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Protein

ETS translocation variant 3

Gene

Etv3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi35 – 11682ETSPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DEAD/H-box RNA helicase binding Source: BHF-UCL
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: BHF-UCL
  • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ETS translocation variant 3
Alternative name(s):
ETS domain transcriptional repressor PE1
Short name:
PE-1
Mitogenic Ets transcriptional suppressor
Gene namesi
Name:Etv3
Synonyms:Mets, Pe1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1350926. Etv3.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • nuclear chromatin Source: BHF-UCL
  • RNA polymerase II transcription repressor complex Source: BHF-UCL
  • transcriptional repressor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 513513ETS translocation variant 3PRO_0000204115Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei139 – 1391PhosphoserineBy similarity
Modified residuei315 – 3151PhosphoserineCombined sources
Cross-linki381 – 381Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei388 – 3881N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8R4Z4.
MaxQBiQ8R4Z4.
PaxDbiQ8R4Z4.
PRIDEiQ8R4Z4.

PTM databases

iPTMnetiQ8R4Z4.
PhosphoSiteiQ8R4Z4.

Expressioni

Gene expression databases

CleanExiMM_ETV3.
ExpressionAtlasiQ8R4Z4. baseline and differential.
GenevisibleiQ8R4Z4. MM.

Interactioni

GO - Molecular functioni

  • DEAD/H-box RNA helicase binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi205105. 2 interactions.
IntActiQ8R4Z4. 1 interaction.
STRINGi10090.ENSMUSP00000112915.

Structurei

3D structure databases

ProteinModelPortaliQ8R4Z4.
SMRiQ8R4Z4. Positions 30-118.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ETS family.Curated
Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3806. Eukaryota.
ENOG410Z0ZF. LUCA.
GeneTreeiENSGT00760000118907.
HOGENOMiHOG000070246.
HOVERGENiHBG005183.
InParanoidiQ8R4Z4.
KOiK09433.
OMAiVPPLQCQ.
OrthoDBiEOG70ZZN1.
TreeFamiTF351065.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000418. Ets_dom.
IPR032929. ETV3.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR11849:SF30. PTHR11849:SF30. 2 hits.
PfamiPF00178. Ets. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R4Z4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAGCSIVEK PEGGGGYQFP DWAYKAESSP GSRQIQLWHF ILELLQKEEF
60 70 80 90 100
RHVIAWQQGE YGEFVIKDPD EVARLWGRRK CKPQMNYDKL SRALRYYYNK
110 120 130 140 150
RILHKTKGKR FTYKFNFNKL VMPNYPFINI RSSGVVPQSA PPVPTASSRF
160 170 180 190 200
HFPPLDSHSP TGDVQPGRFS ASSLSASGPE SGVTTDRKVE PSDLEDGSAS
210 220 230 240 250
DWHRGMDFMP SRNALGGGAV GHQKRKPDIL LPLFTRPAMY PDPHSPFAIS
260 270 280 290 300
PVPGRGGVLN VPISPALSLT PTMFSYSPSP GLSPFTSSSC FSFNPEEMKH
310 320 330 340 350
YLHSQACSVF NYHLSPRTFP RYPGLMVPPL QCQMHPEEPS QFSIKLQPPP
360 370 380 390 400
AGRKNRERVE SREEAVRGSV PASAPVPSRI KVEPATEKDP DSLRQSTQGK
410 420 430 440 450
EEQTQEVDSM RSRTIEEGKG TGFAHPSPTW PSVSISTPSD EPLEGTEDSE
460 470 480 490 500
DRSVREPGVP EKKEDALMPP KLRLKRRWND DPEARELNKT GKFLWNGAGP
510
QGLATTATAA ADA
Length:513
Mass (Da):57,026
Last modified:October 3, 2012 - v2
Checksum:i67BCFA849A3BF7E3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti182 – 1821G → R in AAF09185 (PubMed:10913304).Curated
Sequence conflicti244 – 2441H → R in AAF09185 (PubMed:10913304).Curated
Sequence conflicti410 – 4101M → I in AAK56845 (PubMed:12007404).Curated
Sequence conflicti410 – 4101M → I in AAQ18663 (PubMed:14754893).Curated
Sequence conflicti410 – 4101M → I in AAF09185 (PubMed:10913304).Curated
Sequence conflicti410 – 4101M → I in AAH78636 (PubMed:15489334).Curated
Sequence conflicti454 – 4541V → A in AAK56845 (PubMed:12007404).Curated
Sequence conflicti454 – 4541V → A in AAQ18663 (PubMed:14754893).Curated
Sequence conflicti454 – 4541V → A in AAF09185 (PubMed:10913304).Curated
Sequence conflicti454 – 4541V → A in AAH78636 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF218539 mRNA. Translation: AAK56845.1.
AY274927 Genomic DNA. Translation: AAQ18663.1.
AF156530 mRNA. Translation: AAF09185.1.
AC139241 Genomic DNA. No translation available.
CH466547 Genomic DNA. Translation: EDL15354.1.
BC078636 mRNA. Translation: AAH78636.1.
CCDSiCCDS17453.1.
RefSeqiNP_001076787.1. NM_001083318.2.
NP_001273773.1. NM_001286844.1.
NP_036181.3. NM_012051.4.
UniGeneiMm.219460.

