ID PP14C_RAT Reviewed; 164 AA. AC Q8R4R9; DT 09-NOV-2004, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2002, sequence version 1. DT 24-JAN-2024, entry version 124. DE RecName: Full=Protein phosphatase 1 regulatory subunit 14C; DE AltName: Full=Kinase-enhanced PP1 inhibitor; DE AltName: Full=PKC-potentiated PP1 inhibitory protein; GN Name=Ppp1r14c; Synonyms=Kepi; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=Sprague-Dawley; TISSUE=Brain; RX PubMed=11812771; DOI=10.1074/jbc.m107558200; RA Liu Q.-R., Zhang P.-W., Zhen Q., Walther D., Wang X.-B., Uhl G.; RT "KEPI, a PKC-dependent protein phosphatase 1 inhibitor regulated by RT morphine."; RL J. Biol. Chem. 277:13312-13320(2002). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Heart; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [3] RP PROTEIN SEQUENCE OF 35-44, AND IDENTIFICATION BY MASS SPECTROMETRY. RC STRAIN=Sprague-Dawley; TISSUE=Brain; RA Lubec G., Kang S.U., Lubec S.; RL Submitted (SEP-2007) to UniProtKB. RN [4] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=22673903; DOI=10.1038/ncomms1871; RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., RA Olsen J.V.; RT "Quantitative maps of protein phosphorylation sites across 14 different rat RT organs and tissues."; RL Nat. Commun. 3:876-876(2012). CC -!- FUNCTION: Inhibitor of the PP1 regulatory subunit PPP1CA. CC -!- SUBCELLULAR LOCATION: Endomembrane system {ECO:0000250}; Peripheral CC membrane protein {ECO:0000250}. CC -!- PTM: Has over 600-fold higher inhibitory activity when phosphorylated, CC creating a molecular switch for regulating the phosphorylation status CC of PPP1CA substrates and smooth muscle contraction. The main inhibitory CC site appears to be Thr-72 (By similarity). {ECO:0000250}. CC -!- SIMILARITY: Belongs to the PP1 inhibitor family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF407168; AAL83509.1; -; mRNA. DR EMBL; BC086978; AAH86978.1; -; mRNA. DR RefSeq; NP_596916.1; NM_133425.3. DR AlphaFoldDB; Q8R4R9; -. DR STRING; 10116.ENSRNOP00000022046; -. DR iPTMnet; Q8R4R9; -. DR PhosphoSitePlus; Q8R4R9; -. DR jPOST; Q8R4R9; -. DR PaxDb; 10116-ENSRNOP00000022046; -. DR Ensembl; ENSRNOT00000022046.4; ENSRNOP00000022046.2; ENSRNOG00000016368.5. DR Ensembl; ENSRNOT00055036627; ENSRNOP00055029756; ENSRNOG00055021424. DR Ensembl; ENSRNOT00060000794; ENSRNOP00060000182; ENSRNOG00060000699. DR Ensembl; ENSRNOT00065003467; ENSRNOP00065002399; ENSRNOG00065002604. DR GeneID; 171010; -. DR KEGG; rno:171010; -. DR UCSC; RGD:620538; rat. DR AGR; RGD:620538; -. DR CTD; 81706; -. DR RGD; 620538; Ppp1r14c. DR eggNOG; ENOG502RYQF; Eukaryota. DR GeneTree; ENSGT00950000182985; -. DR HOGENOM; CLU_114155_1_0_1; -. DR InParanoid; Q8R4R9; -. DR OrthoDB; 5321897at2759; -. DR PhylomeDB; Q8R4R9; -. DR TreeFam; TF105546; -. DR PRO; PR:Q8R4R9; -. DR Proteomes; UP000002494; Chromosome 1. DR Bgee; ENSRNOG00000016368; Expressed in heart and 16 other cell types or tissues. DR GO; GO:0005737; C:cytoplasm; IEA:InterPro. DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell. DR GO; GO:0016020; C:membrane; IDA:MGI. DR GO; GO:0004865; F:protein serine/threonine phosphatase inhibitor activity; IDA:RGD. DR GO; GO:0042325; P:regulation of phosphorylation; IEA:InterPro. DR Gene3D; 1.10.150.220; CPI-17; 1. DR InterPro; IPR008025; CPI-17. DR InterPro; IPR036658; CPI-17_sf. DR PANTHER; PTHR16188; PROTEIN PHOSPHATASE 1 INHIBITOR POTENTIATED BY PROTEIN KINASE C; 1. DR PANTHER; PTHR16188:SF6; PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 14C; 1. DR Pfam; PF05361; PP1_inhibitor; 1. DR SUPFAM; SSF81790; Myosin phosphatase inhibitor 17kDa protein, CPI-17; 1. DR Genevisible; Q8R4R9; RN. PE 1: Evidence at protein level; KW Acetylation; Direct protein sequencing; Membrane; Methylation; KW Phosphoprotein; Protein phosphatase inhibitor; Reference proteome. FT INIT_MET 1 FT /note="Removed" FT /evidence="ECO:0000250|UniProtKB:Q8TAE6" FT CHAIN 2..164 FT /note="Protein phosphatase 1 regulatory subunit 14C" FT /id="PRO_0000071496" FT REGION 1..72 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 29..47 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 54..68 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 2 FT /note="N-acetylserine" FT /evidence="ECO:0000250|UniProtKB:Q8TAE6" FT MOD_RES 25 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:22673903" FT MOD_RES 27 FT /note="Omega-N-methylarginine" FT /evidence="ECO:0000250|UniProtKB:Q8R4S0" FT MOD_RES 33 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:Q8TAE6" FT MOD_RES 72 FT /note="Phosphothreonine; by ILK1" FT /evidence="ECO:0000250|UniProtKB:Q8TAE6" SQ SEQUENCE 164 AA; 17980 MW; 2E48BCB85446A4DE CRC64; MSVVTGGGEA AGGTSGGGAR VFFQSPRGGT GGSRESSSHS GSSREDSAPV ATVAAAGQVQ QQQRRHQQGK VTVKYDRKEL RKRLVLEEWI VEQLGQLYGC EEEEMPDVEI DIDDLLDADS EEERASKLQE ALVDCYKPTE EFIRELLSRI RGMRKLSPPQ KKSV //