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Protein

TFIIA-alpha and beta-like factor

Gene

Gtf2a1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May function as a testis specific transcription factor. Binds DNA in conjunction with GTF2A2 and TBP (the TATA-binding protein) and together with GTF2A2, allows mRNA transcription.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
TFIIA-alpha and beta-like factor
Alternative name(s):
General transcription factor II A, 1-like factor
Gene namesi
Name:Gtf2a1l
Synonyms:Alf, Gtf2a1lf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1919078. Gtf2a1l.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleus Source: MGI
  • transcription factor TFIIA complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 468468TFIIA-alpha and beta-like factorPRO_0000072496Add
BLAST

Proteomic databases

PaxDbiQ8R4I4.
PRIDEiQ8R4I4.

PTM databases

PhosphoSiteiQ8R4I4.

Expressioni

Tissue specificityi

Testis specific. Expressed in pachytene spermatocytes and haploid spermatids.2 Publications

Developmental stagei

Expressed from 14 days postnatal day.1 Publication

Gene expression databases

BgeeiQ8R4I4.
CleanExiMM_GTF2A1L.
ExpressionAtlasiQ8R4I4. baseline and differential.
GenevisibleiQ8R4I4. MM.

Interactioni

Protein-protein interaction databases

BioGridi214957. 8 interactions.
MINTiMINT-1348145.
STRINGi10090.ENSMUSP00000024970.

Structurei

3D structure databases

ProteinModelPortaliQ8R4I4.
SMRiQ8R4I4. Positions 7-48, 422-468.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TFIIA subunit 1 family.Curated

Phylogenomic databases

eggNOGiENOG410IPCE. Eukaryota.
ENOG410Y126. LUCA.
GeneTreeiENSGT00830000128302.
HOGENOMiHOG000015236.
HOVERGENiHBG052771.
InParanoidiQ8R4I4.
KOiK03122.
OMAiDNEDHQI.
OrthoDBiEOG7R2BHW.
PhylomeDBiQ8R4I4.
TreeFamiTF350445.

Family and domain databases

Gene3Di1.10.287.100. 1 hit.
2.30.18.10. 1 hit.
InterProiIPR009083. TFIIA_a-hlx.
IPR004855. TFIIA_asu/bsu.
IPR013028. TFIIA_asu_N.
IPR009088. TFIIA_b-brl.
[Graphical view]
PANTHERiPTHR12694. PTHR12694. 1 hit.
PfamiPF03153. TFIIA. 1 hit.
[Graphical view]
SMARTiSM01371. TFIIA. 1 hit.
[Graphical view]
SUPFAMiSSF47396. SSF47396. 1 hit.
SSF50784. SSF50784. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8R4I4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFINLVPKL YQSVIEDVIE GVRDLFAEEG IEEQVLKDLK KLWETKVLQS
60 70 80 90 100
KATEDFFRNS TQVPLLTLQL PHALPPALQP EASLLIPAGR TLPSFTPEDL
110 120 130 140 150
NTANCGANFA FAGYPIHVPA GMAFQTASGH LYKVNVPVMV TQTSGRTEIL
160 170 180 190 200
QHPFQQVLQQ LGQPLVIQTT VPTLHPCSLQ AATEKSLRME AVLQPPPILH
210 220 230 240 250
PPPVDRTHVE NAASDRRLLP GNELRPQESS PYLSLPGVGF PPQAALTESS
260 270 280 290 300
LEPVLGVSAS LTQNLHSDPF SQGPPGPLHH HLLESQLQSL KDSIYGCDST
310 320 330 340 350
KQLRKAEEPS SLRVSEKNCT SERDLNIRVT DDDINEIIQI DGTGDNSSTE
360 370 380 390 400
EMGSIRDADE NEFPGIIDAG DLNVLEEVDS VSNEDSTANS SDNEDHQINA
410 420 430 440 450
PEEDPLNSGD DVSEQDVPDL FDTENVIVCQ YDKIHRSKNR WKFYLKDGVM
460
CFGGRDYVFA KAIGEAEW
Length:468
Mass (Da):51,525
Last modified:August 15, 2003 - v2
Checksum:iEEE36B01A6B85B63
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti229 – 2291S → G in AAG50432 (PubMed:11159353).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF250835 mRNA. Translation: AAG50432.1.
AF452125 Genomic DNA. Translation: AAM12730.1.
AK005881 mRNA. Translation: BAB24296.1.
BC050756 mRNA. Translation: AAH50756.1.
CCDSiCCDS29024.1.
RefSeqiNP_076119.2. NM_023630.2.
UniGeneiMm.61330.

