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Q8R4V2

- DUS15_MOUSE

UniProt

Q8R4V2 - DUS15_MOUSE

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Protein

Dual specificity protein phosphatase 15

Gene

Dusp15

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei88 – 881Phosphocysteine intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. positive regulation of JNK cascade Source: RefGenome
  2. protein dephosphorylation Source: RefGenome
  3. regulation of cell proliferation Source: RefGenome
  4. transforming growth factor beta receptor signaling pathway Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 15 (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
Dual specificity protein phosphatase T-DSP10
Gene namesi
Name:Dusp15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1934928. Dusp15.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 235235Dual specificity protein phosphatase 15PRO_0000094825Add
BLAST

Proteomic databases

PaxDbiQ8R4V2.
PRIDEiQ8R4V2.

PTM databases

PhosphoSiteiQ8R4V2.

Expressioni

Tissue specificityi

Isoform 2 is highly expressed in testis.1 Publication

Gene expression databases

BgeeiQ8R4V2.
CleanExiMM_DUSP15.
GenevestigatoriQ8R4V2.

Structurei

3D structure databases

ProteinModelPortaliQ8R4V2.
SMRiQ8R4V2. Positions 1-156.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini65 – 13571Tyrosine-protein phosphataseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2453.
GeneTreeiENSGT00760000118853.
HOGENOMiHOG000007880.
HOVERGENiHBG054344.
InParanoidiQ8R4V2.
KOiK14165.
OMAiCRQGSAT.
OrthoDBiEOG7966HM.
PhylomeDBiQ8R4V2.
TreeFamiTF105126.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR020417. Atypical_DUSP.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
PRINTSiPR01908. ADSPHPHTASE.
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8R4V2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNGMTKVLP GLYLGNFIDA KDPDQLGRNK ITHIISIHES PQPLLQDITY
60 70 80 90 100
LRISVSDTPE VPIKKHFKEC VHFIHSCRLN GGNCLVHCFA GISRSTTIVI
110 120 130 140 150
AYVMTVTGLG WQEVLEAIKA SRPIANPNPG FRQQLEEFGW ANSQKLRRQL
160 170 180 190 200
EERFGEIPFR DEEDLRALLP LCRRCRQGSA TSAASATTAS SAAEGTLQRL
210 220 230
VPRSPRDSHQ PLPLLARVKQ TFFCLPRCLS RKGGK
Length:235
Mass (Da):26,186
Last modified:September 2, 2008 - v3
Checksum:i09A3EB05A0A7F891
GO
Isoform 2 (identifier: Q8R4V2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     88-105: CFAGISRSTTIVIAYVMT → WPLKHECRARSLSLLQCS
     106-235: Missing.

Note: Inactive. Lacks the active site.

Show »
Length:105
Mass (Da):11,871
Checksum:iF6E95C0B36D45CA2
GO

Sequence cautioni

The sequence BU924460 differs from that shown. Reason: Frameshift at position 120.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei88 – 10518CFAGI…AYVMT → WPLKHECRARSLSLLQCS in isoform 2. 2 PublicationsVSP_007294Add
BLAST
Alternative sequencei106 – 235130Missing in isoform 2. 2 PublicationsVSP_007295Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF357887 mRNA. Translation: AAM00226.1.
AL833801 Genomic DNA. Translation: CAM23680.1.
BC116841 mRNA. Translation: AAI16842.1.
BC116843 mRNA. Translation: AAI16844.1.
BU924460 mRNA. No translation available.
CCDSiCCDS16902.1. [Q8R4V2-2]
CCDS50754.1. [Q8R4V2-1]
RefSeqiNP_001152848.1. NM_001159376.1. [Q8R4V2-1]
NP_665687.1. NM_145744.2. [Q8R4V2-2]
UniGeneiMm.330671.

Genome annotation databases

EnsembliENSMUST00000037715; ENSMUSP00000045815; ENSMUSG00000042662. [Q8R4V2-2]
ENSMUST00000123121; ENSMUSP00000123090; ENSMUSG00000042662. [Q8R4V2-1]
GeneIDi252864.
KEGGimmu:252864.
UCSCiuc008ngu.2. mouse. [Q8R4V2-2]
uc012cgl.1. mouse. [Q8R4V2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF357887 mRNA. Translation: AAM00226.1 .
AL833801 Genomic DNA. Translation: CAM23680.1 .
BC116841 mRNA. Translation: AAI16842.1 .
BC116843 mRNA. Translation: AAI16844.1 .
BU924460 mRNA. No translation available.
CCDSi CCDS16902.1. [Q8R4V2-2 ]
CCDS50754.1. [Q8R4V2-1 ]
RefSeqi NP_001152848.1. NM_001159376.1. [Q8R4V2-1 ]
NP_665687.1. NM_145744.2. [Q8R4V2-2 ]
UniGenei Mm.330671.

3D structure databases

ProteinModelPortali Q8R4V2.
SMRi Q8R4V2. Positions 1-156.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8R4V2.

Proteomic databases

PaxDbi Q8R4V2.
PRIDEi Q8R4V2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000037715 ; ENSMUSP00000045815 ; ENSMUSG00000042662 . [Q8R4V2-2 ]
ENSMUST00000123121 ; ENSMUSP00000123090 ; ENSMUSG00000042662 . [Q8R4V2-1 ]
GeneIDi 252864.
KEGGi mmu:252864.
UCSCi uc008ngu.2. mouse. [Q8R4V2-2 ]
uc012cgl.1. mouse. [Q8R4V2-1 ]

Organism-specific databases

CTDi 128853.
MGIi MGI:1934928. Dusp15.

Phylogenomic databases

eggNOGi COG2453.
GeneTreei ENSGT00760000118853.
HOGENOMi HOG000007880.
HOVERGENi HBG054344.
InParanoidi Q8R4V2.
KOi K14165.
OMAi CRQGSAT.
OrthoDBi EOG7966HM.
PhylomeDBi Q8R4V2.
TreeFami TF105126.

Miscellaneous databases

NextBioi 387351.
PROi Q8R4V2.
SOURCEi Search...

Gene expression databases

Bgeei Q8R4V2.
CleanExi MM_DUSP15.
Genevestigatori Q8R4V2.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR020417. Atypical_DUSP.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view ]
PANTHERi PTHR10159. PTHR10159. 1 hit.
Pfami PF00782. DSPc. 1 hit.
[Graphical view ]
PRINTSi PR01908. ADSPHPHTASE.
SMARTi SM00195. DSPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A growing family of dual specificity phosphatases with low molecular masses."
    Aoki N., Aoyama K., Nagata M., Matsuda T.
    J. Biochem. 130:133-140(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  4. "Gene expression in the developing mouse retina by EST sequencing and microarray analysis."
    Mu X., Zhao S., Pershad R., Hsieh T.-F., Scarpa A., Wang S.W., White R.A., Beremand P.D., Thomas T.L., Gan L., Klein W.H.
    Nucleic Acids Res. 29:4983-4993(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-125 (ISOFORM 1).

Entry informationi

Entry nameiDUS15_MOUSE
AccessioniPrimary (citable) accession number: Q8R4V2
Secondary accession number(s): A2APC1, Q14AH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: September 2, 2008
Last modified: October 29, 2014
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3