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Protein

Zinc transporter 5

Gene

Slc30a5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a zinc transporter. May be a transporter of zinc into beta cells in order to form insulin crystals. Partly regulates cellular zinc homeostasis. Required with ZNT7 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT6 and ZNT7 for the activation of TNAP (By similarity).By similarity

Miscellaneous

The histidine-rich loop is essential for ZNT5 and ZNT6 heterooligomeric complexes to activate TNAP.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Transport, Zinc transport
LigandZinc

Enzyme and pathway databases

ReactomeiR-MMU-264876 Insulin processing
R-MMU-435368 Zinc efflux and compartmentalization by the SLC30 family

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter 5
Short name:
ZnT-5
Alternative name(s):
Solute carrier family 30 member 5
Gene namesi
Name:Slc30a5
Synonyms:Znt5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1916298 Slc30a5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29CytoplasmicSequence analysisAdd BLAST29
Transmembranei30 – 46HelicalSequence analysisAdd BLAST17
Topological domaini47 – 54Exoplasmic loopSequence analysis8
Transmembranei55 – 75HelicalSequence analysisAdd BLAST21
Topological domaini76 – 96CytoplasmicSequence analysisAdd BLAST21
Transmembranei97 – 117HelicalSequence analysisAdd BLAST21
Topological domaini118Exoplasmic loopSequence analysis1
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Topological domaini140 – 150CytoplasmicSequence analysisAdd BLAST11
Transmembranei151 – 171HelicalSequence analysisAdd BLAST21
Topological domaini172 – 191Exoplasmic loopSequence analysisAdd BLAST20
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Topological domaini213 – 236CytoplasmicSequence analysisAdd BLAST24
Transmembranei237 – 257HelicalSequence analysisAdd BLAST21
Topological domaini258 – 264Exoplasmic loopSequence analysis7
Transmembranei265 – 285HelicalSequence analysisAdd BLAST21
Topological domaini286 – 301CytoplasmicSequence analysisAdd BLAST16
Transmembranei302 – 322HelicalSequence analysisAdd BLAST21
Topological domaini323 – 340Exoplasmic loopSequence analysisAdd BLAST18
Transmembranei341 – 361HelicalSequence analysisAdd BLAST21
Topological domaini362 – 416CytoplasmicSequence analysisAdd BLAST55
Transmembranei417 – 437HelicalSequence analysisAdd BLAST21
Topological domaini438 – 446Exoplasmic loopSequence analysis9
Transmembranei447 – 467HelicalSequence analysisAdd BLAST21
Topological domaini468 – 481CytoplasmicSequence analysisAdd BLAST14
Transmembranei482 – 502HelicalSequence analysisAdd BLAST21
Topological domaini503 – 518Exoplasmic loopSequence analysisAdd BLAST16
Transmembranei519 – 539HelicalSequence analysisAdd BLAST21
Topological domaini540 – 588CytoplasmicSequence analysisAdd BLAST49
Transmembranei589 – 609HelicalSequence analysisAdd BLAST21
Topological domaini610 – 613Exoplasmic loopSequence analysis4
Transmembranei614 – 634HelicalSequence analysisAdd BLAST21
Topological domaini635 – 761CytoplasmicSequence analysisAdd BLAST127

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003142941 – 761Zinc transporter 5Add BLAST761

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8R4H9
MaxQBiQ8R4H9
PaxDbiQ8R4H9
PeptideAtlasiQ8R4H9
PRIDEiQ8R4H9

PTM databases

iPTMnetiQ8R4H9
PhosphoSitePlusiQ8R4H9

Expressioni

Gene expression databases

BgeeiENSMUSG00000021629
GenevisibleiQ8R4H9 MM

Interactioni

Subunit structurei

Heterooligomer. Interacts with ZNT6 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065764

Structurei

3D structure databases

ProteinModelPortaliQ8R4H9
SMRiQ8R4H9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni540 – 574His-rich loopAdd BLAST35

