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Protein

Dual specificity protein phosphatase 15

Gene

Dusp15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei88 – 881Phosphocysteine intermediatePROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 15 (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
Dual specificity protein phosphatase T-DSP10
Gene namesi
Name:Dusp15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1934928. Dusp15.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 235235Dual specificity protein phosphatase 15PRO_0000094825Add
BLAST

Proteomic databases

MaxQBiQ8R4V2.
PaxDbiQ8R4V2.
PRIDEiQ8R4V2.

PTM databases

PhosphoSiteiQ8R4V2.

Expressioni

Tissue specificityi

Isoform 2 is highly expressed in testis.1 Publication

Gene expression databases

BgeeiQ8R4V2.
CleanExiMM_DUSP15.
GenevestigatoriQ8R4V2.

Structurei

3D structure databases

ProteinModelPortaliQ8R4V2.
SMRiQ8R4V2. Positions 1-156.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini65 – 13571Tyrosine-protein phosphataseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2453.
GeneTreeiENSGT00760000118853.
HOGENOMiHOG000007880.
HOVERGENiHBG054344.
InParanoidiQ8R4V2.
KOiK14165.
OMAiCRQGSAT.
OrthoDBiEOG7966HM.
PhylomeDBiQ8R4V2.
TreeFamiTF105126.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR020417. Atypical_DUSP.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
PRINTSiPR01908. ADSPHPHTASE.
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8R4V2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNGMTKVLP GLYLGNFIDA KDPDQLGRNK ITHIISIHES PQPLLQDITY
60 70 80 90 100
LRISVSDTPE VPIKKHFKEC VHFIHSCRLN GGNCLVHCFA GISRSTTIVI
110 120 130 140 150
AYVMTVTGLG WQEVLEAIKA SRPIANPNPG FRQQLEEFGW ANSQKLRRQL
160 170 180 190 200
EERFGEIPFR DEEDLRALLP LCRRCRQGSA TSAASATTAS SAAEGTLQRL
210 220 230
VPRSPRDSHQ PLPLLARVKQ TFFCLPRCLS RKGGK
Length:235
Mass (Da):26,186
Last modified:September 2, 2008 - v3
Checksum:i09A3EB05A0A7F891
GO
Isoform 2 (identifier: Q8R4V2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     88-105: CFAGISRSTTIVIAYVMT → WPLKHECRARSLSLLQCS
     106-235: Missing.

Note: Inactive. Lacks the active site.

Show »
Length:105
Mass (Da):11,871
Checksum:iF6E95C0B36D45CA2
GO

Sequence cautioni

The sequence BU924460 differs from that shown. Reason: Frameshift at position 120. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei88 – 10518CFAGI…AYVMT → WPLKHECRARSLSLLQCS in isoform 2. 2 PublicationsVSP_007294Add
BLAST
Alternative sequencei106 – 235130Missing in isoform 2. 2 PublicationsVSP_007295Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF357887 mRNA. Translation: AAM00226.1.
AL833801 Genomic DNA. Translation: CAM23680.1.
BC116841 mRNA. Translation: AAI16842.1.
BC116843 mRNA. Translation: AAI16844.1.
BU924460 mRNA. No translation available.
CCDSiCCDS16902.1. [Q8R4V2-2]
CCDS50754.1. [Q8R4V2-1]
RefSeqiNP_001152848.1. NM_001159376.1. [Q8R4V2-1]
NP_665687.1. NM_145744.2. [Q8R4V2-2]
UniGeneiMm.330671.

Genome annotation databases

EnsembliENSMUST00000037715; ENSMUSP00000045815; ENSMUSG00000042662. [Q8R4V2-2]
ENSMUST00000123121; ENSMUSP00000123090; ENSMUSG00000042662. [Q8R4V2-1]
GeneIDi252864.
KEGGimmu:252864.
UCSCiuc008ngu.2. mouse. [Q8R4V2-2]
uc012cgl.1. mouse. [Q8R4V2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF357887 mRNA. Translation: AAM00226.1.
AL833801 Genomic DNA. Translation: CAM23680.1.
BC116841 mRNA. Translation: AAI16842.1.
BC116843 mRNA. Translation: AAI16844.1.
BU924460 mRNA. No translation available.
CCDSiCCDS16902.1. [Q8R4V2-2]
CCDS50754.1. [Q8R4V2-1]
RefSeqiNP_001152848.1. NM_001159376.1. [Q8R4V2-1]
NP_665687.1. NM_145744.2. [Q8R4V2-2]
UniGeneiMm.330671.

3D structure databases

ProteinModelPortaliQ8R4V2.
SMRiQ8R4V2. Positions 1-156.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ8R4V2.

Proteomic databases

MaxQBiQ8R4V2.
PaxDbiQ8R4V2.
PRIDEiQ8R4V2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037715; ENSMUSP00000045815; ENSMUSG00000042662. [Q8R4V2-2]
ENSMUST00000123121; ENSMUSP00000123090; ENSMUSG00000042662. [Q8R4V2-1]
GeneIDi252864.
KEGGimmu:252864.
UCSCiuc008ngu.2. mouse. [Q8R4V2-2]
uc012cgl.1. mouse. [Q8R4V2-1]

Organism-specific databases

CTDi128853.
MGIiMGI:1934928. Dusp15.

Phylogenomic databases

eggNOGiCOG2453.
GeneTreeiENSGT00760000118853.
HOGENOMiHOG000007880.
HOVERGENiHBG054344.
InParanoidiQ8R4V2.
KOiK14165.
OMAiCRQGSAT.
OrthoDBiEOG7966HM.
PhylomeDBiQ8R4V2.
TreeFamiTF105126.

Miscellaneous databases

NextBioi387351.
PROiQ8R4V2.
SOURCEiSearch...

Gene expression databases

BgeeiQ8R4V2.
CleanExiMM_DUSP15.
GenevestigatoriQ8R4V2.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR020417. Atypical_DUSP.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
PRINTSiPR01908. ADSPHPHTASE.
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A growing family of dual specificity phosphatases with low molecular masses."
    Aoki N., Aoyama K., Nagata M., Matsuda T.
    J. Biochem. 130:133-140(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  4. "Gene expression in the developing mouse retina by EST sequencing and microarray analysis."
    Mu X., Zhao S., Pershad R., Hsieh T.-F., Scarpa A., Wang S.W., White R.A., Beremand P.D., Thomas T.L., Gan L., Klein W.H.
    Nucleic Acids Res. 29:4983-4993(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-125 (ISOFORM 1).

Entry informationi

Entry nameiDUS15_MOUSE
AccessioniPrimary (citable) accession number: Q8R4V2
Secondary accession number(s): A2APC1, Q14AH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: September 2, 2008
Last modified: March 4, 2015
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.