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Protein

RNA-binding protein 12

Gene

Rbm12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 12
Alternative name(s):
RNA-binding motif protein 12
SH3/WW domain anchor protein in the nucleus
Short name:
SWAN
Gene namesi
Name:Rbm12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1922960. Rbm12.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000817721 – 992RNA-binding protein 12Add BLAST992

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei352PhosphoserineBy similarity1
Modified residuei375PhosphoserineBy similarity1
Modified residuei420PhosphoserineBy similarity1
Modified residuei422PhosphoserineBy similarity1
Modified residuei424PhosphoserineBy similarity1
Modified residuei525PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8R4X3.
MaxQBiQ8R4X3.
PaxDbiQ8R4X3.
PeptideAtlasiQ8R4X3.
PRIDEiQ8R4X3.

PTM databases

iPTMnetiQ8R4X3.
PhosphoSitePlusiQ8R4X3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000089824.
CleanExiMM_RBM12.
ExpressionAtlasiQ8R4X3. baseline and differential.
GenevisibleiQ8R4X3. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8R4X3. 2 interactors.
MINTiMINT-1586673.
STRINGi10090.ENSMUSP00000050461.

Structurei

Secondary structure

1992
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi914 – 922Combined sources9
Helixi929 – 935Combined sources7
Turni936 – 938Combined sources3
Turni943 – 945Combined sources3
Beta strandi947 – 950Combined sources4
Beta strandi952 – 954Combined sources3
Beta strandi956 – 965Combined sources10
Helixi967 – 976Combined sources10
Turni977 – 979Combined sources3
Beta strandi988 – 992Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CQPNMR-A908-992[»]
ProteinModelPortaliQ8R4X3.
SMRiQ8R4X3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8R4X3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini304 – 379RRM 1PROSITE-ProRule annotationAdd BLAST76
Domaini430 – 507RRM 2PROSITE-ProRule annotationAdd BLAST78
Domaini916 – 992RRM 3PROSITE-ProRule annotationAdd BLAST77

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi159 – 256Pro-richAdd BLAST98
Compositional biasi656 – 914Gly-richAdd BLAST259

Sequence similaritiesi

Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4307. Eukaryota.
ENOG4111WZ9. LUCA.
GeneTreeiENSGT00760000119102.
HOVERGENiHBG057691.
InParanoidiQ8R4X3.
OMAiISCFIRC.
OrthoDBiEOG091G05IT.
PhylomeDBiQ8R4X3.
TreeFamiTF331899.

Family and domain databases

Gene3Di3.30.70.330. 5 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
SMARTiSM00360. RRM. 4 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 5 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R4X3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVVIRLQGL PIVAGTMDIR HFFSGLTIPD GGVHIVGGEL GEAFIVFATD
60 70 80 90 100
EDARLGMMRT GGTIKGSKVT LLLSSKTEMQ NMIELSRRRF ETANLDIPPA
110 120 130 140 150
NASRSGPPPS SGMSSRVNLP AIVPNFNNPS PSVVTATTSV HESNKNIQTF
160 170 180 190 200
STASVGTAPP SMGTSFGSPT FSSTIPSTAS PMNTVPPPPI PPIPAMPSLP
210 220 230 240 250
PLPSIPPIPV PPPVPTLPPV PPVPPIPPVP SVPPMTTLPP MSGMPPLNPP
260 270 280 290 300
PVAPLPAGMN GSGAPIGLNN NMNPVFLGPL NPVNSIQMNS QSSVKSLPIN
310 320 330 340 350
PDDLYVSVHG MPFSAMENDV REFFHGLRVD AVHLLKDHVG RNNGNGLVKF
360 370 380 390 400
LSPQDTFEAL KRNRMLMIQR YVEVSPATER QWVAAGGHIT FKQSMGPSGQ
410 420 430 440 450
AHPPPQTLPR SKSPSGQKRS RSRSPHEAGF CVYLKGLPFE AENKHVIDFF
460 470 480 490 500
KKLDIVEDSI YIAYGPNGKA TGEGFVEFRN DADYKAALCR HKQYMGNRFI
510 520 530 540 550
QVHPITKKGM LEKIDMIRKR LQNFSYDQRE LVLNPEGEVS SAKVCAHITN
560 570 580 590 600
IPFSITKMDV LQFLEGIPVD ESAVHVLVDN NGQGLGQALV QFKTEDDAHK
610 620 630 640 650
SEHLHRKKLN GREAFVHIVT LEDMREIEKN PPAQGKKGLK ISVPGNPAVP
660 670 680 690 700
VIPSAGMPAA GIPTAGIPGA GLPSAGMPGA GMPSSGMPGP GMPGPGIPGA
710 720 730 740 750
GIPGPAMPGP AMPGPAMPGP AMPGPAMPGP AMPGPAMPGP AMPGPAIPGP
760 770 780 790 800
AIPGPAIPGA GIPSAGGEEH VFLTVGSKEA NNGPPFNFPG NFGGPNAFGP
810 820 830 840 850
PLPPPGLGGA FGDVRPVMPS VGNSGLPGLG LEVPGFGGAP NNISGPSGFG
860 870 880 890 900
GIPQNFGNGP GSLNAPPGFG SGPPGLGSVP GHLSGPPAFG PGPGPGPIHI
910 920 930 940 950
GGPPGFGASS GKPGPTIIKV QNMPFTVSID EILDFFYGYQ VIPGSVCLKY
960 970 980 990
NEKGMPTGEA MVAFESRDEA TAAVIDLNDR PIGSRKVKLV LG
Length:992
Mass (Da):102,796
Last modified:November 3, 2009 - v3
Checksum:i80FEBFDF17EE564F
GO