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1484 Eukaryota
COG1230 LUCA
GeneTreeiENSGT00630000089781
HOGENOMiHOG000018690
HOVERGENiHBG056637
InParanoidiQ8R4H9
KOiK14692
OMAiICSVKME
OrthoDBiEOG091G030D
PhylomeDBiQ8R4H9
TreeFamiTF315217

Family and domain databases

Gene3Di1.20.1510.10, 2 hits
InterProiView protein in InterPro
IPR002524 Cation_efflux
IPR027469 Cation_efflux_TMD_sf
PfamiView protein in Pfam
PF01545 Cation_efflux, 1 hit
SUPFAMiSSF161111 SSF161111, 2 hits
TIGRFAMsiTIGR01297 CDF, 1 hit

Sequencei

Sequence statusi: Complete.

Q8R4H9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEKYGGDAR PGPGGGLGPV DVPSARLTRY ILLLCLTKCL KAVGLFESYD
60 70 80 90 100
LLKAVHIVQF IFILKLGTAF FMVLFQKPFS SGKPITKHQW IKIFKHAVAG
110 120 130 140 150
CIISLLWFFG LTLCGPLRTL LLFEHSDIVV ISLLSVLFTS SGGGPAKTRG
160 170 180 190 200
AAFFIIAVIC LLLFDNDDLM AKMAEHPEGH HDSALTHMLY TAIAFLGVAD
210 220 230 240 250
HKGGVLLLVL ALCCKVGFHT ASRKLSIDVG GAKRLQALSQ LVSVFLLCPW
260 270 280 290 300
VIVLSVTTES KVESWFSLIM PFTTVIFFVM ILDFYMDSVC SVKMDVSKCA
310 320 330 340 350
RYGSFPIFIS ALLFGNFWTH PITDQLRAMN RAAHQESTEH VLSGGVVVSA
360 370 380 390 400
VFFILSANIL SSPSKRGQKG TLIGYSPEGT PLYHFMGDAF QHSSQSVPRF
410 420 430 440 450
IKDSLKQVLE ESDSRQIFYF LCLNLLFTFV ELFYGVLTNS LGLISDGFHM
460 470 480 490 500
LFDCSALVMG LFAALMSRWK ATRIFSYGYG RIEILSGFIN GLFLIVIAFF
510 520 530 540 550
VFMESVARLI DPPELDTNML TPVSVGGLIV NLIGICAFSH AHSHGHGASQ
560 570 580 590 600
GNCHSDHGHS HHAHGHGHDH GHSHGFTGGG MNANMRGVFL HVLADTLGSI
610 620 630 640 650
GVIVSTVLIE QFGWFIADPL CSLFIAVLIF LSVIPLIKDA CQVLLLRLPP
660 670 680 690 700
DHEKELHIAL EKIQKIEGLI SYRDPHFWRH SASIVAGTIH IQVTSEVLEQ
710 720 730 740 750
RIVQQVTGIL KDAGVNNLTI QVEKEAYFQH MSGLSTGFHD VLAMTKQMES
760
LKYCKDGTYI M
Length:761
Mass (Da):83,773
Last modified:June 1, 2002 - v1
Checksum:i318CBBDEE3D1519B
GO

Sequence cautioni

The sequence BAC34549 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF461761 mRNA Translation: AAL96438.1
AK051183 mRNA Translation: BAC34549.1 Different initiation.
AK166006 mRNA Translation: BAE38515.1
BC029033 mRNA Translation: AAH29033.3
BC033452 mRNA Translation: AAH33452.1
CCDSiCCDS26739.1
RefSeqiNP_075023.2, NM_022885.2
UniGeneiMm.402215

Genome annotation databases

EnsembliENSMUST00000067246; ENSMUSP00000065764; ENSMUSG00000021629
GeneIDi69048
KEGGimmu:69048
UCSCiuc007rrr.1 mouse

Similar proteinsi

Entry informationi

Entry nameiZNT5_MOUSE
AccessioniPrimary (citable) accession number: Q8R4H9
Secondary accession number(s): Q8BQA0, Q8K315
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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