Q8R4K8 (PAPP1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pappalysin-1
EC=3.4.24.79

Alternative name(s):
Insulin-like growth factor-dependent IGF-binding protein 4 protease
Short name=IGF-dependent IGFBP-4 protease
Short name=IGFBP-4ase
Pregnancy-associated plasma protein A
Short name=PAPP-A

Gene names

Name:

Pappa

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1624 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. Isoform 2 cleaves IGFBP-4 very slowly compared to PAPP-A, but its ability to cleave IGFBP-5 is unaffected. Ref.2
Catalytic activity	Cleavage of the 135-Met-|-Lys-136 bond in insulin-like growth factor binding protein (IGFBP)-4, and the 143-Ser-|-Lys-144 bond in IGFBP-5.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Subunit structure	Homodimer; disulfide-linked. In pregnancy serum, predominantly found as a disulfide-linked 2:2 heterotetramer with the proform of PRG2 By similarity.
Subcellular location	Secreted.
Tissue specificity	Detected in kidney, spleen, brain, ovary, breast, skin, prostate, uterus, and placenta. Ref.2 Ref.4
Sequence similarities	Belongs to the peptidase M43B family. Contains 5 Sushi (CCP/SCR) domains.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing
Domain	Repeat Signal Sushi
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
PTM	Disulfide bond Glycoprotein Zymogen
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell differentiation Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW response to follicle-stimulating hormone stimulus Inferred from electronic annotation. Source: Compara response to glucocorticoid stimulus Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular space Inferred from electronic annotation. Source: Compara membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	endopeptidase activity Inferred from direct assay Ref.2. Source: MGI metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8R4K8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8R4K8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     490-490: R → RQSIRKRAHVVEESWLPHGKQKAKKRKRTR

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Propeptide	23 – 80	58	By similarity		PRO_0000029247
	Chain	81 – 1624	1544	Pappalysin-1		PRO_0000029248
Regions
	Domain	1210 – 1279	70	Sushi 1
	Domain	1280 – 1341	62	Sushi 2
	Domain	1342 – 1409	68	Sushi 3
	Domain	1410 – 1470	61	Sushi 4
	Domain	1473 – 1553	81	Sushi 5
	Region	272 – 583	312	Metalloprotease
	Compositional bias	24 – 82	59	Arg-rich
Sites
	Active site	560	1	By similarity
	Metal binding	559	1	Zinc; catalytic By similarity
	Metal binding	563	1	Zinc; catalytic By similarity
	Metal binding	569	1	Zinc; catalytic By similarity
Amino acid modifications
	Glycosylation	387	1	N-linked (GlcNAc...) Potential
	Glycosylation	398	1	N-linked (GlcNAc...) Potential
	Glycosylation	426	1	N-linked (GlcNAc...) Potential
	Glycosylation	516	1	N-linked (GlcNAc...) Potential
	Glycosylation	598	1	N-linked (GlcNAc...) Potential
	Glycosylation	616	1	N-linked (GlcNAc...) Potential
	Glycosylation	722	1	N-linked (GlcNAc...) Potential
	Glycosylation	822	1	N-linked (GlcNAc...) Potential
	Glycosylation	1023	1	N-linked (GlcNAc...) Potential
	Glycosylation	1219	1	N-linked (GlcNAc...) Potential
	Glycosylation	1223	1	N-linked (GlcNAc...) Potential
	Glycosylation	1320	1	N-linked (GlcNAc...) Potential
	Glycosylation	1516	1	N-linked (GlcNAc...) Potential
	Disulfide bond	141 ↔ 232		By similarity
	Disulfide bond	324 ↔ 619		By similarity
	Disulfide bond	329 ↔ 654		By similarity
	Disulfide bond	411 ↔ 425		By similarity
	Disulfide bond	421 ↔ 437		By similarity
	Disulfide bond	454 ↔ 470		By similarity
	Disulfide bond	458		Interchain (with C-49 in PRG2 proform) By similarity
	Disulfide bond	471 ↔ 482		By similarity
	Disulfide bond	580 ↔ 597		Or C-580 with C-609 By similarity
	Disulfide bond	584 ↔ 609		Or C-584 with C-597 By similarity
	Disulfide bond	707 ↔ 875		By similarity
	Disulfide bond	710 ↔ 878		By similarity
	Disulfide bond	729		Interchain (with C-170 in PRG2 proform) By similarity
	Disulfide bond	750 ↔ 832		By similarity
	Disulfide bond	772 ↔ 778		By similarity
	Disulfide bond	944 ↔ 972		By similarity
	Disulfide bond	957 ↔ 968		By similarity
	Disulfide bond	980 ↔ 987		By similarity
	Disulfide bond	996 ↔ 1008		By similarity
	Disulfide bond	1033 ↔ 1067		By similarity
	Disulfide bond	1048 ↔ 1136		By similarity
	Disulfide bond	1189 ↔ 1202		By similarity
	Disulfide bond	1207		Interchain By similarity
	Disulfide bond	1212 ↔ 1266		By similarity
	Disulfide bond	1224 ↔ 1235		By similarity
	Disulfide bond	1239 ↔ 1277		By similarity
	Disulfide bond	1282 ↔ 1326		By similarity
	Disulfide bond	1297 ↔ 1307		By similarity
	Disulfide bond	1311 ↔ 1339		By similarity
	Disulfide bond	1343 ↔ 1396		By similarity
	Disulfide bond	1359 ↔ 1370		By similarity
	Disulfide bond	1374 ↔ 1407		By similarity
	Disulfide bond	1412 ↔ 1455		By similarity
	Disulfide bond	1425 ↔ 1435		By similarity
	Disulfide bond	1439 ↔ 1468		By similarity
	Disulfide bond	1475 ↔ 1536		By similarity
	Disulfide bond	1489 ↔ 1499		By similarity
	Disulfide bond	1503 ↔ 1551		By similarity
	Disulfide bond	1555 ↔ 1573		By similarity
Natural variations
	Alternative sequence	490	1	R → RQSIRKRAHVVEESWLPHGK QKAKKRKRTR in isoform 2.		VSP_012193

