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Q8R4R9 (PP14C_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein phosphatase 1 regulatory subunit 14C
Alternative name(s):
Kinase-enhanced PP1 inhibitor
PKC-potentiated PP1 inhibitory protein
Gene names
Name:Ppp1r14c
Synonyms:Kepi
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length164 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Inhibitor of the PP1 regulatory subunit PPP1CA.

Subcellular location

Endomembrane system; Peripheral membrane protein By similarity.

Post-translational modification

Has over 600-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. The main inhibitory site appears to be Thr-72 By similarity.

Sequence similarities

Belongs to the PP1 inhibitor family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 164163Protein phosphatase 1 regulatory subunit 14C
PRO_0000071496

Regions

Compositional bias58 – 636Poly-Gln
Compositional bias101 – 1044Poly-Glu

Amino acid modifications

Modified residue21N-acetylserine By similarity
Modified residue721Phosphothreonine; by ILK1 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8R4R9 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 2E48BCB85446A4DE

FASTA16417,980
        10         20         30         40         50         60 
MSVVTGGGEA AGGTSGGGAR VFFQSPRGGT GGSRESSSHS GSSREDSAPV ATVAAAGQVQ 

        70         80         90        100        110        120 
QQQRRHQQGK VTVKYDRKEL RKRLVLEEWI VEQLGQLYGC EEEEMPDVEI DIDDLLDADS 

       130        140        150        160 
EEERASKLQE ALVDCYKPTE EFIRELLSRI RGMRKLSPPQ KKSV 

« Hide

References

« Hide 'large scale' references
[1]"KEPI, a PKC-dependent protein phosphatase 1 inhibitor regulated by morphine."
Liu Q.-R., Zhang P.-W., Zhen Q., Walther D., Wang X.-B., Uhl G.
J. Biol. Chem. 277:13312-13320(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Heart.
[3]Lubec G., Kang S.U., Lubec S.
Submitted (SEP-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 35-44, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: Sprague-Dawley.
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF407168 mRNA. Translation: AAL83509.1.
BC086978 mRNA. Translation: AAH86978.1.
RefSeqNP_596916.1. NM_133425.3.
UniGeneRn.87667.

3D structure databases

ProteinModelPortalQ8R4R9.
SMRQ8R4R9. Positions 62-155.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8R4R9.

Proteomic databases

PRIDEQ8R4R9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000022046; ENSRNOP00000022046; ENSRNOG00000016368.
GeneID171010.
KEGGrno:171010.
UCSCRGD:620538. rat.

Organism-specific databases

CTD81706.
RGD620538. Ppp1r14c.

Phylogenomic databases

eggNOGeuNOG04467.
GeneTreeENSGT00390000003608.
HOGENOMHOG000231993.
HOVERGENHBG054419.
InParanoidQ8R4R9.
KOK17556.
OMADCHKPTE.
OrthoDBEOG7RNK21.
PhylomeDBQ8R4R9.
TreeFamTF105546.

Gene expression databases

GenevestigatorQ8R4R9.

Family and domain databases

Gene3D1.10.150.220. 1 hit.
InterProIPR008025. PP1_inhibitor.
[Graphical view]
PANTHERPTHR16188. PTHR16188. 1 hit.
PfamPF05361. PP1_inhibitor. 1 hit.
[Graphical view]
SUPFAMSSF81790. SSF81790. 1 hit.
ProtoNetSearch...

Other

NextBio621491.
PROQ8R4R9.

Entry information

Entry namePP14C_RAT
AccessionPrimary (citable) accession number: Q8R4R9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: June 1, 2002
Last modified: April 16, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families