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Protein

Carboxypeptidase A5

Gene

Cpa5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi196 – 1961Zinc; catalyticBy similarity
Metal bindingi199 – 1991Zinc; catalyticBy similarity
Binding sitei254 – 2541SubstrateBy similarity
Metal bindingi323 – 3231Zinc; catalyticBy similarity
Binding sitei375 – 3751SubstrateBy similarity
Active sitei397 – 3971Proton donor/acceptorBy similarity

GO - Molecular functioni

  • metallocarboxypeptidase activity Source: InterPro
  • peptidase activity Source: MGI
  • zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM14.020.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase A5 (EC:3.4.17.-)
Gene namesi
Name:Cpa5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1921899. Cpa5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence analysisAdd
BLAST
Propeptidei34 – 12693Activation peptideBy similarityPRO_0000004363Add
BLAST
Chaini127 – 436310Carboxypeptidase A5PRO_0000004364Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi265 ↔ 288By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Zymogen

Proteomic databases

PaxDbiQ8R4H4.
PRIDEiQ8R4H4.

Expressioni

Tissue specificityi

Detected in testis germ cells.1 Publication

Gene expression databases

BgeeiQ8R4H4.
CleanExiMM_CPA5.
ExpressionAtlasiQ8R4H4. baseline and differential.
GenevisibleiQ8R4H4. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057722.

Structurei

3D structure databases

ProteinModelPortaliQ8R4H4.
SMRiQ8R4H4. Positions 37-436.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni196 – 1994Substrate bindingBy similarity
Regioni271 – 2722Substrate bindingBy similarity
Regioni324 – 3252Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the peptidase M14 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2650. Eukaryota.
COG2866. LUCA.
GeneTreeiENSGT00760000119103.
HOGENOMiHOG000252967.
HOVERGENiHBG050815.
InParanoidiQ8R4H4.
KOiK08781.
OMAiWRKNKSI.
OrthoDBiEOG7RZ5Q9.
PhylomeDBiQ8R4H4.
TreeFamiTF317197.

Family and domain databases

Gene3Di3.30.70.340. 1 hit.
InterProiIPR000834. Peptidase_M14.
IPR003146. Prot_inh_M14A.
IPR009020. Prot_inh_propept.
[Graphical view]
PfamiPF00246. Peptidase_M14. 1 hit.
PF02244. Propep_M14. 1 hit.
[Graphical view]
PRINTSiPR00765. CRBOXYPTASEA.
SMARTiSM00631. Zn_pept. 1 hit.
[Graphical view]
SUPFAMiSSF54897. SSF54897. 1 hit.
PROSITEiPS00132. CARBOXYPEPT_ZN_1. 1 hit.
PS00133. CARBOXYPEPT_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R4H4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQGTQRGGLV PGLSPLDRRT LLFCNFILAV AWGQVNFTGD QVLRVLAKNE
60 70 80 90 100
KQLSLLRDLE TQKPQKVDFW RGPARPSLPV DMRVPFSELP SVKAYLKSHG
110 120 130 140 150
LAYSIMIKDI QVLLDEERDA MAKSRRLERS TNSFSYSSYH TLDEIYSWID
160 170 180 190 200
NFVAEHSNLV SKIHIGKSFE NRSILVLKFS TGGPNRPAIW IDTGIHSREW
210 220 230 240 250
ITHATGIWIS QKIVNAYGKD HVLKRILNTM DIFIEIVTNP DGFAFTHSMN
260 270 280 290 300
RLWRKNKSSQ PGIFCIGVDL NRNWKAGFGG NGSNKNPCSE TYRGPAPESE
310 320 330 340 350
PEVAAIVDFI TGHGNFKAMI SIHSYSQMVM YPYGHSLEPV PNHEELFNLA
360 370 380 390 400
KDAVKALNKV HGIQYIFGSI STTLYSASGI SVDWAYDSGI KYAFSFELRD
410 420 430
TGQYGFLLPA SQIVPTAEET WMALQTIMKH TLNHPY
Length:436
Mass (Da):49,151
Last modified:June 1, 2002 - v1
Checksum:i798EE817B7EC21F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF466283 mRNA. Translation: AAM19306.1.
CCDSiCCDS19976.1.
RefSeqiNP_653120.1. NM_144537.3.
XP_006505251.1. XM_006505188.1.
XP_006505253.1. XM_006505190.2.
UniGeneiMm.159276.

Genome annotation databases

EnsembliENSMUST00000062758; ENSMUSP00000057722; ENSMUSG00000029788.
ENSMUST00000115139; ENSMUSP00000110792; ENSMUSG00000029788.
GeneIDi74649.
KEGGimmu:74649.
UCSCiuc009bfp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF466283 mRNA. Translation: AAM19306.1.
CCDSiCCDS19976.1.
RefSeqiNP_653120.1. NM_144537.3.
XP_006505251.1. XM_006505188.1.
XP_006505253.1. XM_006505190.2.
UniGeneiMm.159276.

3D structure databases

ProteinModelPortaliQ8R4H4.
SMRiQ8R4H4. Positions 37-436.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057722.

Protein family/group databases

MEROPSiM14.020.

Proteomic databases

PaxDbiQ8R4H4.
PRIDEiQ8R4H4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062758; ENSMUSP00000057722; ENSMUSG00000029788.
ENSMUST00000115139; ENSMUSP00000110792; ENSMUSG00000029788.
GeneIDi74649.
KEGGimmu:74649.
UCSCiuc009bfp.1. mouse.

Organism-specific databases

CTDi93979.
MGIiMGI:1921899. Cpa5.

Phylogenomic databases

eggNOGiKOG2650. Eukaryota.
COG2866. LUCA.
GeneTreeiENSGT00760000119103.
HOGENOMiHOG000252967.
HOVERGENiHBG050815.
InParanoidiQ8R4H4.
KOiK08781.
OMAiWRKNKSI.
OrthoDBiEOG7RZ5Q9.
PhylomeDBiQ8R4H4.
TreeFamiTF317197.

Miscellaneous databases

PROiQ8R4H4.
SOURCEiSearch...

Gene expression databases

BgeeiQ8R4H4.
CleanExiMM_CPA5.
ExpressionAtlasiQ8R4H4. baseline and differential.
GenevisibleiQ8R4H4. MM.

Family and domain databases

Gene3Di3.30.70.340. 1 hit.
InterProiIPR000834. Peptidase_M14.
IPR003146. Prot_inh_M14A.
IPR009020. Prot_inh_propept.
[Graphical view]
PfamiPF00246. Peptidase_M14. 1 hit.
PF02244. Propep_M14. 1 hit.
[Graphical view]
PRINTSiPR00765. CRBOXYPTASEA.
SMARTiSM00631. Zn_pept. 1 hit.
[Graphical view]
SUPFAMiSSF54897. SSF54897. 1 hit.
PROSITEiPS00132. CARBOXYPEPT_ZN_1. 1 hit.
PS00133. CARBOXYPEPT_ZN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification and characterization of three members of the human metallocarboxypeptidase gene family."
    Wei S., Segura S., Vendrell J., Aviles F.X., Lanoue E., Day R., Feng Y., Fricker L.D.
    J. Biol. Chem. 277:14954-14964(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: BALB/cJ.
    Tissue: Testis.

Entry informationi

Entry nameiCBPA5_MOUSE
AccessioniPrimary (citable) accession number: Q8R4H4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: June 1, 2002
Last modified: June 8, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.