Leucine zipper protein 1 - Mus musculus (Mouse)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Leucine zipper protein 1

Alternative name(s):
Leucine zipper motif-containing protein

Gene names

Name:	Luzp1
Synonyms:	Luzp

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1068 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Nucleus. Note: Also detected in soma and dendrites of neurons By similarity.
Tissue specificity	Predominantly expressed in the brain (at protein level). Ref.1

Ontologies

Keywords
Cellular component	Nucleus
Domain	Coiled coil
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	artery development Inferred from mutant phenotype PubMed 18801334. Source: MGI neural fold bending Inferred from mutant phenotype PubMed 18801334. Source: MGI ventricular septum development Inferred from mutant phenotype PubMed 18801334. Source: MGI
Cellular_component	nucleus Inferred from direct assay Ref.1. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

Removed By similarity

Chain

2 – 1068

1067

Leucine zipper protein 1

PRO_0000234551

Regions

Coiled coil

11 – 354

344

Potential

Amino acid modifications

Modified residue

2

1

N-acetylalanine By similarity

Modified residue

261

1

Phosphoserine Ref.6 Ref.7

Modified residue

395

1

Phosphoserine By similarity

Modified residue

571

1

Phosphoserine By similarity

Modified residue

575

1

Phosphoserine By similarity

Modified residue

612

1

Phosphoserine By similarity

Modified residue

660

1

Phosphoserine Ref.6 Ref.7 Ref.8 Ref.9

Modified residue

680

1

Phosphothreonine By similarity

Modified residue

691

1

Phosphoserine By similarity

Modified residue

746

1

Phosphoserine By similarity

Experimental info

Sequence conflict

371

1

R → S in AAM00269. Ref.2

Sequence conflict

499

1

S → N in AAA98795. Ref.1

Sequence conflict

594

1

N → D in AAA98795. Ref.1

Sequence conflict

906

1

S → SASSEV in AAA98795. Ref.1

Sequence conflict

906

1

S → SASSEV in AAH53451. Ref.4

Sequence conflict

925 – 930

6

Missing in AAA98795. Ref.1

Sequence conflict

925 – 930

6

Missing in AAH53451. Ref.4

Sequence conflict

935

1

G → R in AAA98795. Ref.1

Sequence conflict

935

1

G → R in AAM00269. Ref.2

Sequence conflict

935

1

G → R in AAH53451. Ref.4

Sequence conflict

950 – 951

2

PC → SP in AAA98795. Ref.1

Sequence conflict

950 – 951

2

PC → SP in AAH53451. Ref.4

Sequence conflict

956

1

E → R in AAM00269. Ref.2

Sequence conflict

958

1

E → R in AAM00269. Ref.2

Sequence conflict

963

1

Q → H in AAA98795. Ref.1

Sequence conflict

963

1

Q → H in AAM00269. Ref.2

Sequence conflict

963

1

Q → H in AAH53451. Ref.4

Sequence conflict

971

1

R → K in AAA98795. Ref.1

Sequence conflict

971

1

R → K in AAH53451. Ref.4

Sequence conflict

974

1

N → S in AAA98795. Ref.1

Sequence conflict

974

1

N → S in AAH53451. Ref.4

Sequence conflict

981

1

L → R in AAA98795. Ref.1

Sequence conflict

981

1

L → R in AAH53451. Ref.4

Sequence conflict

983

1

P → S in AAA98795. Ref.1

Sequence conflict

983

1

P → S in AAH53451. Ref.4

Sequence conflict

1011

1

C → W in AAA98795. Ref.1

Sequence conflict

1011

1

C → W in AAH53451. Ref.4

Sequences

Sequence

Length

Mass (Da)

Tools

Q8R4U7 [UniParc].

Last modified May 16, 2006. Version 2.
Checksum: 26D88114F44B788C
Show »

FASTA

1,068

119,311

        10         20         30         40         50         60 
MAELTNYKDA ASNRHLRFKL QSLSRRLDEL EEATKNLQRA EDELLDLQDK VIQAEGSDSS 

        70         80         90        100        110        120 
TLAEIEVLRQ RVLKIEGKDE EIKRAEDLCH TMKEKLEEEE NLTRELKSEI ERLQKRMVDL 

       130        140        150        160        170        180 
EKLEEALSRS KNECSQLCLS LNEERNLTKK ISSELEMLRV KVKELESSED RLDKTEQSLV 

       190        200        210        220        230        240 
SELEKLKSLT LSFVNERKYL NEKEKENEKI IKELTQKLEQ NKKMNRDHMR NASTFLERND 

       250        260        270        280        290        300 
LRIEDGISST LSSKESKRKG SLDYLKQVEN ETRDKSENEK NRNQEDNKVK DLNQEIEKLK 

       310        320        330        340        350        360 
TQIKHFESLE EELKKMRAKN NDLQDNYLTE LNRNRSLASQ LEEIKLQVRK QKELGNGDIE 

       370        380        390        400        410        420 
GEDAFLLGRG RHERTKLKGH GSEASVSKHT SRELSPQHKR ERLRNREFAL SNEHYSLSSK 

       430        440        450        460        470        480 
QASSPVFTNK RAAKASNMGM GTDSGTQETK RTEDRFAPGS SHSEGKRGRE QPSVLSRYPP 

       490        500        510        520        530        540 
AAQEHTKVWK GAPKPGTESG LKGKVEKTTR TFSDSTHVSV PNDIVGKGDK TSDLSSEAHC 

