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Q8R4T9

- UT2_MOUSE

UniProt

Q8R4T9 - UT2_MOUSE

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Protein
Urea transporter 2
Gene
Slc14a2, Ut2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism. Vasopressin regulates urea transport by increasing isoform A1 accumulation in the plasma membrane and/or phosphorylation of isoform A1 By similarity.

GO - Molecular functioni

  1. cell adhesion molecule binding Source: MGI
  2. urea transmembrane transporter activity Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_217615. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

Names & Taxonomyi

Protein namesi
Recommended name:
Urea transporter 2
Alternative name(s):
Solute carrier family 14 member 2
Urea transporter, kidney
Gene namesi
Name:Slc14a2
Synonyms:Ut2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:1351653. Slc14a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei145 – 16521Helical; Reviewed prediction
Add
BLAST
Transmembranei185 – 20521Helical; Reviewed prediction
Add
BLAST
Transmembranei213 – 23321Helical; Reviewed prediction
Add
BLAST
Transmembranei242 – 26221Helical; Reviewed prediction
Add
BLAST
Transmembranei280 – 30021Helical; Reviewed prediction
Add
BLAST
Transmembranei311 – 33121Helical; Reviewed prediction
Add
BLAST
Transmembranei350 – 37223Helical; Reviewed prediction
Add
BLAST
Transmembranei401 – 42121Helical; Reviewed prediction
Add
BLAST
Transmembranei610 – 63021Helical; Reviewed prediction
Add
BLAST
Transmembranei648 – 66821Helical; Reviewed prediction
Add
BLAST
Transmembranei676 – 69621Helical; Reviewed prediction
Add
BLAST
Transmembranei705 – 72521Helical; Reviewed prediction
Add
BLAST
Transmembranei774 – 79421Helical; Reviewed prediction
Add
BLAST
Transmembranei813 – 83321Helical; Reviewed prediction
Add
BLAST
Transmembranei842 – 86221Helical; Reviewed prediction
Add
BLAST
Transmembranei864 – 88421Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 930930Urea transporter 2
PRO_0000392531Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei487 – 4871Phosphoserine By similarity
Glycosylationi743 – 7431N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8R4T9.
PRIDEiQ8R4T9.

PTM databases

PhosphoSiteiQ8R4T9.

Expressioni

Tissue specificityi

Highly expressed in kidney medulla. Also detected at the protein level in testes, heart, brain and liver. In the kidney, present in thin descending limbs of the loop of Henle and in the middle and terminal inner medullary collecting ducts. Isoform A5 is expressed in the peritubular myoid cells forming the outermost layer of the seminiferous tubules within the testes and is not detected in kidney. Isoform A5 mRNA levels are coordinated with the stage of testes development and increase 15 days postpartum, commensurate with the start of seminiferous tubule fluid movement.2 Publications

Gene expression databases

BgeeiQ8R4T9.
GenevestigatoriQ8R4T9.

Interactioni

Subunit structurei

Isoform A1 interacts with SNAPIN which may be important for recruitment to the plasma membrane By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025434.

Structurei

3D structure databases

ProteinModelPortaliQ8R4T9.
SMRiQ8R4T9. Positions 106-450, 569-910.

Family & Domainsi

Sequence similaritiesi

Belongs to the urea transporter family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4413.
GeneTreeiENSGT00390000018729.
HOGENOMiHOG000168437.
HOVERGENiHBG073255.
InParanoidiQ8R4T9.
KOiK08716.
PhylomeDBiQ8R4T9.

Family and domain databases

Gene3Di1.10.3430.10. 2 hits.
InterProiIPR029020. Ammonium/urea_transptr.
IPR004937. Urea_transporter.
[Graphical view]
PANTHERiPTHR10464. PTHR10464. 1 hit.
PfamiPF03253. UT. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform A1 (identifier: Q8R4T9-1) [UniParc]FASTAAdd to Basket

Also known as: UTA-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSDHHPLKEM SDSNSSPLLP EPLSSRYKLY ESELSSPTWP SSSQDTHPAL    50
PLLEMPEEKD LRSSDEDSHI VKIEKPNERN KRRESEVSRR ASAGRGGFSL 100
FQAVSYLTGD MKECKNWLKD KPLVLQFLDW VLRGAAQVMF VNNPISGLII 150
FIGLLIQNPW WTIAGTLGTV ASTLAALALS QDRSAIASGL HGYNGMLVGL 200
LMAVFSEKLD YYWWLLFPVT FTSMACPIIS SALSTIFAKW DLPVFTLPFN 250
IALTLYLAAT GHYNLFFPTT LIKPASAAPN ITWTEIEMPL LLQTIPVGVG 300
QVYGCDNPWT GGVILVALFI SSPLICLHAA IGSIVGLLAA LTVATPFETI 350
YLGLWSYNCV LSCIAIGGMF YALTWQTHLL ALVCALFCAY MGAALSNTMA 400
VVGVPSGTWA FCLSTLTFLL LTSNNTGIYK LPLSKVTYPE ANRIYFLTVR 450
RSEEEKSPNG GSGEQSHGSG QWKAEESSET VLPRRRSVFH IEWSSIRRRS 500
KVFGKGEHQE RQTKEPLPCP YRKPTVELFD LDTMEESTEI KVEANTARTS 550
WIQSSMVAGG KRVSKALSYI TGEMKECGEG LKDKSPVFQF LDWVLRGMSQ 600
VMFVNNPLSG ILIVLGLFVQ NPWWAISGCL GTVMSTLTAL ILSQDKSAIA 650
AGLHGYNGVL VGLLMAVFSD KGNYYWWLLL PVIVMSMTCP ILSSALSTVF 700
SKWDLPVFTL PFNIAVTLYL AATGHHNLFF PTTLLQPATT TPNITWSDIQ 750
VSLLLRAIPV GIGQVYGCDN PWTGGIFLVA LFISSPLICL HAAIGSTIGM 800
LAALSIATPF DSIYFGLCGF NSTLACIAIG GMFYVITWQT HLLAIACALF 850
AAYLGAALAN MLSVFGLPPC TWPFCLSALT FLLLTSNNPA IYKLPLSKVT 900
YPEANRIYFL SQEKNRRAST ITKYQAYDVS 930
Length:930
Mass (Da):102,047
Last modified:March 23, 2010 - v2
Checksum:i298727BAFBE66D46
GO
Isoform A2 (identifier: Q8R4T9-2) [UniParc]FASTAAdd to Basket

Also known as: UTA-2

The sequence of this isoform differs from the canonical sequence as follows:
     1-533: Missing.

Show »
Length:397
Mass (Da):43,116
Checksum:i4E24BE4C44956F4B
GO
Isoform A3 (identifier: Q8R4T9-3) [UniParc]FASTAAdd to Basket

Also known as: UTA-3

The sequence of this isoform differs from the canonical sequence as follows:
     461-461: G → D
     462-930: Missing.

Show »
Length:461
Mass (Da):50,615
Checksum:i18B0F3A3B6B18030
GO
Isoform A5 (identifier: Q8R4T9-4) [UniParc]FASTAAdd to Basket

Also known as: UTA-5

The sequence of this isoform differs from the canonical sequence as follows:
     1-138: Missing.
     461-461: G → D
     462-930: Missing.

Note: Implicated in the urea movement across the blood-testis barrier. Does not translocate water. Expressed in testis, not expressed in kidney.

Show »
Length:323
Mass (Da):34,921
Checksum:i6B9774A12E42D609
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 533533Missing in isoform A2.
VSP_038810Add
BLAST
Alternative sequencei1 – 138138Missing in isoform A5.
VSP_038809Add
BLAST
Alternative sequencei461 – 4611G → D in isoform A3 and isoform A5.
VSP_038811
Alternative sequencei462 – 930469Missing in isoform A3 and isoform A5.
VSP_038812Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti313 – 3131V → M in AAG32167. 1 Publication
Sequence conflicti313 – 3131V → M in AAG32168. 1 Publication
Sequence conflicti313 – 3131V → M in AAM00357. 1 Publication
Sequence conflicti313 – 3131V → M in EDL09434. 1 Publication
Sequence conflicti538 – 5381T → A in AAI50681. 1 Publication
Sequence conflicti898 – 8981K → R in AAM00357. 1 Publication
Sequence conflicti898 – 8981K → R in AAM21206. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF258601 mRNA. Translation: AAG32167.1.
AF258602 mRNA. Translation: AAG32168.1.
AF366052 mRNA. Translation: AAM00357.1.
AF367359 mRNA. Translation: AAM21206.1.
CH466528 Genomic DNA. Translation: EDL09434.1.
BC150680 mRNA. Translation: AAI50681.1.
CCDSiCCDS29361.1. [Q8R4T9-1]
CCDS50331.1. [Q8R4T9-4]
RefSeqiNP_001103744.1. NM_001110274.1.
NP_109608.1. NM_030683.3.
UniGeneiMm.44158.