Sequence cautioni

The sequence AAH27810 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti122I → T in AAL83754 (Ref. 1) Curated1
Sequence conflicti122I → T in AAM73683 (Ref. 1) Curated1
Sequence conflicti122I → T in AAM73684 (Ref. 1) Curated1
Sequence conflicti122I → T in AAH26891 (PubMed:15489334).Curated1
Sequence conflicti572S → N in AAL83754 (Ref. 1) Curated1
Sequence conflicti572S → N in AAM73683 (Ref. 1) Curated1
Sequence conflicti572S → N in AAM73684 (Ref. 1) Curated1
Sequence conflicti572S → N in AAH26891 (PubMed:15489334).Curated1
Sequence conflicti719G → S in BAC28911 (PubMed:16141072).Curated1
Sequence conflicti729G → S in BAB30825 (PubMed:16141072).Curated1
Sequence conflicti739G → C in BAB30825 (PubMed:16141072).Curated1
Sequence conflicti756A → AIPGPA in BAC26338 (PubMed:16141072).Curated1
Sequence conflicti756A → AIPGPAIPGPT in AAL83754 (Ref. 1) Curated1
Sequence conflicti756A → AIPGPAIPGPT in AAM73683 (Ref. 1) Curated1
Sequence conflicti756A → AIPGPAIPGPT in AAM73684 (Ref. 1) Curated1
Sequence conflicti756A → AIPGPAIPGPT in AAH26891 (PubMed:15489334).Curated1
Sequence conflicti756A → AIPGPAIPGPT in AAH27810 (PubMed:15489334).Curated1
Sequence conflicti808G → GGG in AAL83754 (Ref. 1) Curated1
Sequence conflicti808G → GGG in AAM73683 (Ref. 1) Curated1
Sequence conflicti808G → GGG in AAM73684 (Ref. 1) Curated1
Sequence conflicti814V → A in AAL83754 (Ref. 1) Curated1
Sequence conflicti814V → A in AAM73683 (Ref. 1) Curated1
Sequence conflicti814V → A in AAM73684 (Ref. 1) Curated1
Sequence conflicti817V → G in AAL83754 (Ref. 1) Curated1
Sequence conflicti817V → G in AAM73683 (Ref. 1) Curated1
Sequence conflicti817V → G in AAM73684 (Ref. 1) Curated1
Sequence conflicti832E → D in AAL83754 (Ref. 1) Curated1
Sequence conflicti832E → D in AAM73683 (Ref. 1) Curated1
Sequence conflicti832E → D in AAM73684 (Ref. 1) Curated1
Sequence conflicti839 – 840AP → G in AAL83754 (Ref. 1) Curated2
Sequence conflicti839 – 840AP → G in AAM73683 (Ref. 1) Curated2
Sequence conflicti839 – 840AP → G in AAM73684 (Ref. 1) Curated2
Sequence conflicti897P → L in AAL83754 (Ref. 1) Curated1
Sequence conflicti897P → L in AAM73683 (Ref. 1) Curated1
Sequence conflicti897P → L in AAM73684 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF345334 mRNA. Translation: AAL83754.1.
AF393215 mRNA. Translation: AAM73683.1.
AF393216 mRNA. Translation: AAM73684.1.
AK017591 mRNA. Translation: BAB30825.1.
AK029180 mRNA. Translation: BAC26338.1.
AK035014 mRNA. Translation: BAC28911.1.
AK080772 mRNA. Translation: BAC38017.1.
AK166833 mRNA. Translation: BAE39056.1.
AL833786 Genomic DNA. Translation: CAM46030.1.
BC026891 mRNA. Translation: AAH26891.2.
BC027810 mRNA. Translation: AAH27810.2. Different initiation.
BC052473 mRNA. Translation: AAH52473.1.
CCDSiCCDS16961.1.
RefSeqiNP_083673.3. NM_029397.3.
NP_733486.2. NM_170598.2.
UniGeneiMm.27660.
Mm.441281.

