Reviewed, UniProtKB/Swiss-Prot Q8R4S5 (AHR_MUSMM)

Names and origin

Protein names

Recommended name:
    Aryl hydrocarbon receptor
      Short name=Ah receptor
      Short name=AhR

Gene names

Name:

Ahr

Organism

Mus musculus molossinus (Japanese house mouse)

Taxonomic identifier

57486 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	883 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues By similarity. UniProtKB P30561
Subunit structure	Efficient DNA binding requires dimerization with another bHLH protein. In the nucleus, heterodimer of AHR and ARNT. Interacts with coactivators including SRC-1, RIP140 and NOCA7, and with the corepressor SMRT. Interacts with MYBBP1A and NEDD8 and IVNS1ABP By similarity. UniProtKB P30561
Subcellular location	Cytoplasm By similarity. Nucleus By similarity. Note: First cytoplasmic, upon binding with ligand and interaction with a HSP90, it translocates to the nucleus By similarity.
Sequence similarities	Contains 1 basic helix-loop-helix (bHLH) domain. Contains 1 PAC (PAS-associated C-terminal) domain. Contains 2 PAS (PER-ARNT-SIM) domains.

Ontologies

Keywords
Biological process	Cell cycle Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Domain	Repeat
Ligand	DNA-binding
Molecular function	Activator Receptor
Gene Ontology (GO)
Biological process	apoptosis Inferred from sequence or structural similarity. Source: UniProtKB cell cycle Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of transcriptional preinitiation complex assembly Inferred from direct assay. Source: MGI response to stress Inferred from sequence or structural similarity. Source: UniProtKB signal transduction Inferred from electronic annotation. Source: InterPro transcription from RNA polymerase II promoter Inferred from sequence or structural similarity. Source: UniProtKB xenobiotic metabolic process Traceable author statement. Source: MGI
Cellular component	cytoplasm Inferred from direct assay. Source: MGI transcription factor complex Traceable author statement. Source: MGI
Molecular function	ligand-dependent nuclear receptor activity Inferred from sequence or structural similarity. Source: UniProtKB transcription factor activity Inferred from direct assay. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Propeptide	1 – 9	9	By similarity UniProtKB P30561		PRO_0000013458
	Chain	10 – 883	874	Aryl hydrocarbon receptor UniProtKB P30561		PRO_0000013459
Regions
	Domain	36 – 80	45	Helix-loop-helix motif
	Domain	111 – 175	65	PAS 1
	Domain	266 – 336	71	PAS 2
	Domain	342 – 383	42	PAC
	DNA binding	12 – 39	28	Basic motif UniProtKB P30561
	Compositional bias	594 – 640	47	Gln-rich

Sequences

	Sequence		Length	Mass (Da)
	Q8R4S5-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: FD038E6CF1173D1F	FASTA	883	99,039
	10 20 30 40 50 60 MSSGANITYA SRKRRKPVQK TVKPIPAEGI KSNPSKRHRD RLNTELDRLA SLLPFPQDVI 70 80 90 100 110 120 NKLDKLSVLR LSVSYLRAKS FFDVALKSTP ADRNGGQDQC RAQIRDWQDL QEGEFLLQAL 130 140 150 160 170 180 NGFVLVVTAD ALVFYASSTI QDYLGFQQSD VIHQSVYELI HTEDRAEFQR QLHWALNPDS 190 200 210 220 230 240 AQGVDEAHGP PQAAVYYTPD QLPPENASFM ERCFRCRLRC LLDNSSGFLA MNFQGRLKYL 250 260 270 280 290 300 HGQNKKGKDG ALLPPQLALF AIATPLQPPS ILEIRTKNFI FRTKHKLDFT PIGCDAKGQL 310 320 330 340 350 360 ILGYTEVELC TRGSGYQFIH AADMLHCAES HIRMIKTGES GMTVFRLLAK HSRWRWVQSN 370 380 390 400 410 420 ARLIYRNGRP DYIIATQRPL TDEEGREHLQ KRSTSLPFMF ATGEAVLYEI SSPFSPIMDP 430 440 450 460 470 480 LPIRTKSNTS RKDWAPQSTP SKDSFHPSSL MSALIQQDES IYLCPPSSPA PLDSHFLMGS 490 500 510 520 530 540 VSKCGSWQDS FAAAGSEAAL KHEQIGHAQD VNLALSGGPS ELFPDNKNND LYNIMRNLGI 550 560 570 580 590 600 DFEDIRSMQN EEFFRTDSTA AGEVDFKDID ITDEILTYVQ DSLNNSTLMN SACQQQPVTQ 610 620 630 640 650 660 HLSCMLQERL QLEQQQQLQQ PPPQALEPQQ QLCQMVCPQQ DLGPKHTQIN GTFASWNPTP 670 680 690 700 710 720 PVSFNCPQQE LKHYQLFSSL QGTAQEFPYK PEVDSVPYTQ NFAPCNQPLL PEHSKSVQLD 730 740 750 760 770 780 FPGRDFEPSL HPTTSNLDFV SCLQVPENQS HGINSQSAMV SPQAYYAGAM SMYQCQPGPQ 790 800 810 820 830 840 RTPVDQTQYS SEIPGSQAFL SKVQSRGVFN ETYSSDLSSI DHAVQTTGHL HHLAEARPLP 850 860 870 880 DISHLVGSCS SHARMKFIQE QDTGTVRVGH QYTFSKTDFD SCI

References

[1]	"Sequence variation and phylogenetic history of the mouse Ahr gene." Thomas R.S., Penn S.G., Holden K., Bradfield C.A., Rank D.R. Pharmacogenetics 12:151-163(2002) [PubMed: 11875369] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: MOLF/Ei.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF405568 mRNA. Translation: AAL89733.1.
UniGene	Mm.341377
3D structure databases
ModBase	Search...
Organism-specific databases
MGI	MGI:105043. Ahr.
Phylogenomic databases
HOVERGEN	Q8R4S5.
Family and domain databases
InterPro	IPR001092. HLH_basic. IPR001610. PAC. IPR000014. PAS. IPR013767. PAS_fold. IPR013655. PAS_fold_3. [Graphical view]
Pfam	PF00010. HLH. 1 hit. PF00989. PAS. 1 hit. PF08447. PAS_3. 1 hit. [Graphical view]
SMART	SM00353. HLH. 1 hit. SM00086. PAC. 1 hit. SM00091. PAS. 2 hits. [Graphical view]
PROSITE	PS50888. HLH. 1 hit. PS50113. PAC. False negative. PS50112. PAS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AHR_MUSMM

Accession

Primary (citable) accession number: Q8R4S5

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2003
Last sequence update:	June 1, 2002
Last modified:	June 16, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)