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Protein

Amyloid beta A4 precursor protein-binding family B member 1-interacting protein

Gene

Apbb1ip

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-354192. Integrin alphaIIb beta3 signaling.
R-MMU-354194. GRB2:SOS provides linkage to MAPK signaling for Integrins.
R-MMU-372708. p130Cas linkage to MAPK signaling for integrins.

Names & Taxonomyi

Protein namesi
Recommended name:
Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
Alternative name(s):
APBB1-interacting protein 1
Proline-rich EVH1 ligand 1
Short name:
PREL-1
Proline-rich protein 48
Gene namesi
Name:Apbb1ip
Synonyms:Prel1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1861354. Apbb1ip.

Subcellular locationi

GO - Cellular componenti

  • cytoskeleton Source: UniProtKB-SubCell
  • cytosol Source: MGI
  • focal adhesion Source: UniProtKB-SubCell
  • lamellipodium Source: UniProtKB-SubCell
  • plasma membrane Source: MGI
  • T cell receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001813481 – 670Amyloid beta A4 precursor protein-binding family B member 1-interacting proteinAdd BLAST670

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei55PhosphoserineCombined sources1
Modified residuei532PhosphoserineCombined sources1
Modified residuei534PhosphothreonineCombined sources1
Modified residuei537PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8R5A3.
MaxQBiQ8R5A3.
PaxDbiQ8R5A3.
PRIDEiQ8R5A3.

PTM databases

iPTMnetiQ8R5A3.
PhosphoSitePlusiQ8R5A3.

Miscellaneous databases

PMAP-CutDBQ8R5A3.

Expressioni

Tissue specificityi

Ubiquitously expressed with high expression in the hematopoietic system.2 Publications

Gene expression databases

BgeeiENSMUSG00000026786.
ExpressionAtlasiQ8R5A3. baseline and differential.
GenevisibleiQ8R5A3. MM.

Interactioni

Subunit structurei

Interacts, through the N-terminal Pro-rich region, with the WW domain of APBB1. Interacts with RAP1A, PFN1, VASP and ENAH.2 Publications

Protein-protein interaction databases

DIPiDIP-29358N.
MINTiMINT-1215604.
STRINGi10090.ENSMUSP00000014290.

Structurei

Secondary structure

1670
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 11Combined sources6
Helixi13 – 22Combined sources10
Beta strandi180 – 187Combined sources8
Beta strandi192 – 198Combined sources7
Helixi203 – 214Combined sources12
Beta strandi222 – 228Combined sources7
Turni229 – 232Combined sources4
Beta strandi233 – 236Combined sources4
Helixi243 – 247Combined sources5
Beta strandi257 – 262Combined sources6
Turni264 – 267Combined sources4
Helixi268 – 271Combined sources4
Helixi273 – 275Combined sources3
Helixi295 – 306Combined sources12
Beta strandi307 – 310Combined sources4
Beta strandi317 – 323Combined sources7
Beta strandi330 – 337Combined sources8
Beta strandi339 – 344Combined sources6
Turni353 – 355Combined sources3
Beta strandi357 – 361Combined sources5
Helixi362 – 364Combined sources3
Beta strandi366 – 370Combined sources5
Helixi373 – 377Combined sources5
Beta strandi380 – 382Combined sources3
Beta strandi384 – 388Combined sources5
Beta strandi400 – 403Combined sources4
Helixi407 – 422Combined sources16
Helixi424 – 434Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3TCAX-ray2.35A/B150-437[»]
4KVGX-ray1.65B/D179-437[»]
4W8PX-ray1.50B5-25[»]
ProteinModelPortaliQ8R5A3.
SMRiQ8R5A3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini179 – 266Ras-associatingPROSITE-ProRule annotationAdd BLAST88
Domaini313 – 422PHPROSITE-ProRule annotationAdd BLAST110

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi129 – 149Pro-richAdd BLAST21
Compositional biasi155 – 158Poly-Glu4
Compositional biasi517 – 635Pro-richAdd BLAST119

Sequence similaritiesi

Belongs to the MRL family.Curated
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 Ras-associating domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3751. Eukaryota.
ENOG410XXC8. LUCA.
GeneTreeiENSGT00550000074537.
HOGENOMiHOG000033749.
HOVERGENiHBG080806.
InParanoidiQ8R5A3.
KOiK17704.
OMAiKVKYKAP.
OrthoDBiEOG091G05PM.
PhylomeDBiQ8R5A3.
TreeFamiTF317511.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000159. RA_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF00788. RA. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00314. RA. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50200. RA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R5A3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGESNEDIDQ MFSTLLGEMD LLTQSLGVDT LPPPDPNPPR EEFNYTVGFK
60 70 80 90 100
DLNESLNALE DQDLDALMAD LVADISEAEQ RTIQAQKESS QNQDRFALLR
110 120 130 140 150
ASDGQGTASG GYGASAAAID VSHHEEALPP PPVEPMLDLL PPPPPPPPPE
160 170 180 190 200
LLSKEEEEAK AKADKIKLAL EKLKEAKVKK LVVKVHMDDS STKSLMVDER
210 220 230 240 250
QLARDVLDNL FEKTHCDCNV DWCLYEIYPE LQIERVFEDH ENVVEVLSDW
260 270 280 290 300
TRDTENKVLF LEKEERYAVF KNPQNFYLDN KGKKENKETN EKMNAKNKEY
310 320 330 340 350
LLEESFCGTS IIVPELEGAL YLKEDGKKSW KRRYFLLRAS GIYYVPKGKT
360 370 380 390 400
KTSRDLACFI QFENVNIYYG IQCKMKYKAP TDHCFVLKHP QIQKESQYIK
410 420 430 440 450
YLCCDDARTL SQWVMGIRIA KYGKTLYDNY QRAVARAGLA SRWTNLGTVG
460 470 480 490 500
TPMPAQPSTV SSGLKTGTSQ PNGQMPQAIP SAGPPLQEAQ TQIETTKDEK
510 520 530 540 550
QGLGNHSPGA TRENHRPKSS LPPPPPPVRR SSDTCGSPAL PSKVKGPGTC
560 570 580 590 600
TFPHPPENFL PPPPPPPPEE DNSGLLPPPP PPPYLEEPPD FVPPPPPPAA
610 620 630 640 650
VEDSALPPPP PPPPCLSQEI TKSSPLPPKK PLVPPKRQEN QGLPGAPGNS
660 670
EQDFMSDLMK ALQKKRGNIP
Length:670
Mass (Da):74,319
Last modified:November 22, 2005 - v2
Checksum:i39EB28E468C479C8
GO