Genome annotation databases

EnsembliENSMUST00000024970; ENSMUSP00000024970; ENSMUSG00000024154.
GeneIDi71828.
KEGGimmu:71828.
UCSCiuc008dvt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF250835 mRNA. Translation: AAG50432.1.
AF452125 Genomic DNA. Translation: AAM12730.1.
AK005881 mRNA. Translation: BAB24296.1.
BC050756 mRNA. Translation: AAH50756.1.
CCDSiCCDS29024.1.
RefSeqiNP_076119.2. NM_023630.2.
UniGeneiMm.61330.

3D structure databases

ProteinModelPortaliQ8R4I4.
SMRiQ8R4I4. Positions 7-48, 422-468.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214957. 8 interactions.
MINTiMINT-1348145.
STRINGi10090.ENSMUSP00000024970.

PTM databases

PhosphoSiteiQ8R4I4.

Proteomic databases

PaxDbiQ8R4I4.
PRIDEiQ8R4I4.

Protocols and materials databases

DNASUi71828.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024970; ENSMUSP00000024970; ENSMUSG00000024154.
GeneIDi71828.
KEGGimmu:71828.
UCSCiuc008dvt.2. mouse.

Organism-specific databases

CTDi11036.
MGIiMGI:1919078. Gtf2a1l.

Phylogenomic databases

eggNOGiENOG410IPCE. Eukaryota.
ENOG410Y126. LUCA.
GeneTreeiENSGT00830000128302.
HOGENOMiHOG000015236.
HOVERGENiHBG052771.
InParanoidiQ8R4I4.
KOiK03122.
OMAiDNEDHQI.
OrthoDBiEOG7R2BHW.
PhylomeDBiQ8R4I4.
TreeFamiTF350445.

Miscellaneous databases

PROiQ8R4I4.
SOURCEiSearch...

Gene expression databases

BgeeiQ8R4I4.
CleanExiMM_GTF2A1L.
ExpressionAtlasiQ8R4I4. baseline and differential.
GenevisibleiQ8R4I4. MM.

Family and domain databases

Gene3Di1.10.287.100. 1 hit.
2.30.18.10. 1 hit.
InterProiIPR009083. TFIIA_a-hlx.
IPR004855. TFIIA_asu/bsu.
IPR013028. TFIIA_asu_N.
IPR009088. TFIIA_b-brl.
[Graphical view]
PANTHERiPTHR12694. PTHR12694. 1 hit.
PfamiPF03153. TFIIA. 1 hit.
[Graphical view]
SMARTiSM01371. TFIIA. 1 hit.
[Graphical view]
SUPFAMiSSF47396. SSF47396. 1 hit.
SSF50784. SSF50784. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "TFIIAalpha/beta-like factor is encoded by a germ cell-specific gene whose expression is up-regulated with other general transcription factors during spermatogenesis in the mouse."
    Han S., Zhou L., Upadhyaya A.B., Lee S.H., Parker K.L., DeJong J.
    Biol. Reprod. 64:507-517(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: CD-1.
    Tissue: Testis.
  2. "Regulation of ALF gene expression in somatic and male germ line tissues involves partial and site-specific patterns of methylation."
    Xie W., Han S., Khan M., DeJong J.
    J. Biol. Chem. 277:17765-17774(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Testis.

Entry informationi

Entry nameiTF2AY_MOUSE
AccessioniPrimary (citable) accession number: Q8R4I4
Secondary accession number(s): Q99PM2, Q9DAF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: August 15, 2003
Last modified: July 6, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.