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Protein

Oncoprotein-induced transcript 3 protein

Gene

Oit3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in hepatocellular function and development.By similarity

GO - Molecular functioni

GO - Biological processi

  • urate homeostasis Source: MGI
Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Oncoprotein-induced transcript 3 protein
Alternative name(s):
Liver-specific zona pellucida domain-containing protein
Gene namesi
Name:Oit3
Synonyms:Lzp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1201782. Oit3.

Subcellular locationi

  • Nucleus envelope 1 Publication

  • Note: Secreted into blood in a truncated form.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000029893220 – 546Oncoprotein-induced transcript 3 proteinAdd BLAST527

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi89N-linked (GlcNAc...)Sequence analysis1
Glycosylationi116N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi186 ↔ 197By similarity
Disulfide bondi193 ↔ 206By similarity
Disulfide bondi208 ↔ 221By similarity
Glycosylationi299N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8R4V5.
PRIDEiQ8R4V5.

PTM databases

PhosphoSitePlusiQ8R4V5.

Expressioni

Tissue specificityi

Liver-specific. Expressed only in the hepatocytes.2 Publications

Developmental stagei

Expression begins as early as E6.5 and very early in fetal liver (at least from E11.5). Expression level changes in different developmental stages. Levels decrease to a minimal level at E17.5 and then increase gradually to the maximal level at about 7 days after birth.1 Publication

Gene expression databases

BgeeiENSMUSG00000009654.
CleanExiMM_OIT3.
GenevisibleiQ8R4V5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000009798.

Structurei

3D structure databases

ProteinModelPortaliQ8R4V5.
SMRiQ8R4V5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini182 – 222EGF-like; calcium-bindingSequence analysisAdd BLAST41
Domaini261 – 516ZPPROSITE-ProRule annotationAdd BLAST256

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi139 – 249Cys-richAdd BLAST111

Sequence similaritiesi

Contains 1 EGF-like domain.Curated
Contains 1 ZP domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Signal

Phylogenomic databases

eggNOGiENOG410IHDE. Eukaryota.
ENOG4110JPJ. LUCA.
GeneTreeiENSGT00530000063244.
HOGENOMiHOG000115262.
HOVERGENiHBG097756.
InParanoidiQ8R4V5.
OMAiDRQTCFD.
OrthoDBiEOG091G03XV.
PhylomeDBiQ8R4V5.
TreeFamiTF330284.

Family and domain databases

InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR000742. EGF-like_dom.
IPR001507. ZP_dom.
[Graphical view]
PfamiPF00100. Zona_pellucida. 1 hit.
[Graphical view]
PRINTSiPR00023. ZPELLUCIDA.
SMARTiSM00181. EGF. 3 hits.
SM00179. EGF_CA. 2 hits.
SM00241. ZP. 1 hit.
[Graphical view]
PROSITEiPS51034. ZP_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8R4V5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPLSLLLTCL STTVTLVSPA VLDPCSAYIS LNEPWRNTDH QFDESQNQPL
60 70 80 90 100
CDNHMNGEWY RFTGMAGDAM PTFCIPENHC GTHAPVWLNG SHPLEEDGIV
110 120 130 140 150
QRQACASFKG NCCLWNATVE VKACPRGYYV YRLARPSVCF HVYCGHFYDI
160 170 180 190 200
CDEDCHGNCL DTTECACSPG TSLGPDGQTC FDENECEHNN GGCSEICVNL
210 220 230 240 250
KNSHRCACGV GRVLRSDGKT CEDIEGCHNN NGGCSHSCLG SEEGYQCECP
260 270 280 290 300
RGLVLSEDNH TCQVPVLCKS SAIEVSVPRE LVGGLELFLT NTSCRGVSNG
310 320 330 340 350
THVNIVFSLK TCGTVVDVVN DKIVASNIVT GLPKETPGSS GDIIIRTSKL
360 370 380 390 400
LIPVTCEFPR LYTISEGYVP NLRNAPLEIR SRNHGIFPFT LEIFKDHEFE
410 420 430 440 450
EPYRETLPTL KLRDSLYFGI EPLVHVNGLE SLVESCFATP TAKMDEILKY
460 470 480 490 500
YLIQDGCVSD DSVKQYSSRD HLAKHFQAPV FKFVGKDHKE VFLHCRVLVC
510 520 530 540
GVLDERSRCA QGCHRRVRRE VGEDEDSAGL QSQTLTGGPI AIDWED
Length:546
Mass (Da):60,316
Last modified:August 21, 2007 - v2
Checksum:iB669D7FBD3105295
GO
Isoform 2 (identifier: Q8R4V5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.

