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Q8R523 (KCNG3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Potassium voltage-gated channel subfamily G member 3
Alternative name(s):
Voltage-gated potassium channel subunit Kv10.1
Voltage-gated potassium channel subunit Kv6.3
Gene names
Name:Kcng3
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length433 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Potassium channel subunit. Modulates channel activity.

Subunit structure

Heteromultimer with KCNB1, KCNC1 and KCNF1. Does not form homomultimers By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein. Cytoplasm By similarity. Note: Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB1 By similarity.

Tissue specificity

Detected in brain, neurons, and at lower levels in glia cells.

Domain

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similarities

Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.3/KCNG3 sub-subfamily. [View classification]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8R523-1)

Also known as: Kv10.1b;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8R523-2)

Also known as: Kv10.1a;

The sequence of this isoform differs from the canonical sequence as follows:
     209-219: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 433433Potassium voltage-gated channel subfamily G member 3
PRO_0000054079

Regions

Topological domain1 – 164164Cytoplasmic Potential
Transmembrane165 – 18521Helical; Name=Segment S1; Potential
Transmembrane219 – 23921Helical; Name=Segment S2; Potential
Topological domain240 – 25213Cytoplasmic Potential
Transmembrane253 – 27321Helical; Name=Segment S3; Potential
Transmembrane284 – 30421Helical; Voltage-sensor; Name=Segment S4; Potential
Topological domain305 – 31915Cytoplasmic Potential
Transmembrane320 – 34021Helical; Name=Segment S5; Potential
Intramembrane358 – 37821Pore-forming; Name=Segment H5; Potential
Transmembrane385 – 41026Helical; Name=Segment S6; Potential
Topological domain411 – 43323Cytoplasmic Potential
Motif370 – 3756Selectivity filter By similarity

Natural variations

Alternative sequence209 – 21911Missing in isoform 2.
VSP_001028

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Kv10.1b) [UniParc].

Last modified October 25, 2002. Version 2.
Checksum: FE404DD18C6D83F1

FASTA43349,291
        10         20         30         40         50         60 
MTFGRGGAAS VVLNVGGARY SLSRELLKDF PLRRVSRLHG CRSERDVLEV CDDYDRERNE 

        70         80         90        100        110        120 
YFFDRHSEAF GFILLYVRGH GKLRFAPRMC ELSFYNEMIY WGLEGAHLEY CCQRRLDDRM 

       130        140        150        160        170        180 
SDTHTFHAAE ELGREQPRPT GPEAAPSRRW LERMRRTFEE PTSSLAAQIL ASVSVVFVIV 

       190        200        210        220        230        240 
SMVVLCASTL PDWRAAAADN RSLDDRSRYS ASPGREPSGI IEAICIGWFT AECIVRFIVS 

       250        260        270        280        290        300 
KNKCEFVKRP LNIIDLLAIT PYYISVLMTV FTGENSQLQR AGVTLRVLRM MRIFWVIKLA 

       310        320        330        340        350        360 
RHFIGLQTLG LTLKRCYREM VMLLVFICVA MAIFSALSQL LEHGLDLETS NKDFASIPAA 

       370        380        390        400        410        420 
CWWVIISMTT VGYGDMYPIT VPGRILGGVC VVSGIVLLAL PITFIYHSFV QCYHELKFRS 

       430 
ARYSRSLSAE FLN

« Hide

Isoform 2 (Kv10.1a) [UniParc].

Checksum: F37BD442519FE4D6
Show »

FASTA42248,202

References

[1]"Kv10.1a and Kv10.1b: two novel alternatively spliced potassium channel subunits."
Vega-Saenz de Miera E.C., Rudy B.
Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[2]"Molecular cloning and characterization of Kv6.3, a novel modulatory subunit for voltage-gated K(+) channel Kv2.1."
Sano Y., Mochizuki S., Miyake A., Kitada C., Inamura K., Yokoi H., Nozawa K., Matsushime H., Furuichi K.
FEBS Lett. 512:230-234(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 89-433 (ISOFORM 1).
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF454549 mRNA. Translation: AAM93550.1.
AF454550 mRNA. Translation: AAM93551.1.
AB070605 mRNA. Translation: BAB85521.1.
IPIIPI00201124.
IPI00231105.
RefSeqNP_001029129.1. NM_001033957.1.
NP_596917.2. NM_133426.2.
UniGeneRn.82689.

3D structure databases

ProteinModelPortalQ8R523.
ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000006094.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID171011.
KEGGrno:171011.
UCSCRGD:628832. rat.

Organism-specific databases

CTD170850.
RGD628832. Kcng3.

Phylogenomic databases

eggNOGCOG1226.
HOGENOMHOG000231014.
HOVERGENHBG100172.
InParanoidQ8R523.
KOK04902.
OrthoDBEOG4BK544.

Gene expression databases

ArrayExpressQ8R523.
GenevestigatorQ8R523.
GermOnlineENSRNOG00000004535. Rattus norvegicus.

Family and domain databases

Gene3D3.30.710.10. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR003131. T1-type_BTB.
[Graphical view]
PANTHERPTHR11537. PTHR11537. 1 hit.
PfamPF00520. Ion_trans. 1 hit.
PF02214. K_tetra. 1 hit.
[Graphical view]
PRINTSPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SMARTSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMSSF54695. BTB/POZ_fold. 1 hit.
ProtoNetSearch...

Other

NextBio621495.

Entry information

Entry nameKCNG3_RAT
AccessionPrimary (citable) accession number: Q8R523
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: October 25, 2002
Last modified: April 3, 2013
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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