Reviewed, UniProtKB/Swiss-Prot Q8R519 (ACMSD_MOUSE)

Names and origin

Protein names

Recommended name:
    2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
    EC=4.1.1.45

Gene names

Name:

Acmsd

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	336 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate, a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. Ref.3 UniProtKB Q8TDX5
Catalytic activity	2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate = 2-aminomuconate semialdehyde + CO2.
Pathway	Secondary metabolite metabolism; quinolate metabolism.
Tissue specificity	Highest expression in kidney with lower levels in liver and brain. Ref.3
Induction	By streptozocin-induced diabetes. Repressed by low protein diet. Ref.3
Sequence similarities	Belongs to the ACMSD family.

Ontologies

Keywords
Molecular function	Decarboxylase Lyase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	quinolinate metabolic process Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	cytosol Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	aminocarboxymuconate-semialdehyde decarboxylase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 336	336	2-amino-3-carboxymuconate-6-semialdehyde decarboxylase		PRO_0000190980
Amino acid modifications
	Modified residue	7	1	Phosphothreonine Ref.4
	Modified residue	116	1	Phosphothreonine Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q8R519-1 [UniParc]. Last modified January 9, 2007. Version 2. Checksum: B01104827D161A9A	FASTA	336	38,027
	10 20 30 40 50 60 MKIDIHTHIL PKEWPDLEKR FGYGGWVQLQ QQGKGEAKMI KDGKLFRVIQ QNCWDPEVRI 70 80 90 100 110 120 REMNQKGVTV QALSTVPVMF SYWAKPKDTL ELCQFLNNDL AATVARYPRR FVGLGTLPMQ 130 140 150 160 170 180 APELAVEEME RCVKALGFPG IQIGSHINTW DLNDPELFPI YAAAERLNCS LFVHPWDMQM 190 200 210 220 230 240 DGRMAKYWLP WLVGMPSETT MAICSMIMGG VFEKFPKLKV CFAHGGGAFP FTIGRIAHGF 250 260 270 280 290 300 NMRPDLCAQD NPSDPRKYLG SFYTDSLVHD PLSLKLLTDV IGKDKVMLGT DYPFPLGEQE 310 320 330 PGKLIESMAE FDEETKDKLT AGNALAFLGL ERKLFE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Kidney.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"Identification and expression of a cDNA encoding human alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD). A key enzyme for the tryptophan-niacine pathway and 'quinolinate hypothesis'." Fukuoka S., Ishiguro K., Yanagihara K., Tanabe A., Egashira Y., Sanada H., Shibata K. J. Biol. Chem. 277:35162-35167(2002) [PubMed: 12140278] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-194, TISSUE SPECIFICITY, INDUCTION.
[4]	"Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry." Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R. J. Proteome Res. 6:250-262(2007) [PubMed: 17203969] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-7 AND THR-116, MASS SPECTROMETRY. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK143962 mRNA. Translation: BAE25634.1. BC139281 mRNA. Translation: AAI39282.1. AB071419 mRNA. Translation: BAB86939.1.
IPI	IPI00378448.
RefSeq	NP_001028213.1.
UniGene	Mm.25735
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q8R519.
PTM databases
PhosphoSite	Q8R519.
Proteomic databases
PRIDE	Q8R519.
Genome annotation databases
Ensembl	ENSMUST00000038006; ENSMUSP00000048482; ENSMUSG00000026348; Mus musculus. [Genome view]
GeneID	266645.
KEGG	mmu:266645.
UCSC	uc007ckv.1. mouse.
Organism-specific databases
CTD	266645.
MGI	MGI:2386323. Acmsd.
Phylogenomic databases
HOGENOM	Q8R519.
HOVERGEN	Q8R519.
OMA	GMPSETT.
Enzyme and pathway databases
BRENDA	4.1.1.45. 244.
Gene expression databases
Bgee	Q8R519.
CleanEx	MM_ACMSD.
Genevestigator	Q8R519.
Family and domain databases
InterPro	IPR006992. Amidohydro_2. [Graphical view]
Pfam	PF04909. Amidohydro_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	392176.
SOURCE	Search...

Entry information

Entry name

ACMSD_MOUSE

Accession

Primary (citable) accession number: Q8R519
Secondary accession number(s): B9EI97, Q3UNW3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 24, 2003
Last sequence update:	January 9, 2007
Last modified:	November 3, 2009
This is version 44 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)