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Protein

E3 ubiquitin-protein ligase MIB2

Gene

Mib2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri85 – 13248ZZ-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri850 – 88536RING-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri929 – 96234RING-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Notch signaling pathway, Ubl conjugation pathway

Keywords - Ligandi

Actin-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase MIB2 (EC:6.3.2.-)
Alternative name(s):
Dystrophin-like protein
Short name:
Dyslike
Mind bomb homolog 2
Short name:
Mind bomb-2
Skeletrophin
Gene namesi
Name:Mib2
Synonyms:Skd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2679684. Mib2.

Subcellular locationi

GO - Cellular componenti

  • early endosome Source: MGI
  • ubiquitin ligase complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi874 – 8741C → S: No effect. 1 Publication
Mutagenesisi951 – 9511C → S: Abolishes ubiquitin ligase activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 973973E3 ubiquitin-protein ligase MIB2PRO_0000055948Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei251 – 2511PhosphoserineBy similarity

Post-translational modificationi

Ubiquitinated. Possibly via autoubiquitination.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8R516.
MaxQBiQ8R516.
PRIDEiQ8R516.

PTM databases

iPTMnetiQ8R516.
PhosphoSiteiQ8R516.

Expressioni

Tissue specificityi

Highly expressed in brain, heart, liver and kidney.1 Publication

Developmental stagei

Highly expressed in neonate and adult, but only slightly in embryos. In E10.5 embryos, it is weakly expressed in the tail bud and limb buds. Expressed in the same pattern than MIB1 in the skin and intestine at postnatal day 1 (P1) and in the hair follicle in the skin in the adult.1 Publication

Gene expression databases

BgeeiQ8R516.
CleanExiMM_MIB2.
ExpressionAtlasiQ8R516. baseline and differential.
GenevisibleiQ8R516. MM.

Interactioni

Subunit structurei

Interacts with actin monomer.By similarity

Protein-protein interaction databases

BioGridi218188. 7 interactions.
IntActiQ8R516. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8R516.
SMRiQ8R516. Positions 11-392, 395-811, 846-890, 921-973.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8080MIB/HERC2 1PROSITE-ProRule annotationAdd
BLAST
Domaini149 – 22779MIB/HERC2 2PROSITE-ProRule annotationAdd
BLAST
Repeati480 – 50930ANK 1Add
BLAST
Repeati513 – 54230ANK 2Add
BLAST
Repeati546 – 57530ANK 3Add
BLAST
Repeati579 – 61133ANK 4Add
BLAST
Repeati615 – 64430ANK 5Add
BLAST
Repeati649 – 67931ANK 6Add
BLAST
Repeati683 – 71230ANK 7Add
BLAST
Repeati716 – 74429ANK 8Add
BLAST
Repeati785 – 81430ANK 9Add
BLAST

