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Q8R4V2

- DUS15_MOUSE

UniProt

Q8R4V2 - DUS15_MOUSE

Protein

Dual specificity protein phosphatase 15

Gene

Dusp15

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 3 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei88 – 881Phosphocysteine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome
    2. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. positive regulation of JNK cascade Source: RefGenome
    2. protein dephosphorylation Source: RefGenome
    3. regulation of cell proliferation Source: RefGenome
    4. transforming growth factor beta receptor signaling pathway Source: RefGenome

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dual specificity protein phosphatase 15 (EC:3.1.3.16, EC:3.1.3.48)
    Alternative name(s):
    Dual specificity protein phosphatase T-DSP10
    Gene namesi
    Name:Dusp15
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1934928. Dusp15.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 235235Dual specificity protein phosphatase 15PRO_0000094825Add
    BLAST

    Proteomic databases

    PaxDbiQ8R4V2.
    PRIDEiQ8R4V2.

    PTM databases

    PhosphoSiteiQ8R4V2.

    Expressioni

    Tissue specificityi

    Isoform 2 is highly expressed in testis.1 Publication

    Gene expression databases

    BgeeiQ8R4V2.
    CleanExiMM_DUSP15.
    GenevestigatoriQ8R4V2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8R4V2.
    SMRiQ8R4V2. Positions 1-156.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini65 – 13571Tyrosine-protein phosphataseAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2453.
    GeneTreeiENSGT00730000110377.
    HOGENOMiHOG000007880.
    HOVERGENiHBG054344.
    InParanoidiQ8R4V2.
    KOiK14165.
    OMAiCRQGSAT.
    OrthoDBiEOG7966HM.
    PhylomeDBiQ8R4V2.
    TreeFamiTF105126.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR020417. Atypical_DUSP.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view]
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiPF00782. DSPc. 1 hit.
    [Graphical view]
    PRINTSiPR01908. ADSPHPHTASE.
    SMARTiSM00195. DSPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8R4V2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGNGMTKVLP GLYLGNFIDA KDPDQLGRNK ITHIISIHES PQPLLQDITY    50
    LRISVSDTPE VPIKKHFKEC VHFIHSCRLN GGNCLVHCFA GISRSTTIVI 100
    AYVMTVTGLG WQEVLEAIKA SRPIANPNPG FRQQLEEFGW ANSQKLRRQL 150
    EERFGEIPFR DEEDLRALLP LCRRCRQGSA TSAASATTAS SAAEGTLQRL 200
    VPRSPRDSHQ PLPLLARVKQ TFFCLPRCLS RKGGK 235
    Length:235
    Mass (Da):26,186
    Last modified:September 2, 2008 - v3
    Checksum:i09A3EB05A0A7F891
    GO
    Isoform 2 (identifier: Q8R4V2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         88-105: CFAGISRSTTIVIAYVMT → WPLKHECRARSLSLLQCS
         106-235: Missing.

    Note: Inactive. Lacks the active site.

    Show »
    Length:105
    Mass (Da):11,871
    Checksum:iF6E95C0B36D45CA2
    GO

    Sequence cautioni

    The sequence BU924460 differs from that shown. Reason: Frameshift at position 120.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei88 – 10518CFAGI…AYVMT → WPLKHECRARSLSLLQCS in isoform 2. 2 PublicationsVSP_007294Add
    BLAST
    Alternative sequencei106 – 235130Missing in isoform 2. 2 PublicationsVSP_007295Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF357887 mRNA. Translation: AAM00226.1.
    AL833801 Genomic DNA. Translation: CAM23680.1.
    BC116841 mRNA. Translation: AAI16842.1.
    BC116843 mRNA. Translation: AAI16844.1.
    BU924460 mRNA. No translation available.
    CCDSiCCDS16902.1. [Q8R4V2-2]
    CCDS50754.1. [Q8R4V2-1]
    RefSeqiNP_001152848.1. NM_001159376.1. [Q8R4V2-1]
    NP_665687.1. NM_145744.2. [Q8R4V2-2]
    UniGeneiMm.330671.

    Genome annotation databases

    EnsembliENSMUST00000037715; ENSMUSP00000045815; ENSMUSG00000042662. [Q8R4V2-2]
    ENSMUST00000123121; ENSMUSP00000123090; ENSMUSG00000042662. [Q8R4V2-1]
    GeneIDi252864.
    KEGGimmu:252864.
    UCSCiuc008ngu.2. mouse. [Q8R4V2-2]
    uc012cgl.1. mouse. [Q8R4V2-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF357887 mRNA. Translation: AAM00226.1 .
    AL833801 Genomic DNA. Translation: CAM23680.1 .
    BC116841 mRNA. Translation: AAI16842.1 .
    BC116843 mRNA. Translation: AAI16844.1 .
    BU924460 mRNA. No translation available.
    CCDSi CCDS16902.1. [Q8R4V2-2 ]
    CCDS50754.1. [Q8R4V2-1 ]
    RefSeqi NP_001152848.1. NM_001159376.1. [Q8R4V2-1 ]
    NP_665687.1. NM_145744.2. [Q8R4V2-2 ]
    UniGenei Mm.330671.

    3D structure databases

    ProteinModelPortali Q8R4V2.
    SMRi Q8R4V2. Positions 1-156.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8R4V2.

    Proteomic databases

    PaxDbi Q8R4V2.
    PRIDEi Q8R4V2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000037715 ; ENSMUSP00000045815 ; ENSMUSG00000042662 . [Q8R4V2-2 ]
    ENSMUST00000123121 ; ENSMUSP00000123090 ; ENSMUSG00000042662 . [Q8R4V2-1 ]
    GeneIDi 252864.
    KEGGi mmu:252864.
    UCSCi uc008ngu.2. mouse. [Q8R4V2-2 ]
    uc012cgl.1. mouse. [Q8R4V2-1 ]

    Organism-specific databases

    CTDi 128853.
    MGIi MGI:1934928. Dusp15.

    Phylogenomic databases

    eggNOGi COG2453.
    GeneTreei ENSGT00730000110377.
    HOGENOMi HOG000007880.
    HOVERGENi HBG054344.
    InParanoidi Q8R4V2.
    KOi K14165.
    OMAi CRQGSAT.
    OrthoDBi EOG7966HM.
    PhylomeDBi Q8R4V2.
    TreeFami TF105126.

    Miscellaneous databases

    NextBioi 387351.
    PROi Q8R4V2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8R4V2.
    CleanExi MM_DUSP15.
    Genevestigatori Q8R4V2.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR020417. Atypical_DUSP.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view ]
    PANTHERi PTHR10159. PTHR10159. 1 hit.
    Pfami PF00782. DSPc. 1 hit.
    [Graphical view ]
    PRINTSi PR01908. ADSPHPHTASE.
    SMARTi SM00195. DSPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A growing family of dual specificity phosphatases with low molecular masses."
      Aoki N., Aoyama K., Nagata M., Matsuda T.
      J. Biochem. 130:133-140(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    4. "Gene expression in the developing mouse retina by EST sequencing and microarray analysis."
      Mu X., Zhao S., Pershad R., Hsieh T.-F., Scarpa A., Wang S.W., White R.A., Beremand P.D., Thomas T.L., Gan L., Klein W.H.
      Nucleic Acids Res. 29:4983-4993(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-125 (ISOFORM 1).

    Entry informationi

    Entry nameiDUS15_MOUSE
    AccessioniPrimary (citable) accession number: Q8R4V2
    Secondary accession number(s): A2APC1, Q14AH2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 30, 2003
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 103 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3