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 7, 2004. Version 2. Checksum: B09404C206CB60D1	FASTA	1,624	181,318
	10 20 30 40 50 60 MRLWSWVLRL GLLSAALGCG LAERPRRVRR DPRAVRPPRP AAGPATCATR AARGRRASPP 70 80 90 100 110 120 PPPGGAWEAV RVPRRRQQRA ARGAEEPSPP SRALYFSGRG EQLRLRADLE LPRDAFTLQV 130 140 150 160 170 180 WLRAEGGQKS PAVITGLYDK CSYTSRDRGW VMGIHTTSDQ GNRDPRYFFS LKTDRARKVT 190 200 210 220 230 240 TIDAHRSYLP GQWVHLAATY DGRLMKLYMN GAQVATSAEQ VGGIFSPLTQ KCKVLMLGGS 250 260 270 280 290 300 ALNHNFRGHI EHFSLWKVAR TQREIVSDME TRGLHTPLPQ LLLQENWDNV KRTWSPMKDG 310 320 330 340 350 360 NSPQVEFSNA HGFLLDTNLE PPLCGQTLCD NTEVISSYNQ LPSFRQPKVV RYRVVNIYDD 370 380 390 400 410 420 HHENPTVSWQ QIDFQHQQLA EAFQHYNISW ELEVLNINSS SLRHRLILAN CDISKIGDEK 430 440 450 460 470 480 CDPECNHTLT GHDGGDCRQL RYPAFMKKQQ NGVCDMDCNY ERFNFDGGEC CDPDITDVTK 490 500 510 520 530 540 TCFDPDSPHR AYLDVNELKN ILRLDGSTHL NIFFANSSEE ELAGVATWPW DKEALMHLGG 550 560 570 580 590 600 IVLNPSFYGI PGHTHTMIHE IGHSLGLYHI FRGISEIQSC SDPCMETEPS FETGDLCNDT 610 620 630 640 650 660 NPAPKHKFCG DPGPGNDTCG FHGFFNTPYN NFMSYADDDC TDSFTPNQVS RMHCYLDLVY 670 680 690 700 710 720 QSWQPSRKPA PVALAPQVVG HTMDSVMLEW FPPIDGHFFE RELGSACDLC LEGRILVQYA 730 740 750 760 770 780 FNASSPMPCG PSGHWSPREA EGHPDVEQPC KSSVRTWSPN SAVNPHTVPP ACPEPQGCYL 790 800 810 820 830 840 ELEFRYPLVP ESLTIWVTFV SSDWDSSGAV NDIKLLTISG KNISLGPQNV FCDIPLTIRL 850 860 870 880 890 900 RDVGEEVYGI QIYTLDEHLE IDAAMLTSTV DSPLCLQCKP LQYKVLRDPP LLEDVASLLH 910 920 930 940 950 960 LNRRFMDTDL KLGSVYQYRI ITISGNEESE PSPAAIYTHG SGYCGDGVIQ KDQGEECDDM 970 980 990 1000 1010 1020 NKVNGDGCSL FCKQEVSFNC IDEPSRCYFH DGDGMCEEFE QKTSIKDCGV YTPQGFLDQW 1030 1040 1050 1060 1070 1080 ASNASVSHQD QQCPGWVVIG QPAASQVCRT KVIDLSEGIS QHAWYPCTIT YPYYHLPQTT 1090 1100 1110 1120 1130 1140 FWLQTYFSQP MVAAAVIIHL VTDGTYYGDQ KQETISVQLL DTKDQSHDLG LHVLSCRNNP 1150 1160 1170 1180 1190 1200 LIIPVVHDLS QPFYHSQAVH VSFSSPLVAI SGVALRSFDN FDPVTLSSCQ RGETYSPAEQ 1210 1220 1230 1240 1250 1260 SCVHFACQAA DCPELAVGNA SLNCSSNHHY HGAQCTVSCQ TGYVLQIQRD DELIKSQVGP 1270 1280 1290 1300 1310 1320 SITVTCTEGK WNKQVACEPV DCGIPDHHHV YAASFSCPEG TTFGRRCSFQ CRHPAQLKGN 1330 1340 1350 1360 1370 1380 NSFLTCMEDG LWSFPEALCE LMCLAPPPVP NADLQTARCR ENKHKVGSFC KYKCKPGYHV 1390 1400 1410 1420 1430 1440 PGSSRKSKKR