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Reviewed, UniProtKB/Swiss-Prot Q8R515 (ZHX1_RAT)

Last modified November 24, 2009. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Zinc fingers and homeoboxes protein 1
Gene names
Name: Zhx1
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length873 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Acts as a transcriptional repressor By similarity. UniProtKB Q9UKY1

Subunit structure

Forms homodimers. Also forms heterodimers with ZHX3 which is a prerequisite for repressor activity and with ZHX2. Interacts with NFYA. Interacts with ATF7IP By similarity. Ref.1 UniProtKB Q9UKY1

Subcellular location

Nucleus.

Tissue specificity

Ubiquitously expressed. Ref.1

Induction

Not induced by gonadotropins. Ref.1

Post-translational modification

Phosphorylated upon DNA damage, probably by ATM or ATR By similarity.

Sequence similarities

Belongs to the ZHX family.

Contains 2 C2H2-type zinc fingers.

Contains 5 homeobox DNA-binding domains.

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Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
Repeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionRepressor
   PTMPhosphoprotein
Gene Ontology (GO)
   Biological processnegative regulation of transcription, DNA-dependent

Inferred from sequence or structural similarity. Source: UniProtKB

transcription

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentnucleus Ref.1

Inferred from direct assay. Source: UniProtKB

   Molecular functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 873873Zinc fingers and homeoboxes protein 1
PRO_0000049390

Regions

Zinc finger70 – 9324C2H2-type 1
Zinc finger102 – 12524C2H2-type 2
DNA binding284 – 34663Homeobox 1
DNA binding464 – 52663Homeobox 2
DNA binding569 – 63163Homeobox 3
DNA binding660 – 72263Homeobox 4
DNA binding777 – 83256Homeobox 5
Region272 – 564293Required for interaction with NFYA By similarity UniProtKB Q9UKY1
Region272 – 432161Required for dimerization By similarity UniProtKB Q9UKY1
Region734 – 76835Required for nuclear localization By similarity UniProtKB Q9UKY1
Region831 – 87343Required for repressor activity By similarity UniProtKB Q9UKY1

Amino acid modifications

Modified residue361Phosphothreonine By similarity
Modified residue451Phosphoserine By similarity
Modified residue471Phosphoserine By similarity
Modified residue481Phosphoserine By similarity
Modified residue2891Phosphotyrosine By similarity
Modified residue3031Phosphotyrosine By similarity
Modified residue6351Phosphoserine By similarity
Modified residue6391Phosphoserine By similarity
Modified residue6481Phosphoserine By similarity
Modified residue6821Phosphothreonine By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q8R515-1 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: DE4F77FC20CC73AD

FASTA87397,570
        10         20         30         40         50         60 
MASRRKSTTP CMVLASEQDP DLELISDLEE GPPVLTPVEN ARAESVSSDE EVHESVDSDN 

        70         80         90        100        110        120 
QQNKKVEGGY ECKYCTFQTP DLNMFTFHVD SEHPNVVLNS SYVCVECNFL TKRYDALSEH 

       130        140        150        160        170        180 
NLKYHPGEEN FKLTMVKRNN QTIFEQTIND LTFDGSFVKE ENTEQGESID VSSSGISISK 

       190        200        210        220        230        240 
TPIMKMMKNK VENKRITVHH NSAEGTSEEK ENGVKASREE NAENTSSSAS ESNTSTSTVN 

       250        260        270        280        290        300 
QVHPSPAGTV VTPTAVLPGL AQVITAVSAQ QNSNLVPKVL IPVNSIPTYN AALDNNPLLL 

       310        320        330        340        350        360 
NTYNKFPYPT MSEITVLSAQ AKYTEEQIKI WFSAQRLKHG VSWTPEEVEE ARRKQFNGTV 

       370        380        390        400        410        420 
HTVPQTITVI PTHISTGSNG LPSILQTCQI VGQPGLVLTQ VAGANTLPVT APIALTVAGV 

       430        440        450        460        470        480 
PNQTNVQKSQ VPAAQPAAET KPATAAVPSS PSVRPEAALV NPDSFGIRAK KTKEQLAELK 

       490        500        510        520        530        540 
VSYLKNQFPH DSEIIRLMKI TGLTKGEIKK WFSDTRYNQR NSKSNQCLHL NNDSSATIII 

       550        560        570        580        590        600 
DSSDETPEPP AAAASQPKQS WNPFPDFAPQ KFKEKTAEQL RVLQASFLNS SVLTDEELNR 

       610        620        630        640        650        660 
LRAQTKLTRR EIDAWFTEKN KTKALKDEKV EVDESNVGSS KEEPGENSPG DEAVAPKSAG 

       670        680        690        700        710        720 
TGKICKKTPE QLHMLKSAFV RTQWPSPEEY DKLAEESGLA RTDIVSWFGD TRYAWKNGNL 

       730        740        750        760        770        780 
KWYYYYQSSN SSSLNGLSSL RKRGRGRPKG RGRGRPRGRP RGGKRMNTWD RVPSLIKFKT 

       790        800        810        820        830        840 
GTAILKDYYL KHKFLNEQDL DELVNRSHMG YEQVREWFAE RQRRSELGIE LFEENEEEDE 

       850        860        870 
VIDDQEEDEE ETDDSDTWEP PRHVKRKLSK SDD

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References

[1]"Rat zinc-fingers and homeoboxes 1 (ZHX1), a nuclear factor-YA-interacting nuclear protein, forms a homodimer."
Hirano S., Yamada K., Kawata H., Shou Z., Mizutani T., Yazawa T., Kajitani T., Sekiguchi T., Yoshino M., Shigematsu Y., Mayumi M., Miyamoto K.
Gene 290:107-114(2002) [PubMed: 12062805] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], HOMODIMERIZATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.
Tissue: Ovary.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AB072439 mRNA. Translation: BAB85763.1.
IPIIPI00201087.
RefSeqNP_598304.1.
UniGeneRn.16902

3D structure databases

SMRQ8R515. Positions 60-153, 565-636.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8R515.

PTM databases

PhosphoSiteQ8R515.

Genome annotation databases

EnsemblENSRNOT00000008454; ENSRNOP00000008454; ENSRNOG00000006412; Rattus norvegicus. [Genome view]
GeneID171159.
KEGGrno:171159.
UCSCNM_133620. rat.

Organism-specific databases

CTD171159.
RGD620010. Zhx1.

Phylogenomic databases

HOVERGENQ8R515.

Gene expression databases

ArrayExpressQ8R515.
GenevestigatorQ8R515.
GermOnlineENSRNOG00000006412. Rattus norvegicus.

Family and domain databases

InterProIPR001356. Homeobox.
IPR009057. Homeodomain-like.
IPR012287. Homeodomain-rel.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
Gene3DG3DSA:1.10.10.60. Homeodomain-rel. 3 hits.
PfamPF00046. Homeobox. 2 hits.
[Graphical view]
SMARTSM00389. HOX. 5 hits.
SM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEPS00027. HOMEOBOX_1. False negative.
PS50071. HOMEOBOX_2. 4 hits.
PS00028. ZINC_FINGER_C2H2_1. False negative.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio622000.

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Entry information

Entry nameZHX1_RAT
AccessionPrimary (citable) accession number: Q8R515
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: June 1, 2002
Last modified: November 24, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents