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Q8R4T5

- GRASP_RAT

UniProt

Q8R4T5 - GRASP_RAT

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Protein
General receptor for phosphoinositides 1-associated scaffold protein
Gene
Grasp
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses.1 Publication

GO - Molecular functioni

  1. ADP-ribosylation factor binding Source: RGD
  2. PDZ domain binding Source: RGD
  3. identical protein binding Source: IntAct
  4. protein binding Source: IntAct

GO - Biological processi

  1. protein localization Source: RGD
  2. signal transduction Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
General receptor for phosphoinositides 1-associated scaffold protein
Short name:
GRP1-associated scaffold protein
Alternative name(s):
95 kDa postsynaptic density protein discs-large ZO-1 domain-containing protein
PSD-95 PDZ domain-containing protein
Tamalin
Gene namesi
Name:Grasp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi70554. Grasp.

Subcellular locationi

Cytoplasmperinuclear region. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junctionsynapsepostsynaptic cell membrane
Note: Localized at postsynaptic membranes.1 Publication

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. perinuclear region of cytoplasm Source: UniProtKB-SubCell
  3. plasma membrane Source: RGD
  4. postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 394394General receptor for phosphoinositides 1-associated scaffold protein
PRO_0000087586Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei236 – 2361Phosphotyrosine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8R4T5.
PRIDEiQ8R4T5.

PTM databases

PhosphoSiteiQ8R4T5.

Expressioni

Tissue specificityi

Expressed in brain.1 Publication

Gene expression databases

GenevestigatoriQ8R4T5.

Interactioni

Subunit structurei

Interacts with PSCD3 By similarity. Heteromer. Composed of GRASP, PSCD2 and at least one GRM1. Also interacts with GRM2, GRM3 and GRM5.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-7361884,EBI-7361884
Apba2O354314EBI-7361884,EBI-2028211
Dlg4P310163EBI-7361884,EBI-375655
Dlgap3P978383EBI-7361884,EBI-375673
Grm5P314245EBI-7361884,EBI-2902734
Magi2O883825EBI-7361884,EBI-696179

Protein-protein interaction databases

BioGridi251380. 14 interactions.
IntActiQ8R4T5. 16 interactions.
MINTiMINT-1790327.
STRINGi10116.ENSRNOP00000009979.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi98 – 1047
Beta strandi107 – 1093
Beta strandi112 – 1198
Beta strandi130 – 1378
Helixi142 – 1454
Beta strandi153 – 1575
Helixi167 – 17610
Turni177 – 1793
Beta strandi180 – 1867

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EGKX-ray2.85A/B/C/D96-394[»]
2EGNX-ray2.40A96-189[»]
2EGOX-ray1.80A/B96-189[»]
ProteinModelPortaliQ8R4T5.
SMRiQ8R4T5. Positions 97-191.

Miscellaneous databases

EvolutionaryTraceiQ8R4T5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini100 – 18990PDZ
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni180 – 25778Interaction with PSCD3 By similarity
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi294 – 32330Pro-rich
Add
BLAST

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.

Phylogenomic databases

eggNOGiNOG244814.
GeneTreeiENSGT00530000063734.
HOGENOMiHOG000231871.
HOVERGENiHBG053061.
InParanoidiQ8R4T5.
OMAiEGFRHKE.
OrthoDBiEOG72NRQP.
PhylomeDBiQ8R4T5.
TreeFamiTF316315.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
[Graphical view]
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R4T5-1 [UniParc]FASTAAdd to Basket

« Hide

MTLRRLRKLQ QKEEATAAPD LAGRAPDSEA ARAAPTPSGP PAAAAPPGAP    50
GDELYAALED YHPAELYRAL AVSGGTLPRR KGSGFRWKNF TQSPEQQRKV 100
LTLEKGDNQT FGFEIQTYGL HHREEQRVEM VTFVCRVHES SPAQLAGLTP 150
GDTIASVNGL NVEGIRHREI VDIIKASGNV LRLETLYGTS IRKAELEARL 200
QYLKQTLYEK WGEYRSLMVQ EQRLVHGLVV KDPSIYDTLE SVRSCLYGAG 250
LLPGSLPFGP LLAAPGGARG GSRRAKGDTD DAVYHTCFFG GAEPQALPPP 300
PPPARAPGPG SAETPASVLC PAPRATLSRS ASVRCAGPGG GGGGGAPGAL 350
WTEAREQALC GAGLRKTKYR SFRRRLLKFI PGLNRSLEEE ESQL 394
Length:394
Mass (Da):42,321
Last modified:June 1, 2002 - v1
Checksum:i520D0AD23CB2B70D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF374272 mRNA. Translation: AAL87038.1.
RefSeqiNP_620249.1. NM_138894.1.
UniGeneiRn.229849.

Genome annotation databases

EnsembliENSRNOT00000009979; ENSRNOP00000009979; ENSRNOG00000007346.
GeneIDi192254.
KEGGirno:192254.
UCSCiRGD:70554. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF374272 mRNA. Translation: AAL87038.1 .
RefSeqi NP_620249.1. NM_138894.1.
UniGenei Rn.229849.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2EGK X-ray 2.85 A/B/C/D 96-394 [» ]
2EGN X-ray 2.40 A 96-189 [» ]
2EGO X-ray 1.80 A/B 96-189 [» ]
ProteinModelPortali Q8R4T5.
SMRi Q8R4T5. Positions 97-191.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 251380. 14 interactions.
IntActi Q8R4T5. 16 interactions.
MINTi MINT-1790327.
STRINGi 10116.ENSRNOP00000009979.

PTM databases

PhosphoSitei Q8R4T5.

Proteomic databases

PaxDbi Q8R4T5.
PRIDEi Q8R4T5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000009979 ; ENSRNOP00000009979 ; ENSRNOG00000007346 .
GeneIDi 192254.
KEGGi rno:192254.
UCSCi RGD:70554. rat.

Organism-specific databases

CTDi 160622.
RGDi 70554. Grasp.

Phylogenomic databases

eggNOGi NOG244814.
GeneTreei ENSGT00530000063734.
HOGENOMi HOG000231871.
HOVERGENi HBG053061.
InParanoidi Q8R4T5.
OMAi EGFRHKE.
OrthoDBi EOG72NRQP.
PhylomeDBi Q8R4T5.
TreeFami TF316315.

Miscellaneous databases

EvolutionaryTracei Q8R4T5.
NextBioi 622908.
PROi Q8R4T5.

Gene expression databases

Genevestigatori Q8R4T5.

Family and domain databases

Gene3Di 2.30.42.10. 1 hit.
InterProi IPR001478. PDZ.
[Graphical view ]
Pfami PF00595. PDZ. 1 hit.
[Graphical view ]
SMARTi SM00228. PDZ. 1 hit.
[Graphical view ]
SUPFAMi SSF50156. SSF50156. 1 hit.
PROSITEi PS50106. PDZ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins."
    Kitano J., Kimura K., Yamazaki Y., Soda T., Shigemoto R., Nakajima Y., Nakanishi S.
    J. Neurosci. 22:1280-1289(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH GRM1; GRM2; GRM3; GRM5 AND PSCD2, SUBCELLULAR LOCATION, FUNCTION.
    Tissue: Brain.

Entry informationi

Entry nameiGRASP_RAT
AccessioniPrimary (citable) accession number: Q8R4T5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: June 1, 2002
Last modified: June 11, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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