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Q8R4E4

- MYOZ3_MOUSE

UniProt

Q8R4E4 - MYOZ3_MOUSE

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Protein
Myozenin-3
Gene
Myoz3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.1 Publication

GO - Molecular functioni

  1. protein binding Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Myozenin-3
Alternative name(s):
Calsarcin-3
FATZ-related protein 3
Gene namesi
Name:Myoz3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:2179296. Myoz3.

Subcellular locationi

CytoplasmmyofibrilsarcomereZ line
Note: Localized at the Z-line of skeletal muscle.1 Publication

GO - Cellular componenti

  1. Z disc Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 245245Myozenin-3
PRO_0000111103Add
BLAST

Proteomic databases

MaxQBiQ8R4E4.
PRIDEiQ8R4E4.

PTM databases

PhosphoSiteiQ8R4E4.

Expressioni

Tissue specificityi

Expressed specifically in skeletal muscle and is enriched in fast-twitch muscle fibers. Not detected in heart.1 Publication

Gene expression databases

CleanExiMM_MYOZ3.
GenevestigatoriQ8R4E4.

Interactioni

Subunit structurei

Interacts with ACTN2, LDB3, FLNC, PPP3CA and TCAP By similarity.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063108.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni50 – 6718Binding to ACTN2, PPP3CA and TCAP By similarityBy similarity
Add
BLAST
Regioni67 – 10842Binding to FLNC By similarityBy similarity
Add
BLAST
Regioni180 – 20122Binding to ACTN2 By similarityBy similarity
Add
BLAST

Sequence similaritiesi

Belongs to the myozenin family.

Phylogenomic databases

eggNOGiNOG41196.
HOGENOMiHOG000030910.
HOVERGENiHBG071289.
InParanoidiQ8R4E4.
PhylomeDBiQ8R4E4.

Family and domain databases

InterProiIPR008438. MYOZ.
[Graphical view]
PANTHERiPTHR15941. PTHR15941. 1 hit.
PfamiPF05556. Calsarcin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8R4E4-1 [UniParc]FASTAAdd to Basket

« Hide

MIPKEQKEPV MAVPGDLAEP VPSLDLGKKL SVPQDLMIEE LSLRNNRGSL    50
LFQKRQRRVQ KFTFELSESL QAILASSARG KVAGRAAQAT VPNGLEEQNH 100
HSETHVFQGS PGDPGITHLG AAGTGSVRSP SALAPGYAEP LKGVPPEKFN 150
HTAIPKGYRC PWQEFTSYQD YSSGSRSHTP IPRDYRNFNK TPVPFGGPHV 200
REAIFHAGTP FVPESFSGLE LLRLRPNFNR VAQGWVRKLP ESEEL 245
Length:245
Mass (Da):26,982
Last modified:June 1, 2002 - v1
Checksum:iCF3FB6C4114FF03E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF480442 mRNA. Translation: AAL79335.1.
BC104046 mRNA. Translation: AAI04047.1.
BC104047 mRNA. Translation: AAI04048.1.
CCDSiCCDS29273.1.
RefSeqiNP_579941.2. NM_133363.3.
UniGeneiMm.159257.

Genome annotation databases

GeneIDi170947.
KEGGimmu:170947.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF480442 mRNA. Translation: AAL79335.1 .
BC104046 mRNA. Translation: AAI04047.1 .
BC104047 mRNA. Translation: AAI04048.1 .
CCDSi CCDS29273.1.
RefSeqi NP_579941.2. NM_133363.3.
UniGenei Mm.159257.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000063108.

PTM databases

PhosphoSitei Q8R4E4.

Proteomic databases

MaxQBi Q8R4E4.
PRIDEi Q8R4E4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 170947.
KEGGi mmu:170947.

Organism-specific databases

CTDi 91977.
MGIi MGI:2179296. Myoz3.

Phylogenomic databases

eggNOGi NOG41196.
HOGENOMi HOG000030910.
HOVERGENi HBG071289.
InParanoidi Q8R4E4.
PhylomeDBi Q8R4E4.

Miscellaneous databases

NextBioi 370536.
PROi Q8R4E4.
SOURCEi Search...

Gene expression databases

CleanExi MM_MYOZ3.
Genevestigatori Q8R4E4.

Family and domain databases

InterProi IPR008438. MYOZ.
[Graphical view ]
PANTHERi PTHR15941. PTHR15941. 1 hit.
Pfami PF05556. Calsarcin. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins."
    Frey N., Olson E.N.
    J. Biol. Chem. 277:13998-14004(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: BALB/c.
    Tissue: Skeletal muscle.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiMYOZ3_MOUSE
AccessioniPrimary (citable) accession number: Q8R4E4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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