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Q8R523

- KCNG3_RAT

UniProt

Q8R523 - KCNG3_RAT

Protein

Potassium voltage-gated channel subfamily G member 3

Gene

Kcng3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 2 (25 Oct 2002)
      Previous versions | rss
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    Functioni

    Potassium channel subunit. Modulates channel activity.

    GO - Molecular functioni

    1. delayed rectifier potassium channel activity Source: RefGenome
    2. voltage-gated potassium channel activity Source: MGI

    GO - Biological processi

    1. potassium ion transport Source: MGI
    2. protein homooligomerization Source: InterPro

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Protein family/group databases

    TCDBi1.A.1.2.17. the voltage-gated ion channel (vic) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily G member 3
    Alternative name(s):
    Voltage-gated potassium channel subunit Kv10.1
    Voltage-gated potassium channel subunit Kv6.3
    Gene namesi
    Name:Kcng3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi628832. Kcng3.

    Subcellular locationi

    Cell membrane; Multi-pass membrane protein. Cytoplasm By similarity
    Note: Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB1 By similarity.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. voltage-gated potassium channel complex Source: InterPro

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 433433Potassium voltage-gated channel subfamily G member 3PRO_0000054079Add
    BLAST

    Expressioni

    Tissue specificityi

    Detected in brain, neurons, and at lower levels in glia cells.

    Gene expression databases

    GenevestigatoriQ8R523.

    Interactioni

    Subunit structurei

    Heteromultimer with KCNB1, KCNC1 and KCNF1. Does not form homomultimers By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000006094.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8R523.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 164164CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini240 – 25213CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini305 – 31915CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini411 – 43323CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei358 – 37821Pore-forming; Name=Segment H5Sequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei165 – 18521Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei219 – 23921Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei253 – 27321Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei284 – 30421Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei320 – 34021Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei385 – 41026Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi370 – 3756Selectivity filterBy similarity

    Domaini

    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1226.
    HOGENOMiHOG000231014.
    HOVERGENiHBG100172.
    InParanoidiQ8R523.
    KOiK04902.
    PhylomeDBiQ8R523.

    Family and domain databases

    Gene3Di1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003971. K_chnl_volt-dep_Kv9.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view]
    PANTHERiPTHR11537. PTHR11537. 1 hit.
    PfamiPF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view]
    PRINTSiPR00169. KCHANNEL.
    PR01494. KV9CHANNEL.
    PR01491. KVCHANNEL.
    SMARTiSM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8R523-1) [UniParc]FASTAAdd to Basket

    Also known as: Kv10.1b

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTFGRGGAAS VVLNVGGARY SLSRELLKDF PLRRVSRLHG CRSERDVLEV    50
    CDDYDRERNE YFFDRHSEAF GFILLYVRGH GKLRFAPRMC ELSFYNEMIY 100
    WGLEGAHLEY CCQRRLDDRM SDTHTFHAAE ELGREQPRPT GPEAAPSRRW 150
    LERMRRTFEE PTSSLAAQIL ASVSVVFVIV SMVVLCASTL PDWRAAAADN 200
    RSLDDRSRYS ASPGREPSGI IEAICIGWFT AECIVRFIVS KNKCEFVKRP 250
    LNIIDLLAIT PYYISVLMTV FTGENSQLQR AGVTLRVLRM MRIFWVIKLA 300
    RHFIGLQTLG LTLKRCYREM VMLLVFICVA MAIFSALSQL LEHGLDLETS 350
    NKDFASIPAA CWWVIISMTT VGYGDMYPIT VPGRILGGVC VVSGIVLLAL 400
    PITFIYHSFV QCYHELKFRS ARYSRSLSAE FLN 433
    Length:433
    Mass (Da):49,291
    Last modified:October 25, 2002 - v2
    Checksum:iFE404DD18C6D83F1
    GO
    Isoform 2 (identifier: Q8R523-2) [UniParc]FASTAAdd to Basket

    Also known as: Kv10.1a

    The sequence of this isoform differs from the canonical sequence as follows:
         209-219: Missing.

    Show »
    Length:422
    Mass (Da):48,202
    Checksum:iF37BD442519FE4D6
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei209 – 21911Missing in isoform 2. 1 PublicationVSP_001028Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF454549 mRNA. Translation: AAM93550.1.
    AF454550 mRNA. Translation: AAM93551.1.
    AB070605 mRNA. Translation: BAB85521.1.
    RefSeqiNP_001029129.1. NM_001033957.1. [Q8R523-2]
    NP_596917.2. NM_133426.2. [Q8R523-1]
    UniGeneiRn.82689.

    Genome annotation databases

    GeneIDi171011.
    KEGGirno:171011.
    UCSCiRGD:628832. rat. [Q8R523-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF454549 mRNA. Translation: AAM93550.1 .
    AF454550 mRNA. Translation: AAM93551.1 .
    AB070605 mRNA. Translation: BAB85521.1 .
    RefSeqi NP_001029129.1. NM_001033957.1. [Q8R523-2 ]
    NP_596917.2. NM_133426.2. [Q8R523-1 ]
    UniGenei Rn.82689.

    3D structure databases

    ProteinModelPortali Q8R523.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000006094.

    Protein family/group databases

    TCDBi 1.A.1.2.17. the voltage-gated ion channel (vic) superfamily.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 171011.
    KEGGi rno:171011.
    UCSCi RGD:628832. rat. [Q8R523-1 ]

    Organism-specific databases

    CTDi 170850.
    RGDi 628832. Kcng3.

    Phylogenomic databases

    eggNOGi COG1226.
    HOGENOMi HOG000231014.
    HOVERGENi HBG100172.
    InParanoidi Q8R523.
    KOi K04902.
    PhylomeDBi Q8R523.

    Miscellaneous databases

    NextBioi 621495.
    PROi Q8R523.

    Gene expression databases

    Genevestigatori Q8R523.

    Family and domain databases

    Gene3Di 1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003971. K_chnl_volt-dep_Kv9.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view ]
    PANTHERi PTHR11537. PTHR11537. 1 hit.
    Pfami PF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    PRINTSi PR00169. KCHANNEL.
    PR01494. KV9CHANNEL.
    PR01491. KVCHANNEL.
    SMARTi SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Kv10.1a and Kv10.1b: two novel alternatively spliced potassium channel subunits."
      Vega-Saenz de Miera E.C., Rudy B.
      Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    2. "Molecular cloning and characterization of Kv6.3, a novel modulatory subunit for voltage-gated K(+) channel Kv2.1."
      Sano Y., Mochizuki S., Miyake A., Kitada C., Inamura K., Yokoi H., Nozawa K., Matsushime H., Furuichi K.
      FEBS Lett. 512:230-234(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 89-433 (ISOFORM 1).
      Tissue: Brain.

    Entry informationi

    Entry nameiKCNG3_RAT
    AccessioniPrimary (citable) accession number: Q8R523
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2002
    Last sequence update: October 25, 2002
    Last modified: October 1, 2014
    This is version 94 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3