Genome annotation databases

EnsembliENSMUST00000163367; ENSMUSP00000126416; ENSMUSG00000024552.
GeneIDi27411.
KEGGimmu:27411.
UCSCiuc008fsh.2. mouse. [Q8R4T9-3]
uc012bfh.1. mouse. [Q8R4T9-4]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF258601 mRNA. Translation: AAG32167.1 .
AF258602 mRNA. Translation: AAG32168.1 .
AF366052 mRNA. Translation: AAM00357.1 .
AF367359 mRNA. Translation: AAM21206.1 .
CH466528 Genomic DNA. Translation: EDL09434.1 .
BC150680 mRNA. Translation: AAI50681.1 .
CCDSi CCDS29361.1. [Q8R4T9-1 ]
CCDS50331.1. [Q8R4T9-4 ]
RefSeqi NP_001103744.1. NM_001110274.1.
NP_109608.1. NM_030683.3.
UniGenei Mm.44158.

3D structure databases

ProteinModelPortali Q8R4T9.
SMRi Q8R4T9. Positions 106-450, 569-910.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000025434.

PTM databases

PhosphoSitei Q8R4T9.

Proteomic databases

PaxDbi Q8R4T9.
PRIDEi Q8R4T9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000163367 ; ENSMUSP00000126416 ; ENSMUSG00000024552 .
GeneIDi 27411.
KEGGi mmu:27411.
UCSCi uc008fsh.2. mouse. [Q8R4T9-3 ]
uc012bfh.1. mouse. [Q8R4T9-4 ]

Organism-specific databases

CTDi 8170.
MGIi MGI:1351653. Slc14a2.

Phylogenomic databases

eggNOGi COG4413.
GeneTreei ENSGT00390000018729.
HOGENOMi HOG000168437.
HOVERGENi HBG073255.
InParanoidi Q8R4T9.
KOi K08716.
PhylomeDBi Q8R4T9.

Enzyme and pathway databases

Reactomei REACT_217615. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

Miscellaneous databases

NextBioi 305432.
PROi Q8R4T9.
SOURCEi Search...

Gene expression databases

Bgeei Q8R4T9.
Genevestigatori Q8R4T9.

Family and domain databases

Gene3Di 1.10.3430.10. 2 hits.
InterProi IPR029020. Ammonium/urea_transptr.
IPR004937. Urea_transporter.
[Graphical view ]
PANTHERi PTHR10464. PTHR10464. 1 hit.
Pfami PF03253. UT. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of a novel UT-A urea transporter isoform (UT-A5) in testis."
    Fenton R.A., Howorth A., Cooper G.J., Meccariello R., Morris I.D., Smith C.P.
    Am. J. Physiol. 279:C1425-C1431(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A3 AND A5), TISSUE SPECIFICITY (ISOFORM A5).
    Strain: MF1.
    Tissue: Kidney inner medulla and Testis.
  2. "Structure and characterization of the mouse UT-A gene (Slc14a2)."
    Fenton R.A., Cottingham C.A., Stewart G.S., Howorth A., Hewitt J.A., Smith C.P.
    Am. J. Physiol. 282:F630-F638(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A1 AND A2).
    Strain: MF1.
    Tissue: Kidney inner medulla.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A2), TISSUE SPECIFICITY.
    Strain: MF1.
    Tissue: Kidney inner medulla.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A1).
    Tissue: Brain.

Entry informationi

Entry nameiUT2_MOUSE
AccessioniPrimary (citable) accession number: Q8R4T9
Secondary accession number(s): B2RWS5
, Q8K5D0, Q9ES04, Q9ES05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: March 23, 2010
Last modified: September 3, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi