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Protein

BTB/POZ domain-containing protein KCTD1

Gene

Kctd1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May repress the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C to various extent.By similarity

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD1
Alternative name(s):
Vitamin A-deficient testicular protein 6
Gene namesi
Name:Kctd1
Synonyms:Vad6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621566 Kctd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002471461 – 257BTB/POZ domain-containing protein KCTD1Add BLAST257

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineCombined sources1
Modified residuei12PhosphoserineCombined sources1

Post-translational modificationi

Sumoylated.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ8R4G8
PRIDEiQ8R4G8

PTM databases

iPTMnetiQ8R4G8
PhosphoSitePlusiQ8R4G8

Expressioni

Developmental stagei

Expressed during spermatogenesis in stage-synchronized testes.

Gene expression databases

GenevisibleiQ8R4G8 RN

Interactioni

Subunit structurei

Can form homodimers. Interacts with TFAP2A, TFAP2B and TFAP2C via the BTB domain (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000058222

Structurei

3D structure databases

ProteinModelPortaliQ8R4G8
SMRiQ8R4G8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 100BTBAdd BLAST71

Phylogenomic databases

eggNOGiKOG2723 Eukaryota
ENOG410Z155 LUCA
HOGENOMiHOG000232179
HOVERGENiHBG055358
InParanoidiQ8R4G8
OrthoDBiEOG091G0SU5
PhylomeDBiQ8R4G8

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit

Sequencei

Sequence statusi: Complete.

Q8R4G8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRPLITRSP ASPLNNQGIP TPAQLTKSNA PVHIDVGGHM YTSSLATLTK
60 70 80 90 100
YPESRIGRLF DGTEPIVLDS LKQHYFIDRD GQMFRYILNF LRTSKLLIPD
110 120 130 140 150
DFKDYTLLYE EAKYFQLQPM LLEMERWKQD RETSRFSRPC ECLVVRVAPD
160 170 180 190 200
LGERITLSGD KSLIEEVFPE IGDVMCNSVN AGWNHDSTHV IRFPLNGYCH
210 220 230 240 250
LNSVQVLERL QQRGFEIVGS CGGGVDSSQF SEYVLRRELR RTPRVPSVIR

IKQEPLD
Length:257
Mass (Da):29,435
Last modified:July 25, 2006 - v2
Checksum:i050E3341FA2813A6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti250R → W in AAL86414 (PubMed:12878178).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03109459 Genomic DNA No translation available.
AABR03110870 Genomic DNA No translation available.
AABR03110947 Genomic DNA No translation available.
AF473845 mRNA Translation: AAL86414.1
UniGeneiRn.27416

Similar proteinsi

Entry informationi

Entry nameiKCTD1_RAT
AccessioniPrimary (citable) accession number: Q8R4G8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: May 23, 2018
This is version 82 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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