       550        560        570        580        590        600 
GKRGQVPGHA SQGTQAVESS CSKAIGALSS SQKASSEGLS KGKKTANGLA ADANFSNSKA 

       610        620        630        640        650        660 
PILSKYPYSS RSQENILQGF SLPNKEGVDQ PVAVVMEDSS QHEALRCRVI KSSGREKPDS 

       670        680        690        700        710        720 
DDDLDIESFV TAKLVNTTIT PEPEPKPQPN SREKVKSRGG TRTALFENDK NAAIENDSVK 

       730        740        750        760        770        780 
PTRPSSNAIE FPDANCAGVK NQRPFSPREA LRSRAIIKPV IIDKDVKKIM GGSGTEVVLE 

       790        800        810        820        830        840 
KQKSTSKSVT SKVTSSITIY PSDSSGPRAV PSEAPRERHT STSNIQVGPP ELTAISNHVS 

       850        860        870        880        890        900 
SPLELSIHKH DITLQLTEAE RVGDGSPKNR AEMVVSRSSI LIKPSESVEK NSHVPPAETI 

       910        920        930        940        950        960 
RWKSHSASSD SRHITVRNAW KSKRDLKCSE DPPTGIGRNM EATNAYTQRP CTDFLELEQP 

       970        980        990       1000       1010       1020 
RSQPSEQGAR RVGNSGDAPE LSPRRTQSSL TASEVLTRRD RMGGAITAAS CNHSSSMEEG 

      1030       1040       1050       1060 
EDSTFVTSRR IHNPLEHSEL PGKQGLPEPE PVWTEERLHP AKPYAEED

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification, molecular characterization, and chromosomal localization of the cDNA encoding a novel leucine zipper motif-containing protein." Sun D.-S., Chang A.C., Jenkins N.A., Gilbert D.J., Copeland N.G., Chang N.-C.A. Genomics 36:54-62(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Strain: 129/SvJ.
[2]	"Restricted expression of LUZP in neural lineage cells: a study in embryonic stem cells." Lee M.W.-Y., Chang A.C., Sun D.-S., Hsu C.-Y., Chang N.-C.A. J. Biomed. Sci. 8:504-511(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/SvJ. Tissue: Peritoneal exudate.
[3]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[4]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-318 AND 661-1068. Strain: C57BL/6J. Tissue: Corpora quadrigemina, Embryo and Vagina.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 522-1068. Tissue: Limb.
[6]	"Comprehensive identification of phosphorylation sites in postsynaptic density preparations." Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L. Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-261 AND SER-660, MASS SPECTROMETRY. Tissue: Brain.
[7]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-261 AND SER-660, MASS SPECTROMETRY. Tissue: Melanoma.
[8]	"The phagosomal proteome in interferon-gamma-activated macrophages." Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P. Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-660, MASS SPECTROMETRY. Tissue: Macrophage.
[9]	"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry." Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J. Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-660, MASS SPECTROMETRY. Tissue: Embryonic fibroblast.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L49344 mRNA. Translation: AAA98795.1. AF362727 Genomic DNA. Translation: AAM00269.1. AL671173 Genomic DNA. Translation: CAM46203.1. AK012514 mRNA. Translation: BAB28289.1. AK046323 mRNA. Translation: BAC32681.2. Sequence problems. AK137669 mRNA. Translation: BAE23455.1. BC053451 mRNA. Translation: AAH53451.1.
IPI	IPI00322204.
RefSeq	NP_077772.2. NM_024452.2.
UniGene	Mm.485824.
3D structure databases
ProteinModelPortal	Q8R4U7.
SMR	Q8R4U7. Positions 312-345.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-4119192.
PTM databases
PhosphoSite	Q8R4U7.
Proteomic databases
PaxDb	Q8R4U7.
PRIDE	Q8R4U7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000001116; ENSMUSP00000001116; ENSMUSG00000001089. ENSMUST00000063021; ENSMUSP00000060619; ENSMUSG00000001089. ENSMUST00000105849; ENSMUSP00000101475; ENSMUSG00000001089. ENSMUST00000170102; ENSMUSP00000130758; ENSMUSG00000001089.
GeneID	269593.
KEGG	mmu:269593.
UCSC	uc008vie.1. mouse.
Organism-specific databases
CTD	7798.
MGI	MGI:107629. Luzp1.
Phylogenomic databases
eggNOG	NOG10839.
GeneTree	ENSGT00680000099614.
HOVERGEN	HBG081939.
InParanoid	A3KG96.
OMA	VKKIMGG.
OrthoDB	EOG4XPQF7.
Gene expression databases
ArrayExpress	Q8R4U7.
Bgee	Q8R4U7.
CleanEx	MM_LUZP1.
Genevestigator	Q8R4U7.
GermOnline	ENSMUSG00000001089. Mus musculus.
Family and domain databases
InterPro	IPR026734. Luzp1. [Graphical view]
PANTHER	PTHR23166:SF1. PTHR23166:SF1. 1 hit.
ProtoNet	Search...
Other
NextBio	392911.
SOURCE	Search...

Entry information

Entry name

LUZP1_MOUSE

Accession

Primary (citable) accession number: Q8R4U7
Secondary accession number(s): A3KG96

Q9CSL6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	May 16, 2006
Last modified:	May 29, 2013
This is version 69 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents