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Protein

Potassium voltage-gated channel subfamily G member 3

Gene

Kcng3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Potassium channel subunit. Modulates channel activity.

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: GO_Central
  2. voltage-gated potassium channel activity Source: MGI

GO - Biological processi

  1. potassium ion transmembrane transport Source: GO_Central
  2. potassium ion transport Source: MGI
  3. protein homooligomerization Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Protein family/group databases

TCDBi1.A.1.2.17. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily G member 3
Alternative name(s):
Voltage-gated potassium channel subunit Kv10.1
Voltage-gated potassium channel subunit Kv6.3
Gene namesi
Name:Kcng3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi628832. Kcng3.

Subcellular locationi

Cell membrane; Multi-pass membrane protein. Cytoplasm By similarity
Note: Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB1 (By similarity).By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 164164CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei165 – 18521Helical; Name=Segment S1Sequence AnalysisAdd
BLAST
Transmembranei219 – 23921Helical; Name=Segment S2Sequence AnalysisAdd
BLAST
Topological domaini240 – 25213CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei253 – 27321Helical; Name=Segment S3Sequence AnalysisAdd
BLAST
Transmembranei284 – 30421Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
BLAST
Topological domaini305 – 31915CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei320 – 34021Helical; Name=Segment S5Sequence AnalysisAdd
BLAST
Intramembranei358 – 37821Pore-forming; Name=Segment H5Sequence AnalysisAdd
BLAST
Transmembranei385 – 41026Helical; Name=Segment S6Sequence AnalysisAdd
BLAST
Topological domaini411 – 43323CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. integral component of membrane Source: GO_Central
  3. voltage-gated potassium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Potassium voltage-gated channel subfamily G member 3PRO_0000054079Add
BLAST

Expressioni

Tissue specificityi

Detected in brain, neurons, and at lower levels in glia cells.

Gene expression databases

GenevestigatoriQ8R523.

Interactioni

Subunit structurei

Heteromultimer with KCNB1, KCNC1 and KCNF1. Does not form homomultimers (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006094.

Structurei

3D structure databases

ProteinModelPortaliQ8R523.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi370 – 3756Selectivity filterBy similarity

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
HOGENOMiHOG000231014.
HOVERGENiHBG100172.
InParanoidiQ8R523.
KOiK04902.
PhylomeDBiQ8R523.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8R523-1) [UniParc]FASTAAdd to basket

Also known as: Kv10.1b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTFGRGGAAS VVLNVGGARY SLSRELLKDF PLRRVSRLHG CRSERDVLEV
60 70 80 90 100
CDDYDRERNE YFFDRHSEAF GFILLYVRGH GKLRFAPRMC ELSFYNEMIY
110 120 130 140 150
WGLEGAHLEY CCQRRLDDRM SDTHTFHAAE ELGREQPRPT GPEAAPSRRW
160 170 180 190 200
LERMRRTFEE PTSSLAAQIL ASVSVVFVIV SMVVLCASTL PDWRAAAADN
210 220 230 240 250
RSLDDRSRYS ASPGREPSGI IEAICIGWFT AECIVRFIVS KNKCEFVKRP
260 270 280 290 300
LNIIDLLAIT PYYISVLMTV FTGENSQLQR AGVTLRVLRM MRIFWVIKLA
310 320 330 340 350
RHFIGLQTLG LTLKRCYREM VMLLVFICVA MAIFSALSQL LEHGLDLETS
360 370 380 390 400
NKDFASIPAA CWWVIISMTT VGYGDMYPIT VPGRILGGVC VVSGIVLLAL
410 420 430
PITFIYHSFV QCYHELKFRS ARYSRSLSAE FLN
Length:433
Mass (Da):49,291
Last modified:October 25, 2002 - v2
Checksum:iFE404DD18C6D83F1
GO
Isoform 2 (identifier: Q8R523-2) [UniParc]FASTAAdd to basket

Also known as: Kv10.1a

The sequence of this isoform differs from the canonical sequence as follows:
     209-219: Missing.

Show »
Length:422
Mass (Da):48,202
Checksum:iF37BD442519FE4D6
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei209 – 21911Missing in isoform 2. 1 PublicationVSP_001028Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF454549 mRNA. Translation: AAM93550.1.
AF454550 mRNA. Translation: AAM93551.1.
AB070605 mRNA. Translation: BAB85521.1.
RefSeqiNP_001029129.1. NM_001033957.1. [Q8R523-2]
NP_596917.2. NM_133426.2. [Q8R523-1]
UniGeneiRn.82689.

Genome annotation databases

GeneIDi171011.
KEGGirno:171011.
UCSCiRGD:628832. rat. [Q8R523-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF454549 mRNA. Translation: AAM93550.1.
AF454550 mRNA. Translation: AAM93551.1.
AB070605 mRNA. Translation: BAB85521.1.
RefSeqiNP_001029129.1. NM_001033957.1. [Q8R523-2]
NP_596917.2. NM_133426.2. [Q8R523-1]
UniGeneiRn.82689.

3D structure databases

ProteinModelPortaliQ8R523.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006094.

Protein family/group databases

TCDBi1.A.1.2.17. the voltage-gated ion channel (vic) superfamily.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi171011.
KEGGirno:171011.
UCSCiRGD:628832. rat. [Q8R523-1]

Organism-specific databases

CTDi170850.
RGDi628832. Kcng3.

Phylogenomic databases

eggNOGiCOG1226.
HOGENOMiHOG000231014.
HOVERGENiHBG100172.
InParanoidiQ8R523.
KOiK04902.
PhylomeDBiQ8R523.

Miscellaneous databases

NextBioi621495.
PROiQ8R523.

Gene expression databases

GenevestigatoriQ8R523.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Kv10.1a and Kv10.1b: two novel alternatively spliced potassium channel subunits."
    Vega-Saenz de Miera E.C., Rudy B.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  2. "Molecular cloning and characterization of Kv6.3, a novel modulatory subunit for voltage-gated K(+) channel Kv2.1."
    Sano Y., Mochizuki S., Miyake A., Kitada C., Inamura K., Yokoi H., Nozawa K., Matsushime H., Furuichi K.
    FEBS Lett. 512:230-234(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 89-433 (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiKCNG3_RAT
AccessioniPrimary (citable) accession number: Q8R523
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: October 25, 2002
Last modified: February 4, 2015
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.