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Protein

Multidrug resistance-associated protein 7

Gene

Abcc10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusion.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi634 – 641ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1289 – 1296ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-382556. ABC-family proteins mediated transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance-associated protein 7
Alternative name(s):
ATP-binding cassette sub-family C member 10
Gene namesi
Name:Abcc10
Synonyms:Mrp7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2386976. Abcc10.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei32 – 52HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei70 – 90HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei102 – 122HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei133 – 153HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei172 – 192HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei294 – 314HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei321 – 341HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei392 – 412HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei415 – 435HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei508 – 528HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei539 – 559HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei877 – 897HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei969 – 989HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1033 – 1053HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1056 – 1076HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1158 – 1178HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1187 – 1207HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002535771 – 1501Multidrug resistance-associated protein 7Add BLAST1501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei464PhosphothreonineBy similarity1
Modified residuei468PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8R4P9.
PRIDEiQ8R4P9.

PTM databases

iPTMnetiQ8R4P9.
PhosphoSitePlusiQ8R4P9.

Expressioni

Tissue specificityi

Expressed in all tissues tested including liver, brain, heart, skeletal muscle, kidney and spleen.1 Publication

Developmental stagei

Expressed in embryo.1 Publication

Gene expression databases

BgeeiENSMUSG00000032842.
ExpressionAtlasiQ8R4P9. baseline and differential.
GenevisibleiQ8R4P9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000131843.

Structurei

3D structure databases

ProteinModelPortaliQ8R4P9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini286 – 564ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST279
Domaini599 – 825ABC transporter 1PROSITE-ProRule annotationAdd BLAST227
Domaini887 – 1215ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST329
Domaini1255 – 1488ABC transporter 2PROSITE-ProRule annotationAdd BLAST234

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00860000133687.
HOVERGENiHBG107141.
InParanoidiQ8R4P9.
KOiK05674.
OMAiLCTHRVE.
OrthoDBiEOG091G00IN.
PhylomeDBiQ8R4P9.
TreeFamiTF105203.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030249. ABCC10.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24223:SF235. PTHR24223:SF235. 2 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8R4P9-1) [UniParc]FASTAAdd to basket
Also known as: Mrp7B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGLLAQLCG TDAARPLPLW EGDTTGHCFT QLVLSALPHA LLAVLSACHL
60 70 80 90 100
GTPRTTNHSP ALNPGWRLRL AASFLLSIFP LLDLLPVVLP PGSRPGPLWL
110 120 130 140 150
EVLAGCVTAV AWFTHSLALW ALVHSPHGRS RGPLALALAA FLPTPALVLT
160 170 180 190 200
LLWHCQRGTF LPPLLPGPLG RVCLLILQLA AVLAYGLGWA APGGPQEPWT
210 220 230 240 250
HDPFLSSESQ ETEVAEDGES WLSRFSYAWL APLLARGVRG ELQQPRDTCR
260 270 280 290 300
LPRRLHPAFL ARVFQAHWKE GAQLWRALYR AFGCCYLALG LLKMVGTMLG
310 320 330 340 350
FSGPLLLSLL VGFLEEGQEP LSHGLLYVLG LAGGTVISAV LQNQYGYEVR
360 370 380 390 400
KVTLQARVAV LSTLYRKALK LGPSRPPTGE VLNLLGTDSE RLLNFAGSFH
410 420 430 440 450
EAWGLPLQLA ITLYLLYQQV GMAFLAGLVL ALLLVPVNKV IATRIMASNQ
460 470 480 490 500
EMLRHKDARV KLMTELLSGI RVIKFFRWEQ ALGDRVKACR TKELGRLRVI
510 520 530 540 550
KYLDAACVYL WAALPVVICI TIFITYVLMG HQLTATKVFT ALALVRMLIL
560 570 580 590 600
PLNNFPWVIN GLLESKVSLD RIQRFLDLPS YSPEAYYSPD PPAEPSTALE
610 620 630 640 650
LHEALFSWDP IGASQKTFIS HLQVKKGMLV GIVGKVGCGK SSLLAAITGE
660 670 680 690 700
LHRLCGWVAV SELSKGFGLA TQEPWIQCAT IRDNILFGKT FDAQLYREVL
710 720 730 740 750
EACALNDDLS ILPAGDQTEV GEKGVTLSGG QRARIALARA VYQEKALYLL
760 770 780 790 800
DDPLAAVDAD VANHLLHRCI LGVLSHTTRL LCTHRTEYLE RADVVLLMEA
810 820 830 840 850
GQLVRTGPPS EILPLVQAVP TAWAEKEQVA TSGQSPSVCD LERTTEEELE
860 870 880 890 900
VEQSTCGCLV QEESKSEGAV ALHVYRAYWR AMGSGLAAAI LVSLLLMQAT
910 920 930 940 950
RNGADWWLAH WLSQLKAGRN GSREDPASCS PGSTALFSPR LLLFSPGNLY
960 970 980 990 1000
TPLLSTPLHK AASNGTADVH FYLIVYATIA GVNSLCTLLR AVLFAAGALQ
1010 1020 1030 1040 1050
AAASLHHRLL HRLLMAPVTF YDSTPSGRVL NRFSSDVACV DDSLPFLLNI
1060 1070 1080 1090 1100
LLANSVGLLG LLAVLGSGLP WLLLLLPPLS FVYYSVQGYY RASFRELRRL
1110 1120 1130 1140 1150
GSLTWSPLYS HLADTLAGLP VLRAAGATYR FEEENQRLLE LNQRCQFASY
1160 1170 1180 1190 1200
ATMQWLDIRL QLMGAAVVSA IAGIALVQHQ QGLANPGLVG LVLSYALSLT
1210 1220 1230 1240 1250
GLLSGLVSSF TQTEAMMVSV ERLEEYSCDV PQEPHSQPLQ SPHQQRISWL
1260 1270 1280 1290 1300
TQGSVEFQDV VLVYRPGLPN ALDGVTFRVE PGEKLGIVGR TGSGKSSLFL
1310 1320 1330 1340 1350
VLFRLLEPNA GRVLLDNVDT SQLELAELRS QLAVIPQEPF LFSGTIRENL
1360 1370 1380 1390 1400
DPQGLHEDRA LWQALEQCHL SEVAVAMGGL DGELGERGQN LSLGQRQLLC
1410 1420 1430 1440 1450
LARALLTDAK ILCIDEATAS VDQKTDQLLQ QTICKRFANK TVLTIAHRLN
1460 1470 1480 1490 1500
TILNSDRVLV LQAGRVVELD SPSALRNQPH SLFQQLLQSS QQGAHSGPSG