Genome annotation databases

EnsembliENSMUST00000119109; ENSMUSP00000112915; ENSMUSG00000003382.
ENSMUST00000170036; ENSMUSP00000127419; ENSMUSG00000003382.
GeneIDi27049.
KEGGimmu:27049.
UCSCiuc008psh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF218539 mRNA. Translation: AAK56845.1.
AY274927 Genomic DNA. Translation: AAQ18663.1.
AF156530 mRNA. Translation: AAF09185.1.
AC139241 Genomic DNA. No translation available.
CH466547 Genomic DNA. Translation: EDL15354.1.
BC078636 mRNA. Translation: AAH78636.1.
CCDSiCCDS17453.1.
RefSeqiNP_001076787.1. NM_001083318.2.
NP_001273773.1. NM_001286844.1.
NP_036181.3. NM_012051.4.
UniGeneiMm.219460.

3D structure databases

ProteinModelPortaliQ8R4Z4.
SMRiQ8R4Z4. Positions 30-118.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205105. 2 interactions.
IntActiQ8R4Z4. 1 interaction.
STRINGi10090.ENSMUSP00000112915.

PTM databases

iPTMnetiQ8R4Z4.
PhosphoSiteiQ8R4Z4.

Proteomic databases

EPDiQ8R4Z4.
MaxQBiQ8R4Z4.
PaxDbiQ8R4Z4.
PRIDEiQ8R4Z4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000119109; ENSMUSP00000112915; ENSMUSG00000003382.
ENSMUST00000170036; ENSMUSP00000127419; ENSMUSG00000003382.
GeneIDi27049.
KEGGimmu:27049.
UCSCiuc008psh.2. mouse.

Organism-specific databases

CTDi2117.
MGIiMGI:1350926. Etv3.

Phylogenomic databases

eggNOGiKOG3806. Eukaryota.
ENOG410Z0ZF. LUCA.
GeneTreeiENSGT00760000118907.
HOGENOMiHOG000070246.
HOVERGENiHBG005183.
InParanoidiQ8R4Z4.
KOiK09433.
OMAiVPPLQCQ.
OrthoDBiEOG70ZZN1.
TreeFamiTF351065.

Miscellaneous databases

PROiQ8R4Z4.
SOURCEiSearch...

Gene expression databases

CleanExiMM_ETV3.
ExpressionAtlasiQ8R4Z4. baseline and differential.
GenevisibleiQ8R4Z4. MM.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000418. Ets_dom.
IPR032929. ETV3.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR11849:SF30. PTHR11849:SF30. 2 hits.
PfamiPF00178. Ets. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation."
    Klappacher G.W., Lunyak V.V., Sykes D.B., Sawka-Verhelle D., Sage J., Brard G., Ngo S.D., Gangadharan D., Jacks T., Kamps M.P., Rose D.W., Rosenfeld M.G., Glass C.K.
    Cell 109:169-180(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
  2. "PE-1/METS, an antiproliferative Ets repressor factor, is induced by CREB-1/CREM-1 during macrophage differentiation."
    Sawka-Verhelle D., Escoubet-Lozach L., Fong A.L., Hester K.D., Herzig S., Lebrun P., Glass C.K.
    J. Biol. Chem. 279:17772-17784(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  3. "Ets domain transcription factor PE1 suppresses human interstitial collagenase promoter activity by antagonizing protein-DNA interactions at a critical AP1 element."
    Bidder M., Loewy A.P., Latifi T., Newberry E.P., Ferguson G., Willis D.M., Towler D.A.
    Biochemistry 39:8917-8928(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NMRI.
    Tissue: Mammary tumor.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-315, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Spleen.

Entry informationi

Entry nameiETV3_MOUSE
AccessioniPrimary (citable) accession number: Q8R4Z4
Secondary accession number(s): G5E907, Q9QZW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: October 3, 2012
Last modified: June 8, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.