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Q8R554 (OTU7A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
OTU domain-containing protein 7A
EC=3.4.19.12
Alternative name(s):
Zinc finger protein Cezanne 2
Gene names
Name:Otud7a
Synonyms:Cezanne2, Otud7
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length926 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Has deubiquitinating activity that is directed towards 'Lys-48' or 'Lys-63'-linked polyubiquitin chains. Hydrolyzes both linear and branched forms of polyubiquitin By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the peptidase C64 family.

Contains 1 A20-type zinc finger.

Contains 1 OTU domain.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   Cellular componentCytoplasm
Nucleus
   DomainZinc-finger
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
Protease
Thiol protease
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: InterPro

cysteine-type peptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 926926OTU domain-containing protein 7A
PRO_0000188790

Regions

Domain201 – 377177OTU
Zinc finger884 – 91936A20-type
Region170 – 413244TRAF-binding By similarity
Region185 – 452268Catalytic By similarity
Motif497 – 51216Nuclear localization signal Potential

Sites

Active site2121Nucleophile By similarity
Active site3701Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8R554 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 4D6BD05A0410BED9

FASTA926100,797
        10         20         30         40         50         60 
MVSSLLPNPP SAECWAALLH DPMTLDMDAV LSDFVRSTGA EPGLARDLLE GKNWDLTAAL 

        70         80         90        100        110        120 
SDYEQLRQVH TANLPHVFNE GRCAKQAERE LPQPGHKVER PCLQRQDDIA QAEKRLSRGI 

       130        140        150        160        170        180 
SHASSAIVSL ARSHVANECN NEQFPLEMPI YTFQLPDLSV YSEDFRSFIE RDLIEQATMV 

       190        200        210        220        230        240 
ALEQAGRLNW WSTVCTSCKR LLPLATTGDG NCLLHAASLG MWGFHDRDLV LRKALYTMMR 

       250        260        270        280        290        300 
TGAEREALKR RWRWQQTQQN KEEEWEREWT ELLKLASSEP RTHFSKNGSG TGGGVDNSED 

       310        320        330        340        350        360 
PVYESLEEFH VFVLAHILRR PIVVVADTML RDSGGEAFAP IPFGGIYLPL EVPPNRCHCS 

       370        380        390        400        410        420 
PLVLAYDQAH FSALVSMEQR DQQREQAVIP LTDSEHKLLP LHFAVDPGKD WEWGKDDNDN 

       430        440        450        460        470        480 
ARLANLILSL EAKLNLLHSY MNVTWIRIPS ETRAPLAQPE SPTASAGEDV QSLAESLDSD 

       490        500        510        520        530        540 
RDSVCSNSNS NNGKNGKDKE KEKQRKDKDK TRADSVANKL GSFSKTLGIK LKKNMGGLGG 

       550        560        570        580        590        600 
LVHGKMGRAN SANGKNGDSA ERNKEKKSKS RKGSKEESGA SASTSPSEKT TPSPTDKASG 

       610        620        630        640        650        660 
ASPADKGSGS RGDAWKYSTD VKLSLNILRA AMQGERKFIF AGLLLTSHRH QFHEEMIGYY 

       670        680        690        700        710        720 
LTSAQERFSA EQEQRRRDAA AAAAAATATA TVKRPARRPE AEGAPGPERA SPGPTAAQPT 

       730        740        750        760        770        780 
QLVLKLKERP SPGTGASARA ARAAGGAASP GPGGGARRAA PGTGGPTPGR SPPAPARQSV 

       790        800        810        820        830        840 
IHVQAAARDE ACAPTVGALR PCATYPQQNR SLWSQSYSPA RSALRTVNTV ESLAPGGADA 

       850        860        870        880        890        900 
PGPAEHKSQT YSNGFGAARD GLEFADADAP AARSNAECGR GGPGPAQRRC QRENCAFYGR 

       910        920 
AETEHFCSYC YREELRRRRE ARAARP

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References

[1]"Isolation of a novel murine gene, Cezanne 2."
Evans P.C., Coadwell W.J., Kilshaw P.J.
Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ430384 mRNA. Translation: CAD23048.1.
IPIIPI00153939.
RefSeqNP_570950.1. NM_130880.1.
UniGeneMm.156872.

3D structure databases

ProteinModelPortalQ8R554.
SMRQ8R554. Positions 11-82, 148-407.
ModBaseSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000057282.

Protein family/group databases

MEROPSC64.002.

PTM databases

PhosphoSiteQ8R554.

Proteomic databases

PaxDbQ8R554.
PRIDEQ8R554.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000058476; ENSMUSP00000057282; ENSMUSG00000033510.
GeneID170711.
KEGGmmu:170711.
UCSCuc009hfl.1. mouse.

Organism-specific databases

CTD161725.
MGIMGI:2158505. Otud7a.

Phylogenomic databases

eggNOGNOG282016.
GeneTreeENSGT00530000062989.
HOGENOMHOG000048103.
HOVERGENHBG050904.
InParanoidQ8R554.
KOK11860.
OMAFNEGRGP.
OrthoDBEOG4BRWK6.

Gene expression databases

ArrayExpressQ8R554.
BgeeQ8R554.
CleanExMM_OTUD7A.
GenevestigatorQ8R554.
GermOnlineENSMUSG00000033510. Mus musculus.

Family and domain databases

InterProIPR003323. OTU.
IPR009060. UBA-like.
IPR002653. Znf_A20.
[Graphical view]
PfamPF02338. OTU. 1 hit.
[Graphical view]
SUPFAMSSF46934. UBA_like. 1 hit.
PROSITEPS50802. OTU. 1 hit.
PS51036. ZF_A20. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio370222.
SOURCESearch...

Entry information

Entry nameOTU7A_MOUSE
AccessionPrimary (citable) accession number: Q8R554
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2002
Last modified: May 1, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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