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Protein
Submitted name:

Low affinity Na-dependent glucose transporter SGLT2 delta e trans

Gene

Slc5a2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Sugar transportImported, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Low affinity Na-dependent glucose transporter SGLT2 delta e transImported
Gene namesi
Name:Slc5a2Imported
Synonyms:sglt2 deltaImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi620217. Slc5a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei24 – 4320HelicalSequence analysisAdd
BLAST
Transmembranei55 – 8026HelicalSequence analysisAdd
BLAST
Transmembranei100 – 12425HelicalSequence analysisAdd
BLAST
Transmembranei136 – 15520HelicalSequence analysisAdd
BLAST
Transmembranei167 – 18822HelicalSequence analysisAdd
BLAST
Transmembranei200 – 21819HelicalSequence analysisAdd
BLAST
Transmembranei272 – 29019HelicalSequence analysisAdd
BLAST
Transmembranei311 – 33222HelicalSequence analysisAdd
BLAST
Transmembranei452 – 47524HelicalSequence analysisAdd
BLAST
Transmembranei574 – 59724HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ8R520.

Expressioni

Gene expression databases

GenevisibleiQ8R520. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027265.

Family & Domainsi

Sequence similaritiesi

Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IP49. Eukaryota.
COG4146. LUCA.
HOVERGENiHBG052859.
KOiK14382.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 2 hits.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R520-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGHVEEGSE LGEQKVLIDN PADILVIAAY FLLVIGVGLW SMFRTNRGTV
60 70 80 90 100
GGYFLAGRSM VWWPVGASLF ASNIGSGHFV GLAGTGATSG LAVAGFEWNA
110 120 130 140 150
LFVVLLLGWL FVPVYLTAGV ITMPQYLRKR FGGRRIRLYL SVLSLFLYIF
160 170 180 190 200
TKISVDMFSG AVFIQQALGW NIYASVIALL GITMIYTVTG GLAALMYTDT
210 220 230 240 250
VQTFVILAGA FILTGYAFHE VGGYSGLFDK YLGAVTSLTV SKDPAVGNIS
260 270 280 290 300
STCYQPRPDS YHLLRDPVTG DLPWPALLLG LTIVSGWYWC SDQVIVQRCL
310 320 330 340 350
AGKNLTHIKA GCILCGYLKL MPMFLMVMPG MISRILYPDE VACVVPERPS
360 370 380 390 400
LTAAAHSSPW ISTHACGLGR VIGSCCWLEG FGWCSLWQCP WLGCQWCRQH
410 420 430 440 450
RAASSSITFS LSPATWRLQC PLSLCWHSLC PVLMRSCVRP SACPAIFCRV
460 470 480 490 500
HYPYFAIILF FCSGFLTLAI SLCTAPIPQK HLHRLVFSLR HSKEEREDLD
510 520 530 540 550
AEELEGPAPP PVQNGCQECA MGIEEVQSPA PGLLRQCLLW FCGMSKSGSG
560 570 580 590
SPPPTTEEVA ATTRRLEDIS EDPSWARVVN LNALLMMTVA VFLWGFYA
Length:598
Mass (Da):65,536
Last modified:June 1, 2002 - v1
Checksum:i39850D4439D902F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB070976 mRNA. Translation: BAB86937.1.
RefSeqiNP_072112.2. NM_022590.2.
UniGeneiRn.5887.

Genome annotation databases

GeneIDi64522.
KEGGirno:64522.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB070976 mRNA. Translation: BAB86937.1.
RefSeqiNP_072112.2. NM_022590.2.
UniGeneiRn.5887.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027265.

Proteomic databases

PaxDbiQ8R520.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi64522.
KEGGirno:64522.

Organism-specific databases

CTDi6524.
RGDi620217. Slc5a2.

Phylogenomic databases

eggNOGiENOG410IP49. Eukaryota.
COG4146. LUCA.
HOVERGENiHBG052859.
KOiK14382.

Miscellaneous databases

NextBioi613334.

Gene expression databases

GenevisibleiQ8R520. RN.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 2 hits.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of three novel isoforms for Na-dependent glucose cotransporter in rat kidney."
    Murao H., Ohno M., Tsuji S., Ikari A., Suketa Y.
    Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.
    Tissue: Kidney cortexImported.

Entry informationi

Entry nameiQ8R520_RAT
AccessioniPrimary (citable) accession number: Q8R520
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: March 16, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.