C
Length:1,501
Mass (Da):163,735
Last modified:June 1, 2002 - v1
Checksum:i573D5CFA52DDF3BA
GO
Isoform 2 (identifier: Q8R4P9-2) [UniParc]FASTAAdd to basket
Also known as: Mrp7A

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: Missing.
     42-53: LAVLSACHLGTP → MICGLLFFSFFP

Show »
Length:1,460
Mass (Da):159,646
Checksum:i3C1471FEE43339E1
GO
Isoform 3 (identifier: Q8R4P9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1377-1377: M → MGESQACQRSQREAKNGHWQCSALLT

Note: No experimental confirmation available.
Show »
Length:1,526
Mass (Da):166,506
Checksum:iCD55D65669560B95
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0210811 – 41Missing in isoform 2. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_02108242 – 53LAVLS…HLGTP → MICGLLFFSFFP in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_0210831377M → MGESQACQRSQREAKNGHWQ CSALLT in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF406642 mRNA. Translation: AAM18535.1.
AF417121 mRNA. Translation: AAM18536.1.
AK133240 mRNA. Translation: BAE21573.1.
AK170600 mRNA. Translation: BAE41905.1.
CCDSiCCDS28825.1. [Q8R4P9-2]
CCDS50124.1. [Q8R4P9-1]
RefSeqiNP_660122.1. NM_145140.2. [Q8R4P9-2]
NP_733780.1. NM_170680.2. [Q8R4P9-1]
XP_006524205.1. XM_006524142.3. [Q8R4P9-3]
UniGeneiMm.76543.

Genome annotation databases

EnsembliENSMUST00000047970; ENSMUSP00000038041; ENSMUSG00000032842. [Q8R4P9-3]
ENSMUST00000095261; ENSMUSP00000092895; ENSMUSG00000032842. [Q8R4P9-2]
ENSMUST00000167360; ENSMUSP00000131843; ENSMUSG00000032842. [Q8R4P9-1]
GeneIDi224814.
KEGGimmu:224814.
UCSCiuc008csn.1. mouse. [Q8R4P9-2]
uc008cso.1. mouse. [Q8R4P9-1]
uc012auq.1. mouse. [Q8R4P9-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF406642 mRNA. Translation: AAM18535.1.
AF417121 mRNA. Translation: AAM18536.1.
AK133240 mRNA. Translation: BAE21573.1.
AK170600 mRNA. Translation: BAE41905.1.
CCDSiCCDS28825.1. [Q8R4P9-2]
CCDS50124.1. [Q8R4P9-1]
RefSeqiNP_660122.1. NM_145140.2. [Q8R4P9-2]
NP_733780.1. NM_170680.2. [Q8R4P9-1]
XP_006524205.1. XM_006524142.3. [Q8R4P9-3]
UniGeneiMm.76543.

3D structure databases

ProteinModelPortaliQ8R4P9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000131843.

PTM databases

iPTMnetiQ8R4P9.
PhosphoSitePlusiQ8R4P9.

Proteomic databases

PaxDbiQ8R4P9.
PRIDEiQ8R4P9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047970; ENSMUSP00000038041; ENSMUSG00000032842. [Q8R4P9-3]
ENSMUST00000095261; ENSMUSP00000092895; ENSMUSG00000032842. [Q8R4P9-2]
ENSMUST00000167360; ENSMUSP00000131843; ENSMUSG00000032842. [Q8R4P9-1]
GeneIDi224814.
KEGGimmu:224814.
UCSCiuc008csn.1. mouse. [Q8R4P9-2]
uc008cso.1. mouse. [Q8R4P9-1]
uc012auq.1. mouse. [Q8R4P9-3]

Organism-specific databases

CTDi89845.
MGIiMGI:2386976. Abcc10.

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00860000133687.
HOVERGENiHBG107141.
InParanoidiQ8R4P9.
KOiK05674.
OMAiLCTHRVE.
OrthoDBiEOG091G00IN.
PhylomeDBiQ8R4P9.
TreeFamiTF105203.

Enzyme and pathway databases

ReactomeiR-MMU-382556. ABC-family proteins mediated transport.

Miscellaneous databases

ChiTaRSiAbcc10. mouse.
PROiQ8R4P9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032842.
ExpressionAtlasiQ8R4P9. baseline and differential.
GenevisibleiQ8R4P9. MM.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030249. ABCC10.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24223:SF235. PTHR24223:SF235. 2 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMRP7_MOUSE
AccessioniPrimary (citable) accession number: Q8R4P9
Secondary accession number(s): Q3TCQ0, Q3V0D1, Q8R4S1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: June 1, 2002
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.