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Q8R4Z1

- SPA12_RAT

UniProt

Q8R4Z1 - SPA12_RAT

Protein

Serpin A12

Gene

Serpina12

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Adipokine that modulates insulin action by specifically inhibiting its target protease KLK7 in white adipose tissues.By similarity

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: RefGenome

    GO - Biological processi

    1. glucose metabolic process Source: RGD
    2. negative regulation of endopeptidase activity Source: RefGenome
    3. regulation of proteolysis Source: RefGenome

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Protein family/group databases

    MEROPSiI04.091.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serpin A12
    Alternative name(s):
    Visceral adipose tissue-derived serine protease inhibitor
    Short name:
    Vaspin
    Visceral adipose-specific serpin
    Gene namesi
    Name:Serpina12
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi708485. Serpina12.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular space Source: InterPro

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020By similarityAdd
    BLAST
    Chaini21 – 411391Serpin A12PRO_0000041978Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi92 – 921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi267 – 2671N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ8R4Z1.

    PTM databases

    PhosphoSiteiQ8R4Z1.

    Expressioni

    Tissue specificityi

    Expressed in visceral adipose tissues.1 Publication

    Developmental stagei

    Barely detectable in at 6 weeks and is highly expressed in adipocytes of visceral white adipose tissues at 30 weeks.1 Publication

    Gene expression databases

    GenevestigatoriQ8R4Z1.

    Interactioni

    Subunit structurei

    Forms a stable complex with KLK7.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000012960.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8R4Z1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni364 – 38219RCLBy similarityAdd
    BLAST

    Domaini

    The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable By similarity.By similarity

    Sequence similaritiesi

    Belongs to the serpin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG4826.
    HOGENOMiHOG000238521.
    HOVERGENiHBG005957.
    PhylomeDBiQ8R4Z1.

    Family and domain databases

    InterProiIPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8R4Z1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNLVLGLGLF LAGLLTVKGL LQDRDAPDTY ESPVRVQEWR GKKDARELTR    50
    HNMEFGFKLL QRLASNSRQG NIFLSPLSIS TAFSMLSLGA QNSTLEEIRE 100
    GFNFKEMSDR DMHMGFHYLL QKLNRETQDV KMSIGNALFM DQRLRPQQRF 150
    LKLAKNLYDA DMILTNFQDL ENTQKNINKY ISRKTHNRIE NMVKNIDPGT 200
    VMLLTNYIYF QGRWQYEFDP KQTKEEDFFI EEGKTVKVPM MFQRGMYDMA 250
    YDSQLSCTIL EMPYRGNITA TFVLPDSGKL RLLEQGLQAD IFAKWKSLLS 300
    KRVVDVWVPR LHISATYNMK KVLSRLGISK IFEEHGDLTR ISSHRSLKVG 350
    EAVHKAELRM NEKGTEGAAG SGAQTLPMET PRRMKLNAPF LMMIYENLMP 400
    SMIFLARIYN P 411
    Length:411
    Mass (Da):47,527
    Last modified:June 1, 2002 - v1
    Checksum:i29FA271FF8CC8A2D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF245398 mRNA. Translation: AAL99574.1.
    UniGeneiRn.79035.

    Genome annotation databases

    UCSCiRGD:708485. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF245398 mRNA. Translation: AAL99574.1 .
    UniGenei Rn.79035.

    3D structure databases

    ProteinModelPortali Q8R4Z1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000012960.

    Protein family/group databases

    MEROPSi I04.091.

    PTM databases

    PhosphoSitei Q8R4Z1.

    Proteomic databases

    PRIDEi Q8R4Z1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:708485. rat.

    Organism-specific databases

    RGDi 708485. Serpina12.

    Phylogenomic databases

    eggNOGi COG4826.
    HOGENOMi HOG000238521.
    HOVERGENi HBG005957.
    PhylomeDBi Q8R4Z1.

    Miscellaneous databases

    PROi Q8R4Z1.

    Gene expression databases

    Genevestigatori Q8R4Z1.

    Family and domain databases

    InterProi IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Strain: OLETF.
      Tissue: Adipose tissue.

    Entry informationi

    Entry nameiSPA12_RAT
    AccessioniPrimary (citable) accession number: Q8R4Z1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2005
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3