Sequence similaritiesi

Contains 9 ANK repeats.PROSITE-ProRule annotation
Contains 2 MIB/HERC2 domains.PROSITE-ProRule annotation
Contains 2 RING-type zinc fingers.PROSITE-ProRule annotation
Contains 1 ZZ-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri85 – 13248ZZ-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri850 – 88536RING-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri929 – 96234RING-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00790000122981.
HOGENOMiHOG000231158.
HOVERGENiHBG068386.
InParanoidiQ8R516.
KOiK10645.
OMAiYETAHSQ.
OrthoDBiEOG7WHH8P.
PhylomeDBiQ8R516.
TreeFamiTF324147.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR010606. Mib_Herc2.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF06701. MIB_HERC2. 2 hits.
PF00569. ZZ. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 8 hits.
SM00184. RING. 2 hits.
SM00291. ZnF_ZZ. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS51416. MIB_HERC2. 2 hits.
PS50089. ZF_RING_2. 2 hits.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8R516-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDLDPHAGVQ VGMRVVRGMD WKWGQQDGGE GGVGTVVELG RHGSPSTPDR
60 70 80 90 100
TVVVQWDQGT RTNYRAGYQG AHDLLLYDNA QIGIRHPNII CDCCKKHGLR
110 120 130 140 150
GMRWKCRVCF DYDLCTQCYM HNKHDLTHAF ERYETSHSRP VTLSPRQGLP
160 170 180 190 200
RIPLRGIFQG AKVVRGPDWE WGSQDGGEGK TGRVVDIRGW DVETGRSVAS
210 220 230 240 250
VTWADGTTNV YRVGHKGKVD LRCVGEAAGG FYYKEHLPKL GKPAELQRRV
260 270 280 290 300
SADGQPFQRG DKVKCLLDTD VLRDMQEGHG GWNPRMAEFI GQMGTVHRIT
310 320 330 340 350
DRGDVRVQFN HETRWTFHPG ALTKHNSFWV GDVVRVIGDL DTVKRLQAGH
360 370 380 390 400
GEWTDDMAPA LGRVGKVVKV FGDGNLRVAV GGQRWTFSPS CLVAYRPEED
410 420 430 440 450
ANLDVAERAR ENKSAASVSV AGSLSVALDK LRTQKSDPEH PGRLVVEAAL
460 470 480 490 500
GNVARALDLL RRHPEQASYH PALVVDTKNQ GRTALQVAAY LGQVELVRLL
510 520 530 540 550
LQARASMDLP DDEGNTVLHY TAMGNQPEAT RVLLSAGCAV DARNGTRSTA
560 570 580 590 600
LHVAVQRGFL EVVKILCERG CDVNLPDAHA DTPLHSAISA GAGASSIVEV
610 620 630 640 650
LTEVPGIDVT ATNSQGFTLL HHASLKGHVL AVRKILARAR QLVDAKKEDG
660 670 680 690 700
FTALHLAALN NHREVAQVLI REGRCDVNVR NRKLQSPLHL AVQQAHLGLV
710 720 730 740 750
PLLVDAGCSV NTEDEEGDTA LHVALQRHQL LPLVADRAGG DPGPLQLLSR
760 770 780 790 800
LQASGLPGCT ELTVGAAVAC FLALEGADVS YANHRGRSPL DLATEGRVLK
810 820 830 840 850
ALQGCAQRFR ERQAGGGGGV PPGPRHVLST PNTVTNLHVS GTAGPEAAEC
860 870 880 890 900
LVCSELALLI LFSPCQHRTV CEECARRMKK CIRCQVVISK KLRPDGSEVV
910 920 930 940 950
NAIQVPGPPR QLVEELQSRY RQMEERITCP ICIDSHIRLV FQCGHGACAP
960 970
CGAALNACPI CRQPIRDRIQ IFV
Length:973
Mass (Da):105,961
Last modified:July 5, 2005 - v2
Checksum:i3E9406DEB30541D7
GO
Isoform 2 (identifier: Q8R516-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     289-324: Missing.
     415-422: Missing.
     467-474: Missing.

Show »
Length:921
Mass (Da):100,287
Checksum:i5D2B2CBFBFA9EA69
GO
Isoform 3 (identifier: Q8R516-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     289-294: FIGQMG → VSHLFC
     295-973: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.
Show »
Length:294
Mass (Da):32,911
Checksum:i8D99C17F39E05DB0
GO

Sequence cautioni

The sequence BAB79447.1 differs from that shown. Reason: Frameshift at positions 151 and 161. Curated
The sequence BAB86856.1 differs from that shown. Reason: Frameshift at positions 780 and 840. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti89 – 891I → T in BAB79447 (Ref. 2) Curated
Sequence conflicti89 – 891I → T in BAB86856 (Ref. 2) Curated
Sequence conflicti131 – 1311E → G in BAB79447 (Ref. 2) Curated
Sequence conflicti131 – 1311E → G in BAB86856 (Ref. 2) Curated
Sequence conflicti138 – 1381S → L in BAB79447 (Ref. 2) Curated
Sequence conflicti138 – 1381S → L in BAB86856 (Ref. 2) Curated
Sequence conflicti393 – 3931V → S in BAB86856 (Ref. 2) Curated
Sequence conflicti407 – 4071E → D in BAB86856 (Ref. 2) Curated
Sequence conflicti465 – 4651E → D in BAB86856 (Ref. 2) Curated
Sequence conflicti487 – 4871V → L in BAB86856 (Ref. 2) Curated
Sequence conflicti537 – 5371G → R in BAB86856 (Ref. 2) Curated
Sequence conflicti626 – 6261K → R in BAB86856 (Ref. 2) Curated
Sequence conflicti745 – 7506LQLLSR → CSCCQG in BAC25227 (PubMed:16141072).Curated
Sequence conflicti904 – 9041Q → R in BAB86856 (Ref. 2) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei289 – 32436Missing in isoform 2. 1 PublicationVSP_014397Add
BLAST
Alternative sequencei289 – 2946FIGQMG → VSHLFC in isoform 3. 1 PublicationVSP_014398
Alternative sequencei295 – 973679Missing in isoform 3. 1 PublicationVSP_014399Add
BLAST
Alternative sequencei415 – 4228Missing in isoform 2. 1 PublicationVSP_014400
Alternative sequencei467 – 4748Missing in isoform 2. 1 PublicationVSP_014401

