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Protein

Synaptosomal-associated protein 47

Gene

Snap47

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in intracellular membrane fusion.1 Publication

GO - Molecular functioni

GO - Biological processi

  • exocytic insertion of neurotransmitter receptor to postsynaptic membrane Source: SynGO
  • long-term synaptic potentiation Source: MGI
  • synaptic vesicle fusion to presynaptic active zone membrane Source: GO_Central
  • synaptic vesicle priming Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptosomal-associated protein 47
Short name:
SNAP-47
Alternative name(s):
Synaptosomal-associated 47 kDa protein
Gene namesi
Name:Snap47
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:1915076 Snap47

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003071521 – 413Synaptosomal-associated protein 47Add BLAST413

Proteomic databases

EPDiQ8R570
PaxDbiQ8R570
PeptideAtlasiQ8R570
PRIDEiQ8R570

PTM databases

iPTMnetiQ8R570
PhosphoSitePlusiQ8R570

Expressioni

Tissue specificityi

Ubiquitously expressed with the most abundant expression in the brain. In brain, most highly expressed in the glomerular layer of the olfactory bulb, the cortex, striatum, hippocampus, and colliculi (at protein level).1 Publication

Developmental stagei

Expressed as early as E10 in developing brain and reaches maximal levels at E18.1 Publication

Gene expression databases

BgeeiENSMUSG00000009894
ExpressionAtlasiQ8R570 baseline and differential
GenevisibleiQ8R570 MM

Interactioni

Subunit structurei

Associates with the BLOC-1 complex. Interacts with BLOC1S6 (By similarity). Forms a complex containing SNAP47, VAMP2 and STX1A.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi212462, 3 interactors
IntActiQ8R570, 1 interactor
STRINGi10090.ENSMUSP00000010038

Structurei

3D structure databases

ProteinModelPortaliQ8R570
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini109 – 171t-SNARE coiled-coil homology 1PROSITE-ProRule annotationAdd BLAST63
Domaini350 – 412t-SNARE coiled-coil homology 2PROSITE-ProRule annotationAdd BLAST63

Sequence similaritiesi

Belongs to the SVAP1 family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG3065 Eukaryota
ENOG410Y3Y0 LUCA
GeneTreeiENSGT00390000000182
HOGENOMiHOG000056669
HOVERGENiHBG057915
InParanoidiQ8R570
KOiK18212
OMAiQGEQFDN
OrthoDBiEOG091G0TY9
PhylomeDBiQ8R570
TreeFamiTF331066

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR000727 T_SNARE_dom
PROSITEiView protein in PROSITE
PS50192 T_SNARE, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8R570-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSDMRVHSW SCSYYLDLEK QWVSGKLTLT PHSLKFIVEK TEEVLVGLPL
60 70 80 90 100
SSIIEIRKES SLFIFGAITV LEKGQTKHWF SSLQPSRNVV FNVIEHFWRE
110 120 130 140 150
LLLSQPGTAA NIPSHVTRGQ ELIGLMANSQ KRMEDTAKDL QQQSEQLDSV
160 170 180 190 200
LKGLEKMESD LDVADRLLTE LETPSWWPFG SKFWKMPAEE NLKEGVSSTC
210 220 230 240 250
EPFGKEGVVI TVPAIISERA ESHSKLGKLT VLVSALEIYD SCSLLLHRFE
260 270 280 290 300
KEDVDDIKVH SPYEVSIRQR FIGKPDVAYQ LISAKMPEVI PILEVQFSSK
310 320 330 340 350
IELLEDALVL RNKVFASSAE RHAASRPKGC TPHRELPTGG QEGEQLQLQK
360 370 380 390 400
NLPLFSEGEA QELTQILSKM KGLALDTEAE LERQDAALDG ITVAVDRATL
410
NVDKQNRRMR KLM
Length:413
Mass (Da):46,524
Last modified:June 1, 2002 - v1
Checksum:iA923C061BE7E569D
GO
Isoform 2 (identifier: Q8R570-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     326-333: RPKGCTPH → CHLFLIIS
     334-413: Missing.

Note: No experimental confirmation available.
Show »
Length:333
Mass (Da):37,642
Checksum:iAAB32C4F9FBA3175
GO

Sequence cautioni

The sequence BAC35874 differs from that shown. Reason: Frameshift at positions 312 and 330.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti355F → S in BAC35874 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_028615326 – 333RPKGCTPH → CHLFLIIS in isoform 2. 1 Publication8
Alternative sequenceiVSP_028616334 – 413Missing in isoform 2. 1 PublicationAdd BLAST80

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028053 mRNA Translation: BAC25723.1
AK049330 mRNA Translation: BAC33686.1
AK075640 mRNA Translation: BAC35874.1 Frameshift.
AK144165 mRNA Translation: BAE25743.1
AL713994 Genomic DNA No translation available.
BC023182 mRNA Translation: AAH23182.1
BC029025 mRNA Translation: AAH29025.1
CCDSiCCDS24767.1 [Q8R570-1]
RefSeqiNP_653104.1, NM_144521.2 [Q8R570-1]
XP_006534084.1, XM_006534021.2
XP_006534085.1, XM_006534022.3 [Q8R570-1]
XP_006534086.1, XM_006534023.1 [Q8R570-1]
XP_006534087.1, XM_006534024.3 [Q8R570-1]
UniGeneiMm.26680

Genome annotation databases

EnsembliENSMUST00000010038; ENSMUSP00000010038; ENSMUSG00000009894 [Q8R570-1]
GeneIDi67826
KEGGimmu:67826
UCSCiuc007jds.1 mouse [Q8R570-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSNP47_MOUSE
AccessioniPrimary (citable) accession number: Q8R570
Secondary accession number(s): Q3UNK4, Q8BK87
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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