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Protein

Zinc fingers and homeoboxes protein 1

Gene

Zhx1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri70 – 93C2H2-type 1PROSITE-ProRule annotationCuratedAdd BLAST24
Zinc fingeri102 – 125C2H2-type 2PROSITE-ProRule annotationCuratedAdd BLAST24
DNA bindingi284 – 346Homeobox 1PROSITE-ProRule annotationCuratedAdd BLAST63
DNA bindingi464 – 526Homeobox 2PROSITE-ProRule annotationCuratedAdd BLAST63
DNA bindingi569 – 631Homeobox 3PROSITE-ProRule annotationCuratedAdd BLAST63
DNA bindingi660 – 722Homeobox 4PROSITE-ProRule annotationCuratedAdd BLAST63
DNA bindingi777 – 832Homeobox 5PROSITE-ProRule annotationCuratedAdd BLAST56

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc fingers and homeoboxes protein 1
Gene namesi
Name:Zhx1
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620010. Zhx1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000493901 – 873Zinc fingers and homeoboxes protein 1Add BLAST873

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei36PhosphothreonineBy similarity1
Modified residuei45PhosphoserineBy similarity1
Modified residuei47PhosphoserineCombined sources1
Modified residuei48PhosphoserineCombined sources1
Cross-linki159Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei202PhosphoserineBy similarity1
Cross-linki441Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki485Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki629Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei648PhosphoserineBy similarity1
Modified residuei774PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ8R515.
PRIDEiQ8R515.

PTM databases

iPTMnetiQ8R515.
PhosphoSitePlusiQ8R515.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Inductioni

Not induced by gonadotropins.1 Publication

Interactioni

Subunit structurei

Forms homodimers. Heterodimer (via HD1 domain) with ZHX2 (via HD1 domain). Also forms a heterodimer with ZHX3 which is a prerequisite for repressor activity. Interacts with ATF7IP and NFYA. Interacts (via homeobox domains) with DNMT3B (via PWWP domain) (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi251160. 2 interactors.
IntActiQ8R515. 1 interactor.
MINTiMINT-1790457.
STRINGi10116.ENSRNOP00000008454.

Structurei

3D structure databases

ProteinModelPortaliQ8R515.
SMRiQ8R515.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni272 – 564Required for interaction with NFYABy similarityAdd BLAST293
Regioni272 – 432Required for dimerizationBy similarityAdd BLAST161
Regioni734 – 768Required for nuclear localizationBy similarityAdd BLAST35
Regioni831 – 873Required for repressor activityBy similarityAdd BLAST43

Sequence similaritiesi

Belongs to the ZHX family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri70 – 93C2H2-type 1PROSITE-ProRule annotationCuratedAdd BLAST24
Zinc fingeri102 – 125C2H2-type 2PROSITE-ProRule annotationCuratedAdd BLAST24

Keywords - Domaini

Homeobox, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IHET. Eukaryota.
ENOG410Z8A2. LUCA.
HOGENOMiHOG000013231.
HOVERGENiHBG007920.
InParanoidiQ8R515.
PhylomeDBiQ8R515.

Family and domain databases

CDDicd00086. homeodomain. 5 hits.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR001356. Homeobox_dom.
IPR024578. Homez_homeobox_dom.
IPR013087. Znf_C2H2_type.
PfamiView protein in Pfam
PF00046. Homeobox. 4 hits.
PF11569. Homez. 1 hit.
SMARTiView protein in SMART
SM00389. HOX. 5 hits.
SM00355. ZnF_C2H2. 2 hits.
SUPFAMiSSF46689. SSF46689. 5 hits.
SSF57667. SSF57667. 2 hits.
PROSITEiView protein in PROSITE
PS50071. HOMEOBOX_2. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8R515-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRRKSTTP CMVLASEQDP DLELISDLEE GPPVLTPVEN ARAESVSSDE
60 70 80 90 100
EVHESVDSDN QQNKKVEGGY ECKYCTFQTP DLNMFTFHVD SEHPNVVLNS
110 120 130 140 150
SYVCVECNFL TKRYDALSEH NLKYHPGEEN FKLTMVKRNN QTIFEQTIND
160 170 180 190 200
LTFDGSFVKE ENTEQGESID VSSSGISISK TPIMKMMKNK VENKRITVHH
210 220 230 240 250
NSAEGTSEEK ENGVKASREE NAENTSSSAS ESNTSTSTVN QVHPSPAGTV
260 270 280 290 300
VTPTAVLPGL AQVITAVSAQ QNSNLVPKVL IPVNSIPTYN AALDNNPLLL
310 320 330 340 350
NTYNKFPYPT MSEITVLSAQ AKYTEEQIKI WFSAQRLKHG VSWTPEEVEE
360 370 380 390 400
ARRKQFNGTV HTVPQTITVI PTHISTGSNG LPSILQTCQI VGQPGLVLTQ
410 420 430 440 450
VAGANTLPVT APIALTVAGV PNQTNVQKSQ VPAAQPAAET KPATAAVPSS
460 470 480 490 500
PSVRPEAALV NPDSFGIRAK KTKEQLAELK VSYLKNQFPH DSEIIRLMKI
510 520 530 540 550
TGLTKGEIKK WFSDTRYNQR NSKSNQCLHL NNDSSATIII DSSDETPEPP
560 570 580 590 600
AAAASQPKQS WNPFPDFAPQ KFKEKTAEQL RVLQASFLNS SVLTDEELNR
610 620 630 640 650
LRAQTKLTRR EIDAWFTEKN KTKALKDEKV EVDESNVGSS KEEPGENSPG
660 670 680 690 700
DEAVAPKSAG TGKICKKTPE QLHMLKSAFV RTQWPSPEEY DKLAEESGLA
710 720 730 740 750
RTDIVSWFGD TRYAWKNGNL KWYYYYQSSN SSSLNGLSSL RKRGRGRPKG
760 770 780 790 800
RGRGRPRGRP RGGKRMNTWD RVPSLIKFKT GTAILKDYYL KHKFLNEQDL
810 820 830 840 850
DELVNRSHMG YEQVREWFAE RQRRSELGIE LFEENEEEDE VIDDQEEDEE
860 870
ETDDSDTWEP PRHVKRKLSK SDD
Length:873
Mass (Da):97,570
Last modified:June 1, 2002 - v1
Checksum:iDE4F77FC20CC73AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB072439 mRNA. Translation: BAB85763.1.
RefSeqiNP_598304.1. NM_133620.1.
UniGeneiRn.16902.

Genome annotation databases

GeneIDi171159.
KEGGirno:171159.
UCSCiRGD:620010. rat.

Similar proteinsi

Entry informationi

Entry nameiZHX1_RAT
AccessioniPrimary (citable) accession number: Q8R515
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: June 1, 2002
Last modified: September 27, 2017
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families