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Protein

Cytokine receptor-like factor 2

Gene

Crlf2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5 (By similarity). Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system.By similarity1 Publication

GO - Molecular functioni

  • cytokine activity Source: RGD
  • protein heterodimerization activity Source: RGD

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
Cytokine receptor-like factor 2
Alternative name(s):
Thymic stromal lymphopoietin protein receptor
Short name:
TSLP receptor
Gene namesi
Name:Crlf2
Synonyms:Tslpr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621078 Crlf2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 238ExtracellularSequence analysisAdd BLAST212
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Topological domaini260 – 360CytoplasmicSequence analysisAdd BLAST101

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001104319 – 360Cytokine receptor-like factor 2Add BLAST342

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi77 ↔ 90By similarity
Glycosylationi129N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi174N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi185 ↔ 223By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8R4S8
PRIDEiQ8R4S8

Expressioni

Tissue specificityi

Expressed in all tissues examined including brain, thymus, lung, heart, muscle, stomach, small intestine, liver, kidney, spleen, testis and skin. Highest levels in thymus, liver and testis.1 Publication

Interactioni

Subunit structurei

Heterodimer of CRLF2 and IL7R.

GO - Molecular functioni

  • cytokine activity Source: RGD
  • protein heterodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066370

Structurei

3D structure databases

ProteinModelPortaliQ8R4S8
SMRiQ8R4S8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini123 – 214Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST92

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi205 – 209WSXWS motif5
Motifi268 – 276Box 1 motif9

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKHC Eukaryota
ENOG41116BS LUCA
HOVERGENiHBG051120
InParanoidiQ8R4S8
PhylomeDBiQ8R4S8

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
SMARTiView protein in SMART
SM00060 FN3, 1 hit
SUPFAMiSSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R4S8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAVTWAIVA MLLPRVLGAI PTRTPRTGGV GDTLSVAIVC HDLESVEVTW
60 70 80 90 100
GPGSAHHGLS ANLSLEFRYG NQVPQPCPHY FLLDSVRAGC VLPMGKGLLE
110 120 130 140 150
VVLREGGGAK LFSRKKKASA WLRPRPPWNV TLSWVGDTVA VSCPSHSYPG
160 170 180 190 200
LEYEVQHRDD FDPEWQSTSA PFCNLTVGGL DPGRCYDFRV RATPQDFYYG
210 220 230 240 250
PEARPSKWTG VASLQGVGPT GSCTGPTLPR TPGTPTPPLA LACGLAVALL
260 270 280 290 300
TLVLLLALLR MRRVKEALLP GVPDPRGSFP GLFEKHHGNF QAWIADSQAA
310 320 330 340 350
VPTVPEQDKD DDVIRPQTKG VETQEDDDVI APGSPCLGGG ALMSVGGASF
360
LMGDSGYTTL
Length:360
Mass (Da):38,445
Last modified:June 1, 2002 - v1
Checksum:i767B1CE489768870
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF404510 mRNA Translation: AAL90454.1
UniGeneiRn.177948

Similar proteinsi

Entry informationi

Entry nameiCRLF2_RAT
AccessioniPrimary (citable) accession number: Q8R4S8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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