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Protein

Voltage-dependent calcium channel gamma subunit

Gene

Cacng5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Calcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel gamma subunitUniRule annotation
Alternative name(s):
Voltage-dependent calcium channel gamma-5 subunitUniRule annotation
Gene namesi
Name:Cacng5Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:2157946. Cacng5.

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei96 – 11722HelicalUniRule annotationAdd
BLAST
Transmembranei129 – 15527HelicalUniRule annotationAdd
BLAST
Transmembranei175 – 20127HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ8R4I0.

Interactioni

Subunit structurei

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma.UniRule annotation

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047888.

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IXFC. Eukaryota.
ENOG410XUAQ. LUCA.
HOVERGENiHBG025923.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR008369. VDCC_g5su.
IPR008368. VDCC_gsu.
[Graphical view]
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01792. VDCCGAMMA.
PR01793. VDCCGAMMA5.

Sequencei

Sequence statusi: Complete.

Q8R4I0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSACGRKALT LLSSVFAVCG LGLLGIAVST DYWLYLEEGI ILPQNQSTEV
60 70 80 90 100
KMSLHSGLWR VCFLAGEERG RCFTIEYVMP MNSQMTSEST VNVLKMIRSA
110 120 130 140 150
TPFPLVSLFF MFIGFILSNI GHIRPHRTIL AFVSGIFFIL SGLSLVVGLV
160 170 180 190 200
LYISSINDEM LNRTKDAETY FNYKYGWSFA FAAISFLLTE SAGVMSVYLF
210 220 230 240 250
MKRYTAEDTY RPHPGFYRPR LSNCSDYSGQ FLHPDAWIRG RSPSDISSDA
260 270
SLQMNSNYPA LLKCPDYDQM SSSPC
Length:275
Mass (Da):30,864
Last modified:June 1, 2002 - v1
Checksum:i37A0037396DDE6FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF458900 mRNA. Translation: AAM00597.1.
UniGeneiMm.87663.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF458900 mRNA. Translation: AAM00597.1.
UniGeneiMm.87663.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047888.

Proteomic databases

PaxDbiQ8R4I0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:2157946. Cacng5.

Phylogenomic databases

eggNOGiENOG410IXFC. Eukaryota.
ENOG410XUAQ. LUCA.
HOVERGENiHBG025923.

Miscellaneous databases

ChiTaRSiCacng5. mouse.
SOURCEiSearch...

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR008369. VDCC_g5su.
IPR008368. VDCC_gsu.
[Graphical view]
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01792. VDCCGAMMA.
PR01793. VDCCGAMMA5.
ProtoNetiSearch...

Entry informationi

Entry nameiQ8R4I0_MOUSE
AccessioniPrimary (citable) accession number: Q8R4I0
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: September 7, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.