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Q8R554

- OTU7A_MOUSE

UniProt

Q8R554 - OTU7A_MOUSE

Protein

OTU domain-containing protein 7A

Gene

Otud7a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Has deubiquitinating activity towards 'Lys-11'-linked polyubiquitin chains.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei209 – 2091By similarity
    Active sitei212 – 2121NucleophileBy similarity
    Active sitei370 – 3701Proton acceptorBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri884 – 91936A20-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. ubiquitin-specific protease activity Source: UniProtKB
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. protein K11-linked deubiquitination Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiC64.002.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    OTU domain-containing protein 7A (EC:3.4.19.12)
    Alternative name(s):
    Zinc finger protein Cezanne 2
    Gene namesi
    Name:Otud7a
    Synonyms:Cezanne2, Otud7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:2158505. Otud7a.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 926926OTU domain-containing protein 7APRO_0000188790Add
    BLAST

    Proteomic databases

    PaxDbiQ8R554.
    PRIDEiQ8R554.

    PTM databases

    PhosphoSiteiQ8R554.

    Expressioni

    Gene expression databases

    BgeeiQ8R554.
    CleanExiMM_OTUD7A.
    GenevestigatoriQ8R554.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000057282.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8R554.
    SMRiQ8R554. Positions 11-82, 148-407.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini201 – 377177OTUPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni170 – 413244TRAF-bindingBy similarityAdd
    BLAST
    Regioni185 – 452268CatalyticBy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi497 – 51216Nuclear localization signalSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C64 family.Curated
    Contains 1 A20-type zinc finger.PROSITE-ProRule annotation
    Contains 1 OTU domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri884 – 91936A20-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG282016.
    GeneTreeiENSGT00530000062989.
    HOGENOMiHOG000048103.
    HOVERGENiHBG050904.
    InParanoidiQ8R554.
    KOiK11860.
    OMAiKQPEREP.
    OrthoDBiEOG7JHM57.
    PhylomeDBiQ8R554.
    TreeFamiTF323312.

    Family and domain databases

    InterProiIPR003323. OTU.
    IPR002653. Znf_A20.
    [Graphical view]
    PfamiPF02338. OTU. 1 hit.
    [Graphical view]
    PROSITEiPS50802. OTU. 1 hit.
    PS51036. ZF_A20. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8R554-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVSSLLPNPP SAECWAALLH DPMTLDMDAV LSDFVRSTGA EPGLARDLLE    50
    GKNWDLTAAL SDYEQLRQVH TANLPHVFNE GRCAKQAERE LPQPGHKVER 100
    PCLQRQDDIA QAEKRLSRGI SHASSAIVSL ARSHVANECN NEQFPLEMPI 150
    YTFQLPDLSV YSEDFRSFIE RDLIEQATMV ALEQAGRLNW WSTVCTSCKR 200
    LLPLATTGDG NCLLHAASLG MWGFHDRDLV LRKALYTMMR TGAEREALKR 250
    RWRWQQTQQN KEEEWEREWT ELLKLASSEP RTHFSKNGSG TGGGVDNSED 300
    PVYESLEEFH VFVLAHILRR PIVVVADTML RDSGGEAFAP IPFGGIYLPL 350
    EVPPNRCHCS PLVLAYDQAH FSALVSMEQR DQQREQAVIP LTDSEHKLLP 400
    LHFAVDPGKD WEWGKDDNDN ARLANLILSL EAKLNLLHSY MNVTWIRIPS 450
    ETRAPLAQPE SPTASAGEDV QSLAESLDSD RDSVCSNSNS NNGKNGKDKE 500
    KEKQRKDKDK TRADSVANKL GSFSKTLGIK LKKNMGGLGG LVHGKMGRAN 550
    SANGKNGDSA ERNKEKKSKS RKGSKEESGA SASTSPSEKT TPSPTDKASG 600
    ASPADKGSGS RGDAWKYSTD VKLSLNILRA AMQGERKFIF AGLLLTSHRH 650
    QFHEEMIGYY LTSAQERFSA EQEQRRRDAA AAAAAATATA TVKRPARRPE 700
    AEGAPGPERA SPGPTAAQPT QLVLKLKERP SPGTGASARA ARAAGGAASP 750
    GPGGGARRAA PGTGGPTPGR SPPAPARQSV IHVQAAARDE ACAPTVGALR 800
    PCATYPQQNR SLWSQSYSPA RSALRTVNTV ESLAPGGADA PGPAEHKSQT 850
    YSNGFGAARD GLEFADADAP AARSNAECGR GGPGPAQRRC QRENCAFYGR 900
    AETEHFCSYC YREELRRRRE ARAARP 926
    Length:926
    Mass (Da):100,797
    Last modified:June 1, 2002 - v1
    Checksum:i4D6BD05A0410BED9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ430384 mRNA. Translation: CAD23048.1.
    CCDSiCCDS21330.1.
    RefSeqiNP_570950.1. NM_130880.1.
    UniGeneiMm.156872.

    Genome annotation databases

    EnsembliENSMUST00000058476; ENSMUSP00000057282; ENSMUSG00000033510.
    GeneIDi170711.
    KEGGimmu:170711.
    UCSCiuc009hfl.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ430384 mRNA. Translation: CAD23048.1 .
    CCDSi CCDS21330.1.
    RefSeqi NP_570950.1. NM_130880.1.
    UniGenei Mm.156872.

    3D structure databases

    ProteinModelPortali Q8R554.
    SMRi Q8R554. Positions 11-82, 148-407.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000057282.

    Protein family/group databases

    MEROPSi C64.002.

    PTM databases

    PhosphoSitei Q8R554.

    Proteomic databases

    PaxDbi Q8R554.
    PRIDEi Q8R554.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000058476 ; ENSMUSP00000057282 ; ENSMUSG00000033510 .
    GeneIDi 170711.
    KEGGi mmu:170711.
    UCSCi uc009hfl.1. mouse.

    Organism-specific databases

    CTDi 161725.
    MGIi MGI:2158505. Otud7a.

    Phylogenomic databases

    eggNOGi NOG282016.
    GeneTreei ENSGT00530000062989.
    HOGENOMi HOG000048103.
    HOVERGENi HBG050904.
    InParanoidi Q8R554.
    KOi K11860.
    OMAi KQPEREP.
    OrthoDBi EOG7JHM57.
    PhylomeDBi Q8R554.
    TreeFami TF323312.

    Miscellaneous databases

    NextBioi 370222.
    PROi Q8R554.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8R554.
    CleanExi MM_OTUD7A.
    Genevestigatori Q8R554.

    Family and domain databases

    InterProi IPR003323. OTU.
    IPR002653. Znf_A20.
    [Graphical view ]
    Pfami PF02338. OTU. 1 hit.
    [Graphical view ]
    PROSITEi PS50802. OTU. 1 hit.
    PS51036. ZF_A20. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of a novel murine gene, Cezanne 2."
      Evans P.C., Coadwell W.J., Kilshaw P.J.
      Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.

    Entry informationi

    Entry nameiOTU7A_MOUSE
    AccessioniPrimary (citable) accession number: Q8R554
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3