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Protein

Myozenin-3

Gene

Myoz3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Myozenin-3
Alternative name(s):
Calsarcin-3
FATZ-related protein 3
Gene namesi
Name:Myoz3Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2179296. Myoz3.

Subcellular locationi

  • CytoplasmmyofibrilsarcomereZ line 1 Publication

  • Note: Localized at the Z-line of skeletal muscle.

GO - Cellular componenti

  • Z disc Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 245245Myozenin-3PRO_0000111103Add
BLAST

Proteomic databases

MaxQBiQ8R4E4.
PRIDEiQ8R4E4.

PTM databases

PhosphoSiteiQ8R4E4.

Expressioni

Tissue specificityi

Expressed specifically in skeletal muscle and is enriched in fast-twitch muscle fibers. Not detected in heart.1 Publication

Gene expression databases

CleanExiMM_MYOZ3.
GenevestigatoriQ8R4E4.

Interactioni

Subunit structurei

Interacts with ACTN2, LDB3, FLNC, PPP3CA and TCAP.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063108.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni50 – 6718Binding to ACTN2, PPP3CA and TCAPBy similarityAdd
BLAST
Regioni67 – 10842Binding to FLNCBy similarityAdd
BLAST
Regioni180 – 20122Binding to ACTN2By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the myozenin family.Curated

Phylogenomic databases

eggNOGiNOG41196.
HOGENOMiHOG000030910.
HOVERGENiHBG071289.
InParanoidiQ8R4E4.
PhylomeDBiQ8R4E4.

Family and domain databases

InterProiIPR008438. MYOZ.
[Graphical view]
PANTHERiPTHR15941. PTHR15941. 1 hit.
PfamiPF05556. Calsarcin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R4E4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPKEQKEPV MAVPGDLAEP VPSLDLGKKL SVPQDLMIEE LSLRNNRGSL
60 70 80 90 100
LFQKRQRRVQ KFTFELSESL QAILASSARG KVAGRAAQAT VPNGLEEQNH
110 120 130 140 150
HSETHVFQGS PGDPGITHLG AAGTGSVRSP SALAPGYAEP LKGVPPEKFN
160 170 180 190 200
HTAIPKGYRC PWQEFTSYQD YSSGSRSHTP IPRDYRNFNK TPVPFGGPHV
210 220 230 240
REAIFHAGTP FVPESFSGLE LLRLRPNFNR VAQGWVRKLP ESEEL
Length:245
Mass (Da):26,982
Last modified:June 1, 2002 - v1
Checksum:iCF3FB6C4114FF03E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF480442 mRNA. Translation: AAL79335.1.
BC104046 mRNA. Translation: AAI04047.1.
BC104047 mRNA. Translation: AAI04048.1.
CCDSiCCDS29273.1.
RefSeqiNP_579941.2. NM_133363.3.
UniGeneiMm.159257.

Genome annotation databases

GeneIDi170947.
KEGGimmu:170947.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF480442 mRNA. Translation: AAL79335.1.
BC104046 mRNA. Translation: AAI04047.1.
BC104047 mRNA. Translation: AAI04048.1.
CCDSiCCDS29273.1.
RefSeqiNP_579941.2. NM_133363.3.
UniGeneiMm.159257.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063108.

PTM databases

PhosphoSiteiQ8R4E4.

Proteomic databases

MaxQBiQ8R4E4.
PRIDEiQ8R4E4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi170947.
KEGGimmu:170947.

Organism-specific databases

CTDi91977.
MGIiMGI:2179296. Myoz3.

Phylogenomic databases

eggNOGiNOG41196.
HOGENOMiHOG000030910.
HOVERGENiHBG071289.
InParanoidiQ8R4E4.
PhylomeDBiQ8R4E4.

Miscellaneous databases

NextBioi370536.
PROiQ8R4E4.
SOURCEiSearch...

Gene expression databases

CleanExiMM_MYOZ3.
GenevestigatoriQ8R4E4.

Family and domain databases

InterProiIPR008438. MYOZ.
[Graphical view]
PANTHERiPTHR15941. PTHR15941. 1 hit.
PfamiPF05556. Calsarcin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins."
    Frey N., Olson E.N.
    J. Biol. Chem. 277:13998-14004(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: BALB/cImported.
    Tissue: Skeletal muscleImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiMYOZ3_MOUSE
AccessioniPrimary (citable) accession number: Q8R4E4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: June 1, 2002
Last modified: January 7, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.