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Protein

Cytokine receptor-like factor 2

Gene

Crlf2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5 (By similarity). Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system.By similarity1 Publication

GO - Molecular functioni

  • cytokine activity Source: RGD
  • protein heterodimerization activity Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Cytokine receptor-like factor 2
Alternative name(s):
Thymic stromal lymphopoietin protein receptor
Short name:
TSLP receptor
Gene namesi
Name:Crlf2
Synonyms:Tslpr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621078. Crlf2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 238ExtracellularSequence analysisAdd BLAST212
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Topological domaini260 – 360CytoplasmicSequence analysisAdd BLAST101

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001104319 – 360Cytokine receptor-like factor 2Add BLAST342

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi62N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi77 ↔ 90By similarity
Glycosylationi129N-linked (GlcNAc...)Sequence analysis1
Glycosylationi174N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi185 ↔ 223By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8R4S8.
PRIDEiQ8R4S8.

Expressioni

Tissue specificityi

Expressed in all tissues examined including brain, thymus, lung, heart, muscle, stomach, small intestine, liver, kidney, spleen, testis and skin. Highest levels in thymus, liver and testis.1 Publication

Interactioni

Subunit structurei

Heterodimer of CRLF2 and IL7R.

GO - Molecular functioni

  • cytokine activity Source: RGD
  • protein heterodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066370.

Structurei

3D structure databases

ProteinModelPortaliQ8R4S8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini123 – 214Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST92

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi205 – 209WSXWS motif5
Motifi268 – 276Box 1 motif9

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKHC. Eukaryota.
ENOG41116BS. LUCA.
HOVERGENiHBG051120.
InParanoidiQ8R4S8.
PhylomeDBiQ8R4S8.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R4S8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAVTWAIVA MLLPRVLGAI PTRTPRTGGV GDTLSVAIVC HDLESVEVTW
60 70 80 90 100
GPGSAHHGLS ANLSLEFRYG NQVPQPCPHY FLLDSVRAGC VLPMGKGLLE
110 120 130 140 150
VVLREGGGAK LFSRKKKASA WLRPRPPWNV TLSWVGDTVA VSCPSHSYPG
160 170 180 190 200
LEYEVQHRDD FDPEWQSTSA PFCNLTVGGL DPGRCYDFRV RATPQDFYYG
210 220 230 240 250
PEARPSKWTG VASLQGVGPT GSCTGPTLPR TPGTPTPPLA LACGLAVALL
260 270 280 290 300
TLVLLLALLR MRRVKEALLP GVPDPRGSFP GLFEKHHGNF QAWIADSQAA
310 320 330 340 350
VPTVPEQDKD DDVIRPQTKG VETQEDDDVI APGSPCLGGG ALMSVGGASF
360
LMGDSGYTTL
Length:360
Mass (Da):38,445
Last modified:June 1, 2002 - v1
Checksum:i767B1CE489768870
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF404510 mRNA. Translation: AAL90454.1.
UniGeneiRn.177948.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF404510 mRNA. Translation: AAL90454.1.
UniGeneiRn.177948.

3D structure databases

ProteinModelPortaliQ8R4S8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066370.

Proteomic databases

PaxDbiQ8R4S8.
PRIDEiQ8R4S8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi621078. Crlf2.

Phylogenomic databases

eggNOGiENOG410IKHC. Eukaryota.
ENOG41116BS. LUCA.
HOVERGENiHBG051120.
InParanoidiQ8R4S8.
PhylomeDBiQ8R4S8.

Miscellaneous databases

PROiQ8R4S8.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRLF2_RAT
AccessioniPrimary (citable) accession number: Q8R4S8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: June 1, 2002
Last modified: November 30, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.