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Q8R4Z1 (SPA12_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serpin A12
Alternative name(s):
Visceral adipose tissue-derived serine protease inhibitor
Short name=Vaspin
Visceral adipose-specific serpin
Gene names
Name:Serpina12
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length411 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Adipokine that modulates insulin action by specifically inhibiting its target protease KLK7 in white adipose tissues By similarity. Ref.1

Subunit structure

Forms a stable complex with KLK7 By similarity.

Subcellular location

Secreted By similarity.

Tissue specificity

Expressed in visceral adipose tissues. Ref.1

Developmental stage

Barely detectable in at 6 weeks and is highly expressed in adipocytes of visceral white adipose tissues at 30 weeks. Ref.1

Domain

The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable By similarity.

Sequence similarities

Belongs to the serpin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 By similarity
Chain21 – 411391Serpin A12
PRO_0000041978

Regions

Region364 – 38219RCL By similarity

Amino acid modifications

Glycosylation921N-linked (GlcNAc...) Potential
Glycosylation2671N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q8R4Z1 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 29FA271FF8CC8A2D

FASTA41147,527
        10         20         30         40         50         60 
MNLVLGLGLF LAGLLTVKGL LQDRDAPDTY ESPVRVQEWR GKKDARELTR HNMEFGFKLL 

        70         80         90        100        110        120 
QRLASNSRQG NIFLSPLSIS TAFSMLSLGA QNSTLEEIRE GFNFKEMSDR DMHMGFHYLL 

       130        140        150        160        170        180 
QKLNRETQDV KMSIGNALFM DQRLRPQQRF LKLAKNLYDA DMILTNFQDL ENTQKNINKY 

       190        200        210        220        230        240 
ISRKTHNRIE NMVKNIDPGT VMLLTNYIYF QGRWQYEFDP KQTKEEDFFI EEGKTVKVPM 

       250        260        270        280        290        300 
MFQRGMYDMA YDSQLSCTIL EMPYRGNITA TFVLPDSGKL RLLEQGLQAD IFAKWKSLLS 

       310        320        330        340        350        360 
KRVVDVWVPR LHISATYNMK KVLSRLGISK IFEEHGDLTR ISSHRSLKVG EAVHKAELRM 

       370        380        390        400        410 
NEKGTEGAAG SGAQTLPMET PRRMKLNAPF LMMIYENLMP SMIFLARIYN P 

« Hide

References

[1]"Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity."
Hida K., Wada J., Eguchi J., Zhang H., Baba M., Seida A., Hashimoto I., Okada T., Yasuhara A., Nakatsuka A., Shikata K., Hourai S., Futami J., Watanabe E., Matsuki Y., Hiramatsu R., Akagi S., Makino H., Kanwar Y.S.
Proc. Natl. Acad. Sci. U.S.A. 102:10610-10615(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
Strain: OLETF.
Tissue: Adipose tissue.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF245398 mRNA. Translation: AAL99574.1.
UniGeneRn.79035.

3D structure databases

ProteinModelPortalQ8R4Z1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000012960.

Protein family/group databases

MEROPSI04.091.

PTM databases

PhosphoSiteQ8R4Z1.

Proteomic databases

PRIDEQ8R4Z1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:708485. rat.

Organism-specific databases

RGD708485. Serpina12.

Phylogenomic databases

eggNOGCOG4826.
HOGENOMHOG000238521.
HOVERGENHBG005957.
PhylomeDBQ8R4Z1.

Gene expression databases

GenevestigatorQ8R4Z1.

Family and domain databases

InterProIPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERPTHR11461. PTHR11461. 1 hit.
PfamPF00079. Serpin. 1 hit.
[Graphical view]
SMARTSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMSSF56574. SSF56574. 1 hit.
ProtoNetSearch...

Other

PROQ8R4Z1.

Entry information

Entry nameSPA12_RAT
AccessionPrimary (citable) accession number: Q8R4Z1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: June 1, 2002
Last modified: April 16, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families