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Q8R4Z1

- SPA12_RAT

UniProt

Q8R4Z1 - SPA12_RAT

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Protein
Serpin A12
Gene
Serpina12
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Adipokine that modulates insulin action by specifically inhibiting its target protease KLK7 in white adipose tissues By similarity.1 Publication

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: RefGenome
Complete GO annotation...

GO - Biological processi

  1. glucose metabolic process Source: RGD
  2. negative regulation of endopeptidase activity Source: RefGenome
  3. regulation of proteolysis Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.091.

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin A12
Alternative name(s):
Visceral adipose tissue-derived serine protease inhibitor
Short name:
Vaspin
Visceral adipose-specific serpin
Gene namesi
Name:Serpina12
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi708485. Serpina12.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 By similarity
Add
BLAST
Chaini21 – 411391Serpin A12
PRO_0000041978Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi92 – 921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi267 – 2671N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ8R4Z1.

PTM databases

PhosphoSiteiQ8R4Z1.

Expressioni

Tissue specificityi

Expressed in visceral adipose tissues.1 Publication

Developmental stagei

Barely detectable in at 6 weeks and is highly expressed in adipocytes of visceral white adipose tissues at 30 weeks.1 Publication

Gene expression databases

GenevestigatoriQ8R4Z1.

Interactioni

Subunit structurei

Forms a stable complex with KLK7 By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012960.

Structurei

3D structure databases

ProteinModelPortaliQ8R4Z1.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni364 – 38219RCL By similarity
Add
BLAST

Domaini

The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable By similarity.

Sequence similaritiesi

Belongs to the serpin family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4826.
HOGENOMiHOG000238521.
HOVERGENiHBG005957.
PhylomeDBiQ8R4Z1.

Family and domain databases

InterProiIPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R4Z1-1 [UniParc]FASTAAdd to Basket

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MNLVLGLGLF LAGLLTVKGL LQDRDAPDTY ESPVRVQEWR GKKDARELTR    50
HNMEFGFKLL QRLASNSRQG NIFLSPLSIS TAFSMLSLGA QNSTLEEIRE 100
GFNFKEMSDR DMHMGFHYLL QKLNRETQDV KMSIGNALFM DQRLRPQQRF 150
LKLAKNLYDA DMILTNFQDL ENTQKNINKY ISRKTHNRIE NMVKNIDPGT 200
VMLLTNYIYF QGRWQYEFDP KQTKEEDFFI EEGKTVKVPM MFQRGMYDMA 250
YDSQLSCTIL EMPYRGNITA TFVLPDSGKL RLLEQGLQAD IFAKWKSLLS 300
KRVVDVWVPR LHISATYNMK KVLSRLGISK IFEEHGDLTR ISSHRSLKVG 350
EAVHKAELRM NEKGTEGAAG SGAQTLPMET PRRMKLNAPF LMMIYENLMP 400
SMIFLARIYN P 411
Length:411
Mass (Da):47,527
Last modified:June 1, 2002 - v1
Checksum:i29FA271FF8CC8A2D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF245398 mRNA. Translation: AAL99574.1.
UniGeneiRn.79035.

Genome annotation databases

UCSCiRGD:708485. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF245398 mRNA. Translation: AAL99574.1 .
UniGenei Rn.79035.

3D structure databases

ProteinModelPortali Q8R4Z1.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000012960.

Protein family/group databases

MEROPSi I04.091.

PTM databases

PhosphoSitei Q8R4Z1.

Proteomic databases

PRIDEi Q8R4Z1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:708485. rat.

Organism-specific databases

RGDi 708485. Serpina12.

Phylogenomic databases

eggNOGi COG4826.
HOGENOMi HOG000238521.
HOVERGENi HBG005957.
PhylomeDBi Q8R4Z1.

Miscellaneous databases

PROi Q8R4Z1.

Gene expression databases

Genevestigatori Q8R4Z1.

Family and domain databases

InterProi IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view ]
PANTHERi PTHR11461. PTHR11461. 1 hit.
Pfami PF00079. Serpin. 1 hit.
[Graphical view ]
SMARTi SM00093. SERPIN. 1 hit.
[Graphical view ]
SUPFAMi SSF56574. SSF56574. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: OLETF.
    Tissue: Adipose tissue.

Entry informationi

Entry nameiSPA12_RAT
AccessioniPrimary (citable) accession number: Q8R4Z1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: June 1, 2002
Last modified: April 16, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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