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Protein

Synaptosomal-associated protein 47

Gene

Snap47

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in intracellular membrane fusion.1 Publication

GO - Biological processi

  • long-term synaptic potentiation Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptosomal-associated protein 47
Short name:
SNAP-47
Alternative name(s):
Synaptosomal-associated 47 kDa protein
Gene namesi
Name:Snap47
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1915076. Snap47.

Subcellular locationi

GO - Cellular componenti

  • BLOC-1 complex Source: Ensembl
  • dendrite Source: MGI
  • endomembrane system Source: UniProtKB-SubCell
  • membrane Source: MGI
  • neuronal cell body Source: MGI
  • perinuclear region of cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 413413Synaptosomal-associated protein 47PRO_0000307152Add
BLAST

Proteomic databases

EPDiQ8R570.
MaxQBiQ8R570.
PaxDbiQ8R570.
PRIDEiQ8R570.

PTM databases

iPTMnetiQ8R570.
PhosphoSiteiQ8R570.

Expressioni

Tissue specificityi

Ubiquitously expressed with the most abundant expression in the brain. In brain, most highly expressed in the glomerular layer of the olfactory bulb, the cortex, striatum, hippocampus, and colliculi (at protein level).1 Publication

Developmental stagei

Expressed as early as E10 in developing brain and reaches maximal levels at E18.1 Publication

Gene expression databases

BgeeiQ8R570.
ExpressionAtlasiQ8R570. baseline and differential.
GenevisibleiQ8R570. MM.

Interactioni

Subunit structurei

Associates with the BLOC-1 complex. Interacts with BLOC1S6 (By similarity). Forms a complex containing SNAP47, VAMP2 and STX1A.By similarity1 Publication

Protein-protein interaction databases

IntActiQ8R570. 1 interaction.
STRINGi10090.ENSMUSP00000010038.

Structurei

3D structure databases

ProteinModelPortaliQ8R570.
SMRiQ8R570. Positions 119-171, 356-413.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini109 – 17163t-SNARE coiled-coil homology 1PROSITE-ProRule annotationAdd
BLAST
Domaini350 – 41263t-SNARE coiled-coil homology 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the SVAP1 family.Curated
Contains 2 t-SNARE coiled-coil homology domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG3065. Eukaryota.
ENOG410Y3Y0. LUCA.
GeneTreeiENSGT00390000000182.
HOGENOMiHOG000056669.
HOVERGENiHBG057915.
InParanoidiQ8R570.
KOiK18212.
OMAiVLEHFWR.
OrthoDBiEOG70ZZNG.
PhylomeDBiQ8R570.
TreeFamiTF331066.

Family and domain databases

InterProiIPR000727. T_SNARE_dom.
[Graphical view]
PROSITEiPS50192. T_SNARE. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8R570-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSDMRVHSW SCSYYLDLEK QWVSGKLTLT PHSLKFIVEK TEEVLVGLPL
60 70 80 90 100
SSIIEIRKES SLFIFGAITV LEKGQTKHWF SSLQPSRNVV FNVIEHFWRE
110 120 130 140 150
LLLSQPGTAA NIPSHVTRGQ ELIGLMANSQ KRMEDTAKDL QQQSEQLDSV
160 170 180 190 200
LKGLEKMESD LDVADRLLTE LETPSWWPFG SKFWKMPAEE NLKEGVSSTC
210 220 230 240 250
EPFGKEGVVI TVPAIISERA ESHSKLGKLT VLVSALEIYD SCSLLLHRFE
260 270 280 290 300
KEDVDDIKVH SPYEVSIRQR FIGKPDVAYQ LISAKMPEVI PILEVQFSSK
310 320 330 340 350
IELLEDALVL RNKVFASSAE RHAASRPKGC TPHRELPTGG QEGEQLQLQK
360 370 380 390 400
NLPLFSEGEA QELTQILSKM KGLALDTEAE LERQDAALDG ITVAVDRATL
410
NVDKQNRRMR KLM
Length:413
Mass (Da):46,524
Last modified:June 1, 2002 - v1
Checksum:iA923C061BE7E569D
GO
Isoform 2 (identifier: Q8R570-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     326-333: RPKGCTPH → CHLFLIIS
     334-413: Missing.

