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Q8R4V2 (DUS15_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dual specificity protein phosphatase 15

EC=3.1.3.16
EC=3.1.3.48
Alternative name(s):
Dual specificity protein phosphatase T-DSP10
Gene names
Name:Dusp15
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length235 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Tissue specificity

Isoform 2 is highly expressed in testis. Ref.1

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Contains 1 tyrosine-protein phosphatase domain.

Sequence caution

The sequence BU924460 differs from that shown. Reason: Frameshift at position 120.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8R4V2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8R4V2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     88-105: CFAGISRSTTIVIAYVMT → WPLKHECRARSLSLLQCS
     106-235: Missing.
Note: Inactive. Lacks the active site.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 235235Dual specificity protein phosphatase 15
PRO_0000094825

Regions

Domain65 – 13571Tyrosine-protein phosphatase

Sites

Active site881Phosphocysteine intermediate By similarity

Natural variations

Alternative sequence88 – 10518CFAGI…AYVMT → WPLKHECRARSLSLLQCS in isoform 2.
VSP_007294
Alternative sequence106 – 235130Missing in isoform 2.
VSP_007295

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified September 2, 2008. Version 3.
Checksum: 09A3EB05A0A7F891

FASTA23526,186
        10         20         30         40         50         60 
MGNGMTKVLP GLYLGNFIDA KDPDQLGRNK ITHIISIHES PQPLLQDITY LRISVSDTPE 

        70         80         90        100        110        120 
VPIKKHFKEC VHFIHSCRLN GGNCLVHCFA GISRSTTIVI AYVMTVTGLG WQEVLEAIKA 

       130        140        150        160        170        180 
SRPIANPNPG FRQQLEEFGW ANSQKLRRQL EERFGEIPFR DEEDLRALLP LCRRCRQGSA 

       190        200        210        220        230 
TSAASATTAS SAAEGTLQRL VPRSPRDSHQ PLPLLARVKQ TFFCLPRCLS RKGGK 

« Hide

Isoform 2 [UniParc].

Checksum: F6E95C0B36D45CA2
Show »

FASTA10511,871

References

« Hide 'large scale' references
[1]"A growing family of dual specificity phosphatases with low molecular masses."
Aoki N., Aoyama K., Nagata M., Matsuda T.
J. Biochem. 130:133-140(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[4]"Gene expression in the developing mouse retina by EST sequencing and microarray analysis."
Mu X., Zhao S., Pershad R., Hsieh T.-F., Scarpa A., Wang S.W., White R.A., Beremand P.D., Thomas T.L., Gan L., Klein W.H.
Nucleic Acids Res. 29:4983-4993(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-125 (ISOFORM 1).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF357887 mRNA. Translation: AAM00226.1.
AL833801 Genomic DNA. Translation: CAM23680.1.
BC116841 mRNA. Translation: AAI16842.1.
BC116843 mRNA. Translation: AAI16844.1.
BU924460 mRNA. No translation available.
CCDSCCDS16902.1. [Q8R4V2-2]
CCDS50754.1. [Q8R4V2-1]
RefSeqNP_001152848.1. NM_001159376.1. [Q8R4V2-1]
NP_665687.1. NM_145744.2. [Q8R4V2-2]
UniGeneMm.330671.

3D structure databases

ProteinModelPortalQ8R4V2.
SMRQ8R4V2. Positions 1-156.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8R4V2.

Proteomic databases

PaxDbQ8R4V2.
PRIDEQ8R4V2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000037715; ENSMUSP00000045815; ENSMUSG00000042662. [Q8R4V2-2]
ENSMUST00000123121; ENSMUSP00000123090; ENSMUSG00000042662. [Q8R4V2-1]
GeneID252864.
KEGGmmu:252864.
UCSCuc008ngu.2. mouse. [Q8R4V2-2]
uc012cgl.1. mouse. [Q8R4V2-1]

Organism-specific databases

CTD128853.
MGIMGI:1934928. Dusp15.

Phylogenomic databases

eggNOGCOG2453.
GeneTreeENSGT00730000110377.
HOGENOMHOG000007880.
HOVERGENHBG054344.
InParanoidQ8R4V2.
KOK14165.
OMACRQGSAT.
OrthoDBEOG7966HM.
PhylomeDBQ8R4V2.
TreeFamTF105126.

Gene expression databases

BgeeQ8R4V2.
CleanExMM_DUSP15.
GenevestigatorQ8R4V2.

Family and domain databases

Gene3D3.90.190.10. 1 hit.
InterProIPR020417. Atypical_DUSP.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERPTHR10159. PTHR10159. 1 hit.
PfamPF00782. DSPc. 1 hit.
[Graphical view]
PRINTSPR01908. ADSPHPHTASE.
SMARTSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMSSF52799. SSF52799. 1 hit.
PROSITEPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio387351.
PROQ8R4V2.
SOURCESearch...

Entry information

Entry nameDUS15_MOUSE
AccessionPrimary (citable) accession number: Q8R4V2
Secondary accession number(s): A2APC1, Q14AH2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: September 2, 2008
Last modified: July 9, 2014
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot