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Protein

OTU domain-containing protein 7A

Gene

Otud7a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Has deubiquitinating activity towards 'Lys-11'-linked polyubiquitin chains.By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei209 – 2091By similarity
Active sitei212 – 2121NucleophileBy similarity
Active sitei370 – 3701Proton acceptorBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri884 – 91936A20-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. ubiquitin-specific protease activity Source: UniProtKB
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. protein K11-linked deubiquitination Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiC64.002.

Names & Taxonomyi

Protein namesi
Recommended name:
OTU domain-containing protein 7A (EC:3.4.19.12)
Alternative name(s):
Zinc finger protein Cezanne 2
Gene namesi
Name:Otud7a
Synonyms:Cezanne2, Otud7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:2158505. Otud7a.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 926926OTU domain-containing protein 7APRO_0000188790Add
BLAST

Proteomic databases

PaxDbiQ8R554.
PRIDEiQ8R554.

PTM databases

PhosphoSiteiQ8R554.

Expressioni

Gene expression databases

BgeeiQ8R554.
CleanExiMM_OTUD7A.
ExpressionAtlasiQ8R554. baseline and differential.
GenevestigatoriQ8R554.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057282.

Structurei

3D structure databases

ProteinModelPortaliQ8R554.
SMRiQ8R554. Positions 11-82, 148-407.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini201 – 377177OTUPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni170 – 413244TRAF-bindingBy similarityAdd
BLAST
Regioni185 – 452268CatalyticBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi497 – 51216Nuclear localization signalSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C64 family.Curated
Contains 1 A20-type zinc finger.PROSITE-ProRule annotation
Contains 1 OTU domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri884 – 91936A20-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG282016.
GeneTreeiENSGT00530000062989.
HOGENOMiHOG000048103.
HOVERGENiHBG050904.
InParanoidiQ8R554.
KOiK11860.
OMAiLADSMDS.
OrthoDBiEOG7JHM57.
PhylomeDBiQ8R554.
TreeFamiTF323312.

Family and domain databases

InterProiIPR003323. OTU.
IPR002653. Znf_A20.
[Graphical view]
PfamiPF02338. OTU. 1 hit.
[Graphical view]
PROSITEiPS50802. OTU. 1 hit.
PS51036. ZF_A20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R554-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVSSLLPNPP SAECWAALLH DPMTLDMDAV LSDFVRSTGA EPGLARDLLE
60 70 80 90 100
GKNWDLTAAL SDYEQLRQVH TANLPHVFNE GRCAKQAERE LPQPGHKVER
110 120 130 140 150
PCLQRQDDIA QAEKRLSRGI SHASSAIVSL ARSHVANECN NEQFPLEMPI
160 170 180 190 200
YTFQLPDLSV YSEDFRSFIE RDLIEQATMV ALEQAGRLNW WSTVCTSCKR
210 220 230 240 250
LLPLATTGDG NCLLHAASLG MWGFHDRDLV LRKALYTMMR TGAEREALKR
260 270 280 290 300
RWRWQQTQQN KEEEWEREWT ELLKLASSEP RTHFSKNGSG TGGGVDNSED
310 320 330 340 350
PVYESLEEFH VFVLAHILRR PIVVVADTML RDSGGEAFAP IPFGGIYLPL
360 370 380 390 400
EVPPNRCHCS PLVLAYDQAH FSALVSMEQR DQQREQAVIP LTDSEHKLLP
410 420 430 440 450
LHFAVDPGKD WEWGKDDNDN ARLANLILSL EAKLNLLHSY MNVTWIRIPS
460 470 480 490 500
ETRAPLAQPE SPTASAGEDV QSLAESLDSD RDSVCSNSNS NNGKNGKDKE
510 520 530 540 550
KEKQRKDKDK TRADSVANKL GSFSKTLGIK LKKNMGGLGG LVHGKMGRAN
560 570 580 590 600
SANGKNGDSA ERNKEKKSKS RKGSKEESGA SASTSPSEKT TPSPTDKASG
610 620 630 640 650
ASPADKGSGS RGDAWKYSTD VKLSLNILRA AMQGERKFIF AGLLLTSHRH
660 670 680 690 700
QFHEEMIGYY LTSAQERFSA EQEQRRRDAA AAAAAATATA TVKRPARRPE
710 720 730 740 750
AEGAPGPERA SPGPTAAQPT QLVLKLKERP SPGTGASARA ARAAGGAASP
760 770 780 790 800
GPGGGARRAA PGTGGPTPGR SPPAPARQSV IHVQAAARDE ACAPTVGALR
810 820 830 840 850
PCATYPQQNR SLWSQSYSPA RSALRTVNTV ESLAPGGADA PGPAEHKSQT
860 870 880 890 900
YSNGFGAARD GLEFADADAP AARSNAECGR GGPGPAQRRC QRENCAFYGR
910 920
AETEHFCSYC YREELRRRRE ARAARP
Length:926
Mass (Da):100,797
Last modified:June 1, 2002 - v1
Checksum:i4D6BD05A0410BED9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ430384 mRNA. Translation: CAD23048.1.
CCDSiCCDS21330.1.
RefSeqiNP_570950.1. NM_130880.1.
UniGeneiMm.156872.

Genome annotation databases

EnsembliENSMUST00000058476; ENSMUSP00000057282; ENSMUSG00000033510.
GeneIDi170711.
KEGGimmu:170711.
UCSCiuc009hfl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ430384 mRNA. Translation: CAD23048.1.
CCDSiCCDS21330.1.
RefSeqiNP_570950.1. NM_130880.1.
UniGeneiMm.156872.

3D structure databases

ProteinModelPortaliQ8R554.
SMRiQ8R554. Positions 11-82, 148-407.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057282.

Protein family/group databases

MEROPSiC64.002.

PTM databases

PhosphoSiteiQ8R554.

Proteomic databases

PaxDbiQ8R554.
PRIDEiQ8R554.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058476; ENSMUSP00000057282; ENSMUSG00000033510.
GeneIDi170711.
KEGGimmu:170711.
UCSCiuc009hfl.1. mouse.

Organism-specific databases

CTDi161725.
MGIiMGI:2158505. Otud7a.

Phylogenomic databases

eggNOGiNOG282016.
GeneTreeiENSGT00530000062989.
HOGENOMiHOG000048103.
HOVERGENiHBG050904.
InParanoidiQ8R554.
KOiK11860.
OMAiLADSMDS.
OrthoDBiEOG7JHM57.
PhylomeDBiQ8R554.
TreeFamiTF323312.

Miscellaneous databases

NextBioi370222.
PROiQ8R554.
SOURCEiSearch...

Gene expression databases

BgeeiQ8R554.
CleanExiMM_OTUD7A.
ExpressionAtlasiQ8R554. baseline and differential.
GenevestigatoriQ8R554.

Family and domain databases

InterProiIPR003323. OTU.
IPR002653. Znf_A20.
[Graphical view]
PfamiPF02338. OTU. 1 hit.
[Graphical view]
PROSITEiPS50802. OTU. 1 hit.
PS51036. ZF_A20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation of a novel murine gene, Cezanne 2."
    Evans P.C., Coadwell W.J., Kilshaw P.J.
    Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.

Entry informationi

Entry nameiOTU7A_MOUSE
AccessioniPrimary (citable) accession number: Q8R554
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2002
Last modified: January 7, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.