##gff-version 3
Q8R4U2	UniProtKB	Signal peptide	1	19	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
Q8R4U2	UniProtKB	Chain	20	509	.	.	.	ID=PRO_0000034194;Note=Protein disulfide-isomerase	
Q8R4U2	UniProtKB	Domain	20	136	.	.	.	Note=Thioredoxin 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00691	
Q8R4U2	UniProtKB	Domain	335	477	.	.	.	Note=Thioredoxin 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00691	
Q8R4U2	UniProtKB	Region	473	509	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q8R4U2	UniProtKB	Motif	506	509	.	.	.	Note=Prevents secretion from ER;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10138	
Q8R4U2	UniProtKB	Compositional bias	478	509	.	.	.	Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q8R4U2	UniProtKB	Active site	55	55	.	.	.	Note=Nucleophile;Ontology_term=ECO:0000250;evidence=ECO:0000250	
Q8R4U2	UniProtKB	Active site	58	58	.	.	.	Note=Nucleophile;Ontology_term=ECO:0000250;evidence=ECO:0000250	
Q8R4U2	UniProtKB	Active site	399	399	.	.	.	Note=Nucleophile;Ontology_term=ECO:0000250;evidence=ECO:0000250	
Q8R4U2	UniProtKB	Active site	402	402	.	.	.	Note=Nucleophile;Ontology_term=ECO:0000250;evidence=ECO:0000250	
Q8R4U2	UniProtKB	Site	56	56	.	.	.	Note=Contributes to redox potential value;Ontology_term=ECO:0000250;evidence=ECO:0000250	
Q8R4U2	UniProtKB	Site	57	57	.	.	.	Note=Contributes to redox potential value;Ontology_term=ECO:0000250;evidence=ECO:0000250	
Q8R4U2	UniProtKB	Site	122	122	.	.	.	Note=Lowers pKa of C-terminal Cys of first active site;Ontology_term=ECO:0000250;evidence=ECO:0000250	
Q8R4U2	UniProtKB	Site	400	400	.	.	.	Note=Contributes to redox potential value;Ontology_term=ECO:0000250;evidence=ECO:0000250	
Q8R4U2	UniProtKB	Site	401	401	.	.	.	Note=Contributes to redox potential value;Ontology_term=ECO:0000250;evidence=ECO:0000250	
Q8R4U2	UniProtKB	Site	463	463	.	.	.	Note=Lowers pKa of C-terminal Cys of second active site;Ontology_term=ECO:0000250;evidence=ECO:0000250	
Q8R4U2	UniProtKB	Modified residue	202	202	.	.	.	Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09103	
Q8R4U2	UniProtKB	Modified residue	224	224	.	.	.	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09103	
Q8R4U2	UniProtKB	Modified residue	273	273	.	.	.	Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09103	
Q8R4U2	UniProtKB	Modified residue	333	333	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07237	
Q8R4U2	UniProtKB	Modified residue	359	359	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07237	
Q8R4U2	UniProtKB	Modified residue	429	429	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07237	
Q8R4U2	UniProtKB	Disulfide bond	55	58	.	.	.	Note=Redox-active;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00691	
Q8R4U2	UniProtKB	Disulfide bond	399	402	.	.	.	Note=Redox-active;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00691