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Protein

Ankyrin repeat domain-containing protein 1

Gene

Ankrd1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes.2 Publications

GO - Molecular functioni

  • DNA binding Source: Ensembl
  • RNA polymerase II transcription coactivator activity Source: Ensembl
  • titin binding Source: GO_Central
  • transcription cofactor activity Source: RGD
  • transcription corepressor activity Source: Ensembl
  • transcription factor binding Source: RGD

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 1
Alternative name(s):
Cardiac adriamycin-responsive protein
Cardiac ankyrin repeat protein
Gene namesi
Name:Ankrd1
Synonyms:Carp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi61989. Ankrd1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Ensembl
  • I band Source: BHF-UCL
  • nucleolus Source: Ensembl
  • nucleus Source: BHF-UCL
  • transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 319319Ankyrin repeat domain-containing protein 1PRO_0000240483Add
BLAST

Proteomic databases

PaxDbiQ8R560.
PRIDEiQ8R560.

Expressioni

Tissue specificityi

Expressed in heart, cardiac muscle.1 Publication

Inductioni

Down-regulated by doxorubicin (adriamycin), in vitro.1 Publication

Gene expression databases

BgeeiENSRNOG00000018598.
GenevisibleiQ8R560. RN.

Interactioni

Subunit structurei

Interacts with TTN/titin (By similarity). Interacts with YBX1.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PDE4DIPQ5VU43-112EBI-10817505,EBI-10769071From a different organism.

GO - Molecular functioni

  • titin binding Source: GO_Central
  • transcription factor binding Source: RGD

Protein-protein interaction databases

IntActiQ8R560. 1 interaction.
STRINGi10116.ENSRNOP00000025258.

Structurei

3D structure databases

ProteinModelPortaliQ8R560.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati152 – 18130ANK 1Add
BLAST
Repeati185 – 21430ANK 2Add
BLAST
Repeati218 – 24730ANK 3Add
BLAST
Repeati251 – 28030ANK 4Add
BLAST
Repeati284 – 31532ANK 5Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili55 – 8935Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 5 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129743.
HOGENOMiHOG000236321.
HOVERGENiHBG071561.
InParanoidiQ8R560.
OMAiKGDPNVC.
OrthoDBiEOG091G0DCN.
PhylomeDBiQ8R560.
TreeFamiTF331650.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R560-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMVFRVEELV TGKKNSNGSS GEFLPGEFRN GEYEAAVALE KQEDLKTLPA
60 70 80 90 100
NSVNLGEEQR KSEKVREAEL KKKKLEQRSK LENLEDLEII VQLKKRKKYK
110 120 130 140 150
KTKVPVVKEP EPEIITEPVD VPRFLKAALE NKLPVVEKFL SDKNSPDVCD
160 170 180 190 200
EYKRTALHRA CLEGHLAIVE KLMEAGAQIE FRDMLESTAI HWACRGGNLD
210 220 230 240 250
VLKLLLNKGA KISARDKLLS TALHVAVRTG HYECAEHLIA CEADLNAKDR
260 270 280 290 300
EGDTPLHDAV RLNRYKMIRL LMTFGADLNV KNCAGKTPMD LVLHWQNGTK
310
AIFDSLKENA YKNSRIATF
Length:319
Mass (Da):36,064
Last modified:June 1, 2002 - v1
Checksum:iE760BF7BFD6049E0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti287 – 2871T → I in AAD10401 (PubMed:9278441).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L81174 mRNA. Translation: AAL77519.1.
U50736 mRNA. Translation: AAD10401.1.
BC072699 mRNA. Translation: AAH72699.1.
RefSeqiNP_037352.1. NM_013220.1.
UniGeneiRn.3789.

Genome annotation databases

EnsembliENSRNOT00000025258; ENSRNOP00000025258; ENSRNOG00000018598.
GeneIDi27064.
KEGGirno:27064.
UCSCiRGD:61989. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L81174 mRNA. Translation: AAL77519.1.
U50736 mRNA. Translation: AAD10401.1.
BC072699 mRNA. Translation: AAH72699.1.
RefSeqiNP_037352.1. NM_013220.1.
UniGeneiRn.3789.

3D structure databases

ProteinModelPortaliQ8R560.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8R560. 1 interaction.
STRINGi10116.ENSRNOP00000025258.

Proteomic databases

PaxDbiQ8R560.
PRIDEiQ8R560.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025258; ENSRNOP00000025258; ENSRNOG00000018598.
GeneIDi27064.
KEGGirno:27064.
UCSCiRGD:61989. rat.

Organism-specific databases

CTDi27063.
RGDi61989. Ankrd1.

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129743.
HOGENOMiHOG000236321.
HOVERGENiHBG071561.
InParanoidiQ8R560.
OMAiKGDPNVC.
OrthoDBiEOG091G0DCN.
PhylomeDBiQ8R560.
TreeFamiTF331650.

Miscellaneous databases

PROiQ8R560.

Gene expression databases

BgeeiENSRNOG00000018598.
GenevisibleiQ8R560. RN.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANKR1_RAT
AccessioniPrimary (citable) accession number: Q8R560
Secondary accession number(s): Q9Z1F0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2002
Last modified: September 7, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.