Genome annotation databases

EnsembliENSMUST00000059647; ENSMUSP00000050461; ENSMUSG00000089824.
ENSMUST00000109604; ENSMUSP00000105233; ENSMUSG00000089824.
GeneIDi75710.
KEGGimmu:75710.
UCSCiuc008nmh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF345334 mRNA. Translation: AAL83754.1.
AF393215 mRNA. Translation: AAM73683.1.
AF393216 mRNA. Translation: AAM73684.1.
AK017591 mRNA. Translation: BAB30825.1.
AK029180 mRNA. Translation: BAC26338.1.
AK035014 mRNA. Translation: BAC28911.1.
AK080772 mRNA. Translation: BAC38017.1.
AK166833 mRNA. Translation: BAE39056.1.
AL833786 Genomic DNA. Translation: CAM46030.1.
BC026891 mRNA. Translation: AAH26891.2.
BC027810 mRNA. Translation: AAH27810.2. Different initiation.
BC052473 mRNA. Translation: AAH52473.1.
CCDSiCCDS16961.1.
RefSeqiNP_083673.3. NM_029397.3.
NP_733486.2. NM_170598.2.
UniGeneiMm.27660.
Mm.441281.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CQPNMR-A908-992[»]
ProteinModelPortaliQ8R4X3.
SMRiQ8R4X3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8R4X3. 2 interactors.
MINTiMINT-1586673.
STRINGi10090.ENSMUSP00000050461.

PTM databases

iPTMnetiQ8R4X3.
PhosphoSitePlusiQ8R4X3.

Proteomic databases

EPDiQ8R4X3.
MaxQBiQ8R4X3.
PaxDbiQ8R4X3.
PeptideAtlasiQ8R4X3.
PRIDEiQ8R4X3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059647; ENSMUSP00000050461; ENSMUSG00000089824.
ENSMUST00000109604; ENSMUSP00000105233; ENSMUSG00000089824.
GeneIDi75710.
KEGGimmu:75710.
UCSCiuc008nmh.1. mouse.

Organism-specific databases

CTDi10137.
MGIiMGI:1922960. Rbm12.

Phylogenomic databases

eggNOGiKOG4307. Eukaryota.
ENOG4111WZ9. LUCA.
GeneTreeiENSGT00760000119102.
HOVERGENiHBG057691.
InParanoidiQ8R4X3.
OMAiISCFIRC.
OrthoDBiEOG091G05IT.
PhylomeDBiQ8R4X3.
TreeFamiTF331899.

Miscellaneous databases

ChiTaRSiRbm12. mouse.
EvolutionaryTraceiQ8R4X3.
PROiQ8R4X3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000089824.
CleanExiMM_RBM12.
ExpressionAtlasiQ8R4X3. baseline and differential.
GenevisibleiQ8R4X3. MM.

Family and domain databases

Gene3Di3.30.70.330. 5 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
SMARTiSM00360. RRM. 4 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 5 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRBM12_MOUSE
AccessioniPrimary (citable) accession number: Q8R4X3
Secondary accession number(s): B6ICZ5
, Q3TKT7, Q7TT14, Q8K373, Q8R302, Q9CS80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: November 3, 2009
Last modified: November 2, 2016
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.