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Protein

Serpin A12

Gene

Serpina12

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Adipokine that modulates insulin action by specifically inhibiting its target protease KLK7 in white adipose tissues.By similarity

GO - Molecular functioni

GO - Biological processi

  • glucose metabolic process Source: RGD
  • negative regulation of endopeptidase activity Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.052.

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin A12
Alternative name(s):
Visceral adipose tissue-derived serine protease inhibitor
Short name:
Vaspin
Visceral adipose-specific serpin
Gene namesi
Name:Serpina12
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi708485. Serpina12.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020By similarityAdd
BLAST
Chaini21 – 411391Serpin A12PRO_0000041978Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi92 – 921N-linked (GlcNAc...)Sequence Analysis
Glycosylationi267 – 2671N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ8R4Z1.

PTM databases

PhosphoSiteiQ8R4Z1.

Expressioni

Tissue specificityi

Expressed in visceral adipose tissues.1 Publication

Developmental stagei

Barely detectable in at 6 weeks and is highly expressed in adipocytes of visceral white adipose tissues at 30 weeks.1 Publication

Gene expression databases

GenevestigatoriQ8R4Z1.

Interactioni

Subunit structurei

Forms a stable complex with KLK7.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012960.

Structurei

3D structure databases

ProteinModelPortaliQ8R4Z1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni364 – 38219RCLBy similarityAdd
BLAST

Domaini

The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable (By similarity).By similarity

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4826.
HOGENOMiHOG000238521.
HOVERGENiHBG005957.
InParanoidiQ8R4Z1.
PhylomeDBiQ8R4Z1.

Family and domain databases

InterProiIPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R4Z1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLVLGLGLF LAGLLTVKGL LQDRDAPDTY ESPVRVQEWR GKKDARELTR
60 70 80 90 100
HNMEFGFKLL QRLASNSRQG NIFLSPLSIS TAFSMLSLGA QNSTLEEIRE
110 120 130 140 150
GFNFKEMSDR DMHMGFHYLL QKLNRETQDV KMSIGNALFM DQRLRPQQRF
160 170 180 190 200
LKLAKNLYDA DMILTNFQDL ENTQKNINKY ISRKTHNRIE NMVKNIDPGT
210 220 230 240 250
VMLLTNYIYF QGRWQYEFDP KQTKEEDFFI EEGKTVKVPM MFQRGMYDMA
260 270 280 290 300
YDSQLSCTIL EMPYRGNITA TFVLPDSGKL RLLEQGLQAD IFAKWKSLLS
310 320 330 340 350
KRVVDVWVPR LHISATYNMK KVLSRLGISK IFEEHGDLTR ISSHRSLKVG
360 370 380 390 400
EAVHKAELRM NEKGTEGAAG SGAQTLPMET PRRMKLNAPF LMMIYENLMP
410
SMIFLARIYN P
Length:411
Mass (Da):47,527
Last modified:June 1, 2002 - v1
Checksum:i29FA271FF8CC8A2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF245398 mRNA. Translation: AAL99574.1.
UniGeneiRn.79035.

Genome annotation databases

UCSCiRGD:708485. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF245398 mRNA. Translation: AAL99574.1.
UniGeneiRn.79035.

3D structure databases

ProteinModelPortaliQ8R4Z1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012960.

Protein family/group databases

MEROPSiI04.052.

PTM databases

PhosphoSiteiQ8R4Z1.

Proteomic databases

PRIDEiQ8R4Z1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:708485. rat.

Organism-specific databases

RGDi708485. Serpina12.

Phylogenomic databases

eggNOGiCOG4826.
HOGENOMiHOG000238521.
HOVERGENiHBG005957.
InParanoidiQ8R4Z1.
PhylomeDBiQ8R4Z1.

Miscellaneous databases

PROiQ8R4Z1.

Gene expression databases

GenevestigatoriQ8R4Z1.

Family and domain databases

InterProiIPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: OLETF.
    Tissue: Adipose tissue.

Entry informationi

Entry nameiSPA12_RAT
AccessioniPrimary (citable) accession number: Q8R4Z1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: June 1, 2002
Last modified: March 4, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.