Note: No experimental confirmation available.
Show »
Length:333
Mass (Da):37,642
Checksum:iAAB32C4F9FBA3175
GO

Sequence cautioni

The sequence BAC35874.1 differs from that shown. Reason: Frameshift at positions 312 and 330. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti355 – 3551F → S in BAC35874 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei326 – 3338RPKGCTPH → CHLFLIIS in isoform 2. 1 PublicationVSP_028615
Alternative sequencei334 – 41380Missing in isoform 2. 1 PublicationVSP_028616Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028053 mRNA. Translation: BAC25723.1.
AK049330 mRNA. Translation: BAC33686.1.
AK075640 mRNA. Translation: BAC35874.1. Frameshift.
AK144165 mRNA. Translation: BAE25743.1.
AL713994 Genomic DNA. Translation: CAI25399.1.
BC023182 mRNA. Translation: AAH23182.1.
BC029025 mRNA. Translation: AAH29025.1.
CCDSiCCDS24767.1. [Q8R570-1]
RefSeqiNP_653104.1. NM_144521.2. [Q8R570-1]
XP_006534084.1. XM_006534021.2. [Q8R570-1]
XP_006534085.1. XM_006534022.2. [Q8R570-1]
XP_006534086.1. XM_006534023.1. [Q8R570-1]
XP_006534087.1. XM_006534024.2. [Q8R570-1]
UniGeneiMm.26680.

Genome annotation databases

EnsembliENSMUST00000010038; ENSMUSP00000010038; ENSMUSG00000009894. [Q8R570-1]
GeneIDi67826.
KEGGimmu:67826.
UCSCiuc007jds.1. mouse. [Q8R570-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028053 mRNA. Translation: BAC25723.1.
AK049330 mRNA. Translation: BAC33686.1.
AK075640 mRNA. Translation: BAC35874.1. Frameshift.
AK144165 mRNA. Translation: BAE25743.1.
AL713994 Genomic DNA. Translation: CAI25399.1.
BC023182 mRNA. Translation: AAH23182.1.
BC029025 mRNA. Translation: AAH29025.1.
CCDSiCCDS24767.1. [Q8R570-1]
RefSeqiNP_653104.1. NM_144521.2. [Q8R570-1]
XP_006534084.1. XM_006534021.2. [Q8R570-1]
XP_006534085.1. XM_006534022.2. [Q8R570-1]
XP_006534086.1. XM_006534023.1. [Q8R570-1]
XP_006534087.1. XM_006534024.2. [Q8R570-1]
UniGeneiMm.26680.

3D structure databases

ProteinModelPortaliQ8R570.
SMRiQ8R570. Positions 119-171, 356-413.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8R570. 1 interaction.
STRINGi10090.ENSMUSP00000010038.

PTM databases

iPTMnetiQ8R570.
PhosphoSiteiQ8R570.

Proteomic databases

EPDiQ8R570.
MaxQBiQ8R570.
PaxDbiQ8R570.
PRIDEiQ8R570.

Protocols and materials databases

DNASUi67826.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000010038; ENSMUSP00000010038; ENSMUSG00000009894. [Q8R570-1]
GeneIDi67826.
KEGGimmu:67826.
UCSCiuc007jds.1. mouse. [Q8R570-1]

Organism-specific databases

CTDi116841.
MGIiMGI:1915076. Snap47.

Phylogenomic databases

eggNOGiKOG3065. Eukaryota.
ENOG410Y3Y0. LUCA.
GeneTreeiENSGT00390000000182.
HOGENOMiHOG000056669.
HOVERGENiHBG057915.
InParanoidiQ8R570.
KOiK18212.
OMAiVLEHFWR.
OrthoDBiEOG70ZZNG.
PhylomeDBiQ8R570.
TreeFamiTF331066.

Miscellaneous databases

PROiQ8R570.
SOURCEiSearch...

Gene expression databases

BgeeiQ8R570.
ExpressionAtlasiQ8R570. baseline and differential.
GenevisibleiQ8R570. MM.

Family and domain databases

InterProiIPR000727. T_SNARE_dom.
[Graphical view]
PROSITEiPS50192. T_SNARE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of SNAP-47, a novel Qbc-SNARE with ubiquitous expression."
    Holt M., Varoqueaux F., Wiederhold K., Takamori S., Urlaub H., Fasshauer D., Jahn R.
    J. Biol. Chem. 281:17076-17083(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C3H/HeJ and C57BL/6J.
    Tissue: Brain, Cerebellum, Embryo and Embryonic stem cell.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: Czech II and FVB/N.
    Tissue: Mammary tumor.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Kidney, Liver, Lung, Pancreas and Spleen.

Entry informationi

Entry nameiSNP47_MOUSE
AccessioniPrimary (citable) accession number: Q8R570
Secondary accession number(s): Q3UNK4, Q8BK87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: June 1, 2002
Last modified: June 8, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.