Show »
Length:492
Mass (Da):54,304
Checksum:iE7264500A66DB2EC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2P → S in AAO22058 (PubMed:15346761).Curated1
Sequence conflicti271S → I in AAL86587 (PubMed:15346761).Curated1
Sequence conflicti446E → D in AAL86587 (PubMed:15346761).Curated1
Sequence conflicti496R → H in AAM77901 (Ref. 3) Curated1
Sequence conflicti496R → H in AAM77638 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0274841 – 54Missing in isoform 2. 1 PublicationAdd BLAST54

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF356506 mRNA. Translation: AAL86587.1.
AY180915 mRNA. Translation: AAO22058.1.
AF517106 mRNA. Translation: AAM77901.1.
AF517107 mRNA. Translation: AAM77638.1.
AK040570 mRNA. Translation: BAC30631.1.
CCDSiCCDS23865.1. [Q8R4V5-1]
RefSeqiNP_035089.1. NM_010959.2. [Q8R4V5-1]
UniGeneiMm.123013.

Genome annotation databases

EnsembliENSMUST00000009798; ENSMUSP00000009798; ENSMUSG00000009654. [Q8R4V5-1]
GeneIDi18302.
KEGGimmu:18302.
UCSCiuc007fdr.1. mouse. [Q8R4V5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF356506 mRNA. Translation: AAL86587.1.
AY180915 mRNA. Translation: AAO22058.1.
AF517106 mRNA. Translation: AAM77901.1.
AF517107 mRNA. Translation: AAM77638.1.
AK040570 mRNA. Translation: BAC30631.1.
CCDSiCCDS23865.1. [Q8R4V5-1]
RefSeqiNP_035089.1. NM_010959.2. [Q8R4V5-1]
UniGeneiMm.123013.

3D structure databases

ProteinModelPortaliQ8R4V5.
SMRiQ8R4V5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000009798.

PTM databases

PhosphoSitePlusiQ8R4V5.

Proteomic databases

PaxDbiQ8R4V5.
PRIDEiQ8R4V5.

Protocols and materials databases

DNASUi18302.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000009798; ENSMUSP00000009798; ENSMUSG00000009654. [Q8R4V5-1]
GeneIDi18302.
KEGGimmu:18302.
UCSCiuc007fdr.1. mouse. [Q8R4V5-1]

Organism-specific databases

CTDi170392.
MGIiMGI:1201782. Oit3.

Phylogenomic databases

eggNOGiENOG410IHDE. Eukaryota.
ENOG4110JPJ. LUCA.
GeneTreeiENSGT00530000063244.
HOGENOMiHOG000115262.
HOVERGENiHBG097756.
InParanoidiQ8R4V5.
OMAiDRQTCFD.
OrthoDBiEOG091G03XV.
PhylomeDBiQ8R4V5.
TreeFamiTF330284.

Miscellaneous databases

PROiQ8R4V5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000009654.
CleanExiMM_OIT3.
GenevisibleiQ8R4V5. MM.

Family and domain databases

InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR000742. EGF-like_dom.
IPR001507. ZP_dom.
[Graphical view]
PfamiPF00100. Zona_pellucida. 1 hit.
[Graphical view]
PRINTSiPR00023. ZPELLUCIDA.
SMARTiSM00181. EGF. 3 hits.
SM00179. EGF_CA. 2 hits.
SM00241. ZP. 1 hit.
[Graphical view]
PROSITEiPS51034. ZP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOIT3_MOUSE
AccessioniPrimary (citable) accession number: Q8R4V5
Secondary accession number(s): P97806, Q811T0, Q8C9U1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: November 2, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.