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Protein

Dual specificity protein phosphatase 15

Gene

Dusp15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 (By similarity).By similarity
Isoform 1: May play a role in the regulation of oligodendrocyte differentiation (PubMed:22792334). May play a role in the regulation of myelin formation (By similarity). Involved in the regulation of Erk1/2 phosphorylation in Schwann cells; the signaling may be linked to the regulation of myelination (By similarity).By similarity1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotationBy similarity
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei88Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 15By similarity (EC:3.1.3.16PROSITE-ProRule annotationBy similarity, EC:3.1.3.48PROSITE-ProRule annotationBy similarity)
Alternative name(s):
Dual specificity protein phosphatase T-DSP101 Publication
Gene namesi
Name:Dusp15Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1934928 Dusp15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000948252 – 235Dual specificity protein phosphatase 15Add BLAST234

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiQ8R4V2
PeptideAtlasiQ8R4V2
PRIDEiQ8R4V2

PTM databases

iPTMnetiQ8R4V2
PhosphoSitePlusiQ8R4V2
SwissPalmiQ8R4V2

Expressioni

Tissue specificityi

Isoform 1 is expressed in testis; predominantly in developing spermatocytes (at protein level) (PubMed:15138252). Isoform 2 is highly expressed in testis (PubMed:11432789). Expressed in spinal chord and specifically in oligodendroglial cells (PubMed:27532821). Expressed in embryonic brain cortex; down-regulated in mice with experimental autoimmune encephalomyelitis (EAE) (PubMed:22792334).3 Publications

Developmental stagei

Expression increases during oligodendrocyte differentiation. Detected in spinal chord in late fetal (E18.5) and early postnatal (P3 and P7) stages. Expression decreases in later postnatal development (P14 and P30).2 Publications

Inductioni

Down-regulated by nerve injury.1 Publication

Gene expression databases

BgeeiENSMUSG00000042662
CleanExiMM_DUSP15
ExpressionAtlasiQ8R4V2 baseline and differential
GenevisibleiQ8R4V2 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000123090

Structurei

3D structure databases

ProteinModelPortaliQ8R4V2
SMRiQ8R4V2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 135Tyrosine-protein phosphataseAdd BLAST71

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1716 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00760000118853
HOGENOMiHOG000007880
HOVERGENiHBG054344
InParanoidiQ8R4V2
KOiK14165
OMAiSCIPACL
OrthoDBiEOG091G0NE0
PhylomeDBiQ8R4V2
TreeFamiTF105126

Family and domain databases

CDDicd00127 DSPc, 1 hit
Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR020417 Atypical_DUSP
IPR000340 Dual-sp_phosphatase_cat-dom
IPR024950 DUSP
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERiPTHR10159 PTHR10159, 1 hit
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PRINTSiPR01908 ADSPHPHTASE
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50054 TYR_PHOSPHATASE_DUAL, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8R4V2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNGMTKVLP GLYLGNFIDA KDPDQLGRNK ITHIISIHES PQPLLQDITY
60 70 80 90 100
LRISVSDTPE VPIKKHFKEC VHFIHSCRLN GGNCLVHCFA GISRSTTIVI
110 120 130 140 150
AYVMTVTGLG WQEVLEAIKA SRPIANPNPG FRQQLEEFGW ANSQKLRRQL
160 170 180 190 200
EERFGEIPFR DEEDLRALLP LCRRCRQGSA TSAASATTAS SAAEGTLQRL
210 220 230
VPRSPRDSHQ PLPLLARVKQ TFFCLPRCLS RKGGK
Length:235
Mass (Da):26,186
Last modified:September 2, 2008 - v3
Checksum:i09A3EB05A0A7F891
GO
Isoform 2 (identifier: Q8R4V2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     88-105: CFAGISRSTTIVIAYVMT → WPLKHECRARSLSLLQCS
     106-235: Missing.

Note: Inactive. Lacks the active site.
Show »
Length:105
Mass (Da):11,871
Checksum:iF6E95C0B36D45CA2
GO

Sequence cautioni

The sequence BU924460 differs from that shown. Reason: Frameshift at position 120.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00729488 – 105CFAGI…AYVMT → WPLKHECRARSLSLLQCS in isoform 2. 2 PublicationsAdd BLAST18
Alternative sequenceiVSP_007295106 – 235Missing in isoform 2. 2 PublicationsAdd BLAST130

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF357887 mRNA Translation: AAM00226.1
AL833801 Genomic DNA No translation available.
BC116841 mRNA Translation: AAI16842.1
BC116843 mRNA Translation: AAI16844.1
BU924460 mRNA No translation available.
CCDSiCCDS16902.1 [Q8R4V2-2]
CCDS50754.1 [Q8R4V2-1]
RefSeqiNP_001152848.1, NM_001159376.1 [Q8R4V2-1]
NP_665687.1, NM_145744.2 [Q8R4V2-2]
UniGeneiMm.330671

Genome annotation databases

EnsembliENSMUST00000037715; ENSMUSP00000045815; ENSMUSG00000042662 [Q8R4V2-2]
ENSMUST00000123121; ENSMUSP00000123090; ENSMUSG00000042662 [Q8R4V2-1]
GeneIDi252864
KEGGimmu:252864
UCSCiuc008ngu.2 mouse [Q8R4V2-2]
uc012cgl.1 mouse [Q8R4V2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiDUS15_MOUSE
AccessioniPrimary (citable) accession number: Q8R4V2
Secondary accession number(s): A2APC1, Q14AH2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: September 2, 2008
Last modified: May 23, 2018
This is version 130 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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