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Q8R4E4

- MYOZ3_MOUSE

UniProt

Q8R4E4 - MYOZ3_MOUSE

Protein

Myozenin-3

Gene

Myoz3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.

    GO - Molecular functioni

    1. protein binding Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myozenin-3
    Alternative name(s):
    Calsarcin-3
    FATZ-related protein 3
    Gene namesi
    Name:Myoz3Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:2179296. Myoz3.

    Subcellular locationi

    CytoplasmmyofibrilsarcomereZ line 1 Publication
    Note: Localized at the Z-line of skeletal muscle.

    GO - Cellular componenti

    1. Z disc Source: MGI

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 245245Myozenin-3PRO_0000111103Add
    BLAST

    Proteomic databases

    MaxQBiQ8R4E4.
    PRIDEiQ8R4E4.

    PTM databases

    PhosphoSiteiQ8R4E4.

    Expressioni

    Tissue specificityi

    Expressed specifically in skeletal muscle and is enriched in fast-twitch muscle fibers. Not detected in heart.1 Publication

    Gene expression databases

    CleanExiMM_MYOZ3.
    GenevestigatoriQ8R4E4.

    Interactioni

    Subunit structurei

    Interacts with ACTN2, LDB3, FLNC, PPP3CA and TCAP.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000063108.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni50 – 6718Binding to ACTN2, PPP3CA and TCAPBy similarityAdd
    BLAST
    Regioni67 – 10842Binding to FLNCBy similarityAdd
    BLAST
    Regioni180 – 20122Binding to ACTN2By similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the myozenin family.Curated

    Phylogenomic databases

    eggNOGiNOG41196.
    HOGENOMiHOG000030910.
    HOVERGENiHBG071289.
    InParanoidiQ8R4E4.
    PhylomeDBiQ8R4E4.

    Family and domain databases

    InterProiIPR008438. MYOZ.
    [Graphical view]
    PANTHERiPTHR15941. PTHR15941. 1 hit.
    PfamiPF05556. Calsarcin. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8R4E4-1 [UniParc]FASTAAdd to Basket

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    MIPKEQKEPV MAVPGDLAEP VPSLDLGKKL SVPQDLMIEE LSLRNNRGSL    50
    LFQKRQRRVQ KFTFELSESL QAILASSARG KVAGRAAQAT VPNGLEEQNH 100
    HSETHVFQGS PGDPGITHLG AAGTGSVRSP SALAPGYAEP LKGVPPEKFN 150
    HTAIPKGYRC PWQEFTSYQD YSSGSRSHTP IPRDYRNFNK TPVPFGGPHV 200
    REAIFHAGTP FVPESFSGLE LLRLRPNFNR VAQGWVRKLP ESEEL 245
    Length:245
    Mass (Da):26,982
    Last modified:June 1, 2002 - v1
    Checksum:iCF3FB6C4114FF03E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF480442 mRNA. Translation: AAL79335.1.
    BC104046 mRNA. Translation: AAI04047.1.
    BC104047 mRNA. Translation: AAI04048.1.
    CCDSiCCDS29273.1.
    RefSeqiNP_579941.2. NM_133363.3.
    UniGeneiMm.159257.

    Genome annotation databases

    GeneIDi170947.
    KEGGimmu:170947.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF480442 mRNA. Translation: AAL79335.1 .
    BC104046 mRNA. Translation: AAI04047.1 .
    BC104047 mRNA. Translation: AAI04048.1 .
    CCDSi CCDS29273.1.
    RefSeqi NP_579941.2. NM_133363.3.
    UniGenei Mm.159257.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000063108.

    PTM databases

    PhosphoSitei Q8R4E4.

    Proteomic databases

    MaxQBi Q8R4E4.
    PRIDEi Q8R4E4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 170947.
    KEGGi mmu:170947.

    Organism-specific databases

    CTDi 91977.
    MGIi MGI:2179296. Myoz3.

    Phylogenomic databases

    eggNOGi NOG41196.
    HOGENOMi HOG000030910.
    HOVERGENi HBG071289.
    InParanoidi Q8R4E4.
    PhylomeDBi Q8R4E4.

    Miscellaneous databases

    NextBioi 370536.
    PROi Q8R4E4.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_MYOZ3.
    Genevestigatori Q8R4E4.

    Family and domain databases

    InterProi IPR008438. MYOZ.
    [Graphical view ]
    PANTHERi PTHR15941. PTHR15941. 1 hit.
    Pfami PF05556. Calsarcin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins."
      Frey N., Olson E.N.
      J. Biol. Chem. 277:13998-14004(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Strain: BALB/cImported.
      Tissue: Skeletal muscleImported.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiMYOZ3_MOUSE
    AccessioniPrimary (citable) accession number: Q8R4E4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3