AFKTQCTQDG SWQEGTCVPV TCDPPPPKFH GLYQCTNGFQ FNSECRIKCE 1450 1460 1470 1480 1490 1500 DSDASQGRGS NIIHCRKDGT WSGSFHVCRE MQGQCSAPNQ LNSNLKLQCP DGYAIGSECA 1510 1520 1530 1540 1550 1560 ISCLDHNSES IILPVNLTVR DIPHWMNPTR VQRIVCTAGL QWYPHPALIH CVKGCEPFMG 1570 1580 1590 1600 1610 1620 DNYCDAINNR AFCNYDGGDC CTSTVKTKKV TPFPMSCDLQ NDCACRDPEA QEHNRKDLRG YSHG
	Isoform 2 [UniParc]. Checksum: EF7A13AFE698A430	FASTA	1,653	184,839
	10 20 30 40 50 60 MRLWSWVLRL GLLSAALGCG LAERPRRVRR DPRAVRPPRP AAGPATCATR AARGRRASPP 70 80 90 100 110 120 PPPGGAWEAV RVPRRRQQRA ARGAEEPSPP SRALYFSGRG EQLRLRADLE LPRDAFTLQV 130 140 150 160 170 180 WLRAEGGQKS PAVITGLYDK CSYTSRDRGW VMGIHTTSDQ GNRDPRYFFS LKTDRARKVT 190 200 210 220 230 240 TIDAHRSYLP GQWVHLAATY DGRLMKLYMN GAQVATSAEQ VGGIFSPLTQ KCKVLMLGGS 250 260 270 280 290 300 ALNHNFRGHI EHFSLWKVAR TQREIVSDME TRGLHTPLPQ LLLQENWDNV KRTWSPMKDG 310 320 330 340 350 360 NSPQVEFSNA HGFLLDTNLE PPLCGQTLCD NTEVISSYNQ LPSFRQPKVV RYRVVNIYDD 370 380 390 400 410 420 HHENPTVSWQ QIDFQHQQLA EAFQHYNISW ELEVLNINSS SLRHRLILAN CDISKIGDEK 430 440 450 460 470 480 CDPECNHTLT GHDGGDCRQL RYPAFMKKQQ NGVCDMDCNY ERFNFDGGEC CDPDITDVTK 490 500 510 520 530 540 TCFDPDSPHR QSIRKRAHVV EESWLPHGKQ KAKKRKRTRA YLDVNELKNI LRLDGSTHLN 550 560 570 580 590 600 IFFANSSEEE LAGVATWPWD KEALMHLGGI VLNPSFYGIP GHTHTMIHEI GHSLGLYHIF 610 620 630 640 650 660 RGISEIQSCS DPCMETEPSF ETGDLCNDTN PAPKHKFCGD PGPGNDTCGF HGFFNTPYNN 670 680 690 700 710 720 FMSYADDDCT DSFTPNQVSR MHCYLDLVYQ SWQPSRKPAP VALAPQVVGH TMDSVMLEWF 730 740 750 760 770 780 PPIDGHFFER ELGSACDLCL EGRILVQYAF NASSPMPCGP SGHWSPREAE GHPDVEQPCK 790 800 810 820 830 840 SSVRTWSPNS AVNPHTVPPA CPEPQGCYLE LEFRYPLVPE SLTIWVTFVS SDWDSSGAVN 850 860 870 880 890 900 DIKLLTISGK NISLGPQNVF CDIPLTIRLR DVGEEVYGIQ IYTLDEHLEI DAAMLTSTVD 910 920 930 940 950 960 SPLCLQCKPL QYKVLRDPPL LEDVASLLHL NRRFMDTDLK LGSVYQYRII TISGNEESEP 970 980 990 1000 1010 1020 SPAAIYTHGS GYCGDGVIQK DQGEECDDMN KVNGDGCSLF CKQEVSFNCI DEPSRCYFHD 1030 1040 1050 1060 1070 1080 GDGMCEEFEQ KTSIKDCGVY TPQGFLDQWA SNASVSHQDQ QCPGWVVIGQ PAASQVCRTK 1090 1100 1110 1120 1130 1140 VIDLSEGISQ HAWYPCTITY PYYHLPQTTF WLQTYFSQPM VAAAVIIHLV TDGTYYGDQK 1150 1160 1170 1180 1190 1200 QETISVQLLD TKDQSHDLGL HVLSCRNNPL IIPVVHDLSQ PFYHSQAVHV SFSSPLVAIS 1210 1220 1230 1240 1250 1260 GVALRSFDNF