Sequence cautioni

The sequence AAB94880 differs from that shown. Reason: Frameshift at positions 348 and 477.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66 – 69ALMA → EFKP in AAB94880 (PubMed:9407065).Curated4
Sequence conflicti127A → D in AAH03991 (PubMed:15489334).Curated1
Sequence conflicti141Missing (PubMed:15642358).Curated1
Sequence conflicti141Missing (PubMed:15489334).Curated1
Sequence conflicti141Missing (PubMed:9407065).Curated1
Sequence conflicti142Missing (PubMed:15642358).Curated1
Sequence conflicti142Missing in AAH23110 (PubMed:15489334).Curated1
Sequence conflicti142Missing (PubMed:9407065).Curated1
Sequence conflicti461S → P in AAH03991 (PubMed:15489334).Curated1
Sequence conflicti549T → S in AAH03991 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC003991 mRNA. Translation: AAH03991.1.
BC023110 mRNA. Translation: AAH23110.1.
AK041552 mRNA. Translation: BAC30983.1.
AF020313 mRNA. Translation: AAB94880.1. Frameshift.
CCDSiCCDS38056.1.
RefSeqiNP_062329.2. NM_019456.2.
XP_006498249.1. XM_006498186.2.
XP_011237441.1. XM_011239139.2.
UniGeneiMm.14255.

Genome annotation databases

EnsembliENSMUST00000014290; ENSMUSP00000014290; ENSMUSG00000026786.
GeneIDi54519.
KEGGimmu:54519.
UCSCiuc008inn.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC003991 mRNA. Translation: AAH03991.1.
BC023110 mRNA. Translation: AAH23110.1.
AK041552 mRNA. Translation: BAC30983.1.
AF020313 mRNA. Translation: AAB94880.1. Frameshift.
CCDSiCCDS38056.1.
RefSeqiNP_062329.2. NM_019456.2.
XP_006498249.1. XM_006498186.2.
XP_011237441.1. XM_011239139.2.
UniGeneiMm.14255.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3TCAX-ray2.35A/B150-437[»]
4KVGX-ray1.65B/D179-437[»]
4W8PX-ray1.50B5-25[»]
ProteinModelPortaliQ8R5A3.
SMRiQ8R5A3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29358N.
MINTiMINT-1215604.
STRINGi10090.ENSMUSP00000014290.

PTM databases

iPTMnetiQ8R5A3.
PhosphoSitePlusiQ8R5A3.

Proteomic databases

EPDiQ8R5A3.
MaxQBiQ8R5A3.
PaxDbiQ8R5A3.
PRIDEiQ8R5A3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000014290; ENSMUSP00000014290; ENSMUSG00000026786.
GeneIDi54519.
KEGGimmu:54519.
UCSCiuc008inn.2. mouse.

Organism-specific databases

CTDi54518.
MGIiMGI:1861354. Apbb1ip.

Phylogenomic databases

eggNOGiKOG3751. Eukaryota.
ENOG410XXC8. LUCA.
GeneTreeiENSGT00550000074537.
HOGENOMiHOG000033749.
HOVERGENiHBG080806.
InParanoidiQ8R5A3.
KOiK17704.
OMAiKVKYKAP.
OrthoDBiEOG091G05PM.
PhylomeDBiQ8R5A3.
TreeFamiTF317511.

Enzyme and pathway databases

ReactomeiR-MMU-354192. Integrin alphaIIb beta3 signaling.
R-MMU-354194. GRB2:SOS provides linkage to MAPK signaling for Integrins.
R-MMU-372708. p130Cas linkage to MAPK signaling for integrins.

Miscellaneous databases

ChiTaRSiApbb1ip. mouse.
PMAP-CutDBQ8R5A3.
PROiQ8R5A3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026786.
ExpressionAtlasiQ8R5A3. baseline and differential.
GenevisibleiQ8R5A3. MM.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000159. RA_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF00788. RA. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00314. RA. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50200. RA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAB1IP_MOUSE
AccessioniPrimary (citable) accession number: Q8R5A3
Secondary accession number(s): O35329, Q8BRU0, Q99KV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: November 2, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.