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Q8R4E4 (MYOZ3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Myozenin-3
Alternative name(s):
Calsarcin-3
FATZ-related protein 3
Gene names
Name:Myoz3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length245 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis. Ref.1

Subunit structure

Interacts with ACTN2, LDB3, FLNC, PPP3CA and TCAP By similarity. UniProtKB Q8TDC0

Subcellular location

CytoplasmmyofibrilsarcomereZ line. Note: Localized at the Z-line of skeletal muscle. Ref.1

Tissue specificity

Expressed specifically in skeletal muscle and is enriched in fast-twitch muscle fibers. Not detected in heart. Ref.1

Sequence similarities

Belongs to the myozenin family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentZ disc

Inferred from direct assay Ref.1. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 245245Myozenin-3
PRO_0000111103

Regions

Region50 – 6718Binding to ACTN2, PPP3CA and TCAP By similarity UniProtKB Q8TDC0
Region67 – 10842Binding to FLNC By similarity UniProtKB Q8TDC0
Region180 – 20122Binding to ACTN2 By similarity UniProtKB Q8TDC0

Sequences

Sequence LengthMass (Da)Tools
Q8R4E4 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: CF3FB6C4114FF03E

FASTA24526,982
        10         20         30         40         50         60 
MIPKEQKEPV MAVPGDLAEP VPSLDLGKKL SVPQDLMIEE LSLRNNRGSL LFQKRQRRVQ 

        70         80         90        100        110        120 
KFTFELSESL QAILASSARG KVAGRAAQAT VPNGLEEQNH HSETHVFQGS PGDPGITHLG 

       130        140        150        160        170        180 
AAGTGSVRSP SALAPGYAEP LKGVPPEKFN HTAIPKGYRC PWQEFTSYQD YSSGSRSHTP 

       190        200        210        220        230        240 
IPRDYRNFNK TPVPFGGPHV REAIFHAGTP FVPESFSGLE LLRLRPNFNR VAQGWVRKLP 


ESEEL 

« Hide

References

« Hide 'large scale' references
[1]"Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins."
Frey N., Olson E.N.
J. Biol. Chem. 277:13998-14004(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Strain: BALB/c.
Tissue: Skeletal muscle.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF480442 mRNA. Translation: AAL79335.1.
BC104046 mRNA. Translation: AAI04047.1.
BC104047 mRNA. Translation: AAI04048.1.
RefSeqNP_579941.2. NM_133363.3.
UniGeneMm.159257.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000063108.

PTM databases

PhosphoSiteQ8R4E4.

Proteomic databases

PRIDEQ8R4E4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID170947.
KEGGmmu:170947.

Organism-specific databases

CTD91977.
MGIMGI:2179296. Myoz3.

Phylogenomic databases

eggNOGNOG41196.
HOGENOMHOG000030910.
HOVERGENHBG071289.
InParanoidQ8R4E4.
PhylomeDBQ8R4E4.

Gene expression databases

CleanExMM_MYOZ3.
GenevestigatorQ8R4E4.

Family and domain databases

InterProIPR008438. MYOZ.
[Graphical view]
PANTHERPTHR15941. PTHR15941. 1 hit.
PfamPF05556. Calsarcin. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio370536.
PROQ8R4E4.
SOURCESearch...

Entry information

Entry nameMYOZ3_MOUSE
AccessionPrimary (citable) accession number: Q8R4E4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: June 1, 2002
Last modified: April 16, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot