063414; ENSMUSP00000065721; ENSMUSG00000051864 [Q8R5A6-1]
GeneIDi223754
KEGGimmu:223754
UCSCiuc007xea.1 mouse [Q8R5A6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTB22A_MOUSE
AccessioniPrimary (citable) accession number: Q8R5A6
Secondary accession number(s): Q3U268, Q3U3T0, Q8CA49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: December 20, 2005
Last modified: March 28, 2018
This is version 112 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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