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Protein

Mas-related G-protein coupled receptor member X1

Gene

Mrgprx1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Orphan receptor activated by neuropeptides terminating in Arg-Phe or Arg-Phe-amide. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. May regulate the function of nociceptive neurons by modulation of pain perception (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Mas-related G-protein coupled receptor member X1
Alternative name(s):
Sensory neuron-specific G-protein coupled receptor 1
Gene namesi
Name:Mrgprx1
Synonyms:Mrgc, Mrgprc, Mrgprc11, Snsr, Snsr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi632284 Mrgprx1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 30ExtracellularSequence analysisAdd BLAST30
Transmembranei31 – 51Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini52 – 59CytoplasmicSequence analysis8
Transmembranei60 – 80Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini81 – 100ExtracellularSequence analysisAdd BLAST20
Transmembranei101 – 121Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini122 – 143CytoplasmicSequence analysisAdd BLAST22
Transmembranei144 – 164Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini165 – 180ExtracellularSequence analysisAdd BLAST16
Transmembranei181 – 201Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini202 – 226CytoplasmicSequence analysisAdd BLAST25
Transmembranei227 – 247Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini248 – 258ExtracellularSequence analysisAdd BLAST11
Transmembranei259 – 279Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini280 – 323CytoplasmicSequence analysisAdd BLAST44

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3341575

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701091 – 323Mas-related G-protein coupled receptor member X1Add BLAST323

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi16N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8R4G1
PRIDEiQ8R4G1

Expressioni

Tissue specificityi

Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons. Associated preferentially with IB4 class of small-diameter somatosensory afferents (also known as nociceptors).2 Publications

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019061

Structurei

3D structure databases

ProteinModelPortaliQ8R4G1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Mas subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9NM Eukaryota
ENOG4111AUB LUCA
HOGENOMiHOG000015412
HOVERGENiHBG003592
InParanoidiQ8R4G1
KOiK08396
PhylomeDBiQ8R4G1
TreeFamiTF336336

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR026234 MRGPCRFAMILY
PANTHERiPTHR11334 PTHR11334, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR02108 MRGPCRFAMILY
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8R4G1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPTISSLST ESTTLNKTGH PSCRPILTLS FLVPIITLLG LAGNTIVLWL
60 70 80 90 100
LGFRMRRKAI SVYVLNLSLA DSFFLCCHFI DSLMRIMNFY GIYAHKLSKE
110 120 130 140 150
ILGNAAIIPY ISGLSILSAI STERCLSVLW PIWYHCHRPR NMSAIICVLI
160 170 180 190 200
WVLSFLMGIL DWFFSGFLGE THHHLWKNVD FIVTAFLIFL FMLLFGSSLA
210 220 230 240 250
LLVRILCGSR RKPLSRLYVT ISLTVMVYLI CGLPLGLYLF LLYWFGIHLH
260 270 280 290 300
YPFCHIYQVT VLLSCVNSSA NPIIYFLVGS FRHRKKHRSL KMVLKRALEE
310 320
TPEEDEYTDS HVQKPTEISE RRC
Length:323
Mass (Da):37,074
Last modified:July 19, 2004 - v3
Checksum:i40DE6E2C6420EE4B
GO

Sequence cautioni

The sequence AAL86877 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti105 – 107AAI → VAF in AAQ08317 (PubMed:12909716).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF474986 Genomic DNA Translation: AAL86877.2 Different initiation.
AF518245 Genomic DNA Translation: AAQ08317.1
RefSeqiNP_001002286.1, NM_001002286.1
NP_750845.2, NM_172158.2
XP_017444332.1, XM_017588843.1
UniGeneiRn.138128

Genome annotation databases

GeneIDi282547
404646
KEGGirno:282547
rno:404646
UCSCiRGD:632284 rat

Similar proteinsi

Entry informationi

Entry nameiMRGX1_RAT
AccessioniPrimary (citable) accession number: Q8R4G1
Secondary accession number(s): Q7TN42
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: May 23, 2018
This is version 101 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

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