Q8R4V2 (DUS15_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dual specificity protein phosphatase 15
EC=3.1.3.16
EC=3.1.3.48

Alternative name(s):
Dual specificity protein phosphatase T-DSP10

Gene names

Name:

Dusp15

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	235 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. A phosphoprotein + H2O = a protein + phosphate.
Tissue specificity	Isoform 2 is highly expressed in testis. Ref.1
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 tyrosine-protein phosphatase domain.
Sequence caution	The sequence BU924460 differs from that shown. Reason: Frameshift at position 120.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC
Molecular_function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC protein tyrosine/serine/threonine phosphatase activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8R4V2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8R4V2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     88-105: CFAGISRSTTIVIAYVMT → WPLKHECRARSLSLLQCS
     106-235: Missing.

Note: Inactive. Lacks the active site.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 235	235	Dual specificity protein phosphatase 15		PRO_0000094825
Regions
	Domain	65 – 135	71	Tyrosine-protein phosphatase
Sites
	Active site	88	1	Phosphocysteine intermediate By similarity
Natural variations
	Alternative sequence	88 – 105	18	CFAGI…AYVMT → WPLKHECRARSLSLLQCS in isoform 2.		VSP_007294
	Alternative sequence	106 – 235	130	Missing in isoform 2.		VSP_007295

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified September 2, 2008. Version 3. Checksum: 09A3EB05A0A7F891	FASTA	235	26,186
	10 20 30 40 50 60 MGNGMTKVLP GLYLGNFIDA KDPDQLGRNK ITHIISIHES PQPLLQDITY LRISVSDTPE 70 80 90 100 110 120 VPIKKHFKEC VHFIHSCRLN GGNCLVHCFA GISRSTTIVI AYVMTVTGLG WQEVLEAIKA 130 140 150 160 170 180 SRPIANPNPG FRQQLEEFGW ANSQKLRRQL EERFGEIPFR DEEDLRALLP LCRRCRQGSA 190 200 210 220 230 TSAASATTAS SAAEGTLQRL VPRSPRDSHQ PLPLLARVKQ TFFCLPRCLS RKGGK
	Isoform 2 [UniParc]. Checksum: F6E95C0B36D45CA2	FASTA	105	11,871
	10 20 30 40 50 60 MGNGMTKVLP GLYLGNFIDA KDPDQLGRNK ITHIISIHES PQPLLQDITY LRISVSDTPE 70 80 90 100 VPIKKHFKEC VHFIHSCRLN GGNCLVHWPL KHECRARSLS LLQCS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A growing family of dual specificity phosphatases with low molecular masses." Aoki N., Aoyama K., Nagata M., Matsuda T. J. Biochem. 130:133-140(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[4]	"Gene expression in the developing mouse retina by EST sequencing and microarray analysis." Mu X., Zhao S., Pershad R., Hsieh T.-F., Scarpa A., Wang S.W., White R.A., Beremand P.D., Thomas T.L., Gan L., Klein W.H. Nucleic Acids Res. 29:4983-4993(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-125 (ISOFORM 1).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF357887 mRNA. Translation: AAM00226.1. AL833801 Genomic DNA. Translation: CAM23680.1. BC116841 mRNA. Translation: AAI16842.1. BC116843 mRNA. Translation: AAI16844.1. BU924460 mRNA. No translation available.
IPI	IPI00153936. IPI00269461.
RefSeq	NP_001152848.1. NM_001159376.1. NP_665687.1. NM_145744.2.
UniGene	Mm.330671.
3D structure databases
ProteinModelPortal	Q8R4V2.
SMR	Q8R4V2. Positions 1-156.
ModBase	Search...
PTM databases
PhosphoSite	Q8R4V2.
Proteomic databases
PaxDb	Q8R4V2.
PRIDE	Q8R4V2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000037715; ENSMUSP00000045815; ENSMUSG00000042662. ENSMUST00000123121; ENSMUSP00000123090; ENSMUSG00000042662.
GeneID	252864.
KEGG	mmu:252864.
UCSC	uc008ngu.2. mouse. uc012cgl.1. mouse.
Organism-specific databases
CTD	128853.
MGI	MGI:1934928. Dusp15.
Phylogenomic databases
eggNOG	COG2453.
GeneTree	ENSGT00680000099678.
HOGENOM	HOG000007880.
HOVERGEN	HBG054344.
InParanoid	Q8R4V2.
KO	K14165.
OMA	CRQGSAT.
OrthoDB	EOG4RFKT3.
Gene expression databases
ArrayExpress	Q8R4V2.
Bgee	Q8R4V2.
CleanEx	MM_DUSP15.
Genevestigator	Q8R4V2.
GermOnline	ENSMUSG00000042662. Mus musculus.
Family and domain databases
InterPro	IPR020417. Atypical_DUSP. IPR000340. Dual-sp_phosphatase_cat-dom. IPR020422. Dual-sp_phosphatase_subgr_cat. IPR024950. DUSP. IPR000387. Tyr/Dual-sp_Pase. IPR016130. Tyr_Pase_AS. [Graphical view]
PANTHER	PTHR10159. PTHR10159. 1 hit.
Pfam	PF00782. DSPc. 1 hit. [Graphical view]
PRINTS	PR01908. ADSPHPHTASE.
SMART	SM00195. DSPc. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50054. TYR_PHOSPHATASE_DUAL. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	387351.
SOURCE	Search...

Entry information

Entry name

DUS15_MOUSE

Accession

Primary (citable) accession number: Q8R4V2
Secondary accession number(s): A2APC1, Q14AH2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 30, 2003
Last sequence update:	September 2, 2008
Last modified:	April 3, 2013
This is version 91 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program