DPVTLSSCQR GETYSPAEQS CVHFACQAAD CPELAVGNAS LNCSSNHHYH 1270 1280 1290 1300 1310 1320 GAQCTVSCQT GYVLQIQRDD ELIKSQVGPS ITVTCTEGKW NKQVACEPVD CGIPDHHHVY 1330 1340 1350 1360 1370 1380 AASFSCPEGT TFGRRCSFQC RHPAQLKGNN SFLTCMEDGL WSFPEALCEL MCLAPPPVPN 1390 1400 1410 1420 1430 1440 ADLQTARCRE NKHKVGSFCK YKCKPGYHVP GSSRKSKKRA FKTQCTQDGS WQEGTCVPVT 1450 1460 1470 1480 1490 1500 CDPPPPKFHG LYQCTNGFQF NSECRIKCED SDASQGRGSN IIHCRKDGTW SGSFHVCREM 1510 1520 1530 1540 1550 1560 QGQCSAPNQL NSNLKLQCPD GYAIGSECAI SCLDHNSESI ILPVNLTVRD IPHWMNPTRV 1570 1580 1590 1600 1610 1620 QRIVCTAGLQ WYPHPALIHC VKGCEPFMGD NYCDAINNRA FCNYDGGDCC TSTVKTKKVT 1630 1640 1650 PFPMSCDLQN DCACRDPEAQ EHNRKDLRGY SHG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[2]	"Expression of recombinant murine pregnancy-associated plasma protein-A (PAPP-A) and a novel variant (PAPP-Ai) with differential proteolytic activity." Soe R., Overgaard M.T., Thomsen A.R., Laursen L.S., Olsen I.M., Sottrup-Jensen L., Haaning J., Giudice L.C., Conover C.A., Oxvig C. Eur. J. Biochem. 269:2247-2256(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 80-1624 (ISOFORMS 1 AND 2), FUNCTION, TISSUE SPECIFICITY.
[3]	"Differential regulation of pregnancy associated plasma protein (PAPP)-A during pregnancy in human and mouse." Qin X., Sexton C., Byun D., Strong D.D., Baylink D.J., Mohan S. Growth Horm. IGF Res. 12:359-366(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 136-489 (ISOFORM 1). Strain: 129/SvJ.
[4]	"The regulated expression of the pregnancy-associated plasma protein-A in the rodent ovary: a proposed role in the development of dominant follicles and of corpora lutea." Hourvitz A., Kuwahara A., Hennebold J.D., Tavares A.B., Negishi H., Lee T.H., Erickson G.F., Adashi E.Y. Endocrinology 143:1833-1844(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 258-1624 (ISOFORM 1), TISSUE SPECIFICITY. Strain: C57BL/6J.
[5]	"Partial sequence of Mus musculus Mus musculus pregnancy-associated plasma protein A (Pappa)." Olesen C., Hansen C., Hayashizaki Y., Byskov A., Tommerup N. Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1157-1624 (ISOFORM 1). Strain: C57BL/6J. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL691491, AL691454 Genomic DNA. Translation: CAD83034.2. AL691454, AL691491 Genomic DNA. Translation: CAD62274.2. AF439513 mRNA. Translation: AAM12687.1. AF439514 mRNA. Translation: AAM12688.1. AF510317 Genomic DNA. Translation: AAM44048.1. AF258461 mRNA. Translation: AAG09799.1. AF260433 mRNA. Translation: AAF70319.1.
