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Protein

Peroxisomal targeting signal 2 receptor

Gene

PEX7

Organism
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal targeting signal 2 receptor
Short name:
PTS2 receptor
Alternative name(s):
Peroxin-7
Gene namesi
Name:PEX7
OrganismiCricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)Imported
Taxonomic identifieri10029 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeCricetulus

Subcellular locationi

  • Peroxisome 1 Publication
  • Cytoplasm 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000511151 – 318Peroxisomal targeting signal 2 receptorAdd BLAST318

Interactioni

Subunit structurei

Interacts with PEX5.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ8R537.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati60 – 100WD 1CuratedAdd BLAST41
Repeati104 – 145WD 2CuratedAdd BLAST42
Repeati148 – 188WD 3CuratedAdd BLAST41
Repeati191 – 231WD 4CuratedAdd BLAST41
Repeati235 – 275WD 5CuratedAdd BLAST41
Repeati279 – 317WD 6CuratedAdd BLAST39

Sequence similaritiesi

Belongs to the WD repeat peroxin-7 family.Curated
Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOVERGENiHBG003354.
KOiK13341.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R537-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAARTLRVP GRHGYAAEFS PYLPGRLACA AAQHYGIAGC GTLIILDQNQ
60 70 80 90 100
SGLQIFRSFD WSDGLFDVTW SEDNEHVLVT CSGDGSLQLW DTAKATGPLQ
110 120 130 140 150
VYKEHTQEVY SVDWSQTRGE QLVVSGSWDQ TVKVWDPTVG NSLCTFRGHE
160 170 180 190 200
SVIYSTIWSP HIPGCFASAS GDQTLRIWDV KTAGVRIVIP AHQTEILSCD
210 220 230 240 250
WCKYNENLVV TGAVDCSLRG WDLRNVRQPV FELLGHTYAI RRVKFSPFHA
260 270 280 290 300
SVLASCSYDF TVRFWNFSKP DPLLETVEHH TEFTCGLDLS LQSPTEVADC
310
SWDETIKIYD PVCLTVPG
Length:318
Mass (Da):35,460
Last modified:June 1, 2002 - v1
Checksum:i511501A4D0C6DB2E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042621 mRNA. Translation: BAB86040.1.
RefSeqiNP_001231782.1. NM_001244853.1.

Genome annotation databases

GeneIDi100736556.
KEGGicge:100736556.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042621 mRNA. Translation: BAB86040.1.
RefSeqiNP_001231782.1. NM_001244853.1.

3D structure databases

ProteinModelPortaliQ8R537.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100736556.
KEGGicge:100736556.

Organism-specific databases

CTDi5191.

Phylogenomic databases

HOVERGENiHBG003354.
KOiK13341.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPEX7_CRIGR
AccessioniPrimary (citable) accession number: Q8R537
Secondary accession number(s): P83383
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: June 1, 2002
Last modified: May 11, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.