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY974090 mRNA. Translation: AAX84652.1.
AB063290 mRNA. Translation: BAB79447.1. Frameshift.
AB072336 mRNA. Translation: BAB86856.1. Frameshift.
AL627405 Genomic DNA. Translation: CAM16749.1.
CH466594 Genomic DNA. Translation: EDL15023.1.
BC058086 mRNA. No translation available.
AK008671 mRNA. Translation: BAC25227.1.
CCDSiCCDS19035.1. [Q8R516-2]
RefSeqiNP_001243037.2. NM_001256108.2. [Q8R516-2]
NP_660106.2. NM_145124.3. [Q8R516-2]
UniGeneiMm.235738.
Mm.490124.

Genome annotation databases

EnsembliENSMUST00000103176; ENSMUSP00000099465; ENSMUSG00000029060. [Q8R516-2]
GeneIDi76580.
KEGGimmu:76580.
UCSCiuc008wee.2. mouse. [Q8R516-1]
uc008wef.2. mouse. [Q8R516-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY974090 mRNA. Translation: AAX84652.1.
AB063290 mRNA. Translation: BAB79447.1. Frameshift.
AB072336 mRNA. Translation: BAB86856.1. Frameshift.
AL627405 Genomic DNA. Translation: CAM16749.1.
CH466594 Genomic DNA. Translation: EDL15023.1.
BC058086 mRNA. No translation available.
AK008671 mRNA. Translation: BAC25227.1.
CCDSiCCDS19035.1. [Q8R516-2]
RefSeqiNP_001243037.2. NM_001256108.2. [Q8R516-2]
NP_660106.2. NM_145124.3. [Q8R516-2]
UniGeneiMm.235738.
Mm.490124.

3D structure databases

ProteinModelPortaliQ8R516.
SMRiQ8R516. Positions 11-392, 395-811, 846-890, 921-973.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi218188. 7 interactions.
IntActiQ8R516. 1 interaction.

PTM databases

iPTMnetiQ8R516.
PhosphoSiteiQ8R516.

Proteomic databases

EPDiQ8R516.
MaxQBiQ8R516.
PRIDEiQ8R516.

Protocols and materials databases

DNASUi76580.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000103176; ENSMUSP00000099465; ENSMUSG00000029060. [Q8R516-2]
GeneIDi76580.
KEGGimmu:76580.
UCSCiuc008wee.2. mouse. [Q8R516-1]
uc008wef.2. mouse. [Q8R516-2]

Organism-specific databases

CTDi142678.
MGIiMGI:2679684. Mib2.

Phylogenomic databases

GeneTreeiENSGT00790000122981.
HOGENOMiHOG000231158.
HOVERGENiHBG068386.
InParanoidiQ8R516.
KOiK10645.
OMAiYETAHSQ.
OrthoDBiEOG7WHH8P.
PhylomeDBiQ8R516.
TreeFamiTF324147.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

ChiTaRSiMib2. mouse.
PROiQ8R516.
SOURCEiSearch...

Gene expression databases

BgeeiQ8R516.
CleanExiMM_MIB2.
ExpressionAtlasiQ8R516. baseline and differential.
GenevisibleiQ8R516. MM.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR010606. Mib_Herc2.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF06701. MIB_HERC2. 2 hits.
PF00569. ZZ. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 8 hits.
SM00184. RING. 2 hits.
SM00291. ZnF_ZZ. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS51416. MIB_HERC2. 2 hits.
PS50089. ZF_RING_2. 2 hits.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ENZYME ACTIVITY, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, UBIQUITINATION, MUTAGENESIS OF CYS-874 AND CYS-951.
    Strain: C57BL/6J.
    Tissue: Brain and Thymus.
  2. Takeuchi T.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Heart.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Strain: C57BL/6J.
    Tissue: Brain.
  6. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 604-750.
    Strain: C57BL/6J.
    Tissue: Stomach.
  7. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 920-926, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.

Entry informationi

Entry nameiMIB2_MOUSE
AccessioniPrimary (citable) accession number: Q8R516
Secondary accession number(s): A2A9P9
, Q52QU8, Q6PEF6, Q8C1N7, Q8VIB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: June 8, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.