IPI	IPI00267195. IPI00753472.
RefSeq	NP_067337.1. NM_021362.1.
UniGene	Mm.317854.
3D structure databases
ProteinModelPortal	Q8R4K8.
SMR	Q8R4K8. Positions 540-657, 1225-1509.
ModBase	Search...
Protein family/group databases
MEROPS	M43.004.
PTM databases
PhosphoSite	Q8R4K8.
Proteomic databases
PaxDb	Q8R4K8.
PRIDE	Q8R4K8.
Protocols and materials databases
DNASU	18491.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000084501; ENSMUSP00000081545; ENSMUSG00000028370.
GeneID	18491.
KEGG	mmu:18491.
UCSC	uc008thm.1. mouse. uc012dgb.1. mouse.
Organism-specific databases
CTD	5069.
MGI	MGI:97479. Pappa.
Phylogenomic databases
eggNOG	NOG128309.
GeneTree	ENSGT00390000009007.
HOVERGEN	HBG053501.
KO	K07762.
OMA	GIQIYTL.
OrthoDB	EOG4H9XJM.
Gene expression databases
Bgee	Q8R4K8.
CleanEx	MM_PAPPA.
Genevestigator	Q8R4K8.
GermOnline	ENSMUSG00000028370. Mus musculus.
Family and domain databases
Gene3D	2.60.120.200. 1 hit. 3.40.390.10. 1 hit.
InterPro	IPR008985. ConA-like_lec_gl_sf. IPR013320. ConA-like_subgrp. IPR006558. LamG-like. IPR024079. MetalloPept_cat_dom. IPR011936. Myxo_disulph_rpt. IPR000800. Notch_dom. IPR008754. Peptidase_M43. IPR000436. Sushi_SCR_CCP. [Graphical view]
Pfam	PF00066. Notch. 2 hits. PF05572. Peptidase_M43. 1 hit. PF00084. Sushi. 3 hits. [Graphical view]
SMART	SM00032. CCP. 4 hits. SM00560. LamGL. 1 hit. SM00004. NL. 3 hits. [Graphical view]
SUPFAM	SSF57535. Complement_control_module. 4 hits. SSF49899. ConA_like_lec_gl. 1 hit.
TIGRFAMs	TIGR02232. myxo_disulf_rpt. 1 hit.
PROSITE	PS50923. SUSHI. 5 hits. PS00142. ZINC_PROTEASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	294210.
SOURCE	Search...

Entry information

Entry name

PAPP1_MOUSE

Accession

Primary (citable) accession number: Q8R4K8
Secondary accession number(s): Q80VW3 , Q80YY1, Q8K423, Q8R4K7, Q9ES06, Q9JK57

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 7, 2004
Last sequence update:	December 7, 2004
Last modified:	May 1, 2013
This is version 89 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program