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Protein

Serpin A12

Gene

Serpina12

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Adipokine that modulates insulin action by specifically inhibiting its target protease KLK7 in white adipose tissues.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • glucose metabolic process Source: RGD

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.091

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin A12
Alternative name(s):
Visceral adipose tissue-derived serine protease inhibitor
Short name:
Vaspin
Visceral adipose-specific serpin
Gene namesi
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi708485 Serpina12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20By similarityAdd BLAST20
ChainiPRO_000004197821 – 411Serpin A12Add BLAST391

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi92N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi267N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8R4Z1
PRIDEiQ8R4Z1

PTM databases

iPTMnetiQ8R4Z1
PhosphoSitePlusiQ8R4Z1

Expressioni

Tissue specificityi

Expressed in visceral adipose tissues.1 Publication

Developmental stagei

Barely detectable in at 6 weeks and is highly expressed in adipocytes of visceral white adipose tissues at 30 weeks.1 Publication

Interactioni

Subunit structurei

Forms a stable complex with KLK7.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012960

Structurei

3D structure databases

ProteinModelPortaliQ8R4Z1
SMRiQ8R4Z1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni364 – 382RCLBy similarityAdd BLAST19

Domaini

The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable (By similarity).By similarity

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
HOGENOMiHOG000238521
HOVERGENiHBG005957
InParanoidiQ8R4Z1
PhylomeDBiQ8R4Z1

Family and domain databases

InterProiView protein in InterPro
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R4Z1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLVLGLGLF LAGLLTVKGL LQDRDAPDTY ESPVRVQEWR GKKDARELTR
60 70 80 90 100
HNMEFGFKLL QRLASNSRQG NIFLSPLSIS TAFSMLSLGA QNSTLEEIRE
110 120 130 140 150
GFNFKEMSDR DMHMGFHYLL QKLNRETQDV KMSIGNALFM DQRLRPQQRF
160 170 180 190 200
LKLAKNLYDA DMILTNFQDL ENTQKNINKY ISRKTHNRIE NMVKNIDPGT
210 220 230 240 250
VMLLTNYIYF QGRWQYEFDP KQTKEEDFFI EEGKTVKVPM MFQRGMYDMA
260 270 280 290 300
YDSQLSCTIL EMPYRGNITA TFVLPDSGKL RLLEQGLQAD IFAKWKSLLS
310 320 330 340 350
KRVVDVWVPR LHISATYNMK KVLSRLGISK IFEEHGDLTR ISSHRSLKVG
360 370 380 390 400
EAVHKAELRM NEKGTEGAAG SGAQTLPMET PRRMKLNAPF LMMIYENLMP
410
SMIFLARIYN P
Length:411
Mass (Da):47,527
Last modified:June 1, 2002 - v1
Checksum:i29FA271FF8CC8A2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF245398 mRNA Translation: AAL99574.1
UniGeneiRn.79035

Genome annotation databases

UCSCiRGD:708485 rat

Similar proteinsi

Entry informationi

Entry nameiSPA12_RAT
AccessioniPrimary (citable) accession number: Q8R4Z1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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