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Protein

Protein phosphatase 1 regulatory subunit 14C

Gene

Ppp1r14c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitor of the PP1 regulatory subunit PPP1CA.

GO - Molecular functioni

  • protein serine/threonine phosphatase inhibitor activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionProtein phosphatase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 14C
Alternative name(s):
Kinase-enhanced PP1 inhibitor
PKC-potentiated PP1 inhibitory protein
Gene namesi
Name:Ppp1r14c
Synonyms:Kepi
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi620538. Ppp1r14c.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: InterPro
  • endomembrane system Source: UniProtKB-SubCell
  • membrane Source: MGI

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000714962 – 164Protein phosphatase 1 regulatory subunit 14CAdd BLAST163

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei25PhosphoserineCombined sources1
Modified residuei27Omega-N-methylarginineBy similarity1
Modified residuei33PhosphoserineBy similarity1
Modified residuei72Phosphothreonine; by ILK1By similarity1

Post-translational modificationi

Has over 600-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. The main inhibitory site appears to be Thr-72 (By similarity).By similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ8R4R9.
PRIDEiQ8R4R9.

PTM databases

iPTMnetiQ8R4R9.
PhosphoSitePlusiQ8R4R9.

Expressioni

Gene expression databases

BgeeiENSRNOG00000016368.
GenevisibleiQ8R4R9. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022046.

Structurei

3D structure databases

ProteinModelPortaliQ8R4R9.
SMRiQ8R4R9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi58 – 63Poly-Gln6
Compositional biasi101 – 104Poly-Glu4

Sequence similaritiesi

Belongs to the PP1 inhibitor family.Curated

Phylogenomic databases

eggNOGiENOG410IYUT. Eukaryota.
ENOG4112B8C. LUCA.
GeneTreeiENSGT00390000003608.
HOGENOMiHOG000231993.
HOVERGENiHBG054419.
InParanoidiQ8R4R9.
KOiK17556.
OMAiDCHKPTE.
OrthoDBiEOG091G122D.
PhylomeDBiQ8R4R9.
TreeFamiTF105546.

Family and domain databases

Gene3Di1.10.150.220. 1 hit.
InterProiView protein in InterPro
IPR008025. PP1_inhibitor.
PANTHERiPTHR16188. PTHR16188. 1 hit.
PfamiView protein in Pfam
PF05361. PP1_inhibitor. 1 hit.
SUPFAMiSSF81790. SSF81790. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R4R9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVVTGGGEA AGGTSGGGAR VFFQSPRGGT GGSRESSSHS GSSREDSAPV
60 70 80 90 100
ATVAAAGQVQ QQQRRHQQGK VTVKYDRKEL RKRLVLEEWI VEQLGQLYGC
110 120 130 140 150
EEEEMPDVEI DIDDLLDADS EEERASKLQE ALVDCYKPTE EFIRELLSRI
160
RGMRKLSPPQ KKSV
Length:164
Mass (Da):17,980
Last modified:June 1, 2002 - v1
Checksum:i2E48BCB85446A4DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF407168 mRNA. Translation: AAL83509.1.
BC086978 mRNA. Translation: AAH86978.1.
RefSeqiNP_596916.1. NM_133425.3.
UniGeneiRn.87667.

Genome annotation databases

EnsembliENSRNOT00000022046; ENSRNOP00000022046; ENSRNOG00000016368.
GeneIDi171010.
KEGGirno:171010.
UCSCiRGD:620538. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPP14C_RAT
AccessioniPrimary (citable) accession number: Q8R4R9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: June 1, 2002
Last modified: June 7, 2017
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families