Q8R4E4 (MYOZ3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Myozenin-3

Alternative name(s):
Calsarcin-3
FATZ-related protein 3

Gene names

Name:

Myoz3

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	245 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis. Ref.1
Subunit structure	Interacts with ACTN2, LDB3, FLNC, PPP3CA and TCAP By similarity. UniProtKB Q8TDC0
Subcellular location	Cytoplasm › myofibril › sarcomere › Z line. Note: Localized at the Z-line of skeletal muscle. Ref.1
Tissue specificity	Expressed specifically in skeletal muscle and is enriched in fast-twitch muscle fibers. Not detected in heart. Ref.1
Sequence similarities	Belongs to the myozenin family.

Ontologies

Keywords
Cellular component	Cytoplasm
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	Z disc Inferred from direct assay Ref.1. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 245	245	Myozenin-3		PRO_0000111103
Regions
	Region	50 – 67	18	Binding to ACTN2, PPP3CA and TCAP By similarity UniProtKB Q8TDC0
	Region	67 – 108	42	Binding to FLNC By similarity UniProtKB Q8TDC0
	Region	180 – 201	22	Binding to ACTN2 By similarity UniProtKB Q8TDC0

Sequences

	Sequence		Length	Mass (Da)
	Q8R4E4 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: CF3FB6C4114FF03E	FASTA	245	26,982
	10 20 30 40 50 60 MIPKEQKEPV MAVPGDLAEP VPSLDLGKKL SVPQDLMIEE LSLRNNRGSL LFQKRQRRVQ 70 80 90 100 110 120 KFTFELSESL QAILASSARG KVAGRAAQAT VPNGLEEQNH HSETHVFQGS PGDPGITHLG 130 140 150 160 170 180 AAGTGSVRSP SALAPGYAEP LKGVPPEKFN HTAIPKGYRC PWQEFTSYQD YSSGSRSHTP 190 200 210 220 230 240 IPRDYRNFNK TPVPFGGPHV REAIFHAGTP FVPESFSGLE LLRLRPNFNR VAQGWVRKLP ESEEL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins." Frey N., Olson E.N. J. Biol. Chem. 277:13998-14004(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Strain: BALB/c. Tissue: Skeletal muscle.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF480442 mRNA. Translation: AAL79335.1. BC104046 mRNA. Translation: AAI04047.1. BC104047 mRNA. Translation: AAI04048.1.
IPI	IPI00153879.
RefSeq	NP_579941.2. NM_133363.3.
UniGene	Mm.159257.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000063108.
PTM databases
PhosphoSite	Q8R4E4.
Proteomic databases
PRIDE	Q8R4E4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	170947.
KEGG	mmu:170947.
UCSC	uc012bdl.1. mouse.
Organism-specific databases
CTD	91977.
MGI	MGI:2179296. Myoz3.
Phylogenomic databases
eggNOG	NOG41196.
HOGENOM	HOG000030910.
HOVERGEN	HBG071289.
InParanoid	Q8R4E4.
OrthoDB	EOG4TMR2W.
Gene expression databases
CleanEx	MM_MYOZ3.
Genevestigator	Q8R4E4.
GermOnline	ENSMUSG00000049173. Mus musculus.
Family and domain databases
InterPro	IPR008438. Calsarcin-bd. [Graphical view]
PANTHER	PTHR15941. PTHR15941. 1 hit.
Pfam	PF05556. Calsarcin. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	370536.
SOURCE	Search...

Entry information

Entry name

MYOZ3_MOUSE

Accession

Primary (citable) accession number: Q8R4E4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	June 1, 2002
Last modified:	April 3, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program