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Q8R554

- OTU7A_MOUSE

UniProt

Q8R554 - OTU7A_MOUSE

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Protein

OTU domain-containing protein 7A

Gene
Otud7a, Cezanne2, Otud7
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Has deubiquitinating activity towards 'Lys-11'-linked polyubiquitin chains By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei209 – 2091 By similarity
Active sitei212 – 2121Nucleophile By similarity
Active sitei370 – 3701Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri884 – 91936A20-typeAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. ubiquitin-specific protease activity Source: UniProtKB
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. protein K11-linked deubiquitination Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiC64.002.

Names & Taxonomyi

Protein namesi
Recommended name:
OTU domain-containing protein 7A (EC:3.4.19.12)
Alternative name(s):
Zinc finger protein Cezanne 2
Gene namesi
Name:Otud7a
Synonyms:Cezanne2, Otud7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:2158505. Otud7a.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 926926OTU domain-containing protein 7APRO_0000188790Add
BLAST

Proteomic databases

PaxDbiQ8R554.
PRIDEiQ8R554.

PTM databases

PhosphoSiteiQ8R554.

Expressioni

Gene expression databases

BgeeiQ8R554.
CleanExiMM_OTUD7A.
GenevestigatoriQ8R554.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057282.

Structurei

3D structure databases

ProteinModelPortaliQ8R554.
SMRiQ8R554. Positions 11-82, 148-407.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini201 – 377177OTUAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni170 – 413244TRAF-binding By similarityAdd
BLAST
Regioni185 – 452268Catalytic By similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi497 – 51216Nuclear localization signal Reviewed predictionAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C64 family.
Contains 1 OTU domain.

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG282016.
GeneTreeiENSGT00530000062989.
HOGENOMiHOG000048103.
HOVERGENiHBG050904.
InParanoidiQ8R554.
KOiK11860.
OMAiKQPEREP.
OrthoDBiEOG7JHM57.
PhylomeDBiQ8R554.
TreeFamiTF323312.

Family and domain databases

InterProiIPR003323. OTU.
IPR002653. Znf_A20.
[Graphical view]
PfamiPF02338. OTU. 1 hit.
[Graphical view]
PROSITEiPS50802. OTU. 1 hit.
PS51036. ZF_A20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R554-1 [UniParc]FASTAAdd to Basket

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MVSSLLPNPP SAECWAALLH DPMTLDMDAV LSDFVRSTGA EPGLARDLLE    50
GKNWDLTAAL SDYEQLRQVH TANLPHVFNE GRCAKQAERE LPQPGHKVER 100
PCLQRQDDIA QAEKRLSRGI SHASSAIVSL ARSHVANECN NEQFPLEMPI 150
YTFQLPDLSV YSEDFRSFIE RDLIEQATMV ALEQAGRLNW WSTVCTSCKR 200
LLPLATTGDG NCLLHAASLG MWGFHDRDLV LRKALYTMMR TGAEREALKR 250
RWRWQQTQQN KEEEWEREWT ELLKLASSEP RTHFSKNGSG TGGGVDNSED 300
PVYESLEEFH VFVLAHILRR PIVVVADTML RDSGGEAFAP IPFGGIYLPL 350
EVPPNRCHCS PLVLAYDQAH FSALVSMEQR DQQREQAVIP LTDSEHKLLP 400
LHFAVDPGKD WEWGKDDNDN ARLANLILSL EAKLNLLHSY MNVTWIRIPS 450
ETRAPLAQPE SPTASAGEDV QSLAESLDSD RDSVCSNSNS NNGKNGKDKE 500
KEKQRKDKDK TRADSVANKL GSFSKTLGIK LKKNMGGLGG LVHGKMGRAN 550
SANGKNGDSA ERNKEKKSKS RKGSKEESGA SASTSPSEKT TPSPTDKASG 600
ASPADKGSGS RGDAWKYSTD VKLSLNILRA AMQGERKFIF AGLLLTSHRH 650
QFHEEMIGYY LTSAQERFSA EQEQRRRDAA AAAAAATATA TVKRPARRPE 700
AEGAPGPERA SPGPTAAQPT QLVLKLKERP SPGTGASARA ARAAGGAASP 750
GPGGGARRAA PGTGGPTPGR SPPAPARQSV IHVQAAARDE ACAPTVGALR 800
PCATYPQQNR SLWSQSYSPA RSALRTVNTV ESLAPGGADA PGPAEHKSQT 850
YSNGFGAARD GLEFADADAP AARSNAECGR GGPGPAQRRC QRENCAFYGR 900
AETEHFCSYC YREELRRRRE ARAARP 926
Length:926
Mass (Da):100,797
Last modified:June 1, 2002 - v1
Checksum:i4D6BD05A0410BED9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ430384 mRNA. Translation: CAD23048.1.
CCDSiCCDS21330.1.
RefSeqiNP_570950.1. NM_130880.1.
UniGeneiMm.156872.

Genome annotation databases

EnsembliENSMUST00000058476; ENSMUSP00000057282; ENSMUSG00000033510.
GeneIDi170711.
KEGGimmu:170711.
UCSCiuc009hfl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ430384 mRNA. Translation: CAD23048.1 .
CCDSi CCDS21330.1.
RefSeqi NP_570950.1. NM_130880.1.
UniGenei Mm.156872.

3D structure databases

ProteinModelPortali Q8R554.
SMRi Q8R554. Positions 11-82, 148-407.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000057282.

Protein family/group databases

MEROPSi C64.002.

PTM databases

PhosphoSitei Q8R554.

Proteomic databases

PaxDbi Q8R554.
PRIDEi Q8R554.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000058476 ; ENSMUSP00000057282 ; ENSMUSG00000033510 .
GeneIDi 170711.
KEGGi mmu:170711.
UCSCi uc009hfl.1. mouse.

Organism-specific databases

CTDi 161725.
MGIi MGI:2158505. Otud7a.

Phylogenomic databases

eggNOGi NOG282016.
GeneTreei ENSGT00530000062989.
HOGENOMi HOG000048103.
HOVERGENi HBG050904.
InParanoidi Q8R554.
KOi K11860.
OMAi KQPEREP.
OrthoDBi EOG7JHM57.
PhylomeDBi Q8R554.
TreeFami TF323312.

Miscellaneous databases

NextBioi 370222.
PROi Q8R554.
SOURCEi Search...

Gene expression databases

Bgeei Q8R554.
CleanExi MM_OTUD7A.
Genevestigatori Q8R554.

Family and domain databases

InterProi IPR003323. OTU.
IPR002653. Znf_A20.
[Graphical view ]
Pfami PF02338. OTU. 1 hit.
[Graphical view ]
PROSITEi PS50802. OTU. 1 hit.
PS51036. ZF_A20. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation of a novel murine gene, Cezanne 2."
    Evans P.C., Coadwell W.J., Kilshaw P.J.
    Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.

Entry informationi

Entry nameiOTU7A_MOUSE
AccessioniPrimary (citable) accession number: Q8R554
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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