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Protein

Dual specificity protein phosphatase 15

Gene

Dusp15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 (By similarity).By similarity
Isoform 1: May play a role in the regulation of oligodendrocyte differentiation (PubMed:22792334). May play a role in the regulation of myelin formation (By similarity). Involved in the regulation of Erk1/2 phosphorylation in Schwann cells; the signaling may be linked to the regulation of myelination (By similarity).By similarity1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotationBy similarity
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei88Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 15By similarity (EC:3.1.3.16PROSITE-ProRule annotationBy similarity, EC:3.1.3.48PROSITE-ProRule annotationBy similarity)
Alternative name(s):
Dual specificity protein phosphatase T-DSP101 Publication
Gene namesi
Name:Dusp15Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1934928. Dusp15.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000948252 – 235Dual specificity protein phosphatase 15Add BLAST234

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiQ8R4V2.
PeptideAtlasiQ8R4V2.
PRIDEiQ8R4V2.

PTM databases

iPTMnetiQ8R4V2.
PhosphoSitePlusiQ8R4V2.

Expressioni

Tissue specificityi

Isoform 1 is expressed in testis; predominantly in developing spermatocytes (at protein level) (PubMed:15138252). Isoform 2 is highly expressed in testis (PubMed:11432789). Expressed in spinal chord and specifically in oligodendroglial cells (PubMed:27532821). Expressed in embryonic brain cortex; down-regulated in mice with experimental autoimmune encephalomyelitis (EAE) (PubMed:22792334).3 Publications

Developmental stagei

Expression increases during oligodendrocyte differentiation. Detected in spinal chord in late fetal (E18.5) and early postnatal (P3 and P7) stages. Expression decreases in later postnatal development (P14 and P30).2 Publications

Inductioni

Down-regulated by nerve injury.1 Publication

Gene expression databases

BgeeiENSMUSG00000042662.
CleanExiMM_DUSP15.
ExpressionAtlasiQ8R4V2. baseline and differential.
GenevisibleiQ8R4V2. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000123090.

Structurei

3D structure databases

ProteinModelPortaliQ8R4V2.
SMRiQ8R4V2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 135Tyrosine-protein phosphataseAdd BLAST71

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1716. Eukaryota.
COG2453. LUCA.
GeneTreeiENSGT00760000118853.
HOGENOMiHOG000007880.
HOVERGENiHBG054344.
InParanoidiQ8R4V2.
KOiK14165.
OMAiSCIPACL.
OrthoDBiEOG091G0NE0.
PhylomeDBiQ8R4V2.
TreeFamiTF105126.

Family and domain databases

CDDicd00127. DSPc. 1 hit.
Gene3Di3.90.190.10. 1 hit.
InterProiView protein in InterPro
IPR020417. Atypical_DUSP.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiView protein in Pfam
PF00782. DSPc. 1 hit.
PRINTSiPR01908. ADSPHPHTASE.
SMARTiView protein in SMART
SM00195. DSPc. 1 hit.
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiView protein in PROSITE
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8R4V2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNGMTKVLP GLYLGNFIDA KDPDQLGRNK ITHIISIHES PQPLLQDITY
60 70 80 90 100
LRISVSDTPE VPIKKHFKEC VHFIHSCRLN GGNCLVHCFA GISRSTTIVI
110 120 130 140 150
AYVMTVTGLG WQEVLEAIKA SRPIANPNPG FRQQLEEFGW ANSQKLRRQL
160 170 180 190 200
EERFGEIPFR DEEDLRALLP LCRRCRQGSA TSAASATTAS SAAEGTLQRL
210 220 230
VPRSPRDSHQ PLPLLARVKQ TFFCLPRCLS RKGGK
Length:235
Mass (Da):26,186
Last modified:September 2, 2008 - v3
Checksum:i09A3EB05A0A7F891
GO
Isoform 2 (identifier: Q8R4V2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     88-105: CFAGISRSTTIVIAYVMT → WPLKHECRARSLSLLQCS
     106-235: Missing.

Note: Inactive. Lacks the active site.
Show »
Length:105
Mass (Da):11,871
Checksum:iF6E95C0B36D45CA2
GO

Sequence cautioni

The sequence BU924460 differs from that shown. Reason: Frameshift at position 120.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00729488 – 105CFAGI…AYVMT → WPLKHECRARSLSLLQCS in isoform 2. 2 PublicationsAdd BLAST18
Alternative sequenceiVSP_007295106 – 235Missing in isoform 2. 2 PublicationsAdd BLAST130

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF357887 mRNA. Translation: AAM00226.1.
AL833801 Genomic DNA. Translation: CAM23680.1.
BC116841 mRNA. Translation: AAI16842.1.
BC116843 mRNA. Translation: AAI16844.1.
BU924460 mRNA. No translation available.
CCDSiCCDS16902.1. [Q8R4V2-2]
CCDS50754.1. [Q8R4V2-1]
RefSeqiNP_001152848.1. NM_001159376.1. [Q8R4V2-1]
NP_665687.1. NM_145744.2. [Q8R4V2-2]
UniGeneiMm.330671.

Genome annotation databases

EnsembliENSMUST00000037715; ENSMUSP00000045815; ENSMUSG00000042662. [Q8R4V2-2]
ENSMUST00000123121; ENSMUSP00000123090; ENSMUSG00000042662. [Q8R4V2-1]
GeneIDi252864.
KEGGimmu:252864.
UCSCiuc008ngu.2. mouse. [Q8R4V2-2]
uc012cgl.1. mouse. [Q8R4V2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiDUS15_MOUSE
AccessioniPrimary (citable) accession number: Q8R4V2
Secondary accession number(s): A2APC1, Q14AH2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: September 2, 2008
Last modified: July 5, 2017
This is version 125 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families