Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8R4R9

- PP14C_RAT

UniProt

Q8R4R9 - PP14C_RAT

Protein

Protein phosphatase 1 regulatory subunit 14C

Gene

Ppp1r14c

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Inhibitor of the PP1 regulatory subunit PPP1CA.

    GO - Molecular functioni

    1. protein serine/threonine phosphatase inhibitor activity Source: RGD

    GO - Biological processi

    1. negative regulation of catalytic activity Source: GOC
    2. regulation of phosphorylation Source: InterPro

    Keywords - Molecular functioni

    Protein phosphatase inhibitor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase 1 regulatory subunit 14C
    Alternative name(s):
    Kinase-enhanced PP1 inhibitor
    PKC-potentiated PP1 inhibitory protein
    Gene namesi
    Name:Ppp1r14c
    Synonyms:Kepi
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi620538. Ppp1r14c.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro
    2. endomembrane system Source: UniProtKB-SubCell
    3. membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 164163Protein phosphatase 1 regulatory subunit 14CPRO_0000071496Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity
    Modified residuei72 – 721Phosphothreonine; by ILK1By similarity

    Post-translational modificationi

    Has over 600-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. The main inhibitory site appears to be Thr-72 By similarity.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PRIDEiQ8R4R9.

    PTM databases

    PhosphoSiteiQ8R4R9.

    Expressioni

    Gene expression databases

    GenevestigatoriQ8R4R9.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8R4R9.
    SMRiQ8R4R9. Positions 62-155.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi58 – 636Poly-Gln
    Compositional biasi101 – 1044Poly-Glu

    Sequence similaritiesi

    Belongs to the PP1 inhibitor family.Curated

    Phylogenomic databases

    eggNOGieuNOG04467.
    GeneTreeiENSGT00390000003608.
    HOGENOMiHOG000231993.
    HOVERGENiHBG054419.
    InParanoidiQ8R4R9.
    KOiK17556.
    OMAiDCHKPTE.
    OrthoDBiEOG7RNK21.
    PhylomeDBiQ8R4R9.
    TreeFamiTF105546.

    Family and domain databases

    Gene3Di1.10.150.220. 1 hit.
    InterProiIPR008025. PP1_inhibitor.
    [Graphical view]
    PANTHERiPTHR16188. PTHR16188. 1 hit.
    PfamiPF05361. PP1_inhibitor. 1 hit.
    [Graphical view]
    SUPFAMiSSF81790. SSF81790. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8R4R9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVVTGGGEA AGGTSGGGAR VFFQSPRGGT GGSRESSSHS GSSREDSAPV    50
    ATVAAAGQVQ QQQRRHQQGK VTVKYDRKEL RKRLVLEEWI VEQLGQLYGC 100
    EEEEMPDVEI DIDDLLDADS EEERASKLQE ALVDCYKPTE EFIRELLSRI 150
    RGMRKLSPPQ KKSV 164
    Length:164
    Mass (Da):17,980
    Last modified:June 1, 2002 - v1
    Checksum:i2E48BCB85446A4DE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF407168 mRNA. Translation: AAL83509.1.
    BC086978 mRNA. Translation: AAH86978.1.
    RefSeqiNP_596916.1. NM_133425.3.
    UniGeneiRn.87667.

    Genome annotation databases

    EnsembliENSRNOT00000022046; ENSRNOP00000022046; ENSRNOG00000016368.
    GeneIDi171010.
    KEGGirno:171010.
    UCSCiRGD:620538. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF407168 mRNA. Translation: AAL83509.1 .
    BC086978 mRNA. Translation: AAH86978.1 .
    RefSeqi NP_596916.1. NM_133425.3.
    UniGenei Rn.87667.

    3D structure databases

    ProteinModelPortali Q8R4R9.
    SMRi Q8R4R9. Positions 62-155.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8R4R9.

    Proteomic databases

    PRIDEi Q8R4R9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000022046 ; ENSRNOP00000022046 ; ENSRNOG00000016368 .
    GeneIDi 171010.
    KEGGi rno:171010.
    UCSCi RGD:620538. rat.

    Organism-specific databases

    CTDi 81706.
    RGDi 620538. Ppp1r14c.

    Phylogenomic databases

    eggNOGi euNOG04467.
    GeneTreei ENSGT00390000003608.
    HOGENOMi HOG000231993.
    HOVERGENi HBG054419.
    InParanoidi Q8R4R9.
    KOi K17556.
    OMAi DCHKPTE.
    OrthoDBi EOG7RNK21.
    PhylomeDBi Q8R4R9.
    TreeFami TF105546.

    Miscellaneous databases

    NextBioi 621491.
    PROi Q8R4R9.

    Gene expression databases

    Genevestigatori Q8R4R9.

    Family and domain databases

    Gene3Di 1.10.150.220. 1 hit.
    InterProi IPR008025. PP1_inhibitor.
    [Graphical view ]
    PANTHERi PTHR16188. PTHR16188. 1 hit.
    Pfami PF05361. PP1_inhibitor. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81790. SSF81790. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "KEPI, a PKC-dependent protein phosphatase 1 inhibitor regulated by morphine."
      Liu Q.-R., Zhang P.-W., Zhen Q., Walther D., Wang X.-B., Uhl G.
      J. Biol. Chem. 277:13312-13320(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart.
    3. Lubec G., Kang S.U., Lubec S.
      Submitted (SEP-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 35-44, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Sprague-Dawley.
      Tissue: Brain.

    Entry informationi

    Entry nameiPP14C_RAT
    AccessioniPrimary (citable) accession number: Q8R